Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide

Science

Volumn 299, Issue 5610, 2003, Pages 1221-1225

  Kim, Un kyung ^a   Jorgenson, Eric ^b   Coon, Hilary ^c   Leppert, Mark ^c   Risch, Neil ^b,d   Drayna, Dennis ^a  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^d DIVISION OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBONS; GENES; SENSITIVITY ANALYSIS;

POSITIONAL CLONING;

CLONING;

PHENYLTHIOUREA;

GENETICS; SENSORY SYSTEM;

ARTICLE; BITTER TASTE; CHROMOSOME 7Q; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; HAPLOTYPE; HUMAN; INHERITANCE; MOLECULAR CLONING; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TASTE ACUITY; TASTE BUD; UNITED STATES;

ALLELES; AMINO ACID SUBSTITUTION; ANIMALS; CEBIDAE; CHROMOSOMES, HUMAN, PAIR 7; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; CONTINENTAL POPULATION GROUPS; EVOLUTION, MOLECULAR; FEMALE; HAPLOTYPES; HETEROZYGOTE; HOMINIDAE; HOMOZYGOTE; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; MACACA FASCICULARIS; MALE; PHENYLTHIOUREA; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RECEPTORS, CELL SURFACE; SEQUENCE ANALYSIS, DNA; TASTE; TASTE THRESHOLD;

EID: 0037458815     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1080190     Document Type: Article

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38. Supported by the Division of Intramural Research, National Institute on Deafness and Other Communication Disorders (grant Z01-000046-04); the National Human Genome Research Institute (grant T32 HGO0044); the National Center for Research Resources (grant M01-RR00064) to the Huntsman General Clinical Research Center at the University of Utah; the W. M. Keck Foundation; and the George S. and Delores Doré Eccles Foundation. We are indebted to the members of the Utah CEPH families and the NIH research volunteers for their participation. We thank T. Friedman, A. Griffith, S. Sullivan, and the anonymous reviewers for helpful comments on the manuscript. All subjects provided informed consent, indicating the nature and possible consequences of this study, under University of Utah Medical Center protocol 6090-96 and National Institute of Neurological Diseases and Stroke NIH protocol DC-01-230.