Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)

Diabetic Medicine

Volumn 18, Issue 3, 2001, Pages 206-212

  Gloyn, A L ^a,b   Hashim, Y ^a   Ashcroft, S J H ^a   Ashfield, R ^a   Wiltshire, S ^a   Turner, R C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

Genetics; Kir6.2; Promoters; SUR1; Type 2 diabetes mellitus

Indexed keywords

POTASSIUM CHANNEL; SULFONYLUREA;

ARTICLE; GENE EXPRESSION; GENE MUTATION; GENOTYPE; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PROMOTER REGION;

ADULT; ATP-BINDING CASSETTE TRANSPORTERS; DIABETES MELLITUS, TYPE 2; DNA; EXONS; GENOTYPE; HUMANS; HYPOGLYCEMIC AGENTS; MIDDLE AGED; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROMOTER REGIONS (GENETICS); RECEPTORS, DRUG; SULFONYLUREA COMPOUNDS; TRANSCRIPTION FACTORS; VARIATION (GENETICS);

EID: 0035043009     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-5491.2001.00449.x     Document Type: Article

References (16)

1. Variants in the sulphonylurea receptor gene: Association of the exon 16-3t variant with Type II diabetes in Dutch Caucasians
2. Sequence variants in the sulphonylurea receptor (SUR) gene are associated with NIDDM in Caucasians
3. Genetic studies of the sulphonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians
4. Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and Type 2 diabetes but not with altered secretion of insulin
5. + channel gene (KIR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians
6. Cloning of the promoters for the ?-cell ATP-sensitive K-channel subunits Kir6.2 and SUR1
7. Association and stoichiometry of K-ATP channel subunits
8. Study design, progress and performance
9. Diabetes in families study: The insulin resistance syndrome segregates into 5 underlying factors in non-diabetic siblings of Type II diabetic patients
10. Homeostasis model assessment (HOMA): Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
11. Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulphonylurea receptor gene
12. + channel Kir6.2 (Bir) gene. Identification and lack of role in Caucasian patients with NIDDM
13. Sequence variants in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: No association with NIDDM in white Caucasian subjects or evidence of abnormal function when expressed in vitro
14. Amino acid polymorphisms in the ATP-regultable inward rectifier Kir6.2 and their relationships to glucose- and the tolbutamide-induced insulin secretion, insulin sensitivity index, and NIDDM