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Volumn 21, Issue 10, 2016, Pages

Saponins from chinese medicines as anticancer agents

Author keywords

Cancer; Mechanism; Steroid Saponins; Target; Triterpenoid Saponins

Indexed keywords

ANTINEOPLASTIC AGENT; SAPONIN;

EID: 84992336060     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21101326     Document Type: Review
Times cited : (136)

References (218)
  • 1
    • 84866043042 scopus 로고    scopus 로고
    • Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae-A review
    • Lu, J.J.; Dang, Y.Y.; Huang, M.; Xu, W.S.; Chen, X.P.; Wang, Y.T. Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae-A review. J. Ethnopharmacol. 2012, 143, 406-411.
    • (2012) J. Ethnopharmacol , vol.143 , pp. 406-411
    • Lu, J.J.1    Dang, Y.Y.2    Huang, M.3    Xu, W.S.4    Chen, X.P.5    Wang, Y.T.6
  • 4
    • 84992367335 scopus 로고    scopus 로고
    • Ginsenoside Rg1 attenuates hypoxia and hypercapnia-induced vasoconstriction in isolated rat pulmonary arterial rings by reducing the expression of p38
    • Zheng, M.; Zhao, M.; Tang, L.; Zhang, C.; Song, L.; Wang, W. Ginsenoside Rg1 attenuates hypoxia and hypercapnia-induced vasoconstriction in isolated rat pulmonary arterial rings by reducing the expression of p38. J. Thorac. Dis. 2016, 8, 1513-1523.
    • (2016) J. Thorac. Dis , vol.8 , pp. 1513-1523
    • Zheng, M.1    Zhao, M.2    Tang, L.3    Zhang, C.4    Song, L.5    Wang, W.6
  • 5
    • 84982136477 scopus 로고    scopus 로고
    • Antiproliferative and anti-inflammatory polyhydroxylated spirostanol saponins from Tupistra chinensis
    • Xiang, L.; Yi, X.; Wang, Y.; He, X. Antiproliferative and anti-inflammatory polyhydroxylated spirostanol saponins from Tupistra chinensis. Sci. Rep. 2016, 6.
    • (2016) Sci. Rep , vol.6
    • Xiang, L.1    Yi, X.2    Wang, Y.3    He, X.4
  • 6
    • 84967138242 scopus 로고    scopus 로고
    • Structure-Activity relationships of 3-O-chacotriosyl oleanane-Type triterpenoids as potential H5N1 entry inhibitors
    • Song, G.; Shen, X.; Li, S.; Li, Y.; Si, H.; Fan, J.; Li, J.; Gao, E.; Liu, S. Structure-Activity relationships of 3-O-chacotriosyl oleanane-Type triterpenoids as potential H5N1 entry inhibitors. Eur. J. Med. Chem. 2016, 119, 109-121.
    • (2016) Eur. J. Med. Chem , vol.119 , pp. 109-121
    • Song, G.1    Shen, X.2    Li, S.3    Li, Y.4    Si, H.5    Fan, J.6    Li, J.7    Gao, E.8    Liu, S.9
  • 7
    • 84958633827 scopus 로고    scopus 로고
    • Killing cancer with platycodin D through multiple mechanisms
    • Khan, M.; Maryam, A.; Zhang, H.; Mehmood, T.; Ma, T. Killing cancer with platycodin D through multiple mechanisms. J. Cell. Mol. Med. 2016, 20, 389-402.
    • (2016) J. Cell. Mol. Med , vol.20 , pp. 389-402
    • Khan, M.1    Maryam, A.2    Zhang, H.3    Mehmood, T.4    Ma, T.5
  • 8
    • 84983337851 scopus 로고    scopus 로고
    • Saikosaponin D induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells
    • Chen, M.F.; Huang, S.J.; Huang, C.C.; Liu, P.S.; Lin, K.I.; Liu, C.W.; Hsieh, W.C.; Shiu, L.Y.; Chen, C.H. Saikosaponin D induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. BMC Cancer 2016, 16.
    • (2016) BMC Cancer , vol.16
    • Chen, M.F.1    Huang, S.J.2    Huang, C.C.3    Liu, P.S.4    Lin, K.I.5    Liu, C.W.6    Hsieh, W.C.7    Shiu, L.Y.8    Chen, C.H.9
  • 9
    • 84988457182 scopus 로고    scopus 로고
    • Paris saponin vii suppresses osteosarcoma cell migration and invasion by inhibiting MMP-2/9 production via the p38 mapk signaling pathway
    • Cheng, G.; Gao, F.; Sun, X.; Bi, H.; Zhu, Y. Paris saponin vii suppresses osteosarcoma cell migration and invasion by inhibiting MMP-2/9 production via the p38 mapk signaling pathway. Mol. Med. Rep. 2016.
    • (2016) Mol. Med. Rep
    • Cheng, G.1    Gao, F.2    Sun, X.3    Bi, H.4    Zhu, Y.5
  • 10
    • 84921305027 scopus 로고    scopus 로고
    • A bioactive steroidal saponin from Ophitopogin japonicas, inhibits angiogenesis through interruption of SRC tyrosine kinase-dependent matrix metalloproteinase pathway
    • Zeng, K.W.; Song, F.J.; Li, N.; Dong, X.; Jiang, Y.; Tu, P.F. ASC, a bioactive steroidal saponin from Ophitopogin japonicas, inhibits angiogenesis through interruption of SRC tyrosine kinase-dependent matrix metalloproteinase pathway. Basic Clin. Pharmacol. Toxicol. 2015, 116, 115-123.
    • (2015) Basic Clin. Pharmacol. Toxicol , vol.116 , pp. 115-123
    • Zeng, K.W.1    Song, F.J.2    Li, N.3    Dong, X.4    Jiang, Y.5    Asc, F.T.P.6
  • 11
    • 84964838606 scopus 로고    scopus 로고
    • Anticancer effects of paris saponins by apoptosis and PI3k/AKT pathway in gefitinib-resistant non-small cell lung cancer
    • Zhu, X.; Jiang, H.; Li, J.; Xu, J.; Fei, Z. Anticancer effects of paris saponins by apoptosis and PI3k/AKT pathway in gefitinib-resistant non-small cell lung cancer. Med. Sci. Monit. 2016, 22, 1435-1441.
    • (2016) Med. Sci. Monit , vol.22 , pp. 1435-1441
    • Zhu, X.1    Jiang, H.2    Li, J.3    Xu, J.4    Fei, Z.5
  • 12
    • 84958720885 scopus 로고    scopus 로고
    • Paris saponins enhance radiosensitivity in a gefitinib-resistant lung adenocarcinoma cell line by inducing apoptosis and G2/M cell cycle phase arrest
    • Zhao, P.J.; Song, S.C.; Du, L.W.; Zhou, G.H.; Ma, S.L.; Li, J.H.; Feng, J.G.; Zhu, X.H.; Jiang, H. Paris saponins enhance radiosensitivity in a gefitinib-resistant lung adenocarcinoma cell line by inducing apoptosis and G2/M cell cycle phase arrest. Mol. Med. Rep. 2016, 13, 2878-2884.
    • (2016) Mol. Med. Rep , vol.13 , pp. 2878-2884
    • Zhao, P.J.1    Song, S.C.2    Du, L.W.3    Zhou, G.H.4    Ma, S.L.5    Li, J.H.6    Feng, J.G.7    Zhu, X.H.8    Jiang, H.9
  • 13
    • 73849150347 scopus 로고    scopus 로고
    • New achievements in ginseng research and its future prospects
    • Chu, S.F.; Zhang, J.T. New achievements in ginseng research and its future prospects. Chin. J. Integr. Med. 2009, 15, 403-408.
    • (2009) Chin. J. Integr. Med , vol.15 , pp. 403-408
    • Chu, S.F.1    Zhang, J.T.2
  • 15
    • 79959973320 scopus 로고    scopus 로고
    • Rg1 and three extracts of traditional chinese medicine attenuate ultraviolet B-induced G1 growth arrest in hacat cells and dermal fibroblasts involve down-regulating the expression of p16, p21 and p53
    • Wang, X.Y.; Wang, Y.G.; Wang, Y.F. Ginsenoside Rb1, Rg1 and three extracts of traditional chinese medicine attenuate ultraviolet B-induced G1 growth arrest in hacat cells and dermal fibroblasts involve down-regulating the expression of p16, p21 and p53. Photodermatol. Photoimmunol. Photomed. 2011, 27, 203-212.
    • (2011) Photodermatol. Photoimmunol. Photomed , vol.27 , pp. 203-212
    • Wang, X.Y.1    Wang, Y.G.2    Rb Ginsenoside, F.W.Y.3
  • 16
    • 0035206171 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenoside-Rb2 on invasiveness of uterine endometrial cancer cells to the basement membrane
    • Fujimoto, J.; Sakaguchi, H.; Aoki, I.; Toyoki, H.; Khatun, S.; Tamaya, T. Inhibitory effect of ginsenoside-Rb2 on invasiveness of uterine endometrial cancer cells to the basement membrane. Eur. J. Gynaecol. Oncol. 2001, 22, 339-341.
    • (2001) Eur. J. Gynaecol. Oncol , vol.22 , pp. 339-341
    • Fujimoto, J.1    Sakaguchi, H.2    Aoki, I.3    Toyoki, H.4    Khatun, S.5    Tamaya, T.6
  • 17
    • 0042810772 scopus 로고    scopus 로고
    • Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells
    • Lee, Y.J.; Jin, Y.R.; Lim, W.C.; Ji, S.M.; Cho, J.Y.; Ban, J.J.; Lee, S.K. Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells. Arch. Pharm. Res. 2003, 26, 53-57.
    • (2003) Arch. Pharm. Res , vol.26 , pp. 53-57
    • Lee, Y.J.1    Jin, Y.R.2    Lim, W.C.3    Ji, S.M.4    Cho, J.Y.5    Ban, J.J.6    Lee, S.K.7
  • 18
    • 84876032265 scopus 로고    scopus 로고
    • Involvement of melastatin type transient receptor potential 7 channels in ginsenoside Rd-induced apoptosis in gastric and breast cancer cells
    • Kim, B.J. Involvement of melastatin type transient receptor potential 7 channels in ginsenoside Rd-induced apoptosis in gastric and breast cancer cells. J. Ginseng Res. 2013, 37, 201-209.
    • (2013) J. Ginseng Res , vol.37 , pp. 201-209
    • Kim, B.J.1
  • 19
  • 20
    • 84897500610 scopus 로고    scopus 로고
    • Anticarcinogenic effects of products of heat-processed ginsenoside Re, a major constituent of ginseng berry, on human gastric cancer cells
    • Jang, H.J.; Han, I.H.; Kim, Y.J.; Yamabe, N.; Lee, D.; Hwang, G.S.; Oh, M.; Choi, K.C.; Kim, S.N.; Ham, J.; et al. Anticarcinogenic effects of products of heat-processed ginsenoside Re, a major constituent of ginseng berry, on human gastric cancer cells. J. Agric. Food Chem. 2014, 62, 2830-2836.
    • (2014) J. Agric. Food Chem , vol.62 , pp. 2830-2836
    • Jang, H.J.1    Han, I.H.2    Kim, Y.J.3    Yamabe, N.4    Lee, D.5    Hwang, G.S.6    Oh, M.7    Choi, K.C.8    Kim, S.N.9    Ham, J.10
  • 21
    • 84969756258 scopus 로고    scopus 로고
    • Suppression of MAPKs/NF-B activation induces intestinal anti-inflammatory action of ginsenoside Rf in Ht-29 and raw264.7 cells
    • Ahn, S.; Siddiqi, M.H.; Aceituno, V.C.; Simu, S.Y.; Yang, D.C. Suppression of MAPKs/NF-B activation induces intestinal anti-inflammatory action of ginsenoside Rf in Ht-29 and raw264.7 cells. Immunol. Investig. 2016.
    • (2016) Immunol. Investig
    • Ahn, S.1    Siddiqi, M.H.2    Aceituno, V.C.3    Simu, S.Y.4    Yang, D.C.5
  • 22
    • 85027950005 scopus 로고    scopus 로고
    • 20-(S)-ginsenoside Rg3 induces apoptotic cell death in human leukemic U937 and HL-60 cells through PI3K/AKT pathways
    • Qiu, X.M.; Bai, X.; Jiang, H.F.; He, P.; Wang, J.H. 20-(S)-ginsenoside Rg3 induces apoptotic cell death in human leukemic U937 and HL-60 cells through PI3K/AKT pathways. Anti-Cancer Drugs 2014, 25, 1072-1080.
    • (2014) Anti-Cancer Drugs , vol.25 , pp. 1072-1080
    • Qiu, X.M.1    Bai, X.2    Jiang, H.F.3    He, P.4    Wang, J.H.5
  • 23
    • 79954687741 scopus 로고    scopus 로고
    • Immunopotentiation and antitumor effects of a ginsenoside Rg3-fortified red ginseng preparation in mice bearing H460 lung cancer cells
    • Park, D.; Bae, D.K.; Jeon, J.H.; Lee, J.; Oh, N.; Yang, G.; Yang, Y.H.; Kim, T.K.; Song, J.; Lee, S.H.; et al. Immunopotentiation and antitumor effects of a ginsenoside Rg3-fortified red ginseng preparation in mice bearing H460 lung cancer cells. Environ. Toxicol. Pharmacol. 2011, 31, 397-405.
