Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women

Appetite

Volumn 54, Issue 1, 2010, Pages 93-99

  Dotson, Cedrick D ^a   Shaw, Hillary L ^a   Mitchell, Braxton D ^a   Munger, Steven D ^a   Steinle, Nanette I ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Behavioral genetics; Bitter taste; Obesity; PROP; PTC; TAS2R; Taste receptor; Three Factor Eating Questionnaire

Indexed keywords

PHENYLTHIOUREA; PROPYLTHIOURACIL; PROTEIN TAS2R38; RECEPTOR PROTEIN; THIOUREA; UNCLASSIFIED DRUG;

ADULT; AMISH; ARTICLE; BEHAVIOR CONTROL; BEHAVIOR GENETICS; BITTER TASTE; CHROMOSOME 7; CONTROLLED STUDY; EATING HABIT; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUNGER; MALE; PHENOTYPIC VARIATION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TASTE ACUITY; TASTE BUD;

DIET; FEEDING BEHAVIOR; FEMALE; GENETIC VARIATION; HUMANS; HUNGER; HYPERPHAGIA; INHIBITION (PSYCHOLOGY); MALE; MIDDLE AGED; PENNSYLVANIA; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTESTANTISM; QUESTIONNAIRES; RECEPTORS, G-PROTEIN-COUPLED; SEX FACTORS; TASTE;

EID: 74449087964     PISSN: 01956663     EISSN: 10958304     Source Type: Journal    
DOI: 10.1016/j.appet.2009.09.011     Document Type: Article

References (81)

