Diabetes and pancreatic tumours in transgenic mice expressing Pa x 6

Diabetologia

Volumn 43, Issue 3, 2000, Pages 332-339

  Yamaoka, T ^a   Yano, M ^a   Yamada, T ^b   Matsushita, T ^a   Moritani, M ^a   Ii, S ^a   Yoshimoto, K ^a   Hata, J ^b   Itakura, M ^c  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Cell differentiation; Diabetes mellitus; Embryology; Islets of Langerhans; Transcription factors

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; DIABETES MELLITUS; EMBRYOLOGY; FEMALE; MALE; MOUSE; NONHUMAN; PANCREAS CELL; PANCREAS ISLET; PANCREAS TUMOR; PRIORITY JOURNAL;

ANIMALS; CYSTADENOMA; CYSTS; DIABETES MELLITUS; DNA-BINDING PROTEINS; EYE PROTEINS; GENE EXPRESSION; HOMEODOMAIN PROTEINS; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; ORGAN SIZE; PAIRED BOX TRANSCRIPTION FACTORS; PANCREAS; PANCREATIC DISEASES; PANCREATIC NEOPLASMS; PHENOTYPE; REPRESSOR PROTEINS;

EID: 2142856418     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050051     Document Type: Article

References (35)

1. 1. Yamaoka T, Itakura M (1999) Development of pancreatic islets. Int J Mol Med 3: 247-261
2. 2. Jun S, Desplan C (1996) Cooperative interactions between paired domain and homeodomain. Development 22: 2639-2650
3. 3. Hill RE, Favor J, Hogan BL et al. (1991) Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature 354: 552-555
4. 4. Halder G, Callaerts P, Gehring WJ (1995) Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 265: 785-789
5. 5. Jordan T, Hanson I, Zaletayev D et al. (1992) The human PAX6 gene is mutated in two patients with aniridia. Nat Genet 1: 328-332
6. 6. Walther C, Gruss P (1992) Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113: 1435-1449
7. 7. Turque N, Plaza S, Radvanyi F, Carriere C, Saule S (1994) Pax-QNR/Pax, a paired box-and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells. Mol Endocrinol 8: 929-938
8. 8. Sander M, Neubuser A, Kalamaras J et al. (1997) Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev 11: 1662-1673
9. 9. Glaser T, Walton DS, Maas RL (1992) Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene. Nat Genet 2: 232-239
10. 10. Mirzayans F, Pearce WG, MacDonald IM, Walter MA (1995) Mutation of the PAX6 gene in patients with autosomal dominant keratitis. Am J Hum Genet 57: 539-548
11. 11. St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P (1997) Pa × 6 is required for differentiation of glucagon-producing α-cells in mouse pancreas. Nature 387: 406-409
12. 12. Balczarek KA, Lai ZC, Kumar S (1997) Evolution of functional diversification of the paired box (Pax) DNA-binding domains. Mol Biol Evol 14: 829-842
13. 13. Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P (1997) The Pa × 4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas. Nature 386: 399-402
14. 14. Apelqvist A, Ahlgren U, Edlund H (1997) Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol 7: 801-804.
15. 15. Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371: 606-609
16. 16. Ahlgren U, Jonsson J, Edlund H (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF/PDX1-deficient mice. Development 122: 1409-1416
17. 17. Yamaoka T, Idehara C, Yano M et al. (1998) Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants. J Clin Invest 102: 294-301
18. 18. Yamaoka T, Nishimura C, Yamashita K et al. (1995) Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA. Diabetologia 38: 255-261
19. 19. Moritani M, Yoshimoto K, Ii S et al. (1996) Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. J Clin Invest 98: 1851-1859
20. 20. Yamada T, Brunstedt J, Solomon T (1983) Chronic effects of caerulein and secretin on the endocrine pancreas of the rat. Am J Physiol 244: G541-G545
21. 21. Hoist BD, Wang Y, Jones FS, Edelman GM (1997) A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord. Proc Natl Acad Sci USA 94: 1465-1470
22. 22. Schedl A, Ross A, Lee M et al. (1996) Influence of PAX6 gene dosage on development: Overexpression causes severe eye abnormalities. Cell 86: 71-82
23. 23. Maulbecker CC, Gruss P (1993) The oncogenic potential of Pax genes. EMBO J 12: 2361-2367
24. 24. Hanahan D (1985) Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/ simian virus 40 oncogenes. Nature 315: 115-122
25. 25. Kalousova A, Benes V, Paces J, Paces V, Kozmik Z (1999) DNA binding and transactivating properties of the paired and homeobox protein pa × 4. Biochem Biophys Res Commun 259: 510-518
26. 26. Fujitani Y, Kajimoto Y, Yasuda T et al. (1999) Identification of a portable repression domain and an E1A-responsive activation domain in Pa × 4:a possible role of Pa × 4 as a transcriptional represser in the pancreas. Mol Cell Biol 19: 8281-8291
27. 27. Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H (1998) β-cell-specific inactivation of the mouse Ipf1/Pd × 1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev 12: 1763-1768
28. 28. Evan GI, Wyllie AH, Gilbert CS et al. (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119-128
29. 29. Fanidi A, Harrington EA, Evan GI (1992) Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature 359: 554-556
30. 30. Bissonnette RP, Echeverri F, Mahboubi A, Green DR (1992) Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359: 552-554
31. 31. Qin XQ, Livingston DM, Kaelin WG Jr, Adams PD (1994) Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci USA 91: 10918-10922
32. 32. Wu X, Levine AJ (1994) p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA 91: 3602-3606
33. 33. Fueyo J, Gomez-Manzano C, Yung WK et al. (1998) Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. Nat Med 4: 685-690
34. 34. Hermeking H, Eick D (1994) Mediation of c-Myc-induced apoptosis by p53. Science 265: 2091-2093
35. 35. Wagner AJ, Kokontis JM, Hay N (1994) Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/ cip1. Genes Dev 8: 2817-2830