메뉴 건너뛰기




Volumn 12, Issue 12, 1998, Pages 1763-1768

β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

Author keywords

Diabetes; Glucose sensing; Hormone production; Ipf1 Pdx1; cell specific mutants

Indexed keywords

GLUCAGON; INSULIN;

EID: 0032525981     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.12.1763     Document Type: Article
Times cited : (803)

References (37)
  • 1
    • 0029950724 scopus 로고    scopus 로고
    • Arrested development of the pancreas in IPF1/PDX1 deficient mice reveals that the pancreatic mesenchyme develops independently of the pancreatic epithelium
    • Ahlgren, U., J. Jonsson, and H. Edlund. 1996. Arrested development of the pancreas in IPF1/PDX1 deficient mice reveals that the pancreatic mesenchyme develops independently of the pancreatic epithelium. Development 122: 1409-1416.
    • (1996) Development , vol.122 , pp. 1409-1416
    • Ahlgren, U.1    Jonsson, J.2    Edlund, H.3
  • 2
    • 0031020002 scopus 로고    scopus 로고
    • Independent requirement for ISL1 in the formation of pancreatic mesenchyme and islet cells
    • Ahlgren, U., S.L. Pfaff, T.M. Jessell, T. Edlund, and H. Edlund. 1997. Independent requirement for ISL1 in the formation of pancreatic mesenchyme and islet cells. Nature 385: 257-260.
    • (1997) Nature , vol.385 , pp. 257-260
    • Ahlgren, U.1    Pfaff, S.L.2    Jessell, T.M.3    Edlund, T.4    Edlund, H.5
  • 4
    • 0027264139 scopus 로고
    • Genomic targeting with purified Cre recombinase
    • Baubonis, W. and B. Sauer. 1993 Genomic targeting with purified Cre recombinase. Nucleic Acids Res. 21: 2025-2029.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 2025-2029
    • Baubonis, W.1    Sauer, B.2
  • 5
    • 0029793745 scopus 로고    scopus 로고
    • Cadherins regulate aggregation of pancreatic β-cells in vivo
    • Dahl, U., A. Sjödin, and H. Semb. 1996. Cadherins regulate aggregation of pancreatic β-cells in vivo. Development 122: 2895-2902.
    • (1996) Development , vol.122 , pp. 2895-2902
    • Dahl, U.1    Sjödin, A.2    Semb, H.3
  • 7
    • 0001851123 scopus 로고
    • Differentiation and development of the pancreas in animals
    • ed. V.L.W. Go et al., Raven Press, New York, NY
    • Githens, S. 1993. Differentiation and development of the pancreas in animals. In The pancreas: Biology, pathobiology, and disease (ed. V.L.W. Go et al.), pp. 21-55. Raven Press, New York, NY.
    • (1993) The Pancreas: Biology, Pathobiology, and Disease , pp. 21-55
    • Githens, S.1
  • 8
    • 0028826361 scopus 로고
    • Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis
    • Grupe, A., B. Hultgren, A. Ryan, Y.H. Ma, M. Bauer, and T.A. Stewart. 1995. Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis Cell 83: 69-78.
    • (1995) Cell , vol.83 , pp. 69-78
    • Grupe, A.1    Hultgren, B.2    Ryan, A.3    Ma, Y.H.4    Bauer, M.5    Stewart, T.A.6
  • 9
    • 0027280936 scopus 로고
    • Independent control of immunoglobulin switch recombination at individual swotch regions evidenced through Cre-loxP-mediated targeting
    • Gu, H., Y.-R. Zou, and K. Rajewski. 1993. Independent control of immunoglobulin switch recombination at individual swotch regions evidenced through Cre-loxP-mediated targeting. Cell 73: 1155-1164.
    • (1993) Cell , vol.73 , pp. 1155-1164
    • Gu, H.1    Zou, Y.-R.2    Rajewski, K.3
  • 11
    • 0028869514 scopus 로고
    • Expression of murine STF-1, a putative insulin gene transcription factor, in β-cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    • Guz, Y., M.R. Montminy, R. Stein, J. Leonard, L.W. Gamer, C.V. Wright, and G. Teitelman. 1995. Expression of murine STF-1, a putative insulin gene transcription factor, in β-cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121: 11-18.
    • (1995) Development , vol.121 , pp. 11-18
    • Guz, Y.1    Montminy, M.R.2    Stein, R.3    Leonard, J.4    Gamer, L.W.5    Wright, C.V.6    Teitelman, G.7
  • 13
    • 0029763995 scopus 로고    scopus 로고
    • mRNA profiling of rat islet tumors reveals Nkx6.1 as a β-cell-specific homeodomain transcription factor
