Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells

Development

Volumn 125, Issue 12, 1998, Pages 2213-2221

  Sussel, L ^a   Kalamaras, J ^a   Hartigan O'Connor, D J ^a,c   Meneses, J J ^b   Pedersen, R A ^b   Rubenstein, J L R ^a   German, M S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

cells; Diabetes; Nkx2.2; Pancreas; Transcription factors

Indexed keywords

AMYLIN; CELL MARKER; GLUCAGON; GLUCOSE TRANSPORTER; HOMEODOMAIN PROTEIN; INSULIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL SPECIFICITY; CONTROLLED STUDY; DIABETES MELLITUS; EMBRYO; GENE EXPRESSION; GENE MUTATION; HOMEOBOX; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; BLOOD GLUCOSE; CELL DIFFERENTIATION; CELL LINEAGE; DIABETES MELLITUS; DNA-BINDING PROTEINS; EYE PROTEINS; GENE TARGETING; GENES, HOMEOBOX; GLUCAGON; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; MICE; MUTATION; PAIRED BOX TRANSCRIPTION FACTORS; PANCREATIC POLYPEPTIDE; REPRESSOR PROTEINS; SOMATOSTATIN; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0031843386     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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