Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and β cell glucokinase genes: Genetic reconstitution of diabetes as a polygenic disease

Journal of Clinical Investigation

Volumn 99, Issue 5, 1997, Pages 861-866

  Terauchi, Yasuo ^a   Iwamoto, Keiji ^a   Tamemoto, Hiroyuki ^a   Komeda, Kajuro ^b   Ishii, Chikara ^c   Kanazawa, Yasunori ^d   Asanuma, Nahoko ^e   Aizawa, Toru ^e   Akanuma, Yasuo ^f   Yasuda, Kazuki ^f   Kodama, Tatsuhiko ^g   Tobe, Kazuyuki ^a   Yazaki, Yoshio ^a   Kadowaki, Takashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

^d JICHI MEDICAL UNIVERSITY   (Japan)

^e SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f INSTITUTE FOR ADULT DISEASES   (Japan)

^g UNIVERSITY OF TOKYO   (Japan)

Author keywords

glucokinase; insulin receptor substrate 1; insulin resistance; insulin secretory dysfunction; non insulin dependent diabetes mellitus

Indexed keywords

GLUCOKINASE; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN RESISTANCE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL HYPERPLASIA; PRIORITY JOURNAL;

EID: 0030961962     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119250     Document Type: Article

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