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Volumn 18, Issue 8, 2017, Pages 485-497

Taste buds: Cells, signals and synapses

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; NORADRENALIN;

EID: 85025067266     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn.2017.68     Document Type: Review
Times cited : (412)

References (244)
  • 1
    • 0037423367 scopus 로고    scopus 로고
    • Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways
    • Zhang, Y. et al. Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways. Cell 112, 293-301 (2003).
    • (2003) Cell , vol.112 , pp. 293-301
    • Zhang, Y.1
  • 2
    • 0348010256 scopus 로고    scopus 로고
    • Morphologic characterization of rat taste receptor cells that express components of the phospholipase C signaling pathway
    • Clapp, T. R., Yang, R., Stoick, C. L., Kinnamon, S. C. & Kinnamon, J. C. Morphologic characterization of rat taste receptor cells that express components of the phospholipase C signaling pathway. J. Comp. Neurol. 468, 311-321 (2004).
    • (2004) J. Comp. Neurol. , vol.468 , pp. 311-321
    • Clapp, T.R.1    Yang, R.2    Stoick, C.L.3    Kinnamon, S.C.4    Kinnamon, J.C.5
  • 3
    • 33646103668 scopus 로고    scopus 로고
    • Separate populations of receptor cells and presynaptic cells in mouse taste buds
    • DeFazio, R. A. et al. Separate populations of receptor cells and presynaptic cells in mouse taste buds. J. Neurosci. 26, 3971-3980 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 3971-3980
    • DeFazio, R.A.1
  • 4
    • 33747860824 scopus 로고    scopus 로고
    • The cells and logic for mammalian sour taste detection
    • Huang, A. L. et al. The cells and logic for mammalian sour taste detection. Nature 442, 934-938 (2006).
    • (2006) Nature , vol.442 , pp. 934-938
    • Huang, A.L.1
  • 5
    • 45249103556 scopus 로고    scopus 로고
    • Presynaptic (type III) cells in mouse taste buds sense sour (acid) taste
    • Huang, Y. A., Maruyama, Y., Stimac, R. & Roper, S. D. Presynaptic (type III) cells in mouse taste buds sense sour (acid) taste. J. Physiol. 586, 2903-2912 (2008).
    • (2008) J. Physiol. , vol.586 , pp. 2903-2912
    • Huang, Y.A.1    Maruyama, Y.2    Stimac, R.3    Roper, S.D.4
  • 6
    • 84954348494 scopus 로고    scopus 로고
    • The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction
    • Ye, W. et al. The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction. Proc. Natl Acad. Sci. USA 113, E229-E238 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. E229-E238
    • Ye, W.1
  • 7
    • 77949423784 scopus 로고    scopus 로고
    • The cells and peripheral representation of sodium taste in mice
    • Chandrashekar, J. et al. The cells and peripheral representation of sodium taste in mice. Nature 464, 297-301 (2010).
    • (2010) Nature , vol.464 , pp. 297-301
    • Chandrashekar, J.1
  • 8
    • 0033582645 scopus 로고    scopus 로고
    • Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity
    • Hoon, M. A. et al. Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity. Cell 96, 541-551 (1999).
    • (1999) Cell , vol.96 , pp. 541-551
    • Hoon, M.A.1
  • 9
    • 0035030731 scopus 로고    scopus 로고
    • Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac
    • Max, M. et al. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat. Genet. 28, 58-63 (2001).
    • (2001) Nat. Genet. , vol.28 , pp. 58-63
    • Max, M.1
  • 11
    • 0035023861 scopus 로고    scopus 로고
    • Identification of a novel member of the T1R family of putative taste receptors
    • Sainz, E., Korley, J. N., Battey, J. F. & Sullivan, S. L. Identification of a novel member of the T1R family of putative taste receptors. J. Neurochem. 77, 896-903 (2001).
    • (2001) J. Neurochem. , vol.77 , pp. 896-903
    • Sainz, E.1    Korley, J.N.2    Battey, J.F.3    Sullivan, S.L.4
  • 12
    • 0035839040 scopus 로고    scopus 로고
    • Mammalian sweet taste receptors
    • Nelson, G. et al. Mammalian sweet taste receptors. Cell 106, 381-390 (2001).
    • (2001) Cell , vol.106 , pp. 381-390
    • Nelson, G.1
  • 13
    • 0037075555 scopus 로고    scopus 로고
    • An amino-acid taste receptor
    • Nelson, G. et al. An amino-acid taste receptor. Nature 416, 199-202 (2002).
    • (2002) Nature , vol.416 , pp. 199-202
    • Nelson, G.1
  • 14
    • 0038662595 scopus 로고    scopus 로고
    • Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
    • Pin, J. P., Galvez, T. & Prezeau, L. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol. Ther. 98, 325-354 (2003).
    • (2003) Pharmacol. Ther. , vol.98 , pp. 325-354
    • Pin, J.P.1    Galvez, T.2    Prezeau, L.3
  • 15
    • 27644568166 scopus 로고    scopus 로고
    • Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli
    • Nie, Y., Vigues, S., Hobbs, J. R., Conn, G. L. & Munger, S. D. Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Curr. Biol. 15, 1948-1952 (2005).
    • (2005) Curr. Biol. , vol.15 , pp. 1948-1952
    • Nie, Y.1    Vigues, S.2    Hobbs, J.R.3    Conn, G.L.4    Munger, S.D.5
  • 16
    • 4644308014 scopus 로고    scopus 로고
    • Different functional roles of T1R subunits in the heteromeric taste receptors
    • Xu, H. et al. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl Acad. Sci. USA 101, 14258-14263 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 14258-14263
    • Xu, H.1
  • 17
    • 33751505567 scopus 로고    scopus 로고
    • The heterodimeric sweet taste receptor has multiple potential ligand binding sites
    • Cui, M. et al. The heterodimeric sweet taste receptor has multiple potential ligand binding sites. Curr. Pharm. Des. 12, 4591-4600 (2006).
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 4591-4600
    • Cui, M.1
  • 18
    • 84859986450 scopus 로고    scopus 로고
    • Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds
    • Masuda, K. et al. Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds. PLoS ONE 7, e35380 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e35380
    • Masuda, K.1
  • 19
    • 77951901176 scopus 로고    scopus 로고
    • Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor
    • Assadi-Porter, F. M. et al. Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor. J. Mol. Biol. 398, 584-599 (2010).
    • (2010) J. Mol. Biol. , vol.398 , pp. 584-599
    • Assadi-Porter, F.M.1
  • 20
    • 7244238124 scopus 로고    scopus 로고
    • The cysteine-rich region of T1R3 determines responses to intensely sweet proteins
    • Jiang, P. et al. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J. Biol. Chem. 279, 45068-45075 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 45068-45075
    • Jiang, P.1
  • 21
    • 0344823647 scopus 로고    scopus 로고
    • The receptors for mammalian sweet and umami taste
    • Zhao, G. Q. et al. The receptors for mammalian sweet and umami taste. Cell 115, 255-266 (2003).
    • (2003) Cell , vol.115 , pp. 255-266
    • Zhao, G.Q.1
  • 22
    • 0043029571 scopus 로고    scopus 로고
    • Detection of sweet and umami taste in the absence of taste receptor T1r3
    • Damak, S. et al. Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 301, 850-853 (2003).
    • (2003) Science , vol.301 , pp. 850-853
    • Damak, S.1
  • 23
    • 80053460282 scopus 로고    scopus 로고
    • The functional role of the T1R family of receptors in sweet taste and feeding
    • Treesukosol, Y., Smith, K. R. & Spector, A. C. The functional role of the T1R family of receptors in sweet taste and feeding. Physiol. Behav. 105, 14-26 (2011).
    • (2011) Physiol. Behav. , vol.105 , pp. 14-26
    • Treesukosol, Y.1    Smith, K.R.2    Spector, A.C.3
  • 24
    • 79955104461 scopus 로고    scopus 로고
    • Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells
    • Yee, K. K., Sukumaran, S. K., Kotha, R., Gilbertson, T. A. & Margolskee, R. F. Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proc. Natl Acad. Sci. USA 108, 5431-5436 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 5431-5436
    • Yee, K.K.1    Sukumaran, S.K.2    Kotha, R.3    Gilbertson, T.A.4    Margolskee, R.F.5
  • 25
    • 84971440012 scopus 로고    scopus 로고
    • Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides
    • Sukumaran, S. K. et al. Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides. Proc. Natl Acad. Sci. USA 113, 6035-6040 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. 6035-6040
    • Sukumaran, S.K.1
  • 26
    • 0025291968 scopus 로고
    • Large enhancement of canine taste responses to sugars by salts
    • Kumazawa, T. & Kurihara, K. Large enhancement of canine taste responses to sugars by salts. J. Gen. Physiol. 95, 1007-1018 (1990).
    • (1990) J. Gen. Physiol. , vol.95 , pp. 1007-1018
    • Kumazawa, T.1    Kurihara, K.2
  • 27
    • 0021305555 scopus 로고
    • Oral glucose is the prime elicitor of preabsorptive insulin secretion
    • Grill, H. J., Berridge, K. C. & Ganster, D. J. Oral glucose is the prime elicitor of preabsorptive insulin secretion. Am. J. Physiol. 246, R88-R95 (1984).
    • (1984) Am. J. Physiol. , vol.246 , pp. R88-R95
    • Grill, H.J.1    Berridge, K.C.2    Ganster, D.J.3
  • 28
    • 34249796653 scopus 로고    scopus 로고
    • Relationships between insulin release and taste
    • Tonosaki, K., Hori, Y., Shimizu, Y. & Tonosaki, K. Relationships between insulin release and taste. Biomed. Res. 28, 79-83 (2007).
    • (2007) Biomed. Res. , vol.28 , pp. 79-83
    • Tonosaki, K.1    Hori, Y.2    Shimizu, Y.3    Tonosaki, K.4
  • 29
    • 79952489879 scopus 로고    scopus 로고
    • How neural mediation of anticipatory and compensatory insulin release helps us tolerate food
    • Teff, K. L. How neural mediation of anticipatory and compensatory insulin release helps us tolerate food. Physiol. Behav. 103, 44-50 (2011).
    • (2011) Physiol. Behav. , vol.103 , pp. 44-50
    • Teff, K.L.1
  • 30
    • 84901849644 scopus 로고    scopus 로고
    • Endocrine taste cells
    • Kokrashvili, Z. et al. Endocrine taste cells. Br. J. Nutr. 111 (Suppl. 1), S23-S29 (2014).
    • (2014) Br. J. Nutr. , vol.111 , pp. S23-S29
    • Kokrashvili, Z.1
  • 31
    • 84933516513 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 is specifically involved in sweet taste transmission
    • Takai, S. et al. Glucagon-like peptide-1 is specifically involved in sweet taste transmission. FASEB J. 29, 2268-2280 (2015).
    • (2015) FASEB J. , vol.29 , pp. 2268-2280
    • Takai, S.1
  • 32
    • 84940640430 scopus 로고    scopus 로고
    • Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice
    • Glendinning, J. I. et al. Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 309, R552-R560 (2015).