    • (2011) Environ. Toxicol. Pharmacol , vol.31 , pp. 397-405
    • Park, D.1    Bae, D.K.2    Jeon, J.H.3    Lee, J.4    Oh, N.5    Yang, G.6    Yang, Y.H.7    Kim, T.K.8    Song, J.9    Lee, S.H.10
  • 24
    • 85013206526 scopus 로고    scopus 로고
    • Ginsenoside Rg3 enhances the inhibitory effects of chemotherapy on esophageal squamous cell carcinoma in mice
    • Chang, L.; Huo, B.; Lv, Y.;Wang, Y.; Liu, W. Ginsenoside Rg3 enhances the inhibitory effects of chemotherapy on esophageal squamous cell carcinoma in mice. Mol. Clin. Oncol. 2014, 2, 1043-1046.
    • (2014) Mol. Clin. Oncol , vol.2 , pp. 1043-1046
    • Chang, L.1    Huo, B.2    Lv, Y.3    Wang, Y.4    Liu, W.5
  • 25
    • 84893009042 scopus 로고    scopus 로고
    • Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed american ginseng on human gastric cancer cell
    • Park, E.H.; Kim, Y.J.; Yamabe, N.; Park, S.H.; Kim, H.K.; Jang, H.J.; Kim, J.H.; Cheon, G.J.; Ham, J.; Kang, K.S. Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed american ginseng on human gastric cancer cell. J. Ginseng Res. 2014, 38, 22-27.
    • (2014) J. Ginseng Res , vol.38 , pp. 22-27
    • Park, E.H.1    Kim, Y.J.2    Yamabe, N.3    Park, S.H.4    Kim, H.K.5    Jang, H.J.6    Kim, J.H.7    Cheon, G.J.8    Ham, J.9    Kang, K.S.10
  • 26
    • 67649361895 scopus 로고    scopus 로고
    • Inhibition of NF-B by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel
    • Kim, S.M.; Lee, S.Y.; Yuk, D.Y.; Moon, D.C.; Choi, S.S.; Kim, Y.; Han, S.B.; Oh, K.W.; Hong, J.T. Inhibition of NF-B by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel. Arch. Pharm. Res. 2009, 32, 755-765.
    • (2009) Arch. Pharm. Res , vol.32 , pp. 755-765
    • Kim, S.M.1    Lee, S.Y.2    Yuk, D.Y.3    Moon, D.C.4    Choi, S.S.5    Kim, Y.6    Han, S.B.7    Oh, K.W.8    Hong, J.T.9
  • 27
    • 78651246162 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of WNT/SS-catenin signaling
    • He, B.C.; Gao, J.L.; Luo, X.; Luo, J.; Shen, J.;Wang, L.; Zhou, Q.;Wang, Y.T.; Luu, H.H.; Haydon, R.C.; et al. Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of WNT/SS-catenin signaling. Int. J. Oncol. 2011, 38, 437-445.
    • (2011) Int. J. Oncol , vol.38 , pp. 437-445
    • He, B.C.1    Gao, J.L.2    Luo, X.3    Luo, J.4    Shen, J.5    Wang, L.6    Zhou, Q.7    Wang, Y.T.8    Luu, H.H.9    Haydon, R.C.10
  • 29
    • 80053064682 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via intrinsic apoptotic pathway
    • Jiang, J.W.; Chen, X.M.; Chen, X.H.; Zheng, S.S. Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via intrinsic apoptotic pathway. World J. Gastroenterol. 2011, 17, 3605-3613.
    • (2011) World J. Gastroenterol , vol.17 , pp. 3605-3613
    • Jiang, J.W.1    Chen, X.M.2    Chen, X.H.3    Zheng, S.S.4
  • 30
    • 84920507410 scopus 로고    scopus 로고
    • Stereoisomer-specific anticancer activities of ginsenoside Rg3 and RH2 in HepG2 cells: Disparity in cytotoxicity and autophagy-inducing effects due to 20(S)-epimers
    • Cheong, J.H.; Kim, H.; Hong, M.J.; Yang, M.H.; Kim, J.W.; Yoo, H.; Yang, H.; Park, J.H.; Sung, S.H.; Kim, H.P.; et al. Stereoisomer-specific anticancer activities of ginsenoside Rg3 and RH2 in HepG2 cells: Disparity in cytotoxicity and autophagy-inducing effects due to 20(S)-epimers. Biol. Pharma. Bull. 2015, 38, 102-108.
    • (2015) Biol. Pharma. Bull , vol.38 , pp. 102-108
    • Cheong, J.H.1    Kim, H.2    Hong, M.J.3    Yang, M.H.4    Kim, J.W.5    Yoo, H.6    Yang, H.7    Park, J.H.8    Sung, S.H.9    Kim, H.P.10
  • 31
    • 78651228186 scopus 로고    scopus 로고
    • Gensenoside Rg3 inhibits hypoxia-induced VEGF expression in human cancer cells
    • Chen, Q.J.; Zhang, M.Z.; Wang, L.X. Gensenoside Rg3 inhibits hypoxia-induced VEGF expression in human cancer cells. Cell. Physiol. Biochem. 2010, 26, 849-858.
    • (2010) Cell. Physiol. Biochem , vol.26 , pp. 849-858
    • Chen, Q.J.1    Zhang, M.Z.2    Wang, L.X.3
  • 32
    • 84907289379 scopus 로고    scopus 로고
    • Synergistic antitumor effect of ginsenoside Rg3 and cisplatin in cisplatinresistant bladder tumor cell line
    • Lee, Y.J.; Lee, S.; Ho, J.N.; Byun, S.S.; Hong, S.K.; Lee, S.E.; Lee, E. Synergistic antitumor effect of ginsenoside Rg3 and cisplatin in cisplatinresistant bladder tumor cell line. Oncol. Rep. 2014, 32, 1803-1808.
    • (2014) Oncol. Rep , vol.32 , pp. 1803-1808
    • Lee, Y.J.1    Lee, S.2    Ho, J.N.3    Byun, S.S.4    Hong, S.K.5    Lee, S.E.6    Lee, E.7
  • 33
    • 84926138054 scopus 로고    scopus 로고
    • Ginsenoside Rg3 induces apoptosis of human breast cancer (MDA-MB-231) cells
    • Kim, B.M.; Kim, D.H.; Park, J.H.; Na, H.K.; Surh, Y.J. Ginsenoside Rg3 induces apoptosis of human breast cancer (MDA-MB-231) cells. J. Cancer Prev. 2013, 18, 177-185.
    • (2013) J. Cancer Prev , vol.18 , pp. 177-185
    • Kim, B.M.1    Kim, D.H.2    Park, J.H.3    Na, H.K.4    Surh, Y.J.5
  • 34
    • 84907204565 scopus 로고    scopus 로고
    • Ginsenoside 20(S)-Rg3 targets HIF-1-to block hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells
    • Liu, T.; Zhao, L.; Zhang, Y.; Chen, W.; Liu, D.; Hou, H.; Ding, L.; Li, X. Ginsenoside 20(S)-Rg3 targets HIF-1-to block hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells. PLoS ONE 2014, 9, e103887.
    • (2014) PLoS ONE , vol.9 , pp. e103887
    • Liu, T.1    Zhao, L.2    Zhang, Y.3    Chen, W.4    Liu, D.5    Hou, H.6    Ding, L.7    Li, X.8
  • 36
    • 16544379730 scopus 로고    scopus 로고
    • Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells
    • Kim, H.S.; Lee, E.H.; Ko, S.R.; Choi, K.J.; Park, J.H.; Im, D.S. Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch. Pharm. Res. 2004, 27, 429-435.
    • (2004) Arch. Pharm. Res , vol.27 , pp. 429-435
    • Kim, H.S.1    Lee, E.H.2    Ko, S.R.3    Choi, K.J.4    Park, J.H.5    Im, D.S.6
  • 37
    • 84932631859 scopus 로고    scopus 로고
    • Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-B/p65 signaling pathway to promote melanoma cell death
    • Shan, X.; Tian, L.L.; Zhang, Y.M.;Wang, X.Q.; Yan, Q.; Liu, J.W. Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-B/p65 signaling pathway to promote melanoma cell death. Int. J. Oncol. 2015, 47, 701-709.
    • (2015) Int. J. Oncol , vol.47 , pp. 701-709
    • Shan, X.1    Tian, L.L.2    Zhang, Y.M.3    Wang, X.Q.4    Yan, Q.5    Liu, J.W.6
  • 38
    • 53549093298 scopus 로고    scopus 로고
    • Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells
    • Chen, J.; Peng, H.; Ou-Yang, X.; He, X. Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells. Melanoma Res. 2008, 18, 322-329.
    • (2008) Melanoma Res , vol.18 , pp. 322-329
    • Chen, J.1    Peng, H.2    Ou-Yang, X.3    He, X.4
  • 39
    • 84919492823 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation
    • Shan, X.; Fu, Y.S.; Aziz, F.;Wang, X.Q.; Yan, Q.; Liu, J.W. Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation. PLoS ONE 2014, 9, e115401.
    • (2014) PLoS ONE , vol.9 , pp. e115401
    • Shan, X.1    Fu, Y.S.2    Aziz, F.3    Wang, X.Q.4    Yan, Q.5    Liu, J.W.6
  • 40
    • 33644618424 scopus 로고    scopus 로고
    • Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on lewis lung carcinoma
    • Zhang, Q.; Kang, X.; Zhao, W. Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on lewis lung carcinoma. Biochem. Biophys. Res. Commun. 2006, 342, 824-828.
    • (2006) Biochem. Biophys. Res. Commun , vol.342 , pp. 824-828
    • Zhang, Q.1    Kang, X.2    Zhao, W.3
  • 41
    • 34247365969 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer
    • Xu, T.M.; Xin, Y.; Cui, M.H.; Jiang, X.; Gu, L.P. Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer. Chin. Med. J. 2007, 120, 584-588.
    • (2007) Chin. Med. J , vol.120 , pp. 584-588
    • Xu, T.M.1    Xin, Y.2    Cui, M.H.3    Jiang, X.4    Gu, L.P.5
  • 42
    • 38649110477 scopus 로고    scopus 로고
    • Protective effects of ginsenoside Rg3 against cyclophosphamide-induced DNA damage and cell apoptosis in mice
    • Zhang, Q.H.; Wu, C.F.; Duan, L.; Yang, J.Y. Protective effects of ginsenoside Rg3 against cyclophosphamide-induced DNA damage and cell apoptosis in mice. Arch. Toxicol. 2008, 82, 117-123.
    • (2008) Arch. Toxicol , vol.82 , pp. 117-123
    • Zhang, Q.H.1    Wu, C.F.2    Duan, L.3    Yang, J.Y.4
  • 43
    • 55849083086 scopus 로고    scopus 로고
    • Antiangiogenic effect of capecitabine combined with ginsenoside Rg3 on breast cancer in mice
    • Zhang, Q.; Kang, X.; Yang, B.; Wang, J.; Yang, F. Antiangiogenic effect of capecitabine combined with ginsenoside Rg3 on breast cancer in mice. Cancer Biother. Radiopharm. 2008, 23, 647-653.
    • (2008) Cancer Biother. Radiopharm , vol.23 , pp. 647-653
    • Zhang, Q.1    Kang, X.2    Yang, B.3    Wang, J.4    Yang, F.5
  • 44
    • 68249155377 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice
    • Liu, T.G.; Huang, Y.; Cui, D.D.; Huang, X.B.; Mao, S.H.; Ji, L.L.; Song, H.B.; Yi, C. Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice. BMC Cancer 2009, 9.
    • (2009) BMC Cancer , vol.9
    • Liu, T.G.1    Huang, Y.2    Cui, D.D.3    Huang, X.B.4    Mao, S.H.5    Ji, L.L.6    Song, H.B.7    Yi, C.8
  • 45
    • 84862146654 scopus 로고    scopus 로고
    • Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavenging cisplatin-induced intracellular reactive oxygen species
    • Lee, C.K.; Park, K.K.; Chung, A.S.; Chung, W.Y. Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavenging cisplatin-induced intracellular reactive oxygen species. Food Chem. Toxicol. 2012, 50, 2565-2574.
    • (2012) Food Chem. Toxicol , vol.50 , pp. 2565-2574
    • Lee, C.K.1    Park, K.K.2    Chung, A.S.3    Chung, W.Y.4
  • 47
    • 84896734412 scopus 로고    scopus 로고
    • Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells
    • Kim, S.S.; Seong, S.; Kim, S.Y. Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells. Oncol. Lett. 2014, 7, 1265-1269.
    • (2014) Oncol. Lett , vol.7 , pp. 1265-1269
    • Kim, S.S.1    Seong, S.2    Kim, S.Y.3
  • 48
    • 84874859650 scopus 로고    scopus 로고
    • Sensitization of trail-induced cell death by 20(S)-ginsenoside Rg3 via chop-mediated DR5 upregulation in human hepatocellular carcinoma cells
    • Lee, J.Y.; Jung, K.H.; Morgan, M.J.; Kang, Y.R.; Lee, H.S.; Koo, G.B.; Hong, S.S.; Kwon, S.W.; Kim, Y.S. Sensitization of trail-induced cell death by 20(S)-ginsenoside Rg3 via chop-mediated DR5 upregulation in human hepatocellular carcinoma cells. Mol. Cancer Ther. 2013, 12, 274-285.
