GABAergic neurotransmission in rat taste buds: Immunocytochemical study for GABA and GABA transporter subtypes

Molecular Brain Research

Volumn 49, Issue 1-2, 1997, Pages 29-36

  Obata, Hiroshi ^a   Shimada, Keikichi ^b   Sakai, Norio ^a   Saito, Naoaki ^a  

^a KOBE UNIVERSITY   (Japan)

^b KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

aminobutyric acid (GABA); Gustatory; Immunocytochemistry; Taste bud; Tongue; Transporter

Indexed keywords

4 AMINOBUTYRIC ACID; CARRIER PROTEIN;

ANIMAL TISSUE; ARTICLE; EPITHELIUM; GABAERGIC TRANSMISSION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MALE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN VARIANT; RAT; TASTE BUD; TISSUE DISTRIBUTION; TONGUE;

ANIMALS; CARRIER PROTEINS; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MOUTH MUCOSA; ORGANIC ANION TRANSPORTERS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTIC TRANSMISSION; TASTE BUDS; TONGUE;

ANIMALIA;

EID: 0030696652     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00118-6     Document Type: Article

References (35)

1. Borden L.A., Smith K.E., Hartung P.R., Branchek T.A., Weinshank R.L. Molecular heterogeneity of the γ-aminobutyric acid (GABA) transport system. J. Biol. Chem. 267:1992;21105-21111.
2. Clark J.A., Deutch A.Y., Gallipoli P.Z., Amara S.G. Functional expression and CNS distribution of a β-alanine-sensitive neuronal GABA transporter. Neuron. 9:1992;337-348.
3. Delay R.J., Mackay S.A., Roper S.D. Membrane properties of two types of basal cells in Necturus taste buds. J. Neurosci. 14:1994;6132-6143.
4. Delay R.J., Roper S.D. Ultrastructure of taste cells and synapses in the mudpuppy Necturus maculosus. J. Comp. Neurol. 277:1988;268-280.
5. Delay R.J., Taylor R., Roper S.D. Merkel-like basal cells in Necturus taste buds contain serotonin. J. Comp. Neurol. 335:1993;606-613.
6. Ewald D.A., Roper S.D. Bidirectional synaptic transmission in Necturus taste buds. J. Neurosci. 14:1994;3791-3804.
7. Guastella J., Nelson N., Nelson H., Czyzyk L., Keynan S., Miedel M.C., Davidson N., Lester H.A., Kanner B.I. Cloning and expression of a rat brain GABA transporter. Science. 249:1990;1303-1306.
8. Honda S., Yamamoto M., Saito N. Immunocytochemical localization of three subtypes of GABA transporter in rat retina. Mol. Brain Res. 33:1995;319-325.
9. Ikegaki N., Saito N., Hasima M., Tanaka C. Production of specific antibodies against GABA transporter subtypes (GAT1, GAT2, GAT3) and their application to immunocytochemistry. Mol. Brain Res. 26:1994;47-54.
10. Itouji A., Tanaka C., Saito N. Neuronal and glial localization of GABA transporters (GAT1 and GAT3) in the rat cerebellum. Mol. Brain Res. 37:1996;309-316.
11. Iversen L.L., Johnston G.A.R. GABA uptake in rat central nervous system: comparison of uptake in slices and homogenates and the effects of some inhibitors. J. Neurochem. 18:1971;1939-1950.
12. Iversen L.L., Kelly J.S. Uptake and metabolism of γ-aminobutyric acid by neurones and glial cells. Biochem. Pharmacol. 24:1975;933-938.
13. Jain S., Roper S.D. Immunocytochemistry of gamma-aminobutyric acid, glutamate, serotonin, and histamine in Necturus taste buds. J. Comp. Neurol. 307:1991;675-682.
14. E.R. Kandel, J.H. Schwartz and T.M. Jessel (Eds.), Principles of Neural Science, Elsevier, New York, NY, 1991, pp. 400-499.