    • (2015) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.309 , pp. R552-R560
    • Glendinning, J.I.1
  • 33
    • 85017300097 scopus 로고    scopus 로고
    • Glucose elicits cephalic-phase insulin release in mice by activating KATP channels in taste cells
    • Glendinning, J. I. et al. Glucose elicits cephalic-phase insulin release in mice by activating KATP channels in taste cells. Am. J. Physiol. Regul. Integr. Comp. Physiol. 312, R597-R610 (2017).
    • (2017) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.312 , pp. R597-R610
    • Glendinning, J.I.1
  • 34
    • 84994494507 scopus 로고    scopus 로고
    • Humans can taste glucose oligomers independent of the hT1R2/hT1R3 sweet taste receptor
    • Lapis, T. J., Penner, M. H. & Lim, J. Humans can taste glucose oligomers independent of the hT1R2/hT1R3 sweet taste receptor. Chem. Senses 41, 755-762 (2016).
    • (2016) Chem. Senses , vol.41 , pp. 755-762
    • Lapis, T.J.1    Penner, M.H.2    Lim, J.3
  • 35
    • 0023235347 scopus 로고
    • Carbohydrate taste, appetite, and obesity: An overview
    • Sclafani, A. Carbohydrate taste, appetite, and obesity: An overview. Neurosci. Biobehav. Rev. 11, 131-153 (1987).
    • (1987) Neurosci. Biobehav. Rev. , vol.11 , pp. 131-153
    • Sclafani, A.1
  • 37
    • 84863904661 scopus 로고    scopus 로고
    • Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal
    • Treesukosol, Y. & Spector, A. C. Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303, R218-R235 (2012).
    • (2012) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.303 , pp. R218-R235
    • Treesukosol, Y.1    Spector, A.C.2
  • 38
    • 0025804083 scopus 로고
    • Basic properties of umami and effects on humans
    • Yamaguchi, S. Basic properties of umami and effects on humans. Physiol. Behav. 49, 833-841 (1991).
    • (1991) Physiol. Behav. , vol.49 , pp. 833-841
    • Yamaguchi, S.1
  • 39
    • 0037007027 scopus 로고    scopus 로고
    • Human receptors for sweet and umami taste
    • Li, X. et al. Human receptors for sweet and umami taste. Proc. Natl Acad. Sci. USA 99, 4692-4696 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 4692-4696
    • Li, X.1
  • 40
    • 33646873976 scopus 로고    scopus 로고
    • Sucrose and monosodium glutamate taste thresholds and discrimination ability of T1R3 knockout mice
    • Delay, E. R., Hernandez, N. P., Bromley, K. & Margolskee, R. F. Sucrose and monosodium glutamate taste thresholds and discrimination ability of T1R3 knockout mice. Chem. Senses 31, 351-357 (2006).
    • (2006) Chem. Senses , vol.31 , pp. 351-357
    • Delay, E.R.1    Hernandez, N.P.2    Bromley, K.3    Margolskee, R.F.4
  • 41
    • 84875648218 scopus 로고    scopus 로고
    • Taste responses in mice lacking taste receptor subunit T1R1
    • Kusuhara, Y. et al. Taste responses in mice lacking taste receptor subunit T1R1. J. Physiol. 591, 1967-1985 (2013).
    • (2013) J. Physiol. , vol.591 , pp. 1967-1985
    • Kusuhara, Y.1
  • 42
    • 0033993988 scopus 로고    scopus 로고
    • A metabotropic glutamate receptor variant functions as a taste receptor
    • Chaudhari, N., Landin, A. M. & Roper, S. D. A metabotropic glutamate receptor variant functions as a taste receptor. Nat. Neurosci. 3, 113-119 (2000).
    • (2000) Nat. Neurosci. , vol.3 , pp. 113-119
    • Chaudhari, N.1    Landin, A.M.2    Roper, S.D.3
  • 43
    • 70349573545 scopus 로고    scopus 로고
    • Taste receptors for umami: The case for multiple receptors
    • Chaudhari, N., Pereira, E. & Roper, S. D. Taste receptors for umami: The case for multiple receptors. Am. J. Clin. Nutr. 90, 738S-742S (2009).
    • (2009) Am. J. Clin. Nutr. , vol.90 , pp. 738S-742S
    • Chaudhari, N.1    Pereira, E.2    Roper, S.D.3
  • 45
    • 84923395064 scopus 로고    scopus 로고
    • Involvement of multiple taste receptors in umami taste: Analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice
    • Yasumatsu, K. et al. Involvement of multiple taste receptors in umami taste: Analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice. J. Physiol. 593, 1021-1034 (2015).
    • (2015) J. Physiol. , vol.593 , pp. 1021-1034
    • Yasumatsu, K.1
  • 46
    • 84875615895 scopus 로고    scopus 로고
    • Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs
    • Behrens, M. & Meyerhof, W. Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs. Semin. Cell Dev. Biol. 24, 215-221 (2013).
    • (2013) Semin. Cell Dev. Biol. , vol.24 , pp. 215-221
    • Behrens, M.1    Meyerhof, W.2
  • 47
    • 77953892833 scopus 로고    scopus 로고
    • Oligomerization of TAS2R bitter taste receptors
    • Kuhn, C., Bufe, B., Batram, C. & Meyerhof, W. Oligomerization of TAS2R bitter taste receptors. Chem. Senses 35, 395-406 (2010).
    • (2010) Chem. Senses , vol.35 , pp. 395-406
    • Kuhn, C.1    Bufe, B.2    Batram, C.3    Meyerhof, W.4
  • 48
    • 0034611738 scopus 로고    scopus 로고
    • A family of candidate taste receptors in human and mouse
    • Matsunami, H., Montmayeur, J. P. & Buck, L. B. A family of candidate taste receptors in human and mouse. Nature 404, 601-604 (2000).
    • (2000) Nature , vol.404 , pp. 601-604
    • Matsunami, H.1    Montmayeur, J.P.2    Buck, L.B.3
  • 49
    • 36248977649 scopus 로고    scopus 로고
    • Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells
    • Behrens, M., Foerster, S., Staehler, F., Raguse, J. D. & Meyerhof, W. Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. J. Neurosci. 27, 12630-12640 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 12630-12640
    • Behrens, M.1    Foerster, S.2    Staehler, F.3    Raguse, J.D.4    Meyerhof, W.5
  • 50
    • 0034677653 scopus 로고    scopus 로고
    • A novel family of mammalian taste receptors
    • Adler, E. et al. A novel family of mammalian taste receptors. Cell 100, 693-702 (2000).
    • (2000) Cell , vol.100 , pp. 693-702
    • Adler, E.1
  • 51
    • 77950114281 scopus 로고    scopus 로고
    • The molecular receptive ranges of human TAS2R bitter taste receptors
    • Meyerhof, W. et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem. Senses 35, 157-170 (2010).
    • (2010) Chem. Senses , vol.35 , pp. 157-170
    • Meyerhof, W.1
  • 52
    • 20844437913 scopus 로고    scopus 로고
    • Bitter taste receptors for saccharin and acesulfame K
    • Kuhn, C. et al. Bitter taste receptors for saccharin and acesulfame K. J. Neurosci. 24, 10260-10265 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 10260-10265
    • Kuhn, C.1
  • 53
    • 34247859075 scopus 로고    scopus 로고
    • Functional characterization of human bitter taste receptors
    • Sainz, E. et al. Functional characterization of human bitter taste receptors. Biochem. J. 403, 537-543 (2007).
    • (2007) Biochem. J. , vol.403 , pp. 537-543
    • Sainz, E.1
  • 54
    • 84978401133 scopus 로고    scopus 로고
    • Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans
    • Lossow, K. et al. Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans. J. Biol. Chem. 291, 15358-15377 (2016).
    • (2016) J. Biol. Chem. , vol.291 , pp. 15358-15377
    • Lossow, K.1
  • 55
    • 84908100999 scopus 로고    scopus 로고
    • Genetic variation in taste receptor pseudogenes provides evidence for a dynamic role in human evolution
    • Risso, D., Tofanelli, S., Morini, G., Luiselli, D. & Drayna, D. Genetic variation in taste receptor pseudogenes provides evidence for a dynamic role in human evolution. BMC Evol. Biol. 14, 198 (2014).
    • (2014) BMC Evol. Biol. , vol.14 , pp. 198
    • Risso, D.1    Tofanelli, S.2    Morini, G.3    Luiselli, D.4    Drayna, D.5
  • 56
    • 13944250257 scopus 로고    scopus 로고
    • The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception
    • Bufe, B. et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr. Biol. 15, 322-327 (2005).
    • (2005) Curr. Biol. , vol.15 , pp. 322-327
    • Bufe, B.1
  • 57
    • 74449087964 scopus 로고    scopus 로고
    • Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women
    • Dotson, C. D., Shaw, H. L., Mitchell, B. D., Munger, S. D. & Steinle, N. I. Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women. Appetite 54, 93-99 (2010).
    • (2010) Appetite , vol.54 , pp. 93-99
    • Dotson, C.D.1    Shaw, H.L.2    Mitchell, B.D.3    Munger, S.D.4    Steinle, N.I.5
  • 58
    • 0033233484 scopus 로고    scopus 로고
    • Gγ13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.
    • Huang, L. et al. Gγ13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat. Neurosci. 2, 1055-1062 (1999).
    • (1999) Nat. Neurosci. , vol.2 , pp. 1055-1062
    • Huang, L.1
  • 59
    • 0026718951 scopus 로고
    • Gustducin is a taste-cell-specific G protein closely related to the transducins
    • McLaughlin, S. K., McKinnon, P. J. & Margolskee, R. F. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357, 563-569 (1992).
    • (1992) Nature , vol.357 , pp. 563-569
    • McLaughlin, S.K.1    McKinnon, P.J.2    Margolskee, R.F.3
  • 60
    • 57449091058 scopus 로고    scopus 로고
    • Expression of Gα14 in sweet-transducing taste cells of the posterior tongue
    • Tizzano, M. et al. Expression of Gα14 in sweet-transducing taste cells of the posterior tongue. BMC Neurosci. 9, 110 (2008).
    • (2008) BMC Neurosci. , vol.9 , pp. 110
    • Tizzano, M.1
  • 61
    • 0029957779 scopus 로고    scopus 로고
    • Transduction of bitter and sweet taste by gustducin
    • Wong, G. T., Gannon, K. S. & Margolskee, R. F. Transduction of bitter and sweet taste by gustducin. Nature 381, 796-800 (1996).
    • (1996) Nature , vol.381 , pp. 796-800
    • Wong, G.T.1    Gannon, K.S.2    Margolskee, R.F.3
  • 62
    • 54849433765 scopus 로고    scopus 로고
    • Tonic activity of Gα-gustducin regulates taste cell responsivity
    • Clapp, T. R. et al. Tonic activity of Gα-gustducin regulates taste cell responsivity. FEBS Lett. 582, 3783-3787 (2008).
    • (2008) FEBS Lett. , vol.582 , pp. 3783-3787
    • Clapp, T.R.1
  • 63
    • 0036830145 scopus 로고    scopus 로고
    • A transient receptor potential channel expressed in taste receptor cells
    • Perez, C. A. et al. A transient receptor potential channel expressed in taste receptor cells. Nat. Neurosci. 5, 1169-1176 (2002).
