메뉴 건너뛰기




Volumn 3, Issue 2, 2000, Pages 113-119

A metabotropic glutamate receptor variant functions as a taste receptor

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; METABOTROPIC RECEPTOR;

EID: 0033993988     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/72053     Document Type: Article
Times cited : (514)

References (45)
  • 1
    • 0030194456 scopus 로고    scopus 로고
    • Taste reception
    • Lindemann, B. Taste reception. Physiol. Rev. 76, 719-766 (1996).
    • (1996) Physiol. Rev. , vol.76 , pp. 719-766
    • Lindemann, B.1
  • 2
    • 0032959395 scopus 로고    scopus 로고
    • Receptor seeks ligand: On the way to cloning the molecular receptors for sweet and bitter taste
    • Lindemann, B. Receptor seeks ligand: on the way to cloning the molecular receptors for sweet and bitter taste. Nat. Med. 5, 381-382 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 381-382
    • Lindemann, B.1
  • 3
    • 0026718951 scopus 로고
    • Gustducin is a taste-cell-specific G protein closely related to the transducins
    • McLaughlin, S. K., McKinnon, P. J. & Margolskee, R. F. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357, 563-569 (1992).
    • (1992) Nature , vol.357 , pp. 563-569
    • McLaughlin, S.K.1    McKinnon, P.J.2    Margolskee, R.F.3
  • 6
    • 0344936733 scopus 로고    scopus 로고
    • Identification of two alpha-subunit species of GTP-binding proteins, Ga15 and Gaq, expressed in rat taste buds
    • Kusakabe, Y. et al. Identification of two alpha-subunit species of GTP-binding proteins, Ga15 and Gaq, expressed in rat taste buds. Biochim. Biophys. Acta 1403, 265-272 (1998).
    • (1998) Biochim. Biophys. Acta , vol.1403 , pp. 265-272
    • Kusakabe, Y.1
  • 7
    • 0033233484 scopus 로고    scopus 로고
    • 3 responses to bitter denatonium
    • 3 responses to bitter denatonium. Nat. Neurosci. 2, 1055-1062 (1999).
    • (1999) Nat. Neurosci. , vol.2 , pp. 1055-1062
    • Huang, L.1
  • 8
    • 0030921657 scopus 로고    scopus 로고
    • Taste buds have a cyclic nucleotide-activated channel, CNGgust
    • Misaka, T. et al. Taste buds have a cyclic nucleotide-activated channel, CNGgust. J. Biol. Chem. 272, 22623-22629 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 22623-22629
    • Misaka, T.1
  • 9
    • 0032929132 scopus 로고    scopus 로고
    • Differential expression of RNA and protein of the three pore-forming subunits of the amiloride-sensitive epithelial sodium channel in taste buds of the rat
    • Kretz, O., Barbry, P., Bock, R. & Lindemann, B. Differential expression of RNA and protein of the three pore-forming subunits of the amiloride-sensitive epithelial sodium channel in taste buds of the rat. J. Histochem. Cytochem. 47, 51-64 (1999).
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 51-64
    • Kretz, O.1    Barbry, P.2    Bock, R.3    Lindemann, B.4
  • 10
  • 11
    • 0032497489 scopus 로고    scopus 로고
    • Receptor that leaves a sour taste in the mouth
    • Ogawa, S. et al. Receptor that leaves a sour taste in the mouth. Nature 395, 555-556 (1998).
    • (1998) Nature , vol.395 , pp. 555-556
    • Ogawa, S.1
  • 12
    • 0032555142 scopus 로고    scopus 로고
    • Characterization and solubilization of bitter-responsive receptors that couple to gustducin
    • Ming, D., Ruiz-Avila, L. & Margolskee, R. F. Characterization and solubilization of bitter-responsive receptors that couple to gustducin. Proc. Natl. Acad. Sci. USA 95, 8933-8938 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8933-8938
    • Ming, D.1    Ruiz-Avila, L.2    Margolskee, R.F.3
  • 13
    • 0027323362 scopus 로고
    • Identification of novel members of G-protein coupled receptor superfamily expressed in bovine taste tissue
    • Matsuoka, I., Mori, T., Aoki, J., Sato, T. & Kurihara, K. Identification of novel members of G-protein coupled receptor superfamily expressed in bovine taste tissue. Biochem. Biophys. Res. Commun. 194, 504-511 (1993).
    • (1993) Biochem. Biophys. Res. Commun. , vol.194 , pp. 504-511
    • Matsuoka, I.1    Mori, T.2    Aoki, J.3    Sato, T.4    Kurihara, K.5
  • 14
    • 0027298698 scopus 로고
    • Primary structure and cell-type specific expression of a gustatory G protein-coupled receptor related to olfactory receptors
    • Abe, K., Kusakabe, Y., Tanemura, K., Emori, Y. & Arai, S. Primary structure and cell-type specific expression of a gustatory G protein-coupled receptor related to olfactory receptors. J. Biol. Chem. 268, 12033-12039 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 12033-12039
    • Abe, K.1    Kusakabe, Y.2    Tanemura, K.3    Emori, Y.4    Arai, S.5
  • 15
    • 0033582645 scopus 로고    scopus 로고
    • Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity
    • Hoon, M. A. et al. Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 96, 541-551 (1999).
    • (1999) Cell , vol.96 , pp. 541-551
    • Hoon, M.A.1
  • 16
    • 0025905990 scopus 로고
    • Are umami taste receptor sites structurally related to glutamate CNS receptor sites?
    • Faurion, A. Are umami taste receptor sites structurally related to glutamate CNS receptor sites? Physiol. Behav. 49, 905-912 (1991).
    • (1991) Physiol. Behav. , vol.49 , pp. 905-912
    • Faurion, A.1
  • 17
    • 0030006520 scopus 로고    scopus 로고
    • The taste of monosodium glutamate: Membrane receptors in taste buds
    • Chaudhari, N. et al. The taste of monosodium glutamate: Membrane receptors in taste buds. J. Neurosci. 16, 3817-3826 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 3817-3826
    • Chaudhari, N.1
  • 19
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn, P. J. & Pin, J. P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37, 205-237 (1997).
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.P.2
  • 20
    • 0032460588 scopus 로고    scopus 로고
    • Molecular and physiological evidence for glutamate (umami) taste transduction via a G protein-coupled receptor
    • Chaudhari, N. & Roper, S. D. Molecular and physiological evidence for glutamate (umami) taste transduction via a G protein-coupled receptor. Ann. NY Acad. Sci. 855, 398-406 (1998).
    • (1998) Ann. NY Acad. Sci. , vol.855 , pp. 398-406
    • Chaudhari, N.1    Roper, S.D.2
  • 21
    • 0032962092 scopus 로고    scopus 로고
    • An optimized method for in situ hybridization with signal amplification that allows the detection of rare mRNAs
    • Yang, H., Wanner, I. B., Roper, S. D. & Chaudhari, N. An optimized method for in situ hybridization with signal amplification that allows the detection of rare mRNAs. J. Histochem. Cytochem. 47 431-446 (1999).
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 431-446
    • Yang, H.1    Wanner, I.B.2    Roper, S.D.3    Chaudhari, N.4
  • 22
  • 23
    • 0033548030 scopus 로고    scopus 로고
    • Analyses of taste nerve responses with special reference to possible receptor mechanisms of umami taste in the rat
    • Sako, N. & Yamamoto, T. Analyses of taste nerve responses with special reference to possible receptor mechanisms of umami taste in the rat. Neurosci. Lett. 261, 109-112 (1999).
    • (1999) Neurosci. Lett. , vol.261 , pp. 109-112
    • Sako, N.1    Yamamoto, T.2
  • 24
    • 0343433537 scopus 로고    scopus 로고
    • Taste preference synergism between glutamate receptor ligands and IMP in rats
    • in press
    • Delay, E. R. et al. Taste preference synergism between glutamate receptor ligands and IMP in rats. Chem. Senses (in press).
    • Chem. Senses
    • Delay, E.R.1
  • 25
    • 0032719386 scopus 로고    scopus 로고
    • Physiological evidence for ionotropic and metabotropic glutamate receptors in rat taste cells
    • Lin, W. & Kinnamon, S.C. Physiological evidence for ionotropic and metabotropic glutamate receptors in rat taste cells. J. Neurophysiol. 82, 2061-2069 (1999).
    • (1999) J. Neurophysiol. , vol.82 , pp. 2061-2069
    • Lin, W.1    Kinnamon, S.C.2
  • 27
    • 0025872865 scopus 로고
    • Electrophysiological and behavioural studies on the taste of umami substances in the rat
    • Yamamoto, T. et al. Electrophysiological and behavioural studies on the taste of umami substances in the rat. Physiol. Behav. 49, 919-925 (1991).
    • (1991) Physiol. Behav. , vol.49 , pp. 919-925
    • Yamamoto, T.1
  • 28
    • 0032734779 scopus 로고    scopus 로고
    • Effect of the umami peptides on the ligand binding and function of rat mGlu4a receptor might implicate this receptor in the monosodium glutamate taste transduction
    • Monastyrskaia, K. et al. Effect of the umami peptides on the ligand binding and function of rat mGlu4a receptor might implicate this receptor in the monosodium glutamate taste transduction. Br. J. Pharmacol. 128, 1027-1034 (1999).
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 1027-1034
    • Monastyrskaia, K.1
  • 29
    • 0027295942 scopus 로고
    • The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
    • O'Hara, P. J. et al. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron 11, 41-52 (1993).
    • (1993) Neuron , vol.11 , pp. 41-52
    • O'Hara, P.J.1
  • 30
    • 0033538058 scopus 로고    scopus 로고
    • Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor
    • Han, G. & Hampson, D. R. Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J. Biol. Chem. 274, 10008-10013 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 10008-10013
    • Han, G.1    Hampson, D.R.2
  • 31
    • 0027282265 scopus 로고
    • Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination
    • Takahashi, K., Tsuchida, K., Tanabe, Y., Masu, M. & Nakanishi, S. Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination. J. Biol. Chem. 268, 19341-19345 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 19341-19345
    • Takahashi, K.1    Tsuchida, K.2    Tanabe, Y.3    Masu, M.4    Nakanishi, S.5
  • 32
    • 0031052693 scopus 로고    scopus 로고
    • Cloning and characterization of a metabotropic glutamate receptor, mGluR4b
    • Thomsen, C. et al. Cloning and characterization of a metabotropic glutamate receptor, mGluR4b. Neuropharmacology 36, 21-30 (1997).
    • (1997) Neuropharmacology , vol.36 , pp. 21-30
    • Thomsen, C.1
  • 34
    • 0029863890 scopus 로고    scopus 로고
    • Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies
    • Bradley, S. R., Levey, A. I., Hersch, S. M. & Conn, P. J. Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies. J. Neurosci. 16, 2044-2056 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 2044-2056
    • Bradley, S.R.1    Levey, A.I.2    Hersch, S.M.3    Conn, P.J.4
  • 35
    • 0027410488 scopus 로고
    • Signal transduction, pharmacological properties and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4
    • Tanabe, Y. et al. Signal transduction, pharmacological properties and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J. Neurosci. 13, 1372-1378 (1993).
    • (1993) J. Neurosci. , vol.13 , pp. 1372-1378
    • Tanabe, Y.1
  • 36
    • 0029946775 scopus 로고    scopus 로고
    • Are the tastes of polycose and monosodium glutamate unique?
    • Hettinger, T. P., Frank, M. E. & Myers, W. E. Are the tastes of polycose and monosodium glutamate unique? Chem. Senses 21, 341-347 (1996).
    • (1996) Chem. Senses , vol.21 , pp. 341-347
    • Hettinger, T.P.1    Frank, M.E.2    Myers, W.E.3
  • 37
    • 0019305115 scopus 로고
    • Taste synergism between monosodium glutamate and disodium 5'-guanylate
    • Rifkin, B. & Bartoshuk, L.M. Taste synergism between monosodium glutamate and disodium 5'-guanylate. Physiol. Behav. 24, 1169-1172 (1980).
    • (1980) Physiol. Behav. , vol.24 , pp. 1169-1172
    • Rifkin, B.1    Bartoshuk, L.M.2
  • 38
    • 0018828305 scopus 로고
    • 3H]glutamate binding to bovine taste papillae by 5'-ribonucleotides
    • 3H]glutamate binding to bovine taste papillae by 5'-ribonucleotides. Biochim. Biophys. Acta 627, 313-323 (1980).
    • (1980) Biochim. Biophys. Acta , vol.627 , pp. 313-323
    • Torii, K.1    Cagan, R.H.2
  • 39
    • 0034645913 scopus 로고    scopus 로고
    • Glutamate-induced cobalt uptake reveals non-NMDA receptors in rat taste cells
    • in press
    • Caicedo, A., Kim, K. & Roper, S. Glutamate-induced cobalt uptake reveals non-NMDA receptors in rat taste cells. J. Comp. Neurol. (in press).
    • J. Comp. Neurol.
    • Caicedo, A.1    Kim, K.2    Roper, S.3
  • 41
    • 0028912822 scopus 로고
    • The metabotropic glutamate receptors: Structure and functions
    • Pin, J. P. & Duvoisin, R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34, 1-26 (1995).
    • (1995) Neuropharmacology , vol.34 , pp. 1-26
    • Pin, J.P.1    Duvoisin, R.2
  • 42
    • 0026476478 scopus 로고
    • Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes
    • Pin, J.-P., Waeber, C., Prezeau, L., Bockaert, J. & Heinemann, S. F. Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. Proc. Natl. Acad. Sci. USA 89, 10331-10335 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10331-10335
    • Pin, J.-P.1    Waeber, C.2    Prezeau, L.3    Bockaert, J.4    Heinemann, S.F.5
  • 43
    • 0031842523 scopus 로고    scopus 로고
    • Regional expression and regulation of alternative forms of mRNAs derived from two distinct transcription initiation sites of the rat mGluR5 gene
    • Yamaguchi, S. & Nakanishi, S. Regional expression and regulation of alternative forms of mRNAs derived from two distinct transcription initiation sites of the rat mGluR5 gene. J. Neurochem. 71, 60-68 (1998).
    • (1998) J. Neurochem. , vol.71 , pp. 60-68
    • Yamaguchi, S.1    Nakanishi, S.2
  • 44
    • 0024212067 scopus 로고
    • Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer
    • Frohman, M. A., Dush, M. K. & Martin, G. R. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85, 8998-9002 (1988).
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 8998-9002
    • Frohman, M.A.1    Dush, M.K.2    Martin, G.R.3
  • 45
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin, H., Staehelin, T. & Bordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354 (1979).
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Bordon, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.