Lingual lipase activity in the orosensory detection of fat by humans

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 306, Issue 12, 2014, Pages

  Kulkarni, Bhushan V ^a   Mattes, Richard D ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Fat; Human; Lingual; Lipase; Orlistat

Indexed keywords

FAT; FATTY ACID; LAURIC ACID; LINOLEIC ACID; OLEIC ACID; OLIVE OIL; PALMITIC ACID; STEARIC ACID; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE;

ADULT; ALMOND; ARTICLE; BUTTER; COCONUT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HUMAN; IN VITRO STUDY; LIPID ANALYSIS; LIPID COMPOSITION; LIPOLYSIS; MALE; NORMAL HUMAN; PILOT STUDY; PRIORITY JOURNAL; SENSORY EVALUATION; TONGUE; WALNUT;

FAT; HUMAN; LINGUAL; LIPASE; ORLISTAT;

ADOLESCENT; ADULT; COCOS; DIETARY FATS; ENZYME INHIBITORS; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; LACTONES; LIPASE; MALE; MIDDLE AGED; PLANT OILS; PRUNUS; SALIVA; SENSATION; TASTE; TONGUE; YOUNG ADULT;

EID: 84902688557     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00352.2013     Document Type: Article

References (19)

1. Al-Suwailem AK, Al-Tamimi AS, Al-Omar MA, Al-Suhibani MS. Safety and mechanism of action of orlistat (Tetrahydrolipstatin) as the first local antiobesity drug. J Appl Sci Res 2: 205-208, 2006.
2. Chauncey HH, Lionetti F, Winer RA, Vincet VF. Enzymes of human saliva. The determination, distribution and origin of whole saliva enzymes. J Dent Res 33: 321-333, 1954.
3. Folch J, Lees M, Sloane Stanley GH. Simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509, 1957.
4. Hamosh M, Burns WA. Lipolytic activity of human lingual glands (Ebner). Lab Invest 37: 603-608, 1977.
5. Hamosh M. Lingual and gastric lipases. Nutrition 6: 421-428, 1990.
6. Hamosh M, Klaeveman HL, Wolf RO, Scow RO. Pharyngeal lipase and digestion of dietary triglyceride in man. J Clin Invest 55: 908-913, 1975.
7. Hamosh M, Ganot D, Hamosh P. Rat lingual lipase, characteristics of enzyme activity. J Biol Chem 254: 12121-12125, 1979.
8. Kawai T, Fushiki T. Importance of lipolysis in oral cavity for orosensory detection of fat. Am J Physiol Regul Integr Comp Physiol 285: R447-R454, 2003.
9. Kulkarni BV, Wood KV, Mattes RD. Quantitative and qualitative analyses of human salivary NEFA with gas-chromatography and mass spectrometry. Front Physiol 3: 328, 2012.
10. Kulkarni B, Mattes R. Evidence for presence of nonesterified fatty acids as potential gustatory signaling molecules in humans. Chem Sens 38: 119-127, 2013.
11. Mattes RD. Is there a fatty acid taste? Annu Rev Nutr 29: 305-327, 2009.
12. Mattes RD. Accumulating evidence supports a taste component for free fatty acids in humans. Physiol Behav 104: 624-631, 2011.
13. Neyraud E, Palicki O, Schwartz C, Nicklaus S, Feron G. Variability of human saliva composition: possible relationship with fat perception and liking. Arch Oral Biol 57: 556-66, 2011.
14. Pepino MY, Love-Gregory L, Klein S, Abumrad NA. The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects. J Lipid Res 53: 561-566, 2012.
15. Pritchard ET, Dawes C, Philips SR. Apparent lipase activity of human saliva. Arch Oral Biol 12: 1217-1219, 1967.
16. Roberts IM, Montgomery RK, Carey MC. Rat lingual lipase: partial purification, hydrolytic properties, and comparison with pancreatic lipase. Am J Physiol Gastrointest Liver Physiol 247: G385-G393, 1984.
17. Spielman AI, D'abundo S, Field RB, Schmale H. Protein analysis of human von Ebner saliva and a method for its collection from the foliate papillae. J Dent Res 72: 1331-1335, 1993.
18. Stewart JE, Feinle-Bisset C, Golding M, Delahunty C, Clifton PM, Keast RS. Oral sensitivity to fatty acids, food consumption and BMI in human participants. Br J Nutr 104: 145-152, 2010.
19. Yun JW. Possible anti-obesity therapeutics from nature: A review. Phytochemistry 71: 1625-1641, 2010.