    • (2013) Mol. Cancer Ther , vol.12 , pp. 274-285
    • Lee, J.Y.1    Jung, K.H.2    Morgan, M.J.3    Kang, Y.R.4    Lee, H.S.5    Koo, G.B.6    Hong, S.S.7    Kwon, S.W.8    Kim, Y.S.9
  • 49
    • 84926651562 scopus 로고    scopus 로고
    • Ginsenoside Rg3 sensitizes human non-small cell lung cancer cells to-radiation by targeting the nuclear factor-kappab pathway
    • Wang, L.; Li, X.; Song, Y.M.; Wang, B.; Zhang, F.R.; Yang, R.; Wang, H.Q.; Zhang, G.J. Ginsenoside Rg3 sensitizes human non-small cell lung cancer cells to-radiation by targeting the nuclear factor-kappab pathway. Mol. Med. Rep. 2015, 12, 609-614.
    • (2015) Mol. Med. Rep , vol.12 , pp. 609-614
    • Wang, L.1    Li, X.2    Song, Y.M.3    Wang, B.4    Zhang, F.R.5    Yang, R.6    Wang, H.Q.7    Zhang, G.J.8
  • 50
    • 84902520014 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibits HIF-1 and vegf expression in patient with acute leukemia via inhibiting the activation of PI3K/AKT and ERK1/2 pathways
    • Zeng, D.; Wang, J.; Kong, P.; Chang, C.; Li, J.; Li, J. Ginsenoside Rg3 inhibits HIF-1 and vegf expression in patient with acute leukemia via inhibiting the activation of PI3K/AKT and ERK1/2 pathways. Int. J. Clin. Exp. Pathol. 2014, 7, 2172-2178.
    • (2014) Int. J. Clin. Exp. Pathol , vol.7 , pp. 2172-2178
    • Zeng, D.1    Wang, J.2    Kong, P.3    Chang, C.4    Li, J.5    Li, J.6
  • 51
    • 84904262963 scopus 로고    scopus 로고
    • Stereospecificity of ginsenoside Rg3 in the promotion of cellular immunity in hepatoma H22-bearing mice
    • Wu, R.; Ru, Q.; Chen, L.; Ma, B.; Li, C. Stereospecificity of ginsenoside Rg3 in the promotion of cellular immunity in hepatoma H22-bearing mice. J. Food Sci. 2014, 79, H1430-H1435.
    • (2014) J. Food Sci , vol.79 , pp. H1430-H1435
    • Wu, R.1    Ru, Q.2    Chen, L.3    Ma, B.4    Li, C.5
  • 52
    • 84926138166 scopus 로고    scopus 로고
    • Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor
    • Joo, E.J.; Chun, J.; Ha, Y.W.; Ko, H.J.; Xu, M.Y.; Kim, Y.S. Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor. Chem. Biol. Interact. 2015, 233, 25-34.
    • (2015) Chem. Biol. Interact , vol.233 , pp. 25-34
    • Joo, E.J.1    Chun, J.2    Ha, Y.W.3    Ko, H.J.4    Xu, M.Y.5    Kim, Y.S.6
  • 53
    • 84923105992 scopus 로고    scopus 로고
    • Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/ley expression
    • Shan, X.; Aziz, F.; Tian, L.L.; Wang, X.Q.; Yan, Q.; Liu, J.W. Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/ley expression. Int. J. Oncol. 2015, 46, 1667-1676.
    • (2015) Int. J. Oncol , vol.46 , pp. 1667-1676
    • Shan, X.1    Aziz, F.2    Tian, L.L.3    Wang, X.Q.4    Yan, Q.5    Liu, J.W.6
  • 54
    • 84925437706 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibits constitutive activation of NF-B signaling in human breast cancer (MDA-MB-231) cells: ERK and AKT as potential upstream targets
    • Kim, B.M.; Kim, D.H.; Park, J.H.; Surh, Y.J.; Na, H.K. Ginsenoside Rg3 inhibits constitutive activation of NF-B signaling in human breast cancer (MDA-MB-231) cells: ERK and AKT as potential upstream targets. J. Cancer Prev. 2014, 19, 23-30.
    • (2014) J. Cancer Prev , vol.19 , pp. 23-30
    • Kim, B.M.1    Kim, D.H.2    Park, J.H.3    Surh, Y.J.4    Na, H.K.5
  • 55
    • 84862882951 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibits CXCR4 expression and related migrations in a breast cancer cell line
    • Chen, X.P.; Qian, L.L.; Jiang, H.; Chen, J.H. Ginsenoside Rg3 inhibits CXCR4 expression and related migrations in a breast cancer cell line. Int. J. Clin. Oncol. 2011, 16, 519-523.
    • (2011) Int. J. Clin. Oncol , vol.16 , pp. 519-523
    • Chen, X.P.1    Qian, L.L.2    Jiang, H.3    Chen, J.H.4
  • 56
    • 84862791854 scopus 로고    scopus 로고
    • Ginsenoside Rg3 attenuates cell migration via inhibition of aquaporin 1 expression in PC-3M prostate cancer cells
    • Pan, X.Y.; Guo, H.; Han, J.; Hao, F.; An, Y.; Xu, Y.; Xiaokaiti, Y.; Pan, Y.; Li, X.J. Ginsenoside Rg3 attenuates cell migration via inhibition of aquaporin 1 expression in PC-3M prostate cancer cells. Eur. J. Pharmacol. 2012, 683, 27-34.
    • (2012) Eur. J. Pharmacol , vol.683 , pp. 27-34
    • Pan, X.Y.1    Guo, H.2    Han, J.3    Hao, F.4    An, Y.5    Xu, Y.6    Xiaokaiti, Y.7    Pan, Y.8    Li, X.J.9
  • 57
    • 84925285121 scopus 로고    scopus 로고
    • 20(S)-ginsenoside Rg3 promotes apoptosis in human ovarian cancer HO-8910 cells through PI3K/AKT and XIAP pathways
    • Wang, J.H.; Nao, J.F.; Zhang, M.; He, P. 20(S)-ginsenoside Rg3 promotes apoptosis in human ovarian cancer HO-8910 cells through PI3K/AKT and XIAP pathways. Tumour Biol. 2014, 35, 11985-11994.
    • (2014) Tumour Biol , vol.35 , pp. 11985-11994
    • Wang, J.H.1    Nao, J.F.2    Zhang, M.3    He, P.4
  • 58
    • 84901228851 scopus 로고    scopus 로고
    • Stereospecific effects of ginsenoside 20-Rg3 inhibits TGF-1-induced epithelial-mesenchymal transition and suppresses lung cancer migration, invasion and anoikis resistance
    • Kim, Y.J.; Choi, W.I.; Jeon, B.N.; Choi, K.C.; Kim, K.; Kim, T.J.; Ham, J.; Jang, H.J.; Kang, K.S.; Ko, H. Stereospecific effects of ginsenoside 20-Rg3 inhibits TGF-1-induced epithelial-mesenchymal transition and suppresses lung cancer migration, invasion and anoikis resistance. Toxicology 2014, 322, 23-33.
    • (2014) Toxicology , vol.322 , pp. 23-33
    • Kim, Y.J.1    Choi, W.I.2    Jeon, B.N.3    Choi, K.C.4    Kim, K.5    Kim, T.J.6    Ham, J.7    Jang, H.J.8    Kang, K.S.9    Ko, H.10
  • 59
    • 84918570803 scopus 로고    scopus 로고
    • Ginsenoside 20(S) Rg3 inhibits the warburg effect through STAT3 pathways in ovarian cancer cells
    • Li, J.; Liu, T.; Zhao, L.; Chen, W.; Hou, H.; Ye, Z.; Li, X. Ginsenoside 20(S) Rg3 inhibits the warburg effect through STAT3 pathways in ovarian cancer cells. Int. J. Oncol. 2015, 46, 775-781.
    • (2015) Int. J. Oncol , vol.46 , pp. 775-781
    • Li, J.1    Liu, T.2    Zhao, L.3    Chen, W.4    Hou, H.5    Ye, Z.6    Li, X.7
  • 60
    • 84935446324 scopus 로고    scopus 로고
    • Ginsenoside Rg3 induces apoptosis in human multiple myeloma cells via the activation of Bcl-2-Associated x protein
    • Luo, Y.; Zhang, P.; Zeng, H.Q.; Lou, S.F.; Wang, D.X. Ginsenoside Rg3 induces apoptosis in human multiple myeloma cells via the activation of Bcl-2-Associated x protein. Mol. Med. Rep. 2015, 12, 3557-3562.
    • (2015) Mol. Med. Rep , vol.12 , pp. 3557-3562
    • Luo, Y.1    Zhang, P.2    Zeng, H.Q.3    Lou, S.F.4    Wang, D.X.5
  • 61
    • 84962050626 scopus 로고    scopus 로고
    • Effect of amino acids on the generation of ginsenoside Rg3 epimers by heat processing and the anticancer activities of epimers in A2780 human ovarian cancer cells
    • Park, J.Y.; Choi, P.; Lee, D.; Kim, T.; Jung, E.B.; Hwang, B.S.; Kang, K.S.; Ham, J. Effect of amino acids on the generation of ginsenoside Rg3 epimers by heat processing and the anticancer activities of epimers in A2780 human ovarian cancer cells. Evid. Based Complement. Altern. Med. 2016, 2016.
    • (2016) Evid. Based Complement. Altern. Med , vol.2016
    • Park, J.Y.1    Choi, P.2    Lee, D.3    Kim, T.4    Jung, E.B.5    Hwang, B.S.6    Kang, K.S.7    Ham, J.8
  • 62
    • 84949994685 scopus 로고    scopus 로고
    • Ginsenoside Rg3 induces FUT4-mediated apoptosis in h Pylori CAGA-Treated gastric cancer cells by regulating SP1 and HSF1 expressions
    • Aziz, F.; Wang, X.; Liu, J.; Yan, Q. Ginsenoside Rg3 induces FUT4-mediated apoptosis in h. Pylori CAGA-Treated gastric cancer cells by regulating SP1 and HSF1 expressions. Toxicol. in Vitro 2016, 31, 158-166.
    • (2016) Toxicol. in Vitro , vol.31 , pp. 158-166
    • Aziz, F.1    Wang, X.2    Liu, J.3    Yan, Q.4
  • 63
    • 80052685766 scopus 로고    scopus 로고
    • Transient receptor potential melastatin 7 channels are involved in ginsenoside Rg3-induced apoptosis in gastric cancer cells
    • Kim, B.J.; Nah, S.Y.; Jeon, J.H.; So, I.; Kim, S.J. Transient receptor potential melastatin 7 channels are involved in ginsenoside Rg3-induced apoptosis in gastric cancer cells. Basic Clin. Pharmacol. Toxicol. 2011, 109, 233-239.
    • (2011) Basic Clin. Pharmacol. Toxicol , vol.109 , pp. 233-239
    • Kim, B.J.1    Nah, S.Y.2    Jeon, J.H.3    So, I.4    Kim, S.J.5
  • 64
    • 84957719332 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4
    • Tian, L.; Shen, D.; Li, X.; Shan, X.; Wang, X.; Yan, Q.; Liu, J. Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4. Oncotarget 2016, 7, 1619-1632.
    • (2016) Oncotarget , vol.7 , pp. 1619-1632
    • Tian, L.1    Shen, D.2    Li, X.3    Shan, X.4    Wang, X.5    Yan, Q.6    Liu, J.7
  • 65
    • 84904398089 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibition of vasculogenic mimicry in pancreatic cancer through downregulation of vecadherin/EPHA2/MMP9/MMP2 expression
    • Guo, J.Q.; Zheng, Q.H.; Chen, H.; Chen, L.; Xu, J.B.; Chen, M.Y.; Lu, D.; Wang, Z.H.; Tong, H.F.; Lin, S. Ginsenoside Rg3 inhibition of vasculogenic mimicry in pancreatic cancer through downregulation of vecadherin/EPHA2/MMP9/MMP2 expression. Int. J. Oncol. 2014, 45, 1065-1072.
    • (2014) Int. J. Oncol , vol.45 , pp. 1065-1072
    • Guo, J.Q.1    Zheng, Q.H.2    Chen, H.3    Chen, L.4    Xu, J.B.5    Chen, M.Y.6    Lu, D.7    Wang, Z.H.8    Tong, H.F.9    Lin, S.10
  • 67
    • 84866058360 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibits endothelial progenitor cell differentiation through attenuation of VEGF-dependent AKT/ENOS signaling
    • Kim, J.W.; Jung, S.Y.; Kwon, Y.H.; Lee, S.H.; Lee, J.H.; Lee, B.Y.; Kwon, S.M. Ginsenoside Rg3 inhibits endothelial progenitor cell differentiation through attenuation of VEGF-dependent AKT/ENOS signaling. Phytother. Res. 2012, 26, 1286-1293.
    • (2012) Phytother. Res , vol.26 , pp. 1286-1293
    • Kim, J.W.1    Jung, S.Y.2    Kwon, Y.H.3    Lee, S.H.4    Lee, J.H.5    Lee, B.Y.6    Kwon, S.M.7
  • 68
    • 84861176603 scopus 로고    scopus 로고
    • Ginsenoside Rg3 attenuates tumor angiogenesis via inhibiting bioactivities of endothelial progenitor cells
    • Kim, J.W.; Jung, S.Y.; Kwon, Y.H.; Lee, J.H.; Lee, Y.M.; Lee, B.Y.; Kwon, S.M. Ginsenoside Rg3 attenuates tumor angiogenesis via inhibiting bioactivities of endothelial progenitor cells. Cancer Biol. Ther. 2012, 13, 504-515.