    • (2002) Nat. Neurosci. , vol.5 , pp. 1169-1176
    • Perez, C.A.1
  • 64
    • 34250666600 scopus 로고    scopus 로고
    • The transduction channel TRPM5 is gated by intracellular calcium in taste cells
    • Zhang, Z., Zhao, Z., Margolskee, R. & Liman, E. The transduction channel TRPM5 is gated by intracellular calcium in taste cells. J. Neurosci. 27, 5777-5786 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 5777-5786
    • Zhang, Z.1    Zhao, Z.2    Margolskee, R.3    Liman, E.4
  • 65
    • 0344149569 scopus 로고    scopus 로고
    • Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5
    • Liu, D. & Liman, E. R. Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc. Natl Acad. Sci. USA 100, 15160-15165 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 15160-15165
    • Liu, D.1    Liman, E.R.2
  • 66
    • 0034830227 scopus 로고    scopus 로고
    • Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction
    • Lyall, V. et al. Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction. Am. J. Physiol. Cell Physiol. 281, C1005-C1013 (2001).
    • (2001) Am. J. Physiol. Cell Physiol. , vol.281 , pp. C1005-C1013
    • Lyall, V.1
  • 67
    • 0037338441 scopus 로고    scopus 로고
    • Sour taste stimuli evoke Ca2+ and pH responses in mouse taste cells
    • Richter, T. A., Caicedo, A. & Roper, S. D. Sour taste stimuli evoke Ca2+ and pH responses in mouse taste cells. J. Physiol. 547, 475-483 (2003).
    • (2003) J. Physiol. , vol.547 , pp. 475-483
    • Richter, T.A.1    Caicedo, A.2    Roper, S.D.3
  • 68
    • 78650636945 scopus 로고    scopus 로고
    • A proton current drives action potentials in genetically identified sour taste cells
    • Chang, R. B., Waters, H. & Liman, E. R. A proton current drives action potentials in genetically identified sour taste cells. Proc. Natl Acad. Sci. USA 107, 22320-22325 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 22320-22325
    • Chang, R.B.1    Waters, H.2    Liman, E.R.3
  • 69
    • 0026493777 scopus 로고
    • Proton currents through amiloride-sensitive Na channels in hamster taste cells. Role in acid transduction
    • Gilbertson, T. A., Avenet, P., Kinnamon, S. C. & Roper, S. D. Proton currents through amiloride-sensitive Na channels in hamster taste cells. Role in acid transduction. J. Gen. Physiol. 100, 803-824 (1992).
    • (1992) J. Gen. Physiol. , vol.100 , pp. 803-824
    • Gilbertson, T.A.1    Avenet, P.2    Kinnamon, S.C.3    Roper, S.D.4
  • 70
    • 0035846137 scopus 로고    scopus 로고
    • Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli
    • Stevens, D. R. et al. Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Nature 413, 631-635 (2001).
    • (2001) Nature , vol.413 , pp. 631-635
    • Stevens, D.R.1
  • 71
    • 0038206592 scopus 로고    scopus 로고
    • Amiloride-insensitive currents of the acid-sensing ion channel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel
    • Ugawa, S. et al. Amiloride-insensitive currents of the acid-sensing ion channel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel. J. Neurosci. 23, 3616-3622 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 3616-3622
    • Ugawa, S.1
  • 72
    • 33747621396 scopus 로고    scopus 로고
    • Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor
    • Ishimaru, Y. et al. Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc. Natl Acad. Sci. USA 103, 12569-12574 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 12569-12574
    • Ishimaru, Y.1
  • 73
    • 2142707226 scopus 로고    scopus 로고
    • Acid-sensing ion channel-2 is not necessary for sour taste in mice
    • Richter, T. A., Dvoryanchikov, G. A., Roper, S. D. & Chaudhari, N. Acid-sensing ion channel-2 is not necessary for sour taste in mice. J. Neurosci. 24, 4088-4091 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 4088-4091
    • Richter, T.A.1    Dvoryanchikov, G.A.2    Roper, S.D.3    Chaudhari, N.4
  • 74
    • 79956262502 scopus 로고    scopus 로고
    • Sour taste responses in mice lacking PKD channels
    • Horio, N. et al. Sour taste responses in mice lacking PKD channels. PLoS ONE 6, e20007 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e20007
    • Horio, N.1
  • 75
    • 4143072579 scopus 로고    scopus 로고
    • Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds
    • Richter, T. A., Dvoryanchikov, G. A., Chaudhari, N. & Roper, S. D. Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds. J. Neurophysiol. 92, 1928-1936 (2004).
    • (2004) J. Neurophysiol. , vol.92 , pp. 1928-1936
    • Richter, T.A.1    Dvoryanchikov, G.A.2    Chaudhari, N.3    Roper, S.D.4
  • 76
    • 0021350960 scopus 로고
    • Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway
    • Heck, G. L., Mierson, S. & DeSimone, J. A. Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science 223, 403-405 (1984).
    • (1984) Science , vol.223 , pp. 403-405
    • Heck, G.L.1    Mierson, S.2    DeSimone, J.A.3
  • 77
    • 0344701037 scopus 로고    scopus 로고
    • Amiloride and vertebrate gustatory responses to NaCl
    • Halpern, B. P. Amiloride and vertebrate gustatory responses to NaCl. Neurosci. Biobehav. Rev. 23, 5-47 (1998).
    • (1998) Neurosci. Biobehav. Rev. , vol.23 , pp. 5-47
    • Halpern, B.P.1
  • 78
    • 0343289163 scopus 로고    scopus 로고
    • Amiloride suppresses the sourness of NaCl and LiCl
    • Ossebaard, C. A. & Smith, D. V. Amiloride suppresses the sourness of NaCl and LiCl. Physiol. Behav. 60, 1317-1322 (1996).
    • (1996) Physiol. Behav. , vol.60 , pp. 1317-1322
    • Ossebaard, C.A.1    Smith, D.V.2
  • 80
    • 0032929132 scopus 로고    scopus 로고
    • Differential expression of RNA and protein of the three pore-forming subunits of the amiloride-sensitive epithelial sodium channel in taste buds of the rat
    • Kretz, O., Barbry, P. & Bock, R. Differential expression of RNA and protein of the three pore-forming subunits of the amiloride-sensitive epithelial sodium channel in taste buds of the rat. J. Histochem. Cytochem. 47, 51-64 (1999).
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 51-64
    • Kretz, O.1    Barbry, P.2    Bock, R.3
  • 81
    • 84942011681 scopus 로고    scopus 로고
    • Breadth of tuning in taste afferent neurons varies with stimulus strength
    • Wu, A., Dvoryanchikov, G., Pereira, E., Chaudhari, N. & Roper, S. D. Breadth of tuning in taste afferent neurons varies with stimulus strength. Nat. Commun. 6, 8171 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 8171
    • Wu, A.1    Dvoryanchikov, G.2    Pereira, E.3    Chaudhari, N.4    Roper, S.D.5
  • 82
    • 39049105701 scopus 로고    scopus 로고
    • Amiloride-sensitive channels in type i fungiform taste cells in mouse
    • Vandenbeuch, A., Clapp, T. R. & Kinnamon, S. C. Amiloride-sensitive channels in type I fungiform taste cells in mouse. BMC Neurosci. 9, 1 (2008).
    • (2008) BMC Neurosci. , vol.9 , pp. 1
    • Vandenbeuch, A.1    Clapp, T.R.2    Kinnamon, S.C.3
  • 83
    • 35348879132 scopus 로고    scopus 로고
    • Localization of amiloride-sensitive sodium current and voltage-gated calcium currents in rat fungiform taste cells
    • Bigiani, A. & Cuoghi, V. Localization of amiloride-sensitive sodium current and voltage-gated calcium currents in rat fungiform taste cells. J. Neurophysiol. 98, 2483-2487 (2007).
    • (2007) J. Neurophysiol. , vol.98 , pp. 2483-2487
    • Bigiani, A.1    Cuoghi, V.2
  • 84
    • 84958819057 scopus 로고    scopus 로고
    • Amiloride-insensitive salt taste is mediated by two populations of type III taste cells with distinct transduction mechanisms
    • Lewandowski, B. C., Sukumaran, S. K., Margolskee, R. F. & Bachmanov, A. A. Amiloride-insensitive salt taste is mediated by two populations of type III taste cells with distinct transduction mechanisms. J. Neurosci. 36, 1942-1953 (2016).
    • (2016) J. Neurosci. , vol.36 , pp. 1942-1953
    • Lewandowski, B.C.1    Sukumaran, S.K.2    Margolskee, R.F.3    Bachmanov, A.A.4
  • 85
    • 33748940245 scopus 로고    scopus 로고
    • Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats
    • Stratford, J. M., Curtis, K. S. & Contreras, R. J. Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats. Physiol. Behav. 89, 311-319 (2006).
    • (2006) Physiol. Behav. , vol.89 , pp. 311-319
    • Stratford, J.M.1    Curtis, K.S.2    Contreras, R.J.3
  • 86
    • 0041307372 scopus 로고    scopus 로고
    • Importance of lipolysis in oral cavity for orosensory detection of fat
    • Kawai, T. & Fushiki, T. Importance of lipolysis in oral cavity for orosensory detection of fat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285, R447-R454 (2003).
    • (2003) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.285 , pp. R447-R454
    • Kawai, T.1    Fushiki, T.2
  • 87
    • 84899570542 scopus 로고    scopus 로고
    • The role of lipolysis in human orosensory fat perception
    • Voigt, N. et al. The role of lipolysis in human orosensory fat perception. J. Lipid Res. 55, 870-882 (2014).
    • (2014) J. Lipid Res. , vol.55 , pp. 870-882
    • Voigt, N.1
  • 88
  • 89
    • 84855900663 scopus 로고    scopus 로고
    • G protein-coupled receptors in human fat taste perception
    • Galindo, M. M. et al. G protein-coupled receptors in human fat taste perception. Chem. Senses 37, 123-139 (2012).
    • (2012) Chem. Senses , vol.37 , pp. 123-139
    • Galindo, M.M.1
  • 90
    • 0031005212 scopus 로고    scopus 로고
    • Fatty acid modulation of K+ channels in taste receptor cells: Gustatory cues for dietary fat
    • Gilbertson, T. A., Fontenot, D. T., Liu, L., Zhang, H. & Monroe, W. T. Fatty acid modulation of K+ channels in taste receptor cells: Gustatory cues for dietary fat. Am. J. Physiol. 272, C1203-C1210 (1997).
    • (1997) Am. J. Physiol. , vol.272 , pp. C1203-C1210
    • Gilbertson, T.A.1    Fontenot, D.T.2    Liu, L.3    Zhang, H.4    Monroe, W.T.5
  • 91
    • 0031559890 scopus 로고    scopus 로고
    • Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats
    • Fukuwatari, T. et al. Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats. FEBS Lett. 414, 461-464 (1997).
