Pungent products from garlic activate the sensory ion channel TRPA1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 34, 2005, Pages 12248-12252

  Bautista, Diana M ^a   Movahed, Pouya ^b   Hinman, Andrew ^a   Axelsson, Helena E ^b   Sterner, Olov ^c   Högestätt, Edward D ^b   Julius, David ^a   Jordt, Sven Eric ^a,d   Zygmunt, Peter M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Inflammation; Natural products; Pain; TRP channel; Vasodilation

Indexed keywords

ALLICIN; ALLYL ISOTHIOCYANATE; ALLYL SULFIDE; CAPSAICIN; CAPSAZEPINE; GARLIC EXTRACT; ION CHANNEL; ORGANOSULFUR DERIVATIVE;

ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AROMA; ARTICLE; BRASSICA; CELL SUBPOPULATION; CLONE; CONTROLLED STUDY; CONVERGENT EVOLUTION; FEMALE; GARLIC; GENE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; NERVE CELL EXCITABILITY; NERVE ENDING; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SENSORY NERVE CELL; STRUCTURE ACTIVITY RELATION; TRPA1 GENE; VASODILATATION; WASABI;

ALLYL COMPOUNDS; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM CHANNELS; CELLS, CULTURED; DISULFIDES; GARLIC; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NOCICEPTORS; PLANT EXTRACTS; SULFINIC ACIDS; VASODILATION;

ALLIUM; ALLIUM SATIVUM; BRASSICA; EUTREMA WASABI;

EID: 24744446008     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0505356102     Document Type: Article

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