1. Almasy L., and Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. American Journal of Human Genetics 62 5 (1998) 1198-1211
2. Ames B.N., Profet M., and Gold L.S. Dietary pesticides (99.99% all natural). Proceedings of the National Academy of Sciences of the United States of America 87 19 (1990) 7777-7781
3. Bachmanov A.A., and Beauchamp G.K. Taste receptor genes. Annual Review of Nutrition 27 (2007) 389-414
4. Baron R.M., and Kenny D.A. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology 51 6 (1986) 1173-1182
5. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 2 (2005) 263-265
6. Berthoud H.R. Multiple neural systems controlling food intake and body weight. Neuroscience and Biobehavioral Reviews 26 4 (2002) 393-428
7. Bezencon C., le Coutre J., and Damak S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chemical Senses 32 1 (2007) 41-49
8. Blundell J.E., Levin F., King N.A., Barkeling B., Gustafson T., Hellstrom P.M., et al. Overconsumption and obesity: peptides and susceptibility to weight gain. Regulatory Peptides 149 1-3 (2008) 32-38
9. Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutrition Reviews 56 11 (1998) 317-333
10. Bryant E.J., King N.A., and Blundell J.E. Disinhibition: its effects on appetite and weight regulation. Obesity Reviews 9 5 (2008) 409-419
11. Bufe B., Breslin P.A., Kuhn C., Reed D.R., Tharp C.D., Slack J.P., et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Current Biology 15 4 (2005) 322-327
12. Burton P., Smit H.J., and Lightowler H.J. The influence of restrained and external eating patterns on overeating. Appetite 49 1 (2007) 191-197
13. 2+ channels. American Journal of Physiology-Cell Physiology 291 4 (2006) C726-C739
14. Damcott C.M., Pollin T.I., Reinhart L.J., Ott S.H., Shen H., Silver K.D., et al. Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 55 9 (2006) 2654-2659
15. de Krom M., Bauer F., Collier D., Adan R.A., and la Fleur S.E. Genetic variation and effects on human eating behavior. Annual Review of Nutrition 29 (2009) 283-304
16. de Krom M., van der Schouw Y.T., Hendriks J., Ophoff R.A., van Gils C.H., Stolk R.P., et al. Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns. Diabetes 56 1 (2007) 276-280
17. Dinehart M.E., Hayes J.E., Bartoshuk L.M., Lanier S.L., and Duffy V.B. Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiology and Behaviour 87 2 (2006) 304-313
18. Dotson C.D., Zhang L., Xu H., Shin Y.K., Vigues S., Ott S.H., et al. Bitter taste receptors influence glucose homeostasis. PLoS ONE 3 12 (2008) e3974
19. Drewnowski A., Henderson S.A., and Cockroft J.E. Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women. Journal of the American Dietetic Association 107 8 (2007) 1340-1348
20. Drewnowski A., Henderson S.A., Hann C.S., Berg W.A., and Ruffin M.T. Genetic taste markers and preferences for vegetables and fruit of female breast care patients. Journal of the American Dietetic Association 100 2 (2000) 191-197
21. Drewnowski A., Henderson S.A., Levine A., and Hann C. Taste and food preferences as predictors of dietary practices in young women. Public Health Nutrition 2 4 (1999) 513-519
22. Drewnowski A., Henderson S.A., and Shore A.B. Taste responses to naringin, a flavonoid, and the acceptance of grapefruit juice are related to genetic sensitivity to 6-n-propylthiouracil. American Journal of Clinical Nutrition 66 2 (1997) 391-397
23. Drewnowski A., Henderson S.A., Shore A.B., and Barratt-Fornell A. Sensory responses to 6-n-propylthiouracil (PROP) or sucrose solutions and food preferences in young women. Annals of the New York Academy of Sciences 855 (1998) 797-801
24. Duffy V.B. Associations between oral sensation, dietary behaviors and risk of cardiovascular disease (CVD). Appetite 43 1 (2004) 5-9
25. Duffy V.B. Variation in oral sensation: implications for diet and health. Current Opinion in Gastroenterology 23 2 (2007) 171-177
26. Duffy V.B., and Bartoshuk L.M. Food acceptance and genetic variation in taste. Journal of the American Dietetic Association 100 6 (2000) 647-655
27. Fenwick G.R., Heaney R.K., and Mullin W.J. Glucosinolates and their breakdown products in food and food plants. Critical Reviews in Food Science and Nutrition 18 2 (1983) 123-201
28. Fischer R., Griffin F., England S., and Garn S.M. Taste thresholds and food dislikes. Nature 191 (1961) 1328
29. Fushan A.A., Simons C.T., Slack J.P., Manichaikul A., and Drayna D. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. Current Biology 19 15 (2009) 1288-1293
30. Gabriel S.B., Schaffner S.F., Nguyen H., Moore J.M., Roy J., Blumenstiel B., et al. The structure of haplotype blocks in the human genome. Science 296 5576 (2002) 2225-2229