    • (1997) FEBS Lett. , vol.414 , pp. 461-464
    • Fukuwatari, T.1
  • 92
    • 27644533906 scopus 로고    scopus 로고
    • CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions
    • Laugerette, F. et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J. Clin. Invest. 115, 3177-3184 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 3177-3184
    • Laugerette, F.1
  • 93
    • 58149334788 scopus 로고    scopus 로고
    • Colocalization of GPR120 with phospholipase-Cβ2 and α-gustducin in the taste bud cells in mice
    • Matsumura, S. et al. Colocalization of GPR120 with phospholipase-Cβ2 and α-gustducin in the taste bud cells in mice. Neurosci. Lett. 450, 186-190 (2009).
    • (2009) Neurosci. Lett. , vol.450 , pp. 186-190
    • Matsumura, S.1
  • 94
    • 77954134133 scopus 로고    scopus 로고
    • Taste preference for fatty acids is mediated by GPR40 and GPR120
    • Cartoni, C. et al. Taste preference for fatty acids is mediated by GPR40 and GPR120. J. Neurosci. 30, 8376-8382 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 8376-8382
    • Cartoni, C.1
  • 95
    • 84959518053 scopus 로고    scopus 로고
    • The bitter truth about bitter taste receptors: Beyond sensing bitter in the oral cavity
    • Avau, B. & Depoortere, I. The bitter truth about bitter taste receptors: Beyond sensing bitter in the oral cavity. Acta Physiol. (Oxf.) 216, 407-420 (2016).
    • (2016) Acta Physiol. (Oxf.) , vol.216 , pp. 407-420
    • Avau, B.1    Depoortere, I.2
  • 96
    • 43249126281 scopus 로고    scopus 로고
    • The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse
    • Gaillard, D. et al. The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J. 22, 1458-1468 (2008).
    • (2008) FASEB J. , vol.22 , pp. 1458-1468
    • Gaillard, D.1
  • 97
    • 84919687724 scopus 로고    scopus 로고
    • Behavioral palatability of dietary fatty acids correlates with the intracellular calcium ion levels induced by the fatty acids in GPR120-expressing cells
    • Adachi, S. et al. Behavioral palatability of dietary fatty acids correlates with the intracellular calcium ion levels induced by the fatty acids in GPR120-expressing cells. Biomed. Res. 35, 357-367 (2014).
    • (2014) Biomed. Res. , vol.35 , pp. 357-367
    • Adachi, S.1
  • 98
    • 84925857433 scopus 로고    scopus 로고
    • The endocrinology of taste receptors
    • Calvo, S. S. & Egan, J. M. The endocrinology of taste receptors. Nat. Rev. Endocrinol. 11, 213-227 (2015).
    • (2015) Nat. Rev. Endocrinol. , vol.11 , pp. 213-227
    • Calvo, S.S.1    Egan, J.M.2
  • 99
    • 0033528777 scopus 로고    scopus 로고
    • Localization of ATP-gated P2X2 and P2X3 receptor immunoreactive nerves in rat taste buds
    • Bo, X. et al. Localization of ATP-gated P2X2 and P2X3 receptor immunoreactive nerves in rat taste buds. Neuroreport 10, 1107-1111 (1999).
    • (1999) Neuroreport , vol.10 , pp. 1107-1111
    • Bo, X.1
  • 100
    • 28544448048 scopus 로고    scopus 로고
    • ATP signaling is crucial for communication from taste buds to gustatory nerves
    • Finger, T. E. et al. ATP signaling is crucial for communication from taste buds to gustatory nerves. Science 310, 1495-1499 (2005).
    • (2005) Science , vol.310 , pp. 1495-1499
    • Finger, T.E.1
  • 101
    • 80053034884 scopus 로고    scopus 로고
    • Knocking out P2X receptors reduces transmitter secretion in taste buds
    • Huang, Y. A. et al. Knocking out P2X receptors reduces transmitter secretion in taste buds. J. Neurosci. 31, 13654-13661 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 13654-13661
    • Huang, Y.A.1
  • 102
    • 34247631845 scopus 로고    scopus 로고
    • The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds
    • Huang, Y. J. et al. The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc. Natl Acad. Sci. USA 104, 6436-6441 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6436-6441
    • Huang, Y.J.1
  • 103
    • 33846950016 scopus 로고    scopus 로고
    • Afferent neurotransmission mediated by hemichannels in mammalian taste cells
    • Romanov, R. A. et al. Afferent neurotransmission mediated by hemichannels in mammalian taste cells. EMBO J. 26, 657-667 (2007).
    • (2007) EMBO J. , vol.26 , pp. 657-667
    • Romanov, R.A.1
  • 104
    • 70449411706 scopus 로고    scopus 로고
    • Autocrine and paracrine roles for ATP and serotonin in mouse taste buds
    • Huang, Y. A., Dando, R. & Roper, S. D. Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. J. Neurosci. 29, 13909-13918 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 13909-13918
    • Huang, Y.A.1    Dando, R.2    Roper, S.D.3
  • 105
    • 84874956365 scopus 로고    scopus 로고
    • CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes
    • Taruno, A. et al. CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 495, 223-226 (2013).
    • (2013) Nature , vol.495 , pp. 223-226
    • Taruno, A.1
  • 106
    • 29344452180 scopus 로고    scopus 로고
    • Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium
    • Locovei, S., Wang, J. & Dahl, G. Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett. 580, 239-244 (2006).
    • (2006) FEBS Lett. , vol.580 , pp. 239-244
    • Locovei, S.1    Wang, J.2    Dahl, G.3
  • 107
    • 84957949629 scopus 로고    scopus 로고
    • Calcium homeostasis modulator (CALHM) ion channels
    • Ma, Z., Tanis, J. E., Taruno, A. & Foskett, J. K. Calcium homeostasis modulator (CALHM) ion channels. Pflugers Arch. 468, 395-403 (2016).
    • (2016) Pflugers Arch. , vol.468 , pp. 395-403
    • Ma, Z.1    Tanis, J.E.2    Taruno, A.3    Foskett, J.K.4
  • 108
    • 84983113574 scopus 로고    scopus 로고
    • Normal taste acceptance and preference of PANX1 knockout mice
    • Tordoff, M. G. et al. Normal taste acceptance and preference of PANX1 knockout mice. Chem. Senses 40, 453-459 (2015).
    • (2015) Chem. Senses , vol.40 , pp. 453-459
    • Tordoff, M.G.1
  • 109
    • 84983157292 scopus 로고    scopus 로고
    • Mice lacking pannexin 1 release ATP and respond normally to all taste qualities
    • Vandenbeuch, A., Anderson, C. B. & Kinnamon, S. C. Mice lacking pannexin 1 release ATP and respond normally to all taste qualities. Chem. Senses 40, 461-467 (2015).
    • (2015) Chem. Senses , vol.40 , pp. 461-467
    • Vandenbeuch, A.1    Anderson, C.B.2    Kinnamon, S.C.3
  • 110
    • 84902956823 scopus 로고    scopus 로고
    • Salty taste deficits in CALHM1 knockout mice
    • Tordoff, M. G. et al. Salty taste deficits in CALHM1 knockout mice. Chem. Senses 39, 515-528 (2014).
    • (2014) Chem. Senses , vol.39 , pp. 515-528
    • Tordoff, M.G.1
  • 111
    • 84861337308 scopus 로고    scopus 로고
    • Immunocytochemical analysis of P2X2 in rat circumvallate taste buds
    • Yang, R., Montoya, A., Bond, A., Walton, J. & Kinnamon, J. C. Immunocytochemical analysis of P2X2 in rat circumvallate taste buds. BMC Neurosci. 13, 51 (2012).
    • (2012) BMC Neurosci. , vol.13 , pp. 51
    • Yang, R.1    Montoya, A.2    Bond, A.3    Walton, J.4    Kinnamon, J.C.5
  • 112
    • 33744928130 scopus 로고    scopus 로고
    • Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type i cells in taste buds
    • Bartel, D. L., Sullivan, S. L., Lavoie, E. G., Sevigny, J. & Finger, T. E. Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds. J. Comp. Neurol. 497, 1-12 (2006).
    • (2006) J. Comp. Neurol. , vol.497 , pp. 1-12
    • Bartel, D.L.1    Sullivan, S.L.2    Lavoie, E.G.3    Sevigny, J.4    Finger, T.E.5
  • 113
    • 84883351219 scopus 로고    scopus 로고
    • Role of the ectonucleotidase NTPDase2 in taste bud function
    • Vandenbeuch, A. et al. Role of the ectonucleotidase NTPDase2 in taste bud function. Proc. Natl Acad. Sci. USA 110, 14789-14794 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 14789-14794
    • Vandenbeuch, A.1
  • 114
  • 115
    • 12844262129 scopus 로고    scopus 로고
    • Mouse taste buds use serotonin as a neurotransmitter
    • Huang, Y. J. et al. Mouse taste buds use serotonin as a neurotransmitter. J. Neurosci. 25, 843-847 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 843-847
    • Huang, Y.J.1
  • 116
    • 0017563570 scopus 로고
    • The monoamine-containing cell in the gustatory epithelium of some vertebrates
    • Nada, O. & Hirata, K. The monoamine-containing cell in the gustatory epithelium of some vertebrates. Arch. Histol. Jpn 40, 197-206 (1977).
    • (1977) Arch. Histol. Jpn , vol.40 , pp. 197-206
    • Nada, O.1    Hirata, K.2
  • 117
    • 36248953770 scopus 로고    scopus 로고
    • Biogenic amine synthesis and uptake in rodent taste buds
    • Dvoryanchikov, G., Tomchik, S. M. & Chaudhari, N. Biogenic amine synthesis and uptake in rodent taste buds. J. Comp. Neurol. 505, 302-313 (2007).
    • (2007) J. Comp. Neurol. , vol.505 , pp. 302-313
    • Dvoryanchikov, G.1    Tomchik, S.M.2    Chaudhari, N.3
  • 118
    • 0028898512 scopus 로고
    • Localization of serotonin in taste buds: A comparative study in four vertebrates
    • Kim, D. J. & Roper, S. D. Localization of serotonin in taste buds: A comparative study in four vertebrates. J. Comp. Neurol. 353, 364-370 (1995).
    • (1995) J. Comp. Neurol. , vol.353 , pp. 364-370
    • Kim, D.J.1    Roper, S.D.2
  • 119
    • 80054792736 scopus 로고    scopus 로고
    • Acid stimulation (sour taste) elicits GABA and serotonin release from mouse taste cells
    • Huang, Y. A., Pereira, E. & Roper, S. D. Acid stimulation (sour taste) elicits GABA and serotonin release from mouse taste cells. PLoS ONE 6, e25471 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e25471
    • Huang, Y.A.1    Pereira, E.2    Roper, S.D.3
  • 120
    • 78049489054 scopus 로고    scopus 로고
    • Capacitance measurements of regulated exocytosis in mouse taste cells
    • Vandenbeuch, A., Zorec, R. & Kinnamon, S. C. Capacitance measurements of regulated exocytosis in mouse taste cells. J. Neurosci. 30, 14695-14701 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 14695-14701
    • Vandenbeuch, A.1    Zorec, R.2    Kinnamon, S.C.3
  • 121
    • 84911417864 scopus 로고    scopus 로고
    • A physiologic role for serotonergic transmission in adult rat taste buds
    • Jaber, L., Zhao, F. L., Kolli, T. & Herness, S. A physiologic role for serotonergic transmission in adult rat taste buds. PLoS ONE 9, e112152 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e112152
    • Jaber, L.1    Zhao, F.L.2    Kolli, T.3    Herness, S.4
  • 123
    • 84949424293 scopus 로고    scopus 로고
    • The role of 5-HT3 receptors in signaling from taste buds to nerves
    • Larson, E. D. et al. The role of 5-HT3 receptors in signaling from taste buds to nerves. J. Neurosci. 35, 15984-15995 (2015).
