Allelic Polymorphism within the TAS1R3 Promoter Is Associated with Human Taste Sensitivity to Sucrose

Current Biology

Volumn 19, Issue 15, 2009, Pages 1288-1293

  Fushan, Alexey A ^a   Simons, Christopher T ^b   Slack, Jay P ^b   Manichaikul, Ani ^c   Drayna, Dennis ^a  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b Givaudan Roure Corporation   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

EVO_ECOL

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LUCIFERASE; SUCROSE; TASTE RECEPTORS, TYPE 1;

ALLELE; ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; ASIAN; CAUCASIAN; GENETIC TRANSCRIPTION; GENETICS; GENOTYPE; HUMAN; METABOLISM; NEGRO; PHYSIOLOGY; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; TASTE;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; ANALYSIS OF VARIANCE; AREA UNDER CURVE; ASIAN CONTINENTAL ANCESTRY GROUP; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENOTYPE; HUMANS; LUCIFERASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RECEPTORS, G-PROTEIN-COUPLED; SUCROSE; TASTE PERCEPTION; TRANSCRIPTION, GENETIC;

EID: 68149137765     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2009.06.015     Document Type: Article

References (36)

1. Li X., Staszewski L., Xu H., Durick K., Zoller M., and Adler E. Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. USA 99 (2002) 4692-4696
2. Sainz E., Cavenagh M.M., LopezJimenez N.D., Gutierrez J.C., Battey J.F., Northup J.K., and Sullivan S.L. The G-protein coupling properties of the human sweet and amino acid taste receptors. Dev. Neurobiol. 67 (2007) 948-959
3. Zhao G.Q., Zhang Y., Hoon M.A., Chandrashekar J., Erlenbach I., Ryba N.J., and Zuker C.S. The receptors for mammalian sweet and umami taste. Cell 115 (2003) 255-266
4. Bachmanov A.A., Li X., Reed D.R., Ohmen J.D., Li S., Chen Z., Tordoff M.G., de Jong P.J., Wu C., West D.B., et al. Positional cloning of the mouse saccharin preference (Sac) locus. Chem. Senses 26 (2001) 925-933
5. Max M., Shanker Y.G., Huang L., Rong M., Liu Z., Campagne F., Weinstein H., Damak S., and Margolskee R.F. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat. Genet. 28 (2001) 58-63
6. Montmayeur J.P., Liberles S.D., Matsunami H., and Buck L.B. A candidate taste receptor gene near a sweet taste locus. Nat. Neurosci. 4 (2001) 492-498
7. Kitagawa M., Kusakabe Y., Miura H., Ninomiya Y., and Hino A. Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem. Biophys. Res. Commun. 283 (2001) 236-242
8. Kim U.K., Wooding S., Riaz N., Jorde L.B., and Drayna D. Variation in the human TAS1R taste receptor genes. Chem. Senses 31 (2006) 599-611
9. Brown J. Recognition assessed by rating and ranking. Br. J. Psychol. 65 (1974) 13-22
10. O'Mahony M. Understanding discrimination tests: A user-friendly treatment of response bias, rating, and ranking R-index tests and their relationship to signal detection. J. Sens. Stud. 7 (1992) 1-47
11. Fukunaga A., Uematsu H., and Sugimoto K. Influences of aging on taste perception and oral somatic sensation. J. Gerontol. 60 (2005) 109-113
12. Stevens J.C., and Cain W.S. Changes in taste and flavor in aging. Crit. Rev. Food Sci. Nutr. 33 (1993) 27-37
13. Nakamura Y., Sanematsu K., Ohta R., Shirosaki S., Koyano K., Nonaka K., Shigemura N., and Ninomiya Y. Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels. Diabetes 57 (2008) 2661-2665
14. Rodin J. Insulin levels, hunger, and food intake: an example of feedback loops in body weight regulation. Health Psychol. 4 (1985) 1-24
15. Keskitalo K., Silventoinen K., Tuorila H., Perola M., Pietilainen K.H., Rissanen A., and Kaprio J. Genetic and environmental contributions to food use patterns of young adult twins. Physiol. Behav. 93 (2008) 235-242