    • (2012) Cancer Biol. Ther , vol.13 , pp. 504-515
    • Kim, J.W.1    Jung, S.Y.2    Kwon, Y.H.3    Lee, J.H.4    Lee, Y.M.5    Lee, B.Y.6    Kwon, S.M.7
  • 69
    • 84974659433 scopus 로고    scopus 로고
    • Immunogenic cell death induced by ginsenoside Rg3: Significance in dendritic cell-based anti-Tumor immunotherapy
    • Son, K.J.; Choi, K.R.; Lee, S.J.; Lee, H. Immunogenic cell death induced by ginsenoside Rg3: Significance in dendritic cell-based anti-Tumor immunotherapy. Immune Netw. 2016, 16, 75-84.
    • (2016) Immune Netw , vol.16 , pp. 75-84
    • Son, K.J.1    Choi, K.R.2    Lee, S.J.3    Lee, H.4
  • 70
    • 38849101477 scopus 로고    scopus 로고
    • Characterizing the mechanism for ginsenoside-induced cytotoxicity in cultured leukemia (THP-1) cells
    • Kitts, D.D.; Popovich, D.G.; Hu, C. Characterizing the mechanism for ginsenoside-induced cytotoxicity in cultured leukemia (THP-1) cells. Can. J. Physiol. Pharmacol. 2007, 85, 1173-1183.
    • (2007) Can. J. Physiol. Pharmacol , vol.85 , pp. 1173-1183
    • Kitts, D.D.1    Popovich, D.G.2    Hu, C.3
  • 71
    • 84984876753 scopus 로고    scopus 로고
    • Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-signaling pathway
    • Huang, J.; Peng, K.; Wang, L.; Wen, B.; Zhou, L.; Luo, T.; Su, M.; Li, J.; Luo, Z. Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-signaling pathway. Acta Biochim. Biophys. Sin. 2016.
    • (2016) Acta Biochim. Biophys. Sin
    • Huang, J.1    Peng, K.2    Wang, L.3    Wen, B.4    Zhou, L.5    Luo, T.6    Su, M.7    Li, J.8    Luo, Z.9
  • 72
    • 18744403057 scopus 로고    scopus 로고
    • Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells
    • Cheng, C.C.; Yang, S.M.; Huang, C.Y.; Chen, J.C.; Chang, W.M.; Hsu, S.L. Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells. Cancer Chemother. Pharmacol. 2005, 55, 531-540.
    • (2005) Cancer Chemother. Pharmacol , vol.55 , pp. 531-540
    • Cheng, C.C.1    Yang, S.M.2    Huang, C.Y.3    Chen, J.C.4    Chang, W.M.5    Hsu, S.L.6
  • 73
    • 78651445610 scopus 로고    scopus 로고
    • Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53
    • Li, B.; Zhao, J.;Wang, C.Z.; Searle, J.; He, T.C.; Yuan, C.S.; Du, W. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett. 2011, 301, 185-192.
    • (2011) Cancer Lett , vol.301 , pp. 185-192
    • Li, B.1    Zhao, J.2    Wang, C.Z.3    Searle, J.4    He, T.C.5    Yuan, C.S.6    Du, W.7
  • 74
    • 78651342562 scopus 로고    scopus 로고
    • Ginsenoside Rh2 induces Bcl-2 family proteins-mediated apoptosis in vitro and in xenografts in vivo models
    • Choi, S.; Oh, J.Y.; Kim, S.J. Ginsenoside Rh2 induces Bcl-2 family proteins-mediated apoptosis in vitro and in xenografts in vivo models. J. Cell. Biochem. 2011, 112, 330-340.
    • (2011) J. Cell. Biochem , vol.112 , pp. 330-340
    • Choi, S.1    Oh, J.Y.2    Kim, S.J.3
  • 75
    • 69949130845 scopus 로고    scopus 로고
    • Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 INK4B and p27 KIP1-dependent inhibition of cyclin-dependent kinases
    • Choi, S.; Kim, T.W.; Singh, S.V. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 INK4B and p27 KIP1-dependent inhibition of cyclin-dependent kinases. Pharm. Res. 2009, 26, 2280-2288.
    • (2009) Pharm. Res , vol.26 , pp. 2280-2288
    • Choi, S.1    Kim, T.W.2    Singh, S.V.3
  • 76
    • 0026102592 scopus 로고
    • Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside Rh2 and adjuvant effects to cisplatin in vivo
    • Kikuchi, Y.; Sasa, H.; Kita, T.; Hirata, J.; Tode, T.; Nagata, I. Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside Rh2 and adjuvant effects to cisplatin in vivo. Anti-Cancer Drugs 1991, 2, 63-67.
    • (1991) Anti-Cancer Drugs , vol.2 , pp. 63-67
    • Kikuchi, Y.1    Sasa, H.2    Kita, T.3    Hirata, J.4    Tode, T.5    Nagata, I.6
  • 77
    • 69049109763 scopus 로고    scopus 로고
    • Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: Formulation, pharmacokinetics, biodistribution and efficacy
    • Musende, A.G.; Eberding, A.;Wood, C.; Adomat, H.; Fazli, L.; Hurtado-Coll, A.; Jia, W.; Bally, M.B.; Guns, E.T. Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: Formulation, pharmacokinetics, biodistribution and efficacy. Cancer Chemother. Pharmacol. 2009, 64, 1085-1095.
    • (2009) Cancer Chemother. Pharmacol , vol.64 , pp. 1085-1095
    • Musende, A.G.1    Eberding, A.2    Wood, C.3    Adomat, H.4    Fazli, L.5    Hurtado-Coll, A.6    Jia, W.7    Bally, M.B.8    Guns, E.T.9
  • 78
    • 33646002630 scopus 로고    scopus 로고
    • Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate cancer models
    • Xie, X.; Eberding, A.; Madera, C.; Fazli, L.; Jia, W.; Goldenberg, L.; Gleave, M.; Guns, E.S. Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate cancer models. J. Urol. 2006, 175, 1926-1931.
    • (2006) J. Urol , vol.175 , pp. 1926-1931
    • Xie, X.1    Eberding, A.2    Madera, C.3    Fazli, L.4    Jia, W.5    Goldenberg, L.6    Gleave, M.7    Guns, E.S.8
  • 79
    • 16644362651 scopus 로고    scopus 로고
    • Ginsenoside Rh2 induces apoptosis via activation of caspase-1 and-3 and up-regulation of bax in human neuroblastoma
    • Kim, Y.S.; Jin, S.H. Ginsenoside Rh2 induces apoptosis via activation of caspase-1 and-3 and up-regulation of bax in human neuroblastoma. Arch. Pharm. Res. 2004, 27, 834-839.
    • (2004) Arch. Pharm. Res , vol.27 , pp. 834-839
    • Kim, Y.S.1    Jin, S.H.2
  • 80
    • 35348993755 scopus 로고    scopus 로고
    • Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells
    • Kim, S.Y.; Kim, D.H.; Han, S.J.; Hyun, J.W.; Kim, H.S. Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells. Biochem. Pharmacol. 2007, 74, 1642-1651.
    • (2007) Biochem. Pharmacol , vol.74 , pp. 1642-1651
    • Kim, S.Y.1    Kim, D.H.2    Han, S.J.3    Hyun, J.W.4    Kim, H.S.5
  • 81
    • 0036207452 scopus 로고    scopus 로고
    • Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells
    • Fei, X.F.; Wang, B.X.; Tashiro, S.; Li, T.J.; Ma, J.S.; Ikejima, T. Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells. Acta Pharmacol. Sin. 2002, 23, 315-322.
    • (2002) Acta Pharmacol. Sin , vol.23 , pp. 315-322
    • Fei, X.F.1    Wang, B.X.2    Tashiro, S.3    Li, T.J.4    Ma, J.S.5    Ikejima, T.6
  • 82
  • 84
    • 33645702638 scopus 로고    scopus 로고
    • Ginsenoside Rh2 enhances antitumour activity and decreases genotoxic effect of cyclophosphamide
    • Wang, Z.; Zheng, Q.; Liu, K.; Li, G.; Zheng, R. Ginsenoside Rh2 enhances antitumour activity and decreases genotoxic effect of cyclophosphamide. Basic Clin. Pharmacol. Toxicol. 2006, 98, 411-415.
    • (2006) Basic Clin. Pharmacol. Toxicol , vol.98 , pp. 411-415
    • Wang, Z.1    Zheng, Q.2    Liu, K.3    Li, G.4    Zheng, R.5
  • 85
    • 77956624697 scopus 로고    scopus 로고
    • Rh2 or its aglycone appd in combination with docetaxel for treatment of prostate cancer
    • Musende, A.G.; Eberding, A.; Jia, W.; Ramsay, E.; Bally, M.B.; Guns, E.T. Rh2 or its aglycone appd in combination with docetaxel for treatment of prostate cancer. Prostate 2010, 70, 1437-1447.
    • (2010) Prostate , vol.70 , pp. 1437-1447
    • Musende, A.G.1    Eberding, A.2    Jia, W.3    Ramsay, E.4    Bally, M.B.5    Guns, E.T.6
  • 86
    • 84944874407 scopus 로고    scopus 로고
    • Ginsenoside 20(S)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells
    • Liu, Z.H.; Li, J.; Xia, J.; Jiang, R.; Zuo, G.W.; Li, X.P.; Chen, Y.; Xiong, W.; Chen, D.L. Ginsenoside 20(S)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells. Chem. Biol. Interact. 2015, 242, 227-234.
    • (2015) Chem. Biol. Interact , vol.242 , pp. 227-234
    • Liu, Z.H.1    Li, J.2    Xia, J.3    Jiang, R.4    Zuo, G.W.5    Li, X.P.6    Chen, Y.7    Xiong, W.8    Chen, D.L.9
  • 87
    • 84967327805 scopus 로고    scopus 로고
    • Antitumoral activity of (20R)-And (20S)-ginsenoside Rh2 on transplanted hepatocellular carcinoma in mice
    • Lv, Q.; Rong, N.; Liu, L.J.; Xu, X.L.; Liu, J.T.; Jin, F.X.; Wang, C.M. Antitumoral activity of (20R)-And (20S)-ginsenoside Rh2 on transplanted hepatocellular carcinoma in mice. Planta Med. 2016, 82, 705-711.
    • (2016) Planta Med , vol.82 , pp. 705-711
    • Lv, Q.1    Rong, N.2    Liu, L.J.3    Xu, X.L.4    Liu, J.T.5    Jin, F.X.6    Wang, C.M.7
  • 88
    • 84936771227 scopus 로고    scopus 로고
    • Inhibition of prostatic cancer growth by ginsenoside Rh2
    • Zhang, Q.; Hong, B.;Wu, S.; Niu, T. Inhibition of prostatic cancer growth by ginsenoside Rh2. Tumour Biol. 2015, 36, 2377-2381.
    • (2015) Tumour Biol , vol.36 , pp. 2377-2381
    • Zhang, Q.1    Hong, B.2    Wu, S.3    Niu, T.4
  • 89
    • 84904754114 scopus 로고    scopus 로고
    • EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2
    • Li, S.; Gao, Y.; Ma, W.; Guo, W.; Zhou, G.; Cheng, T.; Liu, Y. EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2. Tumour Biol. 2014, 35, 5593-5598.
    • (2014) Tumour Biol , vol.35 , pp. 5593-5598
    • Li, S.1    Gao, Y.2    Ma, W.3    Guo, W.4    Zhou, G.5    Cheng, T.6    Liu, Y.7
  • 90
    • 84955282985 scopus 로고    scopus 로고
    • Ginsenoside Rh2 inhibits hepatocellular carcinoma through-catenin and autophagy
    • Yang, Z.; Zhao, T.; Liu, H.; Zhang, L. Ginsenoside Rh2 inhibits hepatocellular carcinoma through-catenin and autophagy. Sci. Rep. 2016, 6, 19383.
    • (2016) Sci. Rep , vol.6 , pp. 19383
    • Yang, Z.1    Zhao, T.2    Liu, H.3    Zhang, L.4
  • 91
    • 78649580065 scopus 로고    scopus 로고
    • 20(S)-ginsenoside Rh2 noncompetitively inhibits p-glycoprotein in vitro and in vivo: A case for herb-drug interactions
    • Zhang, J.; Zhou, F.;Wu, X.; Gu, Y.; Ai, H.; Zheng, Y.; Li, Y.; Zhang, X.; Hao, G.; Sun, J.; et al. 20(S)-ginsenoside Rh2 noncompetitively inhibits p-glycoprotein in vitro and in vivo: A case for herb-drug interactions. Drug Metab. Dispos. 2010, 38, 2179-2187.
    • (2010) Drug Metab. Dispos , vol.38 , pp. 2179-2187
    • Zhang, J.1    Zhou, F.2    Wu, X.3    Gu, Y.4    Ai, H.5    Zheng, Y.6    Li, Y.7    Zhang, X.8    Hao, G.9    Sun, J.10
  • 92
    • 84855933510 scopus 로고    scopus 로고
    • A dynamic study on reversal of multidrug resistance by ginsenoside Rh2 in adriamycin-resistant human breast cancer MCF-7 cells
    • Zhou, B.; Xiao, X.; Xu, L.; Zhu, L.; Tan, L.; Tang, H.; Zhang, Y.; Xie, Q.; Yao, S. A dynamic study on reversal of multidrug resistance by ginsenoside Rh2 in adriamycin-resistant human breast cancer MCF-7 cells. Talanta 2012, 88, 345-351.