    • (2015) J. Neurosci. , vol.35 , pp. 15984-15995
    • Larson, E.D.1
  • 124
    • 0030696652 scopus 로고    scopus 로고
    • GABAergic neurotransmission in rat taste buds: Immunocytochemical study for GABA and GABA transporter subtypes
    • Obata, H., Shimada, K., Sakai, N. & Saito, N. GABAergic neurotransmission in rat taste buds: Immunocytochemical study for GABA and GABA transporter subtypes. Brain Res. Mol. Brain Res. 49, 29-36 (1997).
    • (1997) Brain Res. Mol. Brain Res. , vol.49 , pp. 29-36
    • Obata, H.1    Shimada, K.2    Sakai, N.3    Saito, N.4
  • 127
    • 0033822041 scopus 로고    scopus 로고
    • Biophysical properties and responses to neurotransmitters of petrosal and geniculate ganglion neurons innervating the tongue
    • Koga, T. & Bradley, R. M. Biophysical properties and responses to neurotransmitters of petrosal and geniculate ganglion neurons innervating the tongue. J. Neurophysiol. 84, 1404-1413 (2000).
    • (2000) J. Neurophysiol. , vol.84 , pp. 1404-1413
    • Koga, T.1    Bradley, R.M.2
  • 128
    • 0016426220 scopus 로고
    • The distribution of acetylcholinesterase in buds of the rat vallate papilla as determined by electron microscope histochemistry
    • Paran, N. & Mattern, C. F. The distribution of acetylcholinesterase in buds of the rat vallate papilla as determined by electron microscope histochemistry. J. Comp. Neurol. 159, 29-44 (1975).
    • (1975) J. Comp. Neurol. , vol.159 , pp. 29-44
    • Paran, N.1    Mattern, C.F.2
  • 129
    • 84863002089 scopus 로고    scopus 로고
    • Acetylcholine is released from taste cells, enhancing taste signalling
    • Dando, R. & Roper, S. D. Acetylcholine is released from taste cells, enhancing taste signalling. J. Physiol. 590, 3009-3017 (2012).
    • (2012) J. Physiol. , vol.590 , pp. 3009-3017
    • Dando, R.1    Roper, S.D.2
  • 130
    • 58149393203 scopus 로고    scopus 로고
    • Norepinephrine is coreleased with serotonin in mouse taste buds
    • Huang, Y. A., Maruyama, Y. & Roper, S. D. Norepinephrine is coreleased with serotonin in mouse taste buds. J. Neurosci. 28, 13088-13093 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 13088-13093
    • Huang, Y.A.1    Maruyama, Y.2    Roper, S.D.3
  • 131
    • 35148813068 scopus 로고    scopus 로고
    • Breadth of tuning and taste coding in mammalian taste buds
    • Tomchik, S. M., Berg, S., Kim, J. W., Chaudhari, N. & Roper, S. D. Breadth of tuning and taste coding in mammalian taste buds. J. Neurosci. 27, 10840-10848 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 10840-10848
    • Tomchik, S.M.1    Berg, S.2    Kim, J.W.3    Chaudhari, N.4    Roper, S.D.5
  • 132
    • 70450191418 scopus 로고    scopus 로고
    • Discrimination of taste qualities among mouse fungiform taste bud cells
    • Yoshida, R. et al. Discrimination of taste qualities among mouse fungiform taste bud cells. J. Physiol. 587, 4425-4439 (2009).
    • (2009) J. Physiol. , vol.587 , pp. 4425-4439
    • Yoshida, R.1
  • 133
    • 84906081617 scopus 로고    scopus 로고
    • Synaptic communication and signal processing among sensory cells in taste buds
    • Chaudhari, N. Synaptic communication and signal processing among sensory cells in taste buds. J. Physiol. 592, 3387-3392 (2014).
    • (2014) J. Physiol. , vol.592 , pp. 3387-3392
    • Chaudhari, N.1
  • 134
    • 0023908679 scopus 로고
    • Interaction among different sensory units within a single fungiform papilla in the frog tongue
    • Murayama, N. Interaction among different sensory units within a single fungiform papilla in the frog tongue. J. Gen. Physiol. 91, 685-701 (1988).
    • (1988) J. Gen. Physiol. , vol.91 , pp. 685-701
    • Murayama, N.1
  • 136
    • 1542509411 scopus 로고    scopus 로고
    • Modulation of taste peripheral signal through interpapillar inhibition in hamsters
    • Vandenbeuch, A., Pillias, A. M. & Faurion, A. Modulation of taste peripheral signal through interpapillar inhibition in hamsters. Neurosci. Lett. 358, 137-141 (2004).
    • (2004) Neurosci. Lett. , vol.358 , pp. 137-141
    • Vandenbeuch, A.1    Pillias, A.M.2    Faurion, A.3
  • 137
    • 84856267976 scopus 로고    scopus 로고
    • Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds
    • Huang, Y. A., Grant, J. & Roper, S. Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. PLoS ONE 7, e30662 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e30662
    • Huang, Y.A.1    Grant, J.2    Roper, S.3
  • 138
    • 77953670602 scopus 로고    scopus 로고
    • Evidence for a role of glutamate as an efferent transmitter in taste buds
    • Vandenbeuch, A. et al. Evidence for a role of glutamate as an efferent transmitter in taste buds. BMC Neurosci. 11, 77 (2010).
    • (2010) BMC Neurosci. , vol.11 , pp. 77
    • Vandenbeuch, A.1
  • 139
    • 33748182023 scopus 로고    scopus 로고
    • Discrete innervation of murine taste buds by peripheral taste neurons
    • Zaidi, F. N. & Whitehead, M. C. Discrete innervation of murine taste buds by peripheral taste neurons. J. Neurosci. 26, 8243-8253 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 8243-8253
    • Zaidi, F.N.1    Whitehead, M.C.2
  • 141
    • 70349984438 scopus 로고    scopus 로고
    • Common sense about taste: From mammals to insects
    • Yarmolinsky, D. A., Zuker, C. S. & Ryba, N. J. Common sense about taste: From mammals to insects. Cell 139, 234-244 (2009).
    • (2009) Cell , vol.139 , pp. 234-244
    • Yarmolinsky, D.A.1    Zuker, C.S.2    Ryba, N.J.3
  • 142
    • 84923213558 scopus 로고    scopus 로고
    • The neural representation of taste quality at the periphery
    • Barretto, R. P. et al. The neural representation of taste quality at the periphery. Nature 517, 373-376 (2014).
    • (2014) Nature , vol.517 , pp. 373-376
    • Barretto, R.P.1
  • 143
    • 0015624280 scopus 로고
    • An analysis of hamster afferent taste nerve response functions
    • Frank, M. An analysis of hamster afferent taste nerve response functions. J. Gen. Physiol. 61, 588-618 (1973).
    • (1973) J. Gen. Physiol. , vol.61 , pp. 588-618
    • Frank, M.1
  • 144
    • 0030977275 scopus 로고    scopus 로고
    • Taste in chimpanzees II: Single chorda tympani fibers
    • Hellekant, G., Ninomiya, Y. & Danilova, V. Taste in chimpanzees II: Single chorda tympani fibers. Physiol. Behav. 61, 829-841 (1997).
    • (1997) Physiol. Behav. , vol.61 , pp. 829-841
    • Hellekant, G.1    Ninomiya, Y.2    Danilova, V.3
  • 145
    • 15044353688 scopus 로고    scopus 로고
    • The receptors and coding logic for bitter taste
    • Mueller, K. L. et al. The receptors and coding logic for bitter taste. Nature 434, 225-229 (2005).
    • (2005) Nature , vol.434 , pp. 225-229
    • Mueller, K.L.1
  • 147
    • 42049123013 scopus 로고    scopus 로고
    • A study of the science of taste: On the origins and influence of the core ideas
    • Erickson, R. P. A study of the science of taste: On the origins and influence of the core ideas. Behav. Brain Sci. 31, 59-75 (2008).
    • (2008) Behav. Brain Sci. , vol.31 , pp. 59-75
    • Erickson, R.P.1
  • 148
    • 0033525727 scopus 로고    scopus 로고
    • Combinatorial receptor codes for odors
    • Malnic, B., Hirono, J., Sato, T. & Buck, L. B. Combinatorial receptor codes for odors. Cell 96, 713-723 (1999).
    • (1999) Cell , vol.96 , pp. 713-723
    • Malnic, B.1    Hirono, J.2    Sato, T.3    Buck, L.B.4
  • 149
    • 0001651067 scopus 로고
    • Gustatory afferent impulses
    • Pfaffmann, C. Gustatory afferent impulses. J. Cell. Comp. Physiol. 17, 243-258 (1941).
    • (1941) J. Cell. Comp. Physiol. , vol.17 , pp. 243-258
    • Pfaffmann, C.1
  • 150
    • 0342445417 scopus 로고    scopus 로고
    • Gustatory neuron types in rat geniculate ganglion
    • Lundy, R. F. Jr & Contreras, R. J. Gustatory neuron types in rat geniculate ganglion. J. Neurophysiol. 82, 2970-2988 (1999).
    • (1999) J. Neurophysiol. , vol.82 , pp. 2970-2988
    • Lundy, R.F.1    Contreras, R.J.2
  • 151
    • 18944400494 scopus 로고    scopus 로고
    • In vivo recordings from rat geniculate ganglia: Taste response properties of individual greater superficial petrosal and chorda tympani neurones
    • Sollars, S. I. & Hill, D. L. In vivo recordings from rat geniculate ganglia: Taste response properties of individual greater superficial petrosal and chorda tympani neurones. J. Physiol. 564, 877-893 (2005).
    • (2005) J. Physiol. , vol.564 , pp. 877-893
    • Sollars, S.I.1    Hill, D.L.2
  • 152
    • 33644857147 scopus 로고    scopus 로고
    • Temperature modulates taste responsiveness and stimulates gustatory neurons in the rat geniculate ganglion
    • Breza, J. M., Curtis, K. S. & Contreras, R. J. Temperature modulates taste responsiveness and stimulates gustatory neurons in the rat geniculate ganglion. J. Neurophysiol. 95, 674-685 (2006).
    • (2006) J. Neurophysiol. , vol.95 , pp. 674-685
    • Breza, J.M.1    Curtis, K.S.2    Contreras, R.J.3
  • 153
    • 33751540387 scopus 로고    scopus 로고
    • Taste responsiveness of fungiform taste cells with action potentials
    • Yoshida, R. et al. Taste responsiveness of fungiform taste cells with action potentials. J. Neurophysiol. 96, 3088-3095 (2006).