31. Glanville E.V., and Kaplan A.R. Food preference and sensitivity of taste for bitter compounds. Nature 205 4974 (1965) 851-853
32. Goldstein G.L., Daun H., and Tepper B.J. Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil. Obesity Research 13 6 (2005) 1017-1023
33. Greenwood J.L., and Stanford J.B. Preventing or improving obesity by addressing specific eating patterns. Journal of the American Board of Family Medicine 21 2 (2008) 135-140
34. Hainer V., Kunesova M., Bellisle F., Parizkova J., Braunerova R., Wagenknecht M., et al. The eating inventory, body adiposity and prevalence of diseases in a quota sample of Czech adults. International Journal of Obesity (London) 30 5 (2006) 830-836
35. Haines J., and Neumark-Sztainer D. Prevention of obesity and eating disorders: a consideration of shared risk factors. Health Education Research 21 6 (2006) 770-782
36. Hayes J.E., Bartoshuk L.M., Kidd J.R., and Duffy V.B. Supertasting and PROP bitterness depends on more than the TAS2R38 gene. Chemical Senses 33 3 (2008) 255-265
37. Hays N.P., Bathalon G.P., McCrory M.A., Roubenoff R., Lipman R., and Roberts S.B. Eating behavior correlates of adult weight gain and obesity in healthy women aged 55-65 years. American Journal of Clinical Nutrition 75 3 (2002) 476-483
38. Hays N.P., and Roberts S.B. Aspects of eating behaviors "disinhibition" and "restraint" are related to weight gain and BMI in women. Obesity (Silver Spring) 16 1 (2008) 52-58
39. Hsueh W.C., Mitchell B.D., Aburomia R., Pollin T., Sakul H., Gelder Ehm M., et al. Diabetes in the Old Order Amish: characterization and heritability analysis of the Amish Family Diabetes Study. Diabetes Care 23 5 (2000) 595-601
40. Hsueh W.C., Silver K.D., Pollin T.I., Bell C.J., O'Connell J.R., Mitchell B.D., et al. A genome-wide linkage scan of insulin level derived traits: the Amish Family Diabetes Study. Diabetes 56 10 (2007) 2643-2648
41. Jang H.J., Kokrashvili Z., Theodorakis M.J., Carlson O.D., Kim B.J., Zhou J., et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proceedings of the National Academy of Sciences of the United States of America 104 38 (2007) 15069-15074
42. Jeon T.I., Zhu B., Larson J.L., and Osborne T.F. SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. Journal of Clinical Investigation 118 11 (2008) 3693-3700
43. Jerzsa-Latta M., Krondl M., and Coleman P. Use and perceived attributes of cruciferous vegetables in terms of genetically mediated taste sensitivity. Appetite 15 2 (1990) 127-134
44. Keskitalo K., Tuorila H., Spector T.D., Cherkas L.F., Knaapila A., Kaprio J., et al. The Three-Factor Eating Questionnaire, body mass index, and responses to sweet and salty fatty foods: a twin study of genetic and environmental associations. American Journal of Clinical Nutrition 88 2 (2008) 263-271
45. Kim U.K., Jorgenson E., Coon H., Leppert M., Risch N., and Drayna D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299 5610 (2003) 1221-1225
46. Kim U.K., Wooding S., Riaz N., Jorde L.B., and Drayna D. Variation in the human TAS1R taste receptor genes. Chemical Senses 31 7 (2006) 599-611
47. Kim U.K., Wooding S., Ricci D., Jorde L.B., and Drayna D. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Human Mutation 26 3 (2005) 199-204
48. Lindroos A.K., Lissner L., Mathiassen M.E., Karlsson J., Sullivan M., Bengtsson C., et al. Dietary intake in relation to restrained eating, disinhibition, and hunger in obese and nonobese Swedish women. Obesity Research 5 3 (1997) 175-182
49. Mace O.J., Affleck J., Patel N., and Kellett G.L. Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. Journal of Physiology 582 Pt 1 (2007) 379-392
50. Mace O.J., Lister N., Morgan E., Shepherd E., Affleck J., Helliwell P., et al. An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine. Journal of Physiology 587 Pt 1 (2009) 195-210
51. +-glucose cotransporter 1. Proceedings of the National Academy of Sciences of the United States of America 104 38 (2007) 15075-15080
52. Mattes R., and Labov J. Bitter taste responses to phenylthiocarbamide are not related to dietary goitrogen intake in human beings. Journal of the American Dietetic Association 89 5 (1989) 692-694
53. Murphy C.L., and Kemmotsu N. "Restrained eaters" show abnormal and differential fMRI activation to sucrose and saccharin. Chem. Senses. 34 7 (2009) A3
54. Nakagawa Y., Nagasawa M., Yamada S., Hara A., Mogami H., Nikolaev V.O., et al. Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS ONE 4 4 (2009) e5106
55. Prodi D.A., Drayna D., Forabosco P., Palmas M.A., Maestrale G.B., Piras D., et al. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. Chemical Senses 29 8 (2004) 697-702
56. Pronin A.N., Xu H., Tang H., Zhang L., Li Q., and Li X. Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Current Biology 17 16 (2007) 1403-1408