    • (2012) Talanta , vol.88 , pp. 345-351
    • Zhou, B.1    Xiao, X.2    Xu, L.3    Zhu, L.4    Tan, L.5    Tang, H.6    Zhang, Y.7    Xie, Q.8    Yao, S.9
  • 93
    • 82955184560 scopus 로고    scopus 로고
    • Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/ADR cells
    • Zhang, J.; Zhou, F.; Wu, X.; Zhang, X.; Chen, Y.; Zha, B.S.; Niu, F.; Lu, M.; Hao, G.; Sun, Y.; et al. Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/ADR cells. Br. J. Pharmacol. 2012, 165, 120-134.
    • (2012) Br. J. Pharmacol , vol.165 , pp. 120-134
    • Zhang, J.1    Zhou, F.2    Wu, X.3    Zhang, X.4    Chen, Y.5    Zha, B.S.6    Niu, F.7    Lu, M.8    Hao, G.9    Sun, Y.10
  • 94
    • 84924220374 scopus 로고    scopus 로고
    • Effect of ginsenoside Rh2 on the migratory ability of HEPG2 liver carcinoma cells: Recruiting histone deacetylase and inhibiting activator protein 1 transcription factors
    • Shi, Q.; Li, J.; Feng, Z.; Zhao, L.; Luo, L.; You, Z.; Li, D.; Xia, J.; Zuo, G.; Chen, D. Effect of ginsenoside Rh2 on the migratory ability of HEPG2 liver carcinoma cells: Recruiting histone deacetylase and inhibiting activator protein 1 transcription factors. Mol. Med. Rep. 2014, 10, 1779-1785.
    • (2014) Mol. Med. Rep , vol.10 , pp. 1779-1785
    • Shi, Q.1    Li, J.2    Feng, Z.3    Zhao, L.4    Luo, L.5    You, Z.6    Li, D.7    Xia, J.8    Zuo, G.9    Chen, D.10
  • 95
    • 84555188034 scopus 로고    scopus 로고
    • The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives
    • Dong, H.; Bai, L.P.;Wong, V.K.; Zhou, H.;Wang, J.R.; Liu, Y.; Jiang, Z.H.; Liu, L. The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives. Molecules 2011, 16, 10619-10630.
    • (2011) Molecules , vol.16 , pp. 10619-10630
    • Dong, H.1    Bai, L.P.2    Wong, V.K.3    Zhou, H.4    Wang, J.R.5    Liu, Y.6    Jiang, Z.H.7    Liu, L.8
  • 98
    • 84921415103 scopus 로고    scopus 로고
    • Ginsenoside Rg1 attenuates invasion and migration by inhibiting transforming growth factor-induced epithelial to mesenchymal transition in HepG2 cells
    • Yu, M.; Yu, X.; Guo, D.; Yu, B.; Li, L.; Liao, Q.; Xing, R. Ginsenoside Rg1 attenuates invasion and migration by inhibiting transforming growth factor-induced epithelial to mesenchymal transition in HepG2 cells. Mol. Med. Rep. 2015, 11, 3167-3173.
    • (2015) Mol. Med. Rep , vol.11 , pp. 3167-3173
    • Yu, M.1    Yu, X.2    Guo, D.3    Yu, B.4    Li, L.5    Liao, Q.6    Xing, R.7
  • 99
    • 84907293011 scopus 로고    scopus 로고
    • Suppression of PMA-induced tumor cell invasion and migration by ginsenoside Rg1 via the inhibition of NF-B-dependent MMP-9 expression
    • Li, L.;Wang, Y.; Qi, B.; Yuan, D.; Dong, S.; Guo, D.; Zhang, C.; Yu, M. Suppression of PMA-induced tumor cell invasion and migration by ginsenoside Rg1 via the inhibition of NF-B-dependent MMP-9 expression. Oncol. Rep. 2014, 32, 1779-1786.
    • (2014) Oncol. Rep , vol.32 , pp. 1779-1786
    • Li, L.1    Wang, Y.2    Qi, B.3    Yuan, D.4    Dong, S.5    Guo, D.6    Zhang, C.7    Yu, M.8
  • 100
    • 84899790223 scopus 로고    scopus 로고
    • Ginsenoside Rg1 induces apoptosis through inhibition of the EPOR-mediated JAK2/STAT5 signalling pathway in the TF-1/EPO human leukemia cell line
    • Li, J.; Wei, Q.; Zuo, G.W.; Xia, J.; You, Z.M.; Li, C.L.; Chen, D.L. Ginsenoside Rg1 induces apoptosis through inhibition of the EPOR-mediated JAK2/STAT5 signalling pathway in the TF-1/EPO human leukemia cell line. Asian Pac. J. Cancer Prev. 2014, 15, 2453-2459.
    • (2014) Asian Pac. J. Cancer Prev , vol.15 , pp. 2453-2459
    • Li, J.1    Wei, Q.2    Zuo, G.W.3    Xia, J.4    You, Z.M.5    Li, C.L.6    Chen, D.L.7
  • 102
    • 0141705407 scopus 로고    scopus 로고
    • Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species
    • Chiang, L.C.; Ng, L.T.; Liu, L.T.; Shieh, D.E.; Lin, C.C. Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species. Planta Medica 2003, 69, 705-709.
    • (2003) Planta Medica , vol.69 , pp. 705-709
    • Chiang, L.C.1    Ng, L.T.2    Liu, L.T.3    Shieh, D.E.4    Lin, C.C.5
  • 103
    • 33745171392 scopus 로고    scopus 로고
    • Antiviral effects of saikosaponins on human coronavirus 229E in vitro
    • Cheng, P.W.; Ng, L.T.; Chiang, L.C.; Lin, C.C. Antiviral effects of saikosaponins on human coronavirus 229E in vitro. Clin. Exp. Pharmacol. Physiol. 2006, 33, 612-616.
    • (2006) Clin. Exp. Pharmacol. Physiol , vol.33 , pp. 612-616
    • Cheng, P.W.1    Ng, L.T.2    Chiang, L.C.3    Lin, C.C.4
  • 104
    • 34250902910 scopus 로고    scopus 로고
    • A survey of chinese herbal ingredients with liver protection activities
    • Wang, R.; Kong, J.;Wang, D.; Lien, L.L.; Lien, E.J. A survey of chinese herbal ingredients with liver protection activities. Chin. Med. 2007, 2.
    • (2007) Chin. Med , vol.2
    • Wang, R.1    Kong, J.2    Wang, D.3    Lien, L.L.4    Lien, E.J.5
  • 105
    • 40249118230 scopus 로고    scopus 로고
    • Effects of bupleurum scorzoneraefolium, bupleurum falcatum, and saponins on nephrotoxic serum nephritis in mice
    • Chen, S.M.; Sato, N.; Yoshida, M.; Satoh, N.; Ueda, S. Effects of bupleurum scorzoneraefolium, bupleurum falcatum, and saponins on nephrotoxic serum nephritis in mice. J. Ethnopharmacol. 2008, 116, 397-402.
    • (2008) J. Ethnopharmacol , vol.116 , pp. 397-402
    • Chen, S.M.1    Sato, N.2    Yoshida, M.3    Satoh, N.4    Ueda, S.5
  • 106
    • 0027972604 scopus 로고
    • The herbal medicine SHO-SAIKO-TO inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase
    • Yano, H.; Mizoguchi, A.; Fukuda, K.; Haramaki, M.; Ogasawara, S.; Momosaki, S.; Kojiro, M. The herbal medicine SHO-SAIKO-TO inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Cancer Res. 1994, 54, 448-454.
    • (1994) Cancer Res , vol.54 , pp. 448-454
    • Yano, H.1    Mizoguchi, A.2    Fukuda, K.3    Haramaki, M.4    Ogasawara, S.5    Momosaki, S.6    Kojiro, M.7
  • 107
    • 0035902794 scopus 로고    scopus 로고
    • The chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest
    • Kao, S.T.; Yeh, C.C.; Hsieh, C.C.; Yang, M.D.; Lee, M.R.; Liu, H.S.; Lin, J.G. The chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest. Life Sci. 2001, 69, 1485-1496.
    • (2001) Life Sci , vol.69 , pp. 1485-1496
    • Kao, S.T.1    Yeh, C.C.2    Hsieh, C.C.3    Yang, M.D.4    Lee, M.R.5    Liu, H.S.6    Lin, J.G.7
  • 108
    • 0025835526 scopus 로고
    • Inhibition by Xiao-Chai-Hu-Tang (TJ-9) of development of hepatic FOCI induced by n-nitrosomorpholine in sprague-dawley rats
    • Tatsuta, M.; Iishi, H.; Baba, M.; Nakaizumi, A.; Uehara, H. Inhibition by Xiao-Chai-Hu-Tang (TJ-9) of development of hepatic FOCI induced by n-nitrosomorpholine in sprague-dawley rats. Jpn. J. Cancer Res. 1991, 82, 987-992.
    • (1991) Jpn. J. Cancer Res , vol.82 , pp. 987-992
    • Tatsuta, M.1    Iishi, H.2    Baba, M.3    Nakaizumi, A.4    Uehara, H.5
  • 109
    • 9644279912 scopus 로고    scopus 로고
    • Saikosaponin c induces endothelial cells growth, migration and capillary tube formation
    • Shyu, K.G.; Tsai, S.C.; Wang, B.W.; Liu, Y.C.; Lee, C.C. Saikosaponin c induces endothelial cells growth, migration and capillary tube formation. Life Sci. 2004, 76, 813-826.
    • (2004) Life Sci , vol.76 , pp. 813-826
    • Shyu, K.G.1    Tsai, S.C.2    Wang, B.W.3    Liu, Y.C.4    Lee, C.C.5
  • 112
    • 84916597314 scopus 로고    scopus 로고
    • Separation of triterpenoid saponins from the root of Bupleurum falcatum by counter current chromatography: The relationship between the partition coefficients and solvent system composition
    • Lee, K.J.; Xu, M.Y.; Shehzad, O.; Seo, E.K.; Kim, Y.S. Separation of triterpenoid saponins from the root of Bupleurum falcatum by counter current chromatography: The relationship between the partition coefficients and solvent system composition. J. Sep. Sci. 2014, 37, 3587-3594.
    • (2014) J. Sep. Sci , vol.37 , pp. 3587-3594
    • Lee, K.J.1    Xu, M.Y.2    Shehzad, O.3    Seo, E.K.4    Kim, Y.S.5
  • 113
    • 0034806214 scopus 로고    scopus 로고
    • Involvement of p-15INK4b and p-16INK4a gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells
    • Wu, W.S.; Hsu, H.Y. Involvement of p-15INK4b and p-16INK4a gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells. Biochem. Biophys. Res. Commun. 2001, 285, 183-187.
    • (2001) Biochem. Biophys. Res. Commun , vol.285 , pp. 183-187
    • Wu, W.S.1    Hsu, H.Y.2
  • 114
    • 0028969829 scopus 로고
    • Saikosaponin a-induced cell death of a human hepatoma cell line (HUH-7): The significance of the sub-G1 peak in a DNA histogram
    • Qian, L.; Murakami, T.; Kimura, Y.; Takahashi, M.; Okita, K. Saikosaponin a-induced cell death of a human hepatoma cell line (HUH-7): The significance of the sub-G1 peak in a DNA histogram. Pathol. Int. 1995, 45, 207-214.
    • (1995) Pathol. Int , vol.45 , pp. 207-214
    • Qian, L.1    Murakami, T.2    Kimura, Y.3    Takahashi, M.4    Okita, K.5
  • 115
    • 9644290789 scopus 로고    scopus 로고
    • Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells
    • Chen, J.C.; Chang, N.W.; Chung, J.G.; Chen, K.C. Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells. Am. J. Chin. Med. 2003, 31, 363-377.
    • (2003) Am. J. Chin. Med , vol.31 , pp. 363-377
    • Chen, J.C.1    Chang, N.W.2    Chung, J.G.3    Chen, K.C.4
  • 116
    • 0036222598 scopus 로고    scopus 로고
    • Induction of differentiation in rat c6 glioma cells with saikosaponins
    • Tsai, Y.J.; Chen, I.L.; Horng, L.Y.;Wu, R.T. Induction of differentiation in rat c6 glioma cells with saikosaponins. Phytother. Res. 2002, 16, 117-121.
    • (2002) Phytother. Res , vol.16 , pp. 117-121
    • Tsai, Y.J.1    Chen, I.L.2    Horng, L.Y.3    Wu, R.T.4
  • 117
    • 79951581748 scopus 로고    scopus 로고
    • Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines
    • Kim, B.M.; Hong, S.H. Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines. Apoptosis 2011, 16, 184-197.
    • (2011) Apoptosis , vol.16 , pp. 184-197
    • Kim, B.M.1    Hong, S.H.2
  • 118
    • 85010841211 scopus 로고    scopus 로고
    • Saikosaponin A an active glycoside from Radix bupleuri, reverses P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cells and HepG2/adm cells
    • Ye, R.P.; Chen, Z.D. Saikosaponin A, an active glycoside from Radix bupleuri, reverses P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cells and HepG2/adm cells. Xenobiotica 2016, 1-9.