    • Jensen, J., P. Serup, C. Karlsen, T. Funder, and O.D. Madsen. 1996. mRNA profiling of rat islet tumors reveals Nkx6.1 as a β-cell-specific homeodomain transcription factor. J. Biol. Chem. 271: 18749-18758.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18749-18758
    • Jensen, J.1    Serup, P.2    Karlsen, C.3    Funder, T.4    Madsen, O.D.5
  • 14
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson, J., L. Carlsson, T. Edlund, and H. Edlund. 1994. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371: 606-609.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 15
    • 0025280050 scopus 로고
    • Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain
    • Karlsson, O., S. Thor, T. Norberg, H. Ohlsson, and T. Edlund. 1990. Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys-His domain. Nature 344: 879-882.
    • (1990) Nature , vol.344 , pp. 879-882
    • Karlsson, O.1    Thor, S.2    Norberg, T.3    Ohlsson, H.4    Edlund, T.5
  • 16
    • 0027422291 scopus 로고
    • Site-specific recombinases: Tools for genome egineering
    • Kilby, N.J., M.R. Snaith, and J.A.H. Murray. 1993. Site-specific recombinases: Tools for genome egineering. Trends Genet. 9: 413-421.
    • (1993) Trends Genet. , vol.9 , pp. 413-421
    • Kilby, N.J.1    Snaith, M.R.2    Murray, J.A.H.3
  • 17
    • 0030726908 scopus 로고    scopus 로고
    • Locus control regions: Overcoming heterochromatin-induced gene inactivation in mammals
    • Kioussis, D. and R. Festenstein. 1997. Locus control regions: Overcoming heterochromatin-induced gene inactivation in mammals. Curr. Opin. Genet. Dev. 5: 614-619.
    • (1997) Curr. Opin. Genet. Dev. , vol.5 , pp. 614-619
    • Kioussis, D.1    Festenstein, R.2
  • 18
    • 0027521060 scopus 로고
    • Gtx: A novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter
    • Komuro, I., M. Schalling, L. Jahn, R. Bodmer, N.A. Jenkins, N.G. Copeland, and S. Izumo. 1993. Gtx: A novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 12: 1387-1401.
    • (1993) EMBO J. , vol.12 , pp. 1387-1401
    • Komuro, I.1    Schalling, M.2    Jahn, L.3    Bodmer, R.4    Jenkins, N.A.5    Copeland, N.G.6    Izumo, S.7
  • 20
    • 0027373441 scopus 로고
    • Characterization of somatostatin transactivating factor-1, a novel homeobox fcator that stimulates somatostatin expression in pancreatic islets
    • Leonard, J., B. Peers, T. Johnson, K. Ferreri, S. Lee, and M.R. Montminy. 1993. Characterization of somatostatin transactivating factor-1, a novel homeobox fcator that stimulates somatostatin expression in pancreatic islets. Mol. Endocrinol. 7: 1275-1283.
    • (1993) Mol. Endocrinol. , vol.7 , pp. 1275-1283
    • Leonard, J.1    Peers, B.2    Johnson, T.3    Ferreri, K.4    Lee, S.5    Montminy, M.R.6
  • 21
    • 0030298416 scopus 로고    scopus 로고
    • The vagaries of variegating transgenes
    • Martin, D.I. and E. Whitelaw. 1996. The vagaries of variegating transgenes. BioEssays 11: 919-923.
    • (1996) BioEssays , vol.11 , pp. 919-923
    • Martin, D.I.1    Whitelaw, E.2
  • 22
    • 0028314969 scopus 로고
    • IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
    • Miller, C.P., R.E. McGehee, Jr., and J.F. Habener. 1994. IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J. 13: 1145-1158.
    • (1994) EMBO J. , vol.13 , pp. 1145-1158
    • Miller, C.P.1    McGehee Jr., R.E.2    Habener, J.F.3
  • 24
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson, H., K. Karlsson, and T. Edlund. 1993. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 12: 4251-4259.
    • (1993) EMBO J. , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 25
    • 0030927342 scopus 로고    scopus 로고
    • The β-cell transcription factors and development of the pancreas
    • Sander, M. and M.S. German. 1997. The β-cell transcription factors and development of the pancreas. J. Mol. Med. 75: 327-340.
    • (1997) J. Mol. Med. , vol.75 , pp. 327-340
    • Sander, M.1    German, M.S.2
  • 26
    • 0025360095 scopus 로고
    • Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase
    • Sauer, B. and N. Henderson. 1990. Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase. New Biol. 2: 441-449.
    • (1990) New Biol. , vol.2 , pp. 441-449
    • Sauer, B.1    Henderson, N.2
  • 27
    • 0029166081 scopus 로고
    • The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site
    • Serup, P., H.V. Petersen, E.E. Pedersen, H. Edlund, J. Leonard, J.S. Petersen, L.I. Larsson, and O.D. Madsen. 1995. The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site. Biochem. J. 310: 997-1003.
    • (1995) Biochem. J. , vol.310 , pp. 997-1003
    • Serup, P.1    Petersen, H.V.2    Pedersen, E.E.3    Edlund, H.4    Leonard, J.5    Petersen, J.S.6    Larsson, L.I.7    Madsen, O.D.8
  • 28
    • 0030897629 scopus 로고    scopus 로고
    • The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
    • Sosa-Pineda, B., K. Chowdhury, M. Torres, G. Oliver, and P. Gruss. 1997. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature 386: 399-402.
    • (1997) Nature , vol.386 , pp. 399-402
    • Sosa-Pineda, B.1    Chowdhury, K.2    Torres, M.3    Oliver, G.4    Gruss, P.5
  • 29
    • 0030914931 scopus 로고    scopus 로고
    • Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas
    • St-Onge, L., B. Sosa-Pineda, K. Chowdhury, A. Mansouri, and P. Gruss. 1997. Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature 387: 406-409.
    • (1997) Nature , vol.387 , pp. 406-409
    • St-Onge, L.1    Sosa-Pineda, B.2    Chowdhury, K.3    Mansouri, A.4    Gruss, P.5
  • 30
    • 0031031571 scopus 로고    scopus 로고
    • Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
    • Stoffers, D.A., N.T. Zinkin, V. Stanojevic, W.L. Clarke, and I.F. Habener. 1997a. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nature Genet. 15: 106-110.
    • (1997) Nature Genet. , vol.15 , pp. 106-110
    • Stoffers, D.A.1    Zinkin, N.T.2    Stanojevic, V.3    Clarke, W.L.4    Habener, I.F.5
  • 31
    • 0031253820 scopus 로고    scopus 로고
    • Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
    • Stoffers, D.A., J. Ferrer, W.L. Clarke, and J.F. Habener. 1997b. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nature Genet. 17: 138-139.
    • (1997) Nature Genet. , vol.17 , pp. 138-139
    • Stoffers, D.A.1    Ferrer, J.2    Clarke, W.L.3    Habener, J.F.4
  • 32
    • 0029311276 scopus 로고
    • Induction of motor neurons by sonic hedgehog is independent of floor plate differentiation
    • Tanabe, Y., H. Roelink, and T.M. Jessell. 1995. Induction of motor neurons by sonic hedgehog is independent of floor plate differentiation. Curr. Biol. 5: 651-658.
    • (1995) Curr. Biol. , vol.5 , pp. 651-658
    • Tanabe, Y.1    Roelink, H.2    Jessell, T.M.3
  • 33
    • 0026335927 scopus 로고
    • The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat
    • Thor, S., J. Ericson, T. Brännström, and T. Edlund. 1991. The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. Neuron 7: 881-889.
    • (1991) Neuron , vol.7 , pp. 881-889
    • Thor, S.1    Ericson, J.2    Brännström, T.3    Edlund, T.4
  • 35
    • 0030457705 scopus 로고    scopus 로고
    • Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor
    • Waeber, G., N. Thompson, P. Nicod, and C. Bonny. 1996. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol. Endocrinol. 10: 1327-1334.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 1327-1334
    • Waeber, G.1    Thompson, N.2    Nicod, P.3    Bonny, C.4
  • 36
    • 0029909387 scopus 로고    scopus 로고
    • The human glucokinase gene β-cell-type promoter: An essential role of insulin promoter factor 1/PDX-1 in its activation in Hit-T15 cells
    • Watada, H., Y. Kajimoto, Y. Umayahara, T. Matsuoka, H. Kaneto, Y. Fujitani, T. Kamada, R. Kawamori, and Y. Yamasaki. 1996a. The human glucokinase gene β-cell-type promoter: An essential role of insulin promoter factor 1/PDX-1 in its activation in Hit-T15 cells. Diabetes 45: 1478-1488.
    • (1996) Diabetes , vol.45 , pp. 1478-1488
    • Watada, H.1    Kajimoto, Y.2    Umayahara, Y.3    Matsuoka, T.4    Kaneto, H.5    Fujitani, Y.6    Kamada, T.7    Kawamori, R.8    Yamasaki, Y.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.