The heterodimeric sweet taste receptor has multiple potential ligand binding sites

Current Pharmaceutical Design

Volumn 12, Issue 35, 2006, Pages 4591-4600

  Cui, Meng ^a   Jiang, Peihua ^b   Maillet, Emeline ^b   Max, Marianna ^b   Margolskee, Robert E ^c   Osman, Roman ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Department of Neuroscience ^*  (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Homology modeling; Molecular docking; Site directed mutagenesis; Sweet proteins; Sweet taste inhibitors; Sweeteners

Indexed keywords

ACESULFAME; ASPARTAME; CYCLAMATE SODIUM; CYSTEINE; FRUCTOSE; G PROTEIN COUPLED RECEPTOR; GALACTOSE; GLUCOSE; HETERODIMER; LACTOSE; MALTOSE; METABOTROPIC RECEPTOR 1; MONELLIN; NEOTAME; RHODOPSIN; SACCHARIN; SUCRALOSE; SUCROSE; SWEETENING AGENT; THAUMATIN; TUMOR NECROSIS FACTOR RECEPTOR;

AMINO TERMINAL SEQUENCE; BINDING SITE; CRYSTAL STRUCTURE; DIABETES MELLITUS; DRUG DESIGN; HUMAN; LIGAND BINDING; MOLECULAR MECHANICS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SWEETNESS; TASTE BUD;

AMINO ACID SEQUENCE; BENZENE DERIVATIVES; BINDING SITES; CYSTEINE; DIMERIZATION; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, G-PROTEIN-COUPLED; SWEETENING AGENTS; TASTE BUDS;

EID: 33751505567     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161206779010350     Document Type: Review

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