    • (2006) J. Neurophysiol. , vol.96 , pp. 3088-3095
    • Yoshida, R.1
  • 154
    • 0035875913 scopus 로고    scopus 로고
    • Dynamic and multimodal responses of gustatory cortical neurons in awake rats
    • Katz, D. B., Simon, S. A. & Nicolelis, M. A. Dynamic and multimodal responses of gustatory cortical neurons in awake rats. J. Neurosci. 21, 4478-4489 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 4478-4489
    • Katz, D.B.1    Simon, S.A.2    Nicolelis, M.A.3
  • 155
    • 0141788659 scopus 로고    scopus 로고
    • Taste response variability and temporal coding in the nucleus of the solitary tract of the rat
    • Di Lorenzo, P. M. & Victor, J. D. Taste response variability and temporal coding in the nucleus of the solitary tract of the rat. J. Neurophysiol. 90, 1418-1431 (2003).
    • (2003) J. Neurophysiol. , vol.90 , pp. 1418-1431
    • Di Lorenzo, P.M.1    Victor, J.D.2
  • 156
    • 84885081495 scopus 로고    scopus 로고
    • Temporal characteristics of gustatory responses in rat parabrachial neurons vary by stimulus and chemosensitive neuron type
    • Geran, L. & Travers, S. Temporal characteristics of gustatory responses in rat parabrachial neurons vary by stimulus and chemosensitive neuron type. PLoS ONE 8, e76828 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e76828
    • Geran, L.1    Travers, S.2
  • 157
    • 84864254568 scopus 로고    scopus 로고
    • Bitter taste stimuli induce differential neural codes in mouse brain
    • Wilson, D. M., Boughter, J. D. Jr & Lemon, C. H. Bitter taste stimuli induce differential neural codes in mouse brain. PLoS ONE 7, e41597 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e41597
    • Wilson, D.M.1    Boughter, J.D.2    Lemon, C.H.3
  • 158
    • 0343671123 scopus 로고
    • Sweetness produced electrically on the tongue and its relation to taste theories
    • Von Bekesy, G. Sweetness produced electrically on the tongue and its relation to taste theories. J. Appl. Physiol. 19, 1105-1113 (1964).
    • (1964) J. Appl. Physiol. , vol.19 , pp. 1105-1113
    • Von Bekesy, G.1
  • 159
    • 33244488783 scopus 로고    scopus 로고
    • The representation of taste quality in the mammalian nervous system
    • Spector, A. C. & Travers, S. P. The representation of taste quality in the mammalian nervous system. Behav. Cogn. Neuroci. Rev. 4, 143-191 (2005).
    • (2005) Behav. Cogn. Neuroci. Rev. , vol.4 , pp. 143-191
    • Spector, A.C.1    Travers, S.P.2
  • 160
    • 77954385728 scopus 로고    scopus 로고
    • Coding in the mammalian gustatory system
    • Carleton, A., Accolla, R. & Simon, S. A. Coding in the mammalian gustatory system. Trends Neurosci. 33, 326-334 (2010).
    • (2010) Trends Neurosci. , vol.33 , pp. 326-334
    • Carleton, A.1    Accolla, R.2    Simon, S.A.3
  • 162
    • 0027431715 scopus 로고
    • Cellular relations in mouse circumvallate taste buds
    • Murray, R. G. Cellular relations in mouse circumvallate taste buds. Microsc. Res. Tech. 26, 209-224 (1993).
    • (1993) Microsc. Res. Tech. , vol.26 , pp. 209-224
    • Murray, R.G.1
  • 163
    • 0031038610 scopus 로고    scopus 로고
    • Light and dark cells of rat vallate taste buds are morphologically distinct cell types
    • Pumplin, D. W., Yu, C. & Smith, D. V. Light and dark cells of rat vallate taste buds are morphologically distinct cell types. J. Comp. Neurol. 378, 389-410 (1997).
    • (1997) J. Comp. Neurol. , vol.378 , pp. 389-410
    • Pumplin, D.W.1    Yu, C.2    Smith, D.V.3
  • 164
    • 0033802656 scopus 로고    scopus 로고
    • Localization of the glutamate- aspartate transporter, GLAST, in rat taste buds
    • Lawton, D. M., Furness, D. N., Lindemann, B. & Hackney, C. M. Localization of the glutamate- aspartate transporter, GLAST, in rat taste buds. Eur. J. Neurosci. 12, 3163-3171 (2000).
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 3163-3171
    • Lawton, D.M.1    Furness, D.N.2    Lindemann, B.3    Hackney, C.M.4
  • 165
    • 70349804450 scopus 로고    scopus 로고
    • Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds
    • Dvoryanchikov, G., Sinclair, M. S., Perea-Martinez, I., Wang, T. & Chaudhari, N. Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds. J. Comp. Neurol. 517, 1-14 (2009).
    • (2009) J. Comp. Neurol. , vol.517 , pp. 1-14
    • Dvoryanchikov, G.1    Sinclair, M.S.2    Perea-Martinez, I.3    Wang, T.4    Chaudhari, N.5
  • 166
    • 0034698967 scopus 로고    scopus 로고
    • Taste cells with synapses in rat circumvallate papillae display SNAP-25-like immunoreactivity
    • Yang, R., Crowley, H. H., Rock, M. E. & Kinnamon, J. C. Taste cells with synapses in rat circumvallate papillae display SNAP-25-like immunoreactivity. J. Comp. Neurol. 424, 205-215 (2000).
    • (2000) J. Comp. Neurol. , vol.424 , pp. 205-215
    • Yang, R.1    Crowley, H.H.2    Rock, M.E.3    Kinnamon, J.C.4
  • 167
    • 1442334280 scopus 로고    scopus 로고
    • Synaptobrevin-2-like immunoreactivity is associated with vesicles at synapses in rat circumvallate taste buds
    • Yang, R., Stoick, C. L. & Kinnamon, J. C. Synaptobrevin-2-like immunoreactivity is associated with vesicles at synapses in rat circumvallate taste buds. J. Comp. Neurol. 471, 59-71 (2004).
    • (2004) J. Comp. Neurol. , vol.471 , pp. 59-71
    • Yang, R.1    Stoick, C.L.2    Kinnamon, J.C.3
  • 168
    • 0024543473 scopus 로고
    • Morphology of fungiform papillae in canine lingual epithelium: Location of intercellular junctions in the epithelium
    • Holland, V. F., Zampighi, G. A. & Simon, S. A. Morphology of fungiform papillae in canine lingual epithelium: Location of intercellular junctions in the epithelium. J. Comp. Neurol. 279, 13-27 (1989).
    • (1989) J. Comp. Neurol. , vol.279 , pp. 13-27
    • Holland, V.F.1    Zampighi, G.A.2    Simon, S.A.3
  • 169
    • 0031780861 scopus 로고    scopus 로고
    • Immunohistochemical distribution of CD44 and some of its isoforms during human taste bud development
    • Witt, M. & Kasper, M. Immunohistochemical distribution of CD44 and some of its isoforms during human taste bud development. Histochem. Cell Biol. 110, 95-103 (1998).
    • (1998) Histochem. Cell Biol. , vol.110 , pp. 95-103
    • Witt, M.1    Kasper, M.2
  • 170
    • 34249297638 scopus 로고    scopus 로고
    • Claudin-based permeability barriers in taste buds
    • Michlig, S., Damak, S. & Le Coutre, J. Claudin-based permeability barriers in taste buds. J. Comp. Neurol. 502, 1003-1011 (2007).
    • (2007) J. Comp. Neurol. , vol.502 , pp. 1003-1011
    • Michlig, S.1    Damak, S.2    Le Coutre, J.3
  • 171
    • 84920901915 scopus 로고    scopus 로고
    • A permeability barrier surrounds taste buds in lingual epithelia
    • Dando, R. et al. A permeability barrier surrounds taste buds in lingual epithelia. Am. J. Physiol. Cell Physiol. 308, C21-C32 (2015).
    • (2015) Am. J. Physiol. Cell Physiol. , vol.308 , pp. C21-C32
    • Dando, R.1
  • 172
    • 0030915416 scopus 로고    scopus 로고
    • Neural responses to bitter compounds in rats
    • Dahl, M., Erickson, R. P. & Simon, S. A. Neural responses to bitter compounds in rats. Brain Res. 756, 22-34 (1997).
    • (1997) Brain Res. , vol.756 , pp. 22-34
    • Dahl, M.1    Erickson, R.P.2    Simon, S.A.3
  • 173
    • 0035936911 scopus 로고    scopus 로고
    • Taste receptor cells that discriminate between bitter stimuli
    • Caicedo, A. & Roper, S. D. Taste receptor cells that discriminate between bitter stimuli. Science 291, 1557-1560 (2001).
    • (2001) Science , vol.291 , pp. 1557-1560
    • Caicedo, A.1    Roper, S.D.2
  • 174
    • 64749100838 scopus 로고    scopus 로고
    • Bitter-responsive gustatory neurons in the rat parabrachial nucleus
    • Geran, L. C. & Travers, S. P. Bitter-responsive gustatory neurons in the rat parabrachial nucleus. J. Neurophysiol. 101, 1598-1612 (2009).
    • (2009) J. Neurophysiol. , vol.101 , pp. 1598-1612
    • Geran, L.C.1    Travers, S.P.2
  • 175
    • 60849129122 scopus 로고    scopus 로고
    • Nicotine activates TRPM5-dependent and independent taste pathways
    • Oliveira-Maia, A. J. et al. Nicotine activates TRPM5-dependent and independent taste pathways. Proc. Natl Acad. Sci. USA 106, 1596-1601 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 1596-1601
    • Oliveira-Maia, A.J.1
  • 176
    • 0035404424 scopus 로고    scopus 로고
    • Covariation in individuals' sensitivities to bitter compounds: Evidence supporting multiple receptor/transduction mechanisms
    • Delwiche, J. F., Buletic, Z. & Breslin, P. A. Covariation in individuals' sensitivities to bitter compounds: Evidence supporting multiple receptor/transduction mechanisms. Percept. Psychophys. 63, 761-776 (2001).
    • (2001) Percept. Psychophys. , vol.63 , pp. 761-776
    • Delwiche, J.F.1    Buletic, Z.2    Breslin, P.A.3
  • 177
    • 0036522960 scopus 로고    scopus 로고
    • Rats fail to discriminate quinine from denatonium: Implications for the neural coding of bitter-tasting compounds
    • Spector, A. C. & Kopka, S. L. Rats fail to discriminate quinine from denatonium: Implications for the neural coding of bitter-tasting compounds. J. Neurosci. 22, 1937-1941 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 1937-1941
    • Spector, A.C.1    Kopka, S.L.2
  • 178
    • 0000336479 scopus 로고
    • Genetics of sensory thresholds: Taste for phenyl thio carbamide
    • Blakeslee, A. F. Genetics of sensory thresholds: Taste for phenyl thio carbamide. Proc. Natl Acad. Sci. USA 18, 120-130 (1932).
