Association of the Pro12Ala variant in the peroxisome proliferator- activated receptor-γ2 gene with obesity in two Caucasian populations

Diabetes

Volumn 47, Issue 11, 1998, Pages 1806-1808

  Beamer, Brock A ^a   Yen, Chung Jen ^a   Andersen, Ross E ^a   Muller, Denis ^b   Elahi, Dariush ^b,d   Cheskin, Lawrence J ^a   Andres, Reubin ^b   Roth, Jesse ^a   Shuldiner, Alan R ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

ADULT; ARTICLE; BODY MASS; CAUCASIAN; FEMALE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; OBESITY; POPULATION RESEARCH; PRIORITY JOURNAL;

ADIPOSE TISSUE; ANIMALS; COHORT STUDIES; HUMANS; MICE; MUSCLE, SKELETAL; MUTATION; OBESITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROLINE; PROSPECTIVE STUDIES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0031667127     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.11.1806     Document Type: Article

References (10)

1. Spiegelman BM: PPAR-γ: adipogenic regulator and thiazolidinedione receptor. Diabetes 47:507-514, 1998
2. Park KS, Ciaraldi TP, Abrams-Carter L, Mudaliar S, Nikoulina SE, Henry RR: PPAR-γ gene expression is elevated in skeletal muscle of obese and type II diabetic subjects. Diabetes 46:1230-1234, 1997
3. Vidal-Puig AJ, Considine RV, Jimenez-Linan M, Werman A, Pories WJ, Caro JF, Flier JS: Peroxisome proliferator-activated receptor gene expression in human tissues: effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 99:2416-2422, 1997
4. Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, Staels B, Auwerx J, Laville M, Vidal H: Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 46:1319-1327, 1997
5. Lefebvre A, Laville M, Vega N, Riou JP, van Gaal L, Auwerx J, Vidal H: Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 47:98-103, 1998
6. Hallakou S, Doare L, Foufelle F, Kergoat M, Guerre-Millo M, Berthault MF, Dugail I, Morin J, Auwerx J, Ferre P: Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat. Diabetes 46:1393-1399, 1997
7. Okuna A, Tamemoto H, Tobe K, Ueki K, Mori Y, Iwamoto K, Umesono K, Akanuma Y, Fujiwara T, Horikoshi H, Yazaki Y, Kadowaki T: Troglitazone increases the number of small adipocytes without the change of white adipose mass in obese Zucker rats. J Clin Invest 101:1354-1361, 1998
8. Elbrecht A, Chen Y, Cullinan CA, Hayes N, Leibowitz MD, Moller DE, Berger J: Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2. Biochem Biophys Res Commun 224:431-437, 1996
9. Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal-Puig AJ, Flier JS: Ligand-independent activation domain in the N-terminus of peroxisome proliferator-activated receptor γ: differential activity of PPARγ-1 and -2 isoforms and influence of insulin. J Biol Chem 272:20230-20235, 1997
10. 2 missense mutation. Biochem Biophys Res Commun 241:270-274, 1997