16. Miller Jr. I.J., and Reedy Jr. F.E. Variations in human taste bud density and taste intensity perception. Physiol. Behav. 47 (1990) 1213-1219
17. Bretz W.A., Corby P.M., Melo M.R., Coelho M.Q., Costa S.M., Robinson M., Schork N.J., Drewnowski A., and Hart T.C. Heritability estimates for dental caries and sucrose sweetness preference. Arch. Oral Biol. 51 (2006) 1156-1160
18. Keskitalo K., Knaapila A., Kallela M., Palotie A., Wessman M., Sammalisto S., Peltonen L., Tuorila H., and Perola M. Sweet taste preferences are partly genetically determined: identification of a trait locus on chromosome 16. Am. J. Clin. Nutr. 86 (2007) 55-63
19. Mizuta E., Kokubo Y., Yamanaka I., Miyamoto Y., Okayama A., Yoshimasa Y., Tomoike H., Morisaki H., and Morisaki T. Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. Hypertens. Res. 31 (2008) 1069-1077
20. Belmont J.W., and Leal S.M. Complex phenotypes and complex genetics: an introduction to genetic studies of complex traits. Curr. Atheroscler. Rep. 7 (2005) 180-187
21. Mackay T.F. The genetic architecture of quantitative traits. Annu. Rev. Genet. 35 (2001) 303-339
22. Frey U.H., Lieb W., Erdmann J., Savidou D., Heusch G., Leineweber K., Jakob H., Hense H.W., Lowel H., Brockmeyer N.H., et al. Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans. Eur. Heart J. 29 (2008) 888-897
23. Pare G., Chasman D.I., Parker A.N., Nathan D.M., Miletich J.P., Zee R.Y., and Ridker P.M. Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study. PLoS Genet. 4 (2008) e1000312
24. Pfeufer A., Jalilzadeh S., Perz S., Mueller J.C., Hinterseer M., Illig T., Akyol M., Huth C., Schopfer-Wendels A., Kuch B., et al. Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study. Circ. Res. 96 (2005) 693-701
25. Jang H.J., Kokrashvili Z., Theodorakis M.J., Carlson O.D., Kim B.J., Zhou J., Kim H.H., Xu X., Chan S.L., Juhaszova M., et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc. Natl. Acad. Sci. USA 104 (2007) 15069-15074
26. Toyono T., Seta Y., Kataoka S., and Toyoshima K. CCAAT/Enhancer-binding protein beta regulates expression of human T1R3 taste receptor gene in the bile duct carcinoma cell line, HuCCT1. Biochim. Biophys. Acta 1769 (2007) 641-648
27. Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J., Devon K., Dewar K., Doyle M., FitzHugh W., et al. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
28. Sharma V.K., Brahmachari S.K., and Ramachandran S. (TG/CA)n repeats in human gene families: Abundance and selective patterns of distribution according to function and gene length. BMC Genomics 6 (2005) 83
29. Epplen J.T., Kyas A., and Maueler W. Genomic simple repetitive DNAs are targets for differential binding of nuclear proteins. FEBS Lett. 389 (1996) 92-95
30. Kashi Y., King D., and Soller M. Simple sequence repeats as a source of quantitative genetic variation. Trends Genet. 13 (1997) 74-78
31. Rockman M.V., and Wray G.A. Abundant raw material for cis-regulatory evolution in humans. Mol. Biol. Evol. 19 (2002) 1991-2004
32. Massari M.E., and Murre C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20 (2000) 429-440
33. Li J.Z., Absher D.M., Tang H., Southwick A.M., Casto A.M., Ramachandran S., Cann H.M., Barsh G.S., Feldman M., Cavalli-Sforza L.L., et al. Worldwide human relationships inferred from genome-wide patterns of variation. Science 319 (2008) 1100-1104
34. Hussain R., Kinghorn A., and Soearto D. Sweetening agents of plant origin: literature search for candidate sweet plants. Econ. Bot. 42 (1988) 267-283
35. Lindemann B., Ogiwara Y., and Ninomiya Y. The discovery of umami. Chem. Senses 27 (2002) 843-844
36. Emilsson V., Thorleifsson G., Zhang B., Leonardson A.S., Zink F., Zhu J., Carlson S., Helgason A., Walters G.B., Gunnarsdottir S., et al. Genetics of gene expression and its effect on disease. Nature 452 (2008) 423-428