    • (1932) Proc. Natl Acad. Sci. USA , vol.18 , pp. 120-130
    • Blakeslee, A.F.1
  • 179
    • 0037458815 scopus 로고    scopus 로고
    • Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
    • Kim, U. K. et al. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299, 1221-1225 (2003).
    • (2003) Science , vol.299 , pp. 1221-1225
    • Kim, U.K.1
  • 180
    • 1842539589 scopus 로고    scopus 로고
    • Natural selection and molecular evolution in PTC, a bitter-taste receptor gene
    • Wooding, S. et al. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am. J. Hum. Genet. 74, 637-646 (2004).
    • (2004) Am. J. Hum. Genet. , vol.74 , pp. 637-646
    • Wooding, S.1
  • 181
    • 22744443058 scopus 로고    scopus 로고
    • Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16
    • Soranzo, N. et al. Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Curr. Biol. 15, 1257-1265 (2005).
    • (2005) Curr. Biol. , vol.15 , pp. 1257-1265
    • Soranzo, N.1
  • 182
    • 84903137414 scopus 로고    scopus 로고
    • Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa
    • Campbell, M. C. et al. Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa. J. Hum. Genet. 59, 349-352 (2014).
    • (2014) J. Hum. Genet. , vol.59 , pp. 349-352
    • Campbell, M.C.1
  • 183
    • 77953195626 scopus 로고    scopus 로고
    • A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer
    • Campa, D. et al. A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer. BMC Med. Genet. 11, 88 (2010).
    • (2010) BMC Med. Genet. , vol.11 , pp. 88
    • Campa, D.1
  • 184
    • 84955095977 scopus 로고    scopus 로고
    • Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes
    • Nolden, A. A., McGeary, J. E. & Hayes, J. E. Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes. Physiol Behav. 156, 117-127 (2016).
    • (2016) Physiol Behav. , vol.156 , pp. 117-127
    • Nolden, A.A.1    McGeary, J.E.2    Hayes, J.E.3
  • 185
    • 84888315239 scopus 로고    scopus 로고
    • Variations in bitter-taste receptor genes, dietary intake, and colorectal adenoma risk
    • Schembre, S. M., Cheng, I., Wilkens, L. R., Albright, C. L. & Marchand le, L. Variations in bitter-taste receptor genes, dietary intake, and colorectal adenoma risk. Nutr. Cancer 65, 982-990 (2013).
    • (2013) Nutr. Cancer , vol.65 , pp. 982-990
    • Schembre, S.M.1    Cheng, I.2    Wilkens, L.R.3    Albright, C.L.4    Marchandle, L.5
  • 186
    • 79957942406 scopus 로고    scopus 로고
    • Association between TAS2R38 gene polymorphisms and colorectal cancer risk: A case-control study in two independent populations of Caucasian origin
    • Carrai, M. et al. Association between TAS2R38 gene polymorphisms and colorectal cancer risk: A case-control study in two independent populations of Caucasian origin. PLoS ONE 6, e20464 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e20464
    • Carrai, M.1
  • 187
  • 188
    • 68149137765 scopus 로고    scopus 로고
    • Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose
    • Fushan, A. A., Simons, C. T., Slack, J. P., Manichaikul, A. & Drayna, D. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. Curr. Biol. 19, 1288-1293 (2009).
    • (2009) Curr. Biol. , vol.19 , pp. 1288-1293
    • Fushan, A.A.1    Simons, C.T.2    Slack, J.P.3    Manichaikul, A.4    Drayna, D.5
  • 189
    • 78651333199 scopus 로고    scopus 로고
    • Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations
    • Eny, K. M., Wolever, T. M., Corey, P. N. & El-Sohemy, A. Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations. Am. J. Clin. Nutr. 92, 1501-1510 (2010).
    • (2010) Am. J. Clin. Nutr. , vol.92 , pp. 1501-1510
    • Eny, K.M.1    Wolever, T.M.2    Corey, P.N.3    El-Sohemy, A.4
  • 190
    • 84958982886 scopus 로고    scopus 로고
    • Sweet taste receptor TAS1R2 polymorphism (Val191Val) is associated with a higher carbohydrate intake and hypertriglyceridemia among the population of West Mexico
    • Ramos-Lopez, O., Panduro, A., Martinez-Lopez, E. & Roman, S. Sweet taste receptor TAS1R2 polymorphism (Val191Val) is associated with a higher carbohydrate intake and hypertriglyceridemia among the population of West Mexico. Nutrients 8, 101 (2016).
    • (2016) Nutrients , vol.8 , pp. 101
    • Ramos-Lopez, O.1    Panduro, A.2    Martinez-Lopez, E.3    Roman, S.4
  • 191
    • 84928674270 scopus 로고    scopus 로고
    • Association of sweet taste receptor gene polymorphisms with dental caries experience in school children
    • Haznedaroglu, E. et al. Association of sweet taste receptor gene polymorphisms with dental caries experience in school children. Caries Res. 49, 275-281 (2015).
    • (2015) Caries Res. , vol.49 , pp. 275-281
    • Haznedaroglu, E.1
  • 192
    • 70349572525 scopus 로고    scopus 로고
    • Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes
    • Chen, Q. Y. et al. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. Am. J. Clin. Nutr. 90, 770S-779S (2009).
    • (2009) Am. J. Clin. Nutr. , vol.90 , pp. 770S-779S
    • Chen, Q.Y.1
  • 193
    • 80053489155 scopus 로고    scopus 로고
    • Taste isn't just for taste buds anymore
    • Finger, T. E. & Kinnamon, S. C. Taste isn't just for taste buds anymore. F1000 Biol. Rep. 3, 20 (2011).
    • (2011) F1000 Biol. Rep. , vol.3 , pp. 20
    • Finger, T.E.1    Kinnamon, S.C.2
  • 194
    • 84873138013 scopus 로고    scopus 로고
    • Nutrient sensing in the gut: New roads to therapeutics?
    • Janssen, S. & Depoortere, I. Nutrient sensing in the gut: new roads to therapeutics?. Trends Endocrinol. Metab. 24, 92-100 (2013).
    • (2013) Trends Endocrinol. Metab. , vol.24 , pp. 92-100
    • Janssen, S.1    Depoortere, I.2
  • 195
  • 196
    • 84907058830 scopus 로고    scopus 로고
    • Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components
    • Lee, R. J., Chen, B., Redding, K. M., Margolskee, R. F. & Cohen, N. A. Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components. Innate Immun. 20, 606-617 (2014).
    • (2014) Innate Immun. , vol.20 , pp. 606-617
    • Lee, R.J.1    Chen, B.2    Redding, K.M.3    Margolskee, R.F.4    Cohen, N.A.5
  • 197
    • 84868610108 scopus 로고    scopus 로고
    • T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
    • Lee, R. J. et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J. Clin. Invest. 122, 4145-4159 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 4145-4159
    • Lee, R.J.1
  • 198
    • 84896770768 scopus 로고    scopus 로고
    • Bitter and sweet taste receptors regulate human upper respiratory innate immunity
    • Lee, R. J. et al. Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J. Clin. Invest. 124, 1393-1405 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 1393-1405
    • Lee, R.J.1
  • 199
    • 0041806520 scopus 로고    scopus 로고
    • Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration
    • Finger, T. E. et al. Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration. Proc. Natl Acad. Sci. USA 100, 8981-8986 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8981-8986
    • Finger, T.E.1
  • 200
    • 84899050450 scopus 로고    scopus 로고
    • Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation
    • Saunders, C. J., Christensen, M., Finger, T. E. & Tizzano, M. Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation. Proc. Natl Acad. Sci. USA 111, 6075-6080 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 6075-6080
    • Saunders, C.J.1    Christensen, M.2    Finger, T.E.3    Tizzano, M.4
  • 201
    • 77649260272 scopus 로고    scopus 로고
    • Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals
    • Tizzano, M. et al. Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. Proc. Natl Acad. Sci. USA 107, 3210-3215 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 3210-3215
    • Tizzano, M.1
  • 202
    • 0037133261 scopus 로고    scopus 로고
    • Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells
    • Wu, S. V. et al. Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc. Natl Acad. Sci. USA 99, 2392-2397 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 2392-2397
    • Wu, S.V.1
  • 203
    • 36549061908 scopus 로고    scopus 로고
    • Taste receptor signaling in the mammalian gut
    • Rozengurt, E. & Sternini, C. Taste receptor signaling in the mammalian gut. Curr. Opin. Pharmacol. 7, 557-562 (2007).
    • (2007) Curr. Opin. Pharmacol. , vol.7 , pp. 557-562
    • Rozengurt, E.1    Sternini, C.2
  • 204
    • 84893347143 scopus 로고    scopus 로고
    • A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131
    • Prandi, S. et al. A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS ONE 8, e82820 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e82820
    • Prandi, S.1
  • 205
    • 33845865790 scopus 로고    scopus 로고
    • Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells
    • Bezencon, C., le Coutre, J. & Damak, S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem. Senses 32, 41-49 (2007).
    • (2007) Chem. Senses , vol.32 , pp. 41-49
    • Bezencon, C.1    Le Coutre, J.2    Damak, S.3
  • 206
    • 84926490123 scopus 로고    scopus 로고
    • Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract
    • Schutz, B. et al. Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract. Front. Physiol. 6, 87 (2015).
    • (2015) Front. Physiol. , vol.6 , pp. 87
    • Schutz, B.1
  • 207
    • 78149355561 scopus 로고    scopus 로고
    • Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
    • Deshpande, D. A. et al. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat. Med. 16, 1299-1234 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 1234-1299
    • Deshpande, D.A.1
  • 210
    • 84958260325 scopus 로고    scopus 로고
    • "Tasting" the cerebrospinal fluid: Another function of the choroid plexus?
    • Tomas, J., Santos, C. R., Quintela, T. & Goncalves, I. "Tasting" the cerebrospinal fluid: Another function of the choroid plexus?. Neuroscience 320, 160-171 (2016).
    • (2016) Neuroscience , vol.320 , pp. 160-171
    • Tomas, J.1    Santos, C.R.2    Quintela, T.3    Goncalves, I.4
  • 211
    • 84877790035 scopus 로고    scopus 로고
    • Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart
    • Foster, S. R. et al. Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart. PLoS ONE 8, e64579 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e64579
    • Foster, S.R.1
  • 212
    • 14644415512 scopus 로고    scopus 로고
    • Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells
    • Dyer, J., Salmon, K. S., Zibrik, L. & Shirazi-Beechey, S. P. Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem. Soc. Trans. 33, 302-305 (2005).
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 302-305
    • Dyer, J.1    Salmon, K.S.2    Zibrik, L.3    Shirazi-Beechey, S.P.4
  • 213
    • 84920845080 scopus 로고    scopus 로고
    • Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes
    • Wolfle, U. et al. Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes. Skin Pharmacol. Physiol. 28, 137-146 (2015).
    • (2015) Skin Pharmacol. Physiol. , vol.28 , pp. 137-146
    • Wolfle, U.1
  • 214
    • 33748753829 scopus 로고    scopus 로고
    • Genomic structure of swine taste receptor family 1 member 3, TAS1R3, and its expression in tissues
    • Kiuchi, S. et al. Genomic structure of swine taste receptor family 1 member 3, TAS1R3, and its expression in tissues. Cytogenet. Genome Res. 115, 51-61 (2006).