57. Rozengurt E., and Sternini C. Taste receptor signaling in the mammalian gut. Current Opinion in Pharmacology 7 6 (2007) 557-562
58. Rozengurt N., Wu S.V., Chen M.C., Huang C., Sternini C., and Rozengurt E. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. American Journal of Physiology-Gastrointestinal and Liver Physiology 291 5 (2006) G792-G802
59. Sacerdote C., Guarrera S., Smith G.D., Grioni S., Krogh V., Masala G., et al. Lactase persistence and bitter taste response: instrumental variables and mendelian randomization in epidemiologic studies of dietary factors and cancer risk. American Journal of Epidemiology 166 5 (2007) 576-581
60. Sandell M.A., and Breslin P.A. Variability in a taste-receptor gene determines whether we taste toxins in food. Current Biology 16 18 (2006) R792-R794
61. Sausenthaler S., Rzehak P., Wichmann H.E., and Heinrich J. Lack of relation between bitter taste receptor TAS2R38 and BMI in adults. Obesity (Silver Spring) 17 5 (2009) 937-938
62. Savage J.S., Hoffman L., and Birch L.L. Dieting, restraint, and disinhibition predict women's weight change over 6 years. American Journal of Clinical Nutrition 90 1 (2009) 33-40
63. Sherry S.T., Ward M.H., Kholodov M., Baker J., Phan L., Smigielski E.M., et al. dbSNP: the NCBI database of genetic variation. Nucleic Acids Research 29 1 (2001) 308-311
64. Shi P., and Zhang J. Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Molecular Biology and Evolution 23 2 (2006) 292-300
65. Shi P., Zhang J., Yang H., and Zhang Y.P. Adaptive diversification of bitter taste receptor genes in mammalian evolution. Molecular Biology and Evolution 20 5 (2003) 805-814
66. Soranzo N., Bufe B., Sabeti P.C., Wilson J.F., Weale M.E., Marguerie R., et al. Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Current Biology 15 14 (2005) 1257-1265
67. Steinle N.I., Hsueh W.C., Snitker S., Pollin T.I., Sakul H., St Jean P.L., et al. Eating behavior in the Old Order Amish: heritability analysis and a genome-wide linkage analysis. American Journal of Clinical Nutrition 75 6 (2002) 1098-1106
68. Stunkard A.J., and Messick S. The Three-Factor Eating Questionnaire to measure dietary restraint, disinhibition and hunger. Journal of Psychosomatic Research 29 1 (1985) 71-83
69. Stunkard A.J., and Wadden T.A. Restrained eating and human obesity. Nutrition Reviews 48 2 (1990) 78-86 [discussion 114-131]
70. Tepper B.J. Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes. Annual Review of Nutrition 28 (2008) 367-388
71. Tepper B.J., Koelliker Y., Zhao L., Ullrich N.V., Lanzara C., d'Adamo P., et al. Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. Obesity (Silver Spring) 16 10 (2008) 2289-2295
72. Tepper B.J., and Ullrich N.V. Influence of genetic taste sensitivity to 6-n-propylthiouracil (PROP), dietary restraint and disinhibition on body mass index in middle-aged women. Physiology and Behaviour 75 3 (2002) 305-312
73. Tepper B.J., Williams T.Z., Burgess J.R., Antalis C.J., and Mattes R.D. Genetic variation in bitter taste and plasma markers of anti-oxidant status in college women. International Journal of Food Sciences and Nutrition 60 S2 (2008) 35-45
74. Tholin S., Rasmussen F., Tynelius P., and Karlsson J. Genetic and environmental influences on eating behavior: the Swedish Young Male Twins Study. American Journal of Clinical Nutrition 81 3 (2005) 564-569
75. Timpson N.J., Christensen M., Lawlor D.A., Gaunt T.R., Day I.N., Ebrahim S., et al. TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study. American Journal of Clinical Nutrition 81 5 (2005) 1005-1011
76. Ullrich N.V., Touger-Decker R., O'Sullivan-Maillet J., and Tepper B.J. PROP taster status and self-perceived food adventurousness influence food preferences. Journal of the American Dietetic Association 104 4 (2004) 543-549
77. Wang X., Thomas S.D., and Zhang J. Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes. Human Molecular Genetics 13 21 (2004) 2671-2678
78. Williamson D.A., Lawson O.J., Brooks E.R., Wozniak P.J., Ryan D.H., Bray G.A., et al. Association of body mass with dietary restraint and disinhibition. Appetite 25 1 (1995) 31-41
79. Wooding S. Phenylthiocarbamide: a 75-year adventure in genetics and natural selection. Genetics 172 4 (2006) 2015-2023
80. Wooding S., Kim U.K., Bamshad M.J., Larsen J., Jorde L.B., and Drayna D. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. American Journal of Human Genetics 74 4 (2004) 637-646
81. Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., and Rozengurt E. Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proceedings of the National Academy of Sciences of the United States of America 99 4 (2002) 2392-2397