Amiloride suppresses the sourness of NaCl and LiCl

Physiology and Behavior

Volumn 60, Issue 5, 1996, Pages 1317-1322

  Ossebaard, Corinne A ^a   Smith, David V ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Amiloride; Gustation; Magnitude estimation; NaCl; Taste; Taste transduction

Indexed keywords

AMILORIDE; CELL RECEPTOR; ION CHANNEL; LITHIUM CHLORIDE; SODIUM CHLORIDE;

ADAPTATION; ARTICLE; ASSAY; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SWEETNESS; TASTE;

EID: 0343289163     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(96)00258-2     Document Type: Article

References (39)

1. Avenet P.P., Lindemann B. Amiloride-blockable sodium currents in isolated taste receptor cells. J. Membrane Biol. 105:1988;245-255.
2. Bartoshuk L.M., Murphy C., Cleveland C.T. Sweet taste of dilute NaCl: Psychophysical evidence for a sweet stimulus. Physiol. Behav. 21:1978;609-613.
3. Brand J.G., Teeter J.H., Silver W.L. Inhibition by amiloride of chorda tympani responses evoked by monovalent salts. Brain Res. 334:1985;207-214.
4. Cardello A.V. Taste quality changes as a function of salt concentration in single human taste papillae. Chem. Sens. Flav. 4:1979;1-12.
5. Clark C.C., Lawless H.T. Limiting response alternatives in time-intensity scaling: An examination of the halo-dumping effect. Chem. Senses. 19:1994;583-594.
6. Dzendolet E., Meiselman H.L. Gustatory quality changes as a function of solution concentration. Percept. Psychophys. 2:1967;29-33.
7. Elliott E.J., Simon S.A. The anion in salt taste: A possible role for paracellular pathways. Brain Res. 53:1990;9-17.
8. Formaker B.K., Hill D.L. An analysis of residual NaCl taste response after amiloride. Am. J. Physiol. 255:1988;R1002-R1007.
9. Frank R.A., Byram J. Taste-smell interactions are tastant and odorant dependent. Chem. Senses. 13:1988;445-455.
10. Frank R.A., van der Klaauw N.J., Schifferstein H.N.J. Both perceptual and conceptual factors influence taste-odor and taste-taste interactions. Percept. Psychophys. 54:1993;343-354.
11. Giza B.K., Scott T.R. The effect of amiloride on taste-evoked activity in the nucleus tractus solitarius of the rat. Brain Res. 550:1991;247-256.
12. Harper H.W. A diffusion potential model of salt taste receptors. Ann. N.Y. Acad. Sci. 510:1987;349-351.
13. Heck G.L., Mierson S., DeSimone J.A. Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science. 233:1984;403-405.
14. Hellekant G., DuBois G.E., Roberts T.W., van der Wel H. On the gustatory effect of amiloride in the monkey (Macaca mulatta). Chem. Senses. 13:1988;89-93.
15. Hettinger T.P., Frank M.E. Specificity of amiloride inhibition of hamster taste responses. Brain Res. 513:1990;24-34.
16. Hill D.L., Bour T.C. Addition of functional amiloride-sensitive components to the receptor membrane: A possible mechanism for altered taste responses during development. Dev. Brain Res. 20:1985;310-313.
17. Huynh H., Feldt L.S. Estimation of the Box correction for degrees of freedom from sample data in the randomized block and split-plot designs. J. Educ. Stat. 1:1976;69-82.
18. McBurney D.H. Magnitude estimation of the taste of sodium chloride after adaptation to sodium chloride. J. Exp. Psychol. 72:1966;869-873.
19. McBurney D.H., Bartoshuk L.M. Interactions between stimuli with different taste qualities. Physiol. Behav. 10:1973;1101-1106.
20. McBurney D.H., Smith D.V., Shick T.R. Gustatory cross adaptation:Sourness and bitterness. Percept. Psychophys. 11:1972;228-232.
21. McCutcheon N.B. Human psychophysical studies of saltiness suppression by amiloride. Physiol. Behav. 51:1992;1069-1074.
22. Nakamura M., Kurihara K. Nonspecific inhibition by amiloride of canine chorda tympani nerve responses to various salts: Do Na-specific channels exist in canine taste receptor membranes. Brain Res. 524:1990;42-48.
23. Ninomiya Y., Funakoshi M. Amiloride inhibition of responses to rat single chorda tympani fibers to chemical and electrical tongue stimulations. Brain Res. 451:1988;319-325.
24. + receptor mechanisms. Chem. Senses. 20:1995;37-46.
25. + channels. J. Membrane Biol. 96:1987;97-106.
26. Rankin K.M., Marks L.E. Differential context effects in taste perception. Chem. Senses. 16:1991;617-629.
27. Sandick B., Cardello A.V. Tastes of salts and acids on circumvallate papillae and anterior tongue. Chem. Senses. 8:1983;59-69.
28. Schifferstein H.N.J. Contextual effects in difference judgements. Percept. Psychophys. 57:1995;56-70.
29. + salts and sweeteners. Proc. Natl. Acad. Sci. USA. 80:1983;6136-6140.
30. Schiffman S.S., McElroy A.E., Erickson R.P. The range of taste quality of sodium salts. Physiol. Behav. 24:1980;217-224.
31. Scott T.R., Giza B.K. Coding channels in the taste system of the rat. Science. 249:1990;1585-1587.
32. Smith D.V., McBurney D.H. Gustatory cross-adaptation: Does a single mechanism code the salty taste. J. Exp. Psychol. 80:1969;101-105.
33. Smith D.V., Ossebaard C.A. Amiloride suppression of the taste intensity of sodium chloride: Evidence from direct magnitude scaling. Physiol. Behav. 57:1995;773-777.
34. Smith D.V., van der Klaauw N.J. The perception of saltiness is eliminated by NaCl adaptation: Implications for gustatory transduction and coding. Chem. Senses. 20:1995;545-557.
35. Tennissen A.M. Amiloride reduces intensity responses of human fungiform papillae. Physiol. Behav. 51:1992;1061-1068.
36. Tennissen A.M., McCutcheon N.B. Anterior tongue stimulation with amiloride suppresses NaCl saltiness, but not citric acid sourness in humans. Chem. Senses. 21:1996;113-120.
37. van der Klaauw N.J., Smith D.V. Taste quality profiles for fifteen organic and inorganic salts. Physiol. Behav. 58:1995;295-306.
38. Ye Q., Heck G.L., DeSimone J.A. The anion paradox in sodium taste reception: Resolution by voltage-clamp studies. Science. 254:1991;724-726.
39. + salts:Implications for the functional organization of taste receptor cells. J. Neurophysiol. 70:1993;167-178.