15. Kim D.J., Roper S.D. Localization of serotonin in taste buds: a comparative study in four vertebrates. J. Comp. Neurol. 353:1995;364-370.
16. Kinnamon J.C., Sherman T.A., Roper S.D. Ultrastructure of mouse vallate taste buds: III Patterns of synaptic connectivity J. Comp. Neurol. 270:1988;1-10.
17. Kinnamon J.C., Taylor B.J., Delay R.J., Roper S.D. Ultrastructure of mouse vallate taste buds. I. Taste cells and their associated synapses J. Comp. Neurol. 235:1985;48-60.
18. S.C. Kinnamon, Organization and Innervation of Taste Buds, Neurobiology of Taste and Smell, Wiley, New York, NY, 1987.
19. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
20. Lam D.M., Laster E.M., Naka K. Gamma aminobutyric acid: a neurotransmitter candidate for cone horizontal cells of the catfish retina. Proc. Natl. Acad. Sci. USA. 75:1978;6310-6313.
21. Liu Q.R., Lopez C.B., Mandiyan S., Nelson H., Nelson N. Molecular characterization of four pharmacologically distinct γ-aminobutyric acid transporters in mouse brain. J. Biol. Chem. 268:1993;2106-2112.
22. Lopez-Corcuera B., Liu Q.-R., Mandiyan S., Nelson H., Nelson N. Expression of a mouse brain cDNA encoding novel γ-aminobutyric acid transporter. J. Biol. Chem. 267:1992;17491-17493.
23. Minelli A., Brecha N.C., Karschin C., DeBiasi S., Conti F. GAT-1, a high-affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex. J. Neurosci. 15:1995;7734-7746.
24. Mroz E.A., Sewell W.F. Pharmacological alterations of the activity of afferent fibers innervating hair cells. Hearing Res. 38:1989;141-162.
25. Murakami M., Ohtsu K., Ohtsuka T. Effects of chemicals on receptors and horizontal cells in the retina. J. Physiol. 227:1972;899-913.
26. R.G. Murray, The ultrastrucutre of taste buds. In I. Friedmann (Ed.), The Ultrastructure of Sensory Organs, Elsevier, New York, NY, 1973, pp. 1-81.
27. M. Nishimura, K. Sato, M. Mizuno, I. Yoshiya, S. Shimada, N. Saito and M. Tohyama, Differential expression patterns of GABA transporters (GAT1-3) in the rat olfactory bulb, Mol. Brain Res. (in press).
28. Ribak C.E., Tong W.M.Y., Brecha N.C. GABA plasma membrane transporters, GAT-1 and GAT-3, display different distributions in the rat hippocampus. J. Comp. Neurol. 367:1996;595-606.
29. Roper S.D. The cell biology of vertebrate taste receptors. Annu. Rev. Neurosci. 12:1989;329-353.
30. Roper S.D., Ewald D.A. Peripheral events in taste transduction. Soc. Gen. Physiol. Ser. 47:1992;281-289.
31. Roper S.D., McBride D.J. Distribution of ion channels on taste cells and its relationship to chemosensory transduction. J. Membr. Biol. 109:1989;29-39.
32. Sakaue M., Kumoi K., Saito N., Tanaka C. Immunohistochemical demonstration of GABA and aspartate-containing neurons in rat inferior olive. Biomed. Res. 10:1989;287-295.
33. Somogyi P., Hodgson A.J., Chubb I.W., Penke B., Erdei A. Antisera to γ-aminobutyric acid. II. Immunocytochemical application to the central nervous system J. Histochem. Cytochem. 33:1985;240-248.
34. Tateda H., Beidler L.M. The receptor potential of the taste cells of the rat. J. Gen. Physiol. 47:1964;479-486.
35. Welton J., Taylor R., Porter A.J., Roper S.D. Immunocytochemical survey of putative neurotransmitters in taste buds from Necturus maculosus. J. Comp. Neurol. 324:1992;509-521.