    • (2006) Cytogenet. Genome Res. , vol.115 , pp. 51-61
    • Kiuchi, S.1
  • 215
    • 16644379784 scopus 로고    scopus 로고
    • Expression of the sweet receptor protein, T1R3, in the human liver and pancreas
    • Taniguchi, K. Expression of the sweet receptor protein, T1R3, in the human liver and pancreas. J. Vet. Med. Sci. 66, 1311-1314 (2004).
    • (2004) J. Vet. Med. Sci. , vol.66 , pp. 1311-1314
    • Taniguchi, K.1
  • 216
    • 84914818951 scopus 로고    scopus 로고
    • Mouse neutrophils express functional umami taste receptor T1R1/T1R3
    • Lee, N. et al. Mouse neutrophils express functional umami taste receptor T1R1/T1R3. BMB Rep. 47, 649-654 (2014).
    • (2014) BMB Rep. , vol.47 , pp. 649-654
    • Lee, N.1
  • 217
    • 84938505828 scopus 로고    scopus 로고
    • Tasting Pseudomonas aeruginosa biofilms: Human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone
    • Maurer, S. et al. Tasting Pseudomonas aeruginosa biofilms: Human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone. Front. Immunol. 6, 369 (2015).
    • (2015) Front. Immunol. , vol.6 , pp. 369
    • Maurer, S.1
  • 218
    • 56449093424 scopus 로고    scopus 로고
    • Glucose sensing in L cells: A primary cell study
    • Reimann, F. et al. Glucose sensing in L cells: A primary cell study. Cell Metab. 8, 532-539 (2008).
    • (2008) Cell Metab. , vol.8 , pp. 532-539
    • Reimann, F.1
  • 219
    • 84880656949 scopus 로고    scopus 로고
    • Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility
    • Mosinger, B. et al. Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility. Proc. Natl Acad. Sci. USA 110, 12319-12324 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 12319-12324
    • Mosinger, B.1
  • 220
    • 84871129066 scopus 로고    scopus 로고
    • Functional characterization of bitter-taste receptors expressed in mammalian testis
    • Xu, J., Cao, J., Iguchi, N., Riethmacher, D. & Huang, L. Functional characterization of bitter-taste receptors expressed in mammalian testis. Mol. Hum. Reprod. 19, 17-28 (2013).
    • (2013) Mol. Hum. Reprod. , vol.19 , pp. 17-28
    • Xu, J.1    Cao, J.2    Iguchi, N.3    Riethmacher, D.4    Huang, L.5
  • 221
    • 84936098219 scopus 로고    scopus 로고
    • TAS2R bitter taste receptors regulate thyroid function
    • Clark, A. A. et al. TAS2R bitter taste receptors regulate thyroid function. FASEB J. 29, 164-172 (2015).
    • (2015) FASEB J. , vol.29 , pp. 164-172
    • Clark, A.A.1
  • 222
    • 0030777012 scopus 로고    scopus 로고
    • The capsaicin receptor: A heat-activated ion channel in the pain pathway
    • Caterina, M. J. et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389, 816-824 (1997).
    • (1997) Nature , vol.389 , pp. 816-824
    • Caterina, M.J.1
  • 223
    • 79951775130 scopus 로고    scopus 로고
    • The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil
    • Everaerts, W. et al. The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr. Biol. 21, 316-321 (2011).
    • (2011) Curr. Biol. , vol.21 , pp. 316-321
    • Everaerts, W.1
  • 224
    • 24744446008 scopus 로고    scopus 로고
    • Pungent products from garlic activate the sensory ion channel TRPA1
    • Bautista, D. M. et al. Pungent products from garlic activate the sensory ion channel TRPA1. Proc. Natl Acad. Sci. USA 102, 12248-12252 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 12248-12252
    • Bautista, D.M.1
  • 225
    • 84958550454 scopus 로고    scopus 로고
    • TRPs in taste and chemesthesis
    • Roper, S. D. TRPs in taste and chemesthesis. Handb. Exp. Pharmacol. 223, 827-871 (2014).
    • (2014) Handb. Exp. Pharmacol. , vol.223 , pp. 827-871
    • Roper, S.D.1
  • 226
    • 0034044221 scopus 로고    scopus 로고
    • Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: Relationship to functional VR1 receptors
    • Liu, L. & Simon, S. A. Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: Relationship to functional VR1 receptors. Physiol. Behav. 69, 363-378 (2000).
    • (2000) Physiol. Behav. , vol.69 , pp. 363-378
    • Liu, L.1    Simon, S.A.2
  • 227
    • 33749560292 scopus 로고    scopus 로고
    • Differential expression of capsaicin-, menthol-, and mustard oil-sensitive receptors in naive rat geniculate ganglion neurons
    • Katsura, H., Tsuzuki, K., Noguchi, K. & Sakagami, M. Differential expression of capsaicin-, menthol-, and mustard oil-sensitive receptors in naive rat geniculate ganglion neurons. Chem. Senses 31, 681-688 (2006).
    • (2006) Chem. Senses , vol.31 , pp. 681-688
    • Katsura, H.1    Tsuzuki, K.2    Noguchi, K.3    Sakagami, M.4
  • 228
    • 83055186778 scopus 로고    scopus 로고
    • Characteristics of sodium currents in rat geniculate ganglion neurons
    • Nakamura, S. & Bradley, R. M. Characteristics of sodium currents in rat geniculate ganglion neurons. J. Neurophysiol. 106, 2982-2991 (2011).
    • (2011) J. Neurophysiol. , vol.106 , pp. 2982-2991
    • Nakamura, S.1    Bradley, R.M.2
  • 229
    • 0022636354 scopus 로고
    • Peptide immunohistochemistry demonstrates multiple classes of perigemmal nerve fibers in the circumvallate papilla of the rat
    • Finger, T. E. Peptide immunohistochemistry demonstrates multiple classes of perigemmal nerve fibers in the circumvallate papilla of the rat. Chem. Senses 11, 135-144 (1986).
    • (1986) Chem. Senses , vol.11 , pp. 135-144
    • Finger, T.E.1
  • 230
    • 0028943719 scopus 로고
    • Modulation of rat chorda tympani nerve activity by lingual nerve stimulation
    • Wang, Y., Erickson, R. P. & Simon, S. A. Modulation of rat chorda tympani nerve activity by lingual nerve stimulation. J. Neurophysiol. 73, 1468-1483 (1995).
    • (1995) J. Neurophysiol. , vol.73 , pp. 1468-1483
    • Wang, Y.1    Erickson, R.P.2    Simon, S.A.3
  • 232
    • 84857439223 scopus 로고    scopus 로고
    • Tachykinins stimulate a subset of mouse taste cells
    • Grant, J. Tachykinins stimulate a subset of mouse taste cells. PLoS ONE 7, e31697 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e31697
    • Grant, J.1
  • 233
    • 84941776797 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide reduces taste-evoked ATP secretion from mouse taste buds
    • Huang, A. Y. & Wu, S. Y. Calcitonin gene-related peptide reduces taste-evoked ATP secretion from mouse taste buds. J. Neurosci. 35, 12714-12724 (2015).
    • (2015) J. Neurosci. , vol.35 , pp. 12714-12724
    • Huang, A.Y.1    Wu, S.Y.2
  • 234
    • 33847217610 scopus 로고    scopus 로고
    • Mechanisms of sensory transduction in the skin
    • Lumpkin, E. A. & Caterina, M. J. Mechanisms of sensory transduction in the skin. Nature 445, 858-865 (2007).
    • (2007) Nature , vol.445 , pp. 858-865
    • Lumpkin, E.A.1    Caterina, M.J.2
  • 235
    • 84943753952 scopus 로고    scopus 로고
    • Keratinocytes can modulate and directly initiate nociceptive responses
    • Baumbauer, K. M. et al. Keratinocytes can modulate and directly initiate nociceptive responses. eLife 4, e09674 (2015).
    • (2015) ELife , vol.4 , pp. e09674
    • Baumbauer, K.M.1
  • 237
    • 34548025819 scopus 로고    scopus 로고
    • Molecular and sensory characterization of γ-glutamyl peptides as key contributors to the kokumi taste of edible beans (Phaseolus vulgaris L.)
    • Dunkel, A., Köster, J. & Hofmann, T. Molecular and sensory characterization of γ-glutamyl peptides as key contributors to the kokumi taste of edible beans (Phaseolus vulgaris L.). J. Agric. Food Chem. 55, 6712-6719 (2007).
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 6712-6719
    • Dunkel, A.1    Köster, J.2    Hofmann, T.3
  • 238
    • 74049148126 scopus 로고    scopus 로고
    • Involvement of the calcium-sensing receptor in human taste perception
    • Ohsu, T. et al. Involvement of the calcium-sensing receptor in human taste perception. J. Biol. Chem. 285, 1016-1022 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 1016-1022
    • Ohsu, T.1
  • 239
    • 84864355215 scopus 로고    scopus 로고
    • Kokumi substances, enhancers of basic tastes, induce responses in calcium-sensing receptor expressing taste cells
    • Maruyama, Y., Yasuda, R., Kuroda, M. & Eto, Y. Kokumi substances, enhancers of basic tastes, induce responses in calcium-sensing receptor expressing taste cells. PLoS ONE 7, e34489 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e34489
    • Maruyama, Y.1    Yasuda, R.2    Kuroda, M.3    Eto, Y.4
  • 240
    • 84994030718 scopus 로고    scopus 로고
    • Positive allosteric modulation of the calcium-sensing receptor by physiological concentrations of glucose
    • Medina, J. et al. Positive allosteric modulation of the calcium-sensing receptor by physiological concentrations of glucose. J. Biol. Chem. 291, 23126-23135 (2016).
    • (2016) J. Biol. Chem. , vol.291 , pp. 23126-23135
    • Medina, J.1
  • 241
    • 0029813089 scopus 로고    scopus 로고
    • Some basic psychophysics of calcium salt solutions
    • Tordoff, M. G. Some basic psychophysics of calcium salt solutions. Chem. Senses 21, 417-424 (1996).
    • (1996) Chem. Senses , vol.21 , pp. 417-424
    • Tordoff, M.G.1
  • 242
    • 13544255398 scopus 로고    scopus 로고
    • Calcium deprivation increases the palatability of calcium solutions in rats
    • McCaughey, S. A., Forestell, C. A. & Tordoff, M. G. Calcium deprivation increases the palatability of calcium solutions in rats. Physiol. Behav. 84, 335-342 (2005).
    • (2005) Physiol. Behav. , vol.84 , pp. 335-342
    • McCaughey, S.A.1    Forestell, C.A.2    Tordoff, M.G.3
  • 243
    • 57049179732 scopus 로고    scopus 로고
    • Involvement of T1R3 in calcium-magnesium taste
    • Tordoff, M. G. et al. Involvement of T1R3 in calcium-magnesium taste. Physiol. Genom. 34, 338-348 (2008).
    • (2008) Physiol. Genom. , vol.34 , pp. 338-348
    • Tordoff, M.G.1


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