    • (2016) Xenobiotica , pp. 1-9
    • Ye, R.P.1    Chen, Z.D.2
  • 119
    • 3042541878 scopus 로고    scopus 로고
    • The proliferative inhibition and apoptotic mechanism of Saikosaponin D in human non-small cell lung cancer A549 cells
    • Hsu, Y.L.; Kuo, P.L.; Lin, C.C. The proliferative inhibition and apoptotic mechanism of Saikosaponin D in human non-small cell lung cancer A549 cells. Life Sci. 2004, 75, 1231-1242.
    • (2004) Life Sci , vol.75 , pp. 1231-1242
    • Hsu, Y.L.1    Kuo, P.L.2    Lin, C.C.3
  • 120
    • 0028110031 scopus 로고
    • Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines
    • Motoo, Y.; Sawabu, N. Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines. Cancer Lett. 1994, 86, 91-95.
    • (1994) Cancer Lett , vol.86 , pp. 91-95
    • Motoo, Y.1    Sawabu, N.2
  • 121
    • 4344636755 scopus 로고    scopus 로고
    • Involvement of p53, nuclear factor kappab and FAS/FAS ligand in induction of apoptosis and cell cycle arrest by saikosaponin D in human hepatoma cell lines
    • Hsu, Y.L.; Kuo, P.L.; Chiang, L.C.; Lin, C.C. Involvement of p53, nuclear factor kappab and FAS/FAS ligand in induction of apoptosis and cell cycle arrest by saikosaponin D in human hepatoma cell lines. Cancer Lett. 2004, 213, 213-221.
    • (2004) Cancer Lett , vol.213 , pp. 213-221
    • Hsu, Y.L.1    Kuo, P.L.2    Chiang, L.C.3    Lin, C.C.4
  • 122
    • 84873454874 scopus 로고    scopus 로고
    • Effects of saikosaponin-d on syndecan-2, matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 in ratswith hepatocellular carcinoma
    • Jia, X.; Dang, S.; Cheng, Y.; Zhang, X.; Li, M.; Li, Y.; Li, S. Effects of saikosaponin-d on syndecan-2, matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 in ratswith hepatocellular carcinoma. J. Tradit. Chin. Med. 2012, 32, 415-422.
    • (2012) J. Tradit. Chin. Med , vol.32 , pp. 415-422
    • Jia, X.1    Dang, S.2    Cheng, Y.3    Zhang, X.4    Li, M.5    Li, Y.6    Li, S.7
  • 123
    • 84901441873 scopus 로고    scopus 로고
    • Saikosaponind inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase
    • Yao, M.; Yang, J.; Cao, L.; Zhang, L.; Qu, S.; Gao, H. Saikosaponind inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase. Mol. Med. Rep. 2014, 10, 365-372.
    • (2014) Mol. Med. Rep , vol.10 , pp. 365-372
    • Yao, M.1    Yang, J.2    Cao, L.3    Zhang, L.4    Qu, S.5    Gao, H.6
  • 124
    • 84928392402 scopus 로고    scopus 로고
    • Saikosaponin-d inhibits proliferation of human undifferentiated thyroid carcinoma cells through induction of apoptosis and cell cycle arrest
    • Liu, R.Y.; Li, J.P. Saikosaponin-d inhibits proliferation of human undifferentiated thyroid carcinoma cells through induction of apoptosis and cell cycle arrest. Eur. Rev. Med. Pharmacol. Sci. 2014, 18, 2435-2443.
    • (2014) Eur. Rev. Med. Pharmacol. Sci , vol.18 , pp. 2435-2443
    • Liu, R.Y.1    Li, J.P.2
  • 125
    • 84891687907 scopus 로고    scopus 로고
    • Saikosaponin-d enhances radiosensitivity of hepatoma cells under hypoxic conditions by inhibiting hypoxia-inducible factor-1
    • Wang, B.F.; Wang, X.J.; Kang, H.F.; Bai, M.H.; Guan, H.T.; Wang, Z.W.; Zan, Y.; Song, L.Q.; Min, W.L.; Lin, S.; et al. Saikosaponin-d enhances radiosensitivity of hepatoma cells under hypoxic conditions by inhibiting hypoxia-inducible factor-1. Cell. Physiol. Biochem. 2014, 33, 37-51.
    • (2014) Cell. Physiol. Biochem , vol.33 , pp. 37-51
    • Wang, B.F.1    Wang, X.J.2    Kang, H.F.3    Bai, M.H.4    Guan, H.T.5    Wang, Z.W.6    Zan, Y.7    Song, L.Q.8    Min, W.L.9    Lin, S.10
  • 126
    • 84863018491 scopus 로고    scopus 로고
    • Chemopreventive effect of saikosaponin-d on diethylinitrosamine-induced hepatocarcinogenesis: Involvement of CCAAT/enhancer binding protein beta and cyclooxygenase-2
    • Lu, X.L.; He, S.X.; Ren, M.D.;Wang, Y.L.; Zhang, Y.X.; Liu, E.Q. Chemopreventive effect of saikosaponin-d on diethylinitrosamine-induced hepatocarcinogenesis: Involvement of CCAAT/enhancer binding protein beta and cyclooxygenase-2. Mol. Med. Rep. 2012, 5, 637-644.
    • (2012) Mol. Med. Rep , vol.5 , pp. 637-644
    • Lu, X.L.1    He, S.X.2    Ren, M.D.3    Wang, Y.L.4    Zhang, Y.X.5    Liu, E.Q.6
  • 127
    • 84907202609 scopus 로고    scopus 로고
    • Saikosaponind suppresses the expression of cyclooxygenase2 through the phosphosignal transducer and activator of transcription 3/hypoxiainducible factor1alpha pathway in hepatocellular carcinoma cells
    • He, S.; Lu, G.; Hou, H.; Zhao, Z.; Zhu, Z.; Lu, X.; Chen, J.; Wang, Z. Saikosaponind suppresses the expression of cyclooxygenase2 through the phosphosignal transducer and activator of transcription 3/hypoxiainducible factor1alpha pathway in hepatocellular carcinoma cells. Mol. Med. Rep. 2014, 10, 2556-2562.
    • (2014) Mol. Med. Rep , vol.10 , pp. 2556-2562
    • He, S.1    Lu, G.2    Hou, H.3    Zhao, Z.4    Zhu, Z.5    Lu, X.6    Chen, J.7    Wang, Z.8
  • 130
    • 84968816648 scopus 로고    scopus 로고
    • A potential chemotherapeutics in castration resistant prostate cancer by suppressing cancer metastases and cancer stem cell phenotypes
    • Zhong, D.; Zhang, H.J.; Jiang, Y.D.; Wu, P.; Qi, H.; Cai, C.; Zheng, S.B.; Dang, Q. Saikosaponin-d: A potential chemotherapeutics in castration resistant prostate cancer by suppressing cancer metastases and cancer stem cell phenotypes. Biochem. Biophys. Res. Commun. 2016, 474, 722-729.
    • (2016) Biochem. Biophys. Res. Commun , vol.474 , pp. 722-729
    • Zhong, D.1    Zhang, H.J.2    Jiang, Y.D.3    Wu, P.4    Qi, H.5    Cai, C.6    Zheng, S.B.7    Saikosaponin-D, D.Q.8
  • 131
    • 84859774949 scopus 로고    scopus 로고
    • Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice
    • Lu, B.; Xu, Y.; Xu, L.; Cong, X.; Yin, L.; Li, H.; Peng, J. Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice. Environ. Toxicol. Pharmacol. 2012, 34, 127-135.
    • (2012) Environ. Toxicol. Pharmacol , vol.34 , pp. 127-135
    • Lu, B.1    Xu, Y.2    Xu, L.3    Cong, X.4    Yin, L.5    Li, H.6    Peng, J.7
  • 132
    • 84928784665 scopus 로고    scopus 로고
    • Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via hmgb-1 inhibition
    • Tao, X.; Sun, X.; Yin, L.; Han, X.; Xu, L.; Qi, Y.; Xu, Y.; Li, H.; Lin, Y.; Liu, K.; et al. Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via hmgb-1 inhibition. Free Radic. Biol. Med. 2015, 84, 103-115.
    • (2015) Free Radic. Biol. Med , vol.84 , pp. 103-115
    • Tao, X.1    Sun, X.2    Yin, L.3    Han, X.4    Xu, L.5    Qi, Y.6    Xu, Y.7    Li, H.8    Lin, Y.9    Liu, K.10
  • 133
    • 84921325073 scopus 로고    scopus 로고
    • Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-induced vcam-1, icam-1and el expression via the NF-B pathway
    • Wu, S.; Xu, H.; Peng, J.;Wang, C.; Jin, Y.; Liu, K.; Sun, H.; Qin, J. Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-induced vcam-1, icam-1and el expression via the NF-B pathway. Biochimie 2015, 110, 62-72.
    • (2015) Biochimie , vol.110 , pp. 62-72
    • Wu, S.1    Xu, H.2    Peng, J.3    Wang, C.4    Jin, Y.5    Liu, K.6    Sun, H.7    Qin, J.8
  • 134
    • 14844347909 scopus 로고    scopus 로고
    • The mitotic-Arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell lines
    • Liu, M.J.;Wang, Z.; Ju, Y.; Zhou, J.B.;Wang, Y.;Wong, R.N. The mitotic-Arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell lines. Biol. Pharm. Bull. 2004, 27, 1059-1065.
    • (2004) Biol. Pharm. Bull , vol.27 , pp. 1059-1065
    • Liu, M.J.1    Wang, Z.2    Ju, Y.3    Zhou, J.B.4    Wang, Y.5    Wong, R.N.6
  • 135
    • 0035112982 scopus 로고    scopus 로고
    • Effects of two saponins extracted from the Polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells
    • Wang, Z.; Zhou, J.; Ju, Y.; Zhang, H.; Liu, M.; Li, X. Effects of two saponins extracted from the Polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells. Biol. Pharm. Bull. 2001, 24, 159-162.
    • (2001) Biol. Pharm. Bull , vol.24 , pp. 159-162
    • Wang, Z.1    Zhou, J.2    Ju, Y.3    Zhang, H.4    Liu, M.5    Li, X.6
  • 136
    • 84885958665 scopus 로고    scopus 로고
    • Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/AKT and ERK and JNK signaling pathways in human lung cancer cell lines
    • Hsieh, M.J.; Tsai, T.L.; Hsieh, Y.S.;Wang, C.J.; Chiou, H.L. Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/AKT and ERK and JNK signaling pathways in human lung cancer cell lines. Arch. Toxicol. 2013, 87, 1927-1937.
    • (2013) Arch. Toxicol , vol.87 , pp. 1927-1937
    • Hsieh, M.J.1    Tsai, T.L.2    Hsieh, Y.S.3    Wang, C.J.4    Chiou, H.L.5
  • 137
    • 84879835143 scopus 로고    scopus 로고
    • Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway
    • Wei, Y.; Xu, Y.; Han, X.; Qi, Y.; Xu, L.; Xu, Y.; Yin, L.; Sun, H.; Liu, K.; Peng, J. Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway. Food Chem. Toxicol. 2013, 59, 118-128.
    • (2013) Food Chem. Toxicol , vol.59 , pp. 118-128
    • Wei, Y.1    Xu, Y.2    Han, X.3    Qi, Y.4    Xu, L.5    Xu, Y.6    Yin, L.7    Sun, H.8    Liu, K.9    Peng, J.10
  • 138
    • 33745967292 scopus 로고    scopus 로고
    • Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines
    • He, X.; Qiao, A.;Wang, X.; Liu, B.; Jiang, M.; Su, L.; Yao, X. Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines. Steroids 2006, 71, 828-833.
    • (2006) Steroids , Issue.71 , pp. 828-833
    • He, X.1    Qiao, A.2    Wang, X.3    Liu, B.4    Jiang, M.5    Su, L.6    Yao, X.7
  • 139
    • 84863131822 scopus 로고    scopus 로고
    • Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins
    • Wang, Z.; Cheng, Y.;Wang, N.;Wang, D.M.; Li, Y.W.; Han, F.; Shen, J.G.; Yang de, P.; Guan, X.Y.; Chen, J.P. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins. Cancer Biol. Ther. 2012, 13, 138-147.
    • (2012) Cancer Biol. Ther , vol.13 , pp. 138-147
    • Wang, Z.1    Cheng, Y.2    Wang, N.3    Wang, D.M.4    Li, Y.W.5    Han, F.6    Shen, J.G.7    De, Y.P.8    Guan, X.Y.9    Chen, J.P.10
  • 141
    • 81755162318 scopus 로고    scopus 로고
    • Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells
    • Gao, L.L.; Li, F.R.; Jiao, P.; Yang, M.F.; Zhou, X.J.; Si, Y.H.; Jiang, W.J.; Zheng, T.T. Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells. World J. Gastroenterol. 2011, 17, 4389-4395.
    • (2011) World J. Gastroenterol , vol.17 , pp. 4389-4395
    • Gao, L.L.1    Li, F.R.2    Jiao, P.3    Yang, M.F.4    Zhou, X.J.5    Si, Y.H.6    Jiang, W.J.7    Zheng, T.T.8
  • 142
    • 84879503246 scopus 로고    scopus 로고
    • Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways
    • Hu, M.; Xu, L.; Yin, L.; Qi, Y.; Li, H.; Xu, Y.; Han, X.; Peng, J.;Wan, X. Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways. J. Appl. Toxicol. 2013, 33, 712-722.
