The Gly972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β cells

Journal of Clinical Investigation

Volumn 104, Issue 3, 1999, Pages 357-364

  Porzio, Ottavia ^a   Federici, Massimo ^a   Hribal, Marta Letizia ^a   Lauro, Davide ^b   Accili, Domenico ^b   Lauro, Renato ^a   Borboni, Patrizia ^a   Sesti, Giorgio ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; ARGININE; GLUCOSE; GLYCINE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE 2 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; RECOMBINANT PROTEIN; SIGNAL PEPTIDE; SULFONYLUREA DERIVATIVE; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INSULIN DEFICIENCY; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; ENZYME SPECIFICITY; ENZYMOLOGY; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENETICS; INSULINOMA; INTRACELLULAR FLUID; METABOLISM; PANCREAS ISLET; PHOSPHORYLATION; RAT; SECRETION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; GLUCOSE; GLYCINE; HUMANS; INSULIN; INSULINOMA; INTRACELLULAR FLUID; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; PHOSPHOPROTEINS; PHOSPHORYLATION; POLYMORPHISM, GENETIC; RATS; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; RNA, MESSENGER; SUBSTRATE SPECIFICITY; SULFONYLUREA COMPOUNDS; TRANSFECTION; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0032587076     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5870     Document Type: Article

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