    • (2013) J. Appl. Toxicol , vol.33 , pp. 712-722
    • Hu, M.1    Xu, L.2    Yin, L.3    Qi, Y.4    Li, H.5    Xu, Y.6    Han, X.7    Peng, J.8    Wan, X.9
  • 143
    • 84892422840 scopus 로고    scopus 로고
    • ITRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells
    • Chen, H.; Xu, L.; Yin, L.; Xu, Y.; Han, X.; Qi, Y.; Zhao, Y.; Liu, K.; Peng, J. ITRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells. Proteomics 2014, 14, 51-73.
    • (2014) Proteomics , vol.14 , pp. 51-73
    • Chen, H.1    Xu, L.2    Yin, L.3    Xu, Y.4    Han, X.5    Qi, Y.6    Zhao, Y.7    Liu, K.8    Peng, J.9
  • 144
    • 0036480566 scopus 로고    scopus 로고
    • Apoptosis induced by dioscin in hela cells
    • Cai, J.; Liu, M.; Wang, Z.; Ju, Y. Apoptosis induced by dioscin in hela cells. Biol. Pharm. Bull. 2002, 25, 193-196.
    • (2002) Biol. Pharm. Bull , vol.25 , pp. 193-196
    • Cai, J.1    Liu, M.2    Wang, Z.3    Ju, Y.4
  • 145
    • 84857974205 scopus 로고    scopus 로고
    • Apoptosis of human ovarian cancer cells induced by paris chinensis dioscin via a Ca2+-mediated mitochondrion pathway
    • Gao, L.L.; Li, F.R.; Jiao, P.; Yao, S.T.; Sang, H.; Si, Y.H. Apoptosis of human ovarian cancer cells induced by paris chinensis dioscin via a Ca2+-mediated mitochondrion pathway. Asian Pac. J. Cancer Prev. 2011, 12, 1361-1366.
    • (2011) Asian Pac. J. Cancer Prev , vol.12 , pp. 1361-1366
    • Gao, L.L.1    Li, F.R.2    Jiao, P.3    Yao, S.T.4    Sang, H.5    Si, Y.H.6
  • 146
    • 84894047961 scopus 로고    scopus 로고
    • Dioscin-induced apoptosis of human lncap prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family
    • Chen, J.; Li, H.M.; Zhang, X.N.; Xiong, C.M.; Ruan, J.L. Dioscin-induced apoptosis of human lncap prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family. J. Huazhong Univ. Sci. Technol. Med. Sci. 2014, 34, 125-130.
    • (2014) J. Huazhong Univ. Sci. Technol. Med. Sci , vol.34 , pp. 125-130
    • Chen, J.1    Li, H.M.2    Zhang, X.N.3    Xiong, C.M.4    Ruan, J.L.5
  • 147
    • 84902539628 scopus 로고    scopus 로고
    • Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells
    • Kim, E.A.; Jang, J.H.; Lee, Y.H.; Sung, E.G.; Song, I.H.; Kim, J.Y.; Kim, S.; Sohn, H.Y.; Lee, T.J. Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells. Apoptosis 2014, 19, 1165-1175.
    • (2014) Apoptosis , vol.19 , pp. 1165-1175
    • Kim, E.A.1    Jang, J.H.2    Lee, Y.H.3    Sung, E.G.4    Song, I.H.5    Kim, J.Y.6    Kim, S.7    Sohn, H.Y.8    Lee, T.J.9
  • 148
    • 84912093121 scopus 로고    scopus 로고
    • Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways
    • Tong, Q.; Qing, Y.; Wu, Y.; Hu, X.; Jiang, L.; Wu, X. Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways. Toxicol. Appl. Pharmacol. 2014, 281, 166-173.
    • (2014) Toxicol. Appl. Pharmacol , vol.281 , pp. 166-173
    • Tong, Q.1    Qing, Y.2    Wu, Y.3    Hu, X.4    Jiang, L.5    Wu, X.6
  • 149
    • 79955074266 scopus 로고    scopus 로고
    • Paridis saponins inhibiting carcinoma growth and metastasis in vitro and in vivo
    • Shuli, M.; Wenyuan, G.; Yanjun, Z.; Chaoyi, M.; Liu, Y.; Yiwen, L. Paridis saponins inhibiting carcinoma growth and metastasis in vitro and in vivo. Arch. Pharm. Res. 2011, 34, 43-50.
    • (2011) Arch. Pharm. Res , vol.34 , pp. 43-50
    • Shuli, M.1    Wenyuan, G.2    Yanjun, Z.3    Chaoyi, M.4    Liu, Y.5    Yiwen, L.6
  • 150
    • 84862808486 scopus 로고    scopus 로고
    • A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in sprague-dawley rats
    • Xu, T.; Zhang, S.; Zheng, L.; Yin, L.; Xu, L.; Peng, J. A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in sprague-dawley rats. Food Chem. Toxicol. 2012, 50, 1279-1287.
    • (2012) Food Chem. Toxicol , vol.50 , pp. 1279-1287
    • Xu, T.1    Zhang, S.2    Zheng, L.3    Yin, L.4    Xu, L.5    Peng, J.6
  • 151
    • 84881237192 scopus 로고    scopus 로고
    • Dioscin a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: A potential new drug for treatment of glioblastoma multiforme
    • Lv, L.; Zheng, L.; Dong, D.; Xu, L.; Yin, L.; Xu, Y.; Qi, Y.; Han, X.; Peng, J. Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: A potential new drug for treatment of glioblastoma multiforme. Food Chem. Toxicol. 2013, 59, 657-669.
    • (2013) Food Chem. Toxicol , vol.59 , pp. 657-669
    • Lv, L.1    Zheng, L.2    Dong, D.3    Xu, L.4    Yin, L.5    Xu, Y.6    Qi, Y.7    Han, X.8    Peng, J.9
  • 152
    • 84899664695 scopus 로고    scopus 로고
    • Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line
    • Wang, Y.; He, Q.Y.; Chiu, J.F. Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line. Eur. J. Pharmacol. 2014, 735, 52-58.
    • (2014) Eur. J. Pharmacol , vol.735 , pp. 52-58
    • Wang, Y.1    He, Q.Y.2    Chiu, J.F.3
  • 153
    • 33646251378 scopus 로고    scopus 로고
    • Proteomic approach to study the cytotoxicity of dioscin (saponin
    • Wang, Y.; Cheung, Y.H.; Yang, Z.; Chiu, J.F.; Che, C.M.; He, Q.Y. Proteomic approach to study the cytotoxicity of dioscin (saponin). Proteomics 2006, 6, 2422-2432.
    • (2006) Proteomics , vol.6 , pp. 2422-2432
    • Wang, Y.1    Cheung, Y.H.2    Yang, Z.3    Chiu, J.F.4    Che, C.M.5    He, Q.Y.6
  • 154
    • 84958879723 scopus 로고    scopus 로고
    • Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and mapk-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion
    • Si, L.; Zheng, L.; Xu, L.; Yin, L.; Han, X.; Qi, Y.; Xu, Y.;Wang, C.; Peng, J. Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and mapk-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion. Eur. J. Pharmacol. 2016, 774, 105-117.
    • (2016) Eur. J. Pharmacol , vol.774 , pp. 105-117
    • Si, L.1    Zheng, L.2    Xu, L.3    Yin, L.4    Han, X.5    Qi, Y.6    Xu, Y.7    Wang, C.8    Peng, J.9
  • 155
    • 84866445045 scopus 로고    scopus 로고
    • Dioscin sensitizes cells to trail-induced apoptosis through downregulation of c-FLIP and Bcl-2
    • Kim, Y.S.; Kim, E.A.; Park, K.G.; Lee, S.J.; Kim, M.S.; Sohn, H.Y.; Lee, T.J. Dioscin sensitizes cells to trail-induced apoptosis through downregulation of c-FLIP and Bcl-2. Oncol. Rep. 2012, 28, 1910-1916.
    • (2012) Oncol. Rep , vol.28 , pp. 1910-1916
    • Kim, Y.S.1    Kim, E.A.2    Park, K.G.3    Lee, S.J.4    Kim, M.S.5    Sohn, H.Y.6    Lee, T.J.7
  • 156
    • 84976523485 scopus 로고    scopus 로고
    • Dioscin induces apoptosis in human cervical carcinoma hela and siha cells through ROS-mediated DNA damage and the mitochondrial signaling pathway
    • Zhao, X.; Tao, X.; Xu, L.; Yin, L.; Qi, Y.; Xu, Y.; Han, X.; Peng, J. Dioscin induces apoptosis in human cervical carcinoma hela and siha cells through ROS-mediated DNA damage and the mitochondrial signaling pathway. Molecules 2016, 21.
    • (2016) Molecules , vol.21
    • Zhao, X.1    Tao, X.2    Xu, L.3    Yin, L.4    Qi, Y.5    Xu, Y.6    Han, X.7    Peng, J.8
  • 157
    • 67650979464 scopus 로고    scopus 로고
    • Screening of some saponins and phenolic components of tribulus terrestris and smilax excelsa as mdr modulators
    • Ivanova, A.; Serly, J.; Dinchev, D.; Ocsovszki, I.; Kostova, I.; Molnar, J. Screening of some saponins and phenolic components of tribulus terrestris and smilax excelsa as mdr modulators. In Vivo 2009, 23, 545-550.
    • (2009) Vivo , vol.23 , pp. 545-550
    • Ivanova, A.1    Serly, J.2    Dinchev, D.3    Ocsovszki, I.4    Kostova, I.5    Molnar, J.6
  • 158
    • 79551604904 scopus 로고    scopus 로고
    • Reversal effect of dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells
    • Sun, B.T.; Zheng, L.H.; Bao, Y.L.; Yu, C.L.; Wu, Y.; Meng, X.Y.; Li, Y.X. Reversal effect of dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells. Eur. J. Pharmacol. 2011, 654, 129-134.
    • (2011) Eur. J. Pharmacol , vol.654 , pp. 129-134
    • Sun, B.T.1    Zheng, L.H.2    Bao, Y.L.3    Yu, C.L.4    Wu, Y.5    Meng, X.Y.6    Li, Y.X.7
  • 159
    • 84878237899 scopus 로고    scopus 로고
    • Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia k562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-B signaling inhibition
    • Wang, L.; Meng, Q.; Wang, C.; Liu, Q.; Peng, J.; Huo, X.; Sun, H.; Ma, X.; Liu, K. Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia k562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-B signaling inhibition. J. Natl. Prod. 2013, 76, 909-914.
    • (2013) J. Natl. Prod , vol.76 , pp. 909-914
    • Wang, L.1    Meng, Q.2    Wang, C.3    Liu, Q.4    Peng, J.5    Huo, X.6    Sun, H.7    Ma, X.8    Liu, K.9
  • 160
    • 36148939533 scopus 로고    scopus 로고
    • Synthesis cytotoxicity, and hemolytic activity of 60-O-substituted dioscin derivatives
    • Li, W.; Qiu, Z.; Wang, Y.; Zhang, Y.; Li, M.; Yu, J.; Zhang, L.; Zhu, Z.; Yu, B. Synthesis, cytotoxicity, and hemolytic activity of 60-O-substituted dioscin derivatives. Carbohydr. Res. 2007, 342, 2705-2715.
    • (2007) Carbohydr. Res , vol.342 , pp. 2705-2715
    • Li, W.1    Qiu, Z.2    Wang, Y.3    Zhang, Y.4    Li, M.5    Yu, J.6    Zhang, L.7    Zhu, Z.8    Yu, B.9
  • 162
    • 84963850951 scopus 로고    scopus 로고
    • Polyphyllin D induces apoptosis and differentiation in K562 human leukemia cells
    • Yang, C.; Cai, H.; Meng, X. Polyphyllin D induces apoptosis and differentiation in K562 human leukemia cells. Int. Immunopharmacol. 2016, 36, 17-22.
    • (2016) Int. Immunopharmacol , vol.36 , pp. 17-22
    • Yang, C.1    Cai, H.2    Meng, X.3
  • 163
    • 84898831238 scopus 로고    scopus 로고
    • Polyphyllin D induces apoptosis in K562/A02 cells through G2/M phase arrest
    • Wu, L.; Li, Q.; Liu, Y. Polyphyllin D induces apoptosis in K562/A02 cells through G2/M phase arrest. J. Pharm. Pharmacol. 2014, 66, 713-721.
    • (2014) J. Pharm. Pharmacol , vol.66 , pp. 713-721
    • Wu, L.1    Li, Q.2    Liu, Y.3
  • 164
    • 33646422206 scopus 로고    scopus 로고
    • Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft
    • Lee, M.S.; Yuet-Wa, J.C.; Kong, S.K.; Yu, B.; Eng-Choon, V.O.; Nai-Ching, H.W.; Chung-Wai, T.M.; Fung, K.P. Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft. Cancer Biol. Ther. 2005, 4, 1248-1254.
    • (2005) Cancer Biol. Ther , vol.4 , pp. 1248-1254
    • Lee, M.S.1    Yuet-Wa, J.C.2    Kong, S.K.3    Yu, B.4    Eng-Choon, V.O.5    Nai-Ching, H.W.6    Chung-Wai, T.M.7    Fung, K.P.8
  • 165
    • 49749104260 scopus 로고    scopus 로고
    • Proteomic and transcriptomic study on the action of a cytotoxic saponin (polyphyllin D): Induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways
    • Siu, F.M.; Ma, D.L.; Cheung, Y.W.; Lok, C.N.; Yan, K.; Yang, Z.; Yang, M.; Xu, S.; Ko, B.C.; He, Q.Y.; et al. Proteomic and transcriptomic study on the action of a cytotoxic saponin (polyphyllin D): Induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways. Proteomics 2008, 8, 3105-3117.
    • (2008) Proteomics , vol.8 , pp. 3105-3117
    • Siu, F.M.1    Ma, D.L.2    Cheung, Y.W.3    Lok, C.N.4    Yan, K.5    Yang, Z.6    Yang, M.7    Xu, S.8    Ko, B.C.9    He, Q.Y.10
  • 167
    • 84906971502 scopus 로고    scopus 로고
    • Polyphyllin D induces apoptosis in U87 human glioma cells through the c-Jun NH2-Terminal kinase pathway
    • Yu, Q.; Li, Q.; Lu, P.; Chen, Q. Polyphyllin D induces apoptosis in U87 human glioma cells through the c-Jun NH2-Terminal kinase pathway. J. Med. Food 2014, 17, 1036-1042.
    • (2014) J. Med. Food , vol.17 , pp. 1036-1042
    • Yu, Q.1    Li, Q.2    Lu, P.3    Chen, Q.4
  • 170
    • 39149090383 scopus 로고    scopus 로고
    • Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells
    • Ong, R.C.; Lei, J.; Lee, R.K.; Cheung, J.Y.; Fung, K.P.; Lin, C.; Ho, H.P.; Yu, B.; Li, M.; Kong, S.K. Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells. Cancer Lett. 2008, 261, 158-164.
    • (2008) Cancer Lett , vol.261 , pp. 158-164
    • Ong, R.C.1    Lei, J.2    Lee, R.K.3    Cheung, J.Y.4    Fung, K.P.5    Lin, C.6    Ho, H.P.7    Yu, B.8    Li, M.9    Kong, S.K.10
  • 171
    • 70349255753 scopus 로고    scopus 로고
    • Polyphyllin D exerts potent anti-Tumour effects on lewis cancer cells under hypoxic conditions
    • Ma, D.D.; Lu, H.X.; Xu, L.S.; Xiao, W. Polyphyllin D exerts potent anti-Tumour effects on lewis cancer cells under hypoxic conditions. J. Int. Med. Res. 2009, 37, 631-640.
    • (2009) J. Int. Med. Res , vol.37 , pp. 631-640
    • Ma, D.D.1    Lu, H.X.2    Xu, L.S.3    Xiao, W.4
  • 172
    • 80052038008 scopus 로고    scopus 로고
    • A steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo
    • Chan, J.Y.; Koon, J.C.; Liu, X.; Detmar, M.; Yu, B.; Kong, S.K.; Fung, K.P. Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo. J. Ethnopharmacol. 2011, 137, 64-69.
    • (2011) J. Ethnopharmacol , vol.137 , pp. 64-69
    • Chan, J.Y.1    Koon, J.C.2    Liu, X.3    Detmar, M.4    Yu, B.5    Kong, S.K.6    Fung, S.K.7    Polyphyllin, D.8
  • 173
    • 84908210397 scopus 로고    scopus 로고
    • Folding fan mode counter-current chromatography offers fast blind screening for drug discovery Case study: Finding anti-enterovirus 71 agents from Anemarrhena asphodeloides
    • Liu, M.; Tao, L.; Chau, S.L.; Wu, R.; Zhang, H.; Yang, Y.; Yang, D.; Bian, Z.; Lu, A.; Han, Q.; et al. Folding fan mode counter-current chromatography offers fast blind screening for drug discovery. Case study: Finding anti-enterovirus 71 agents from Anemarrhena asphodeloides. J. Chromatogr. A 2014, 1368, 116-124.
    • (2014) J. Chromatogr. A , vol.1368 , pp. 116-124
    • Liu, M.1    Tao, L.2    Chau, S.L.3    Wu, R.4    Zhang, H.5    Yang, Y.6    Yang, D.7    Bian, Z.8    Lu, A.9    Han, Q.10
  • 174
    • 84862791139 scopus 로고    scopus 로고
    • Steroidal glycosides from the rhizomes of Anemarrhena asphodeloides and their antiplatelet aggregation activity
    • Kang, L.P.; Zhang, J.; Cong, Y.; Li, B.; Xiong, C.Q.; Zhao, Y.; Tan, D.W.; Yu, H.S.; Yu, Z.Y.; Cong, Y.W.; et al. Steroidal glycosides from the rhizomes of Anemarrhena asphodeloides and their antiplatelet aggregation activity. Planta Medica 2012, 78, 611-616.
    • (2012) Planta Medica , vol.78 , pp. 611-616
    • Kang, L.P.1    Zhang, J.2    Cong, Y.3    Li, B.4    Xiong, C.Q.5    Zhao, Y.6    Tan, D.W.7    Yu, H.S.8    Yu, Z.Y.9    Cong, Y.W.10
  • 175
    • 79959744438 scopus 로고    scopus 로고
    • Antiplatelet and antithrombotic activities of timosaponin B-II, an extract of Anemarrhena asphodeloides
    • Lu, W.Q.; Qiu, Y.; Li, T.J.; Tao, X.; Sun, L.N.; Chen, W.S. Antiplatelet and antithrombotic activities of timosaponin B-II, an extract of Anemarrhena asphodeloides. Clin. Exp. Pharmacol. Physiol. 2011, 38, 430-434.
    • (2011) Clin. Exp. Pharmacol. Physiol , vol.38 , pp. 430-434
    • Lu, W.Q.1    Qiu, Y.2    Li, T.J.3    Tao, X.4    Sun, L.N.5    Chen, W.S.6
  • 176
    • 0037135242 scopus 로고    scopus 로고
    • Effect of timosaponin A-III, from Anemarrhenae asphodeloides Bunge (Liliaceae), on calcium mobilization in vascular endothelial and smooth muscle cells and on vascular tension
    • Wang, G.J.; Lin, L.C.; Chen, C.F.; Cheng, J.S.; Lo, Y.K.; Chou, K.J.; Lee, K.C.; Liu, C.P.;Wu, Y.Y.; Su, W.; et al. Effect of timosaponin A-III, from Anemarrhenae asphodeloides Bunge (Liliaceae), on calcium mobilization in vascular endothelial and smooth muscle cells and on vascular tension. Life Sci. 2002, 71, 1081-1090.
    • (2002) Life Sci , vol.71 , pp. 1081-1090
    • Wang, G.J.1    Lin, L.C.2    Chen, C.F.3    Cheng, J.S.4    Lo, Y.K.5    Chou, K.J.6    Lee, K.C.7    Liu, C.P.8    Wu, Y.Y.9    Su, W.10
  • 177
    • 84962575844 scopus 로고    scopus 로고
    • Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/AKT signaling pathway
    • Chen, J.R.; Jia, X.H.; Wang, H.; Yi, Y.J.; Wang, J.Y.; Li, Y.J. Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/AKT signaling pathway. Int. J. Oncol. 2016, 48, 2063-2070.
    • (2016) Int. J. Oncol , vol.48 , pp. 2063-2070
    • Chen, J.R.1    Jia, X.H.2    Wang, H.3    Yi, Y.J.4    Wang, J.Y.5    Li, Y.J.6
  • 178
    • 84947615920 scopus 로고    scopus 로고
    • Timosaponin B-II inhibits lipopolysaccharide-induced acute lung toxicity via TLR/NF-B pathway
    • Zhang, T.; Wang, J.; Wang, S.; Ma, C. Timosaponin B-II inhibits lipopolysaccharide-induced acute lung toxicity via TLR/NF-B pathway. Toxicol. Mech. Methods 2015, 25, 665-671.
    • (2015) Toxicol. Mech. Methods , vol.25 , pp. 665-671
    • Zhang, T.1    Wang, J.2    Wang, S.3    Ma, C.4
  • 179
    • 34250183791 scopus 로고    scopus 로고
    • Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats
    • Li, T.J.; Qiu, Y.; Yang, P.Y.; Rui, Y.C.; Chen, W.S. Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats. Neurosci. Lett. 2007, 421, 147-151.
    • (2007) Neurosci. Lett , vol.421 , pp. 147-151
    • Li, T.J.1    Qiu, Y.2    Yang, P.Y.3    Rui, Y.C.4    Chen, W.S.5
  • 180
    • 70349645385 scopus 로고    scopus 로고
    • Timosaponin A-III is preferentially cytotoxic to tumor cells through inhibition of mtor and induction of er stress
    • King, F.W.; Fong, S.; Griffin, C.; Shoemaker, M.; Staub, R.; Zhang, Y.L.; Cohen, I.; Shtivelman, E. Timosaponin A-III is preferentially cytotoxic to tumor cells through inhibition of mtor and induction of er stress. PLoS ONE 2009, 4, e7283.
    • (2009) PLoS ONE , vol.4 , pp. e7283
    • King, F.W.1    Fong, S.2    Griffin, C.3    Shoemaker, M.4    Staub, R.5    Zhang, Y.L.6    Cohen, I.7    Shtivelman, E.8
  • 181
    • 79955412969 scopus 로고    scopus 로고
    • Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells
    • Kang, Y.J.; Chung, H.J.; Nam, J.W.; Park, H.J.; Seo, E.K.; Kim, Y.S.; Lee, D.; Lee, S.K. Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells. J. Natl. Prod. 2011, 74, 701-706.
    • (2011) J. Natl. Prod , vol.74 , pp. 701-706
    • Kang, Y.J.1    Chung, H.J.2    Nam, J.W.3    Park, H.J.4    Seo, E.K.5    Kim, Y.S.6    Lee, D.7    Lee, S.K.8
  • 182
    • 84918802171 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel sarsasapogenin derivatives as potential anti-Tumor agents
    • Yin, Y.; Zhao, X.C.;Wang, S.J.; Gao, P.Y.; Li, L.Z.; Ikejima, T.; Song, S.J. Synthesis and biological evaluation of novel sarsasapogenin derivatives as potential anti-Tumor agents. Steroids 2015, 93, 25-31.
    • (2015) Steroids , vol.93 , pp. 25-31
    • Yin, Y.1    Zhao, X.C.2    Wang, S.J.3    Gao, P.Y.4    Li, L.Z.5    Ikejima, T.6    Song, S.J.7
  • 183
    • 80052408968 scopus 로고    scopus 로고
    • Activation of autophagy of aggregation-prone ubiquitinated proteins by timosaponin A-III
    • Lok, C.N.; Sy, L.K.; Liu, F.; Che, C.M. Activation of autophagy of aggregation-prone ubiquitinated proteins by timosaponin A-III. J. Biol. Chem. 2011, 286, 31684-31696.
    • (2011) J. Biol. Chem , vol.286 , pp. 31684-31696
    • Lok, C.N.1    Sy, L.K.2    Liu, F.3    Che, C.M.4
  • 184
    • 84929951447 scopus 로고    scopus 로고
    • Timosaponin aiii mediates caspase activation and induces apoptosis through JNK1/2 pathway in human promyelocytic leukemia cells
    • Huang, H.L.; Chiang, W.L.; Hsiao, P.C.; Chien, M.H.; Chen, H.Y.; Weng, W.C.; Hsieh, M.J.; Yang, S.F. Timosaponin aiii mediates caspase activation and induces apoptosis through JNK1/2 pathway in human promyelocytic leukemia cells. Tumour Biol. 2015, 36, 3489-3497.
    • (2015) Tumour Biol , vol.36 , pp. 3489-3497
    • Huang, H.L.1    Chiang, W.L.2    Hsiao, P.C.3    Chien, M.H.4    Chen, H.Y.5    Weng, W.C.6    Hsieh, M.J.7    Yang, S.F.8
  • 185
    • 57749085555 scopus 로고    scopus 로고
    • Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in hela cancer cells
    • Sy, L.K.; Yan, S.C.; Lok, C.N.; Man, R.Y.; Che, C.M. Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in hela cancer cells. Cancer Res. 2008, 68, 10229-10237.
    • (2008) Cancer Res , vol.68 , pp. 10229-10237
    • Sy, L.K.1    Yan, S.C.2    Lok, C.N.3    Man, R.Y.4    Che, C.M.5
  • 187
    • 84958931726 scopus 로고    scopus 로고
    • Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis
    • Kim, K.M.; Im, A.R.; Kim, S.H.; Hyun, J.W.; Chae, S. Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis. Cancer Sci. 2016, 107, 181-188.
    • (2016) Cancer Sci , vol.107 , pp. 181-188
    • Kim, K.M.1    Im, A.R.2    Kim, S.H.3    Hyun, J.W.4    Chae, S.5
  • 188
    • 84957709183 scopus 로고    scopus 로고
    • Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro
    • Sun, C.; Yu, Y.; Wang, L.; Wu, B.; Xia, L.; Feng, F.; Ling, Z.; Wang, S. Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro. J. Exp. Clin. Cancer Res. 2016, 35, 32.
    • (2016) J. Exp. Clin. Cancer Res , vol.35 , pp. 32
    • Sun, C.1    Yu, Y.2    Wang, L.3    Wu, B.4    Xia, L.5    Feng, F.6    Ling, Z.7    Wang, S.8
  • 189
    • 84876545441 scopus 로고    scopus 로고
    • Saikosaponin-D enhances the anticancer potency of TNF-via overcoming its undesirable response of activating NF-B signalling in cancer cells
    • Wong, V.K.; Zhang, M.M.; Zhou, H.; Lam, K.Y.; Chan, P.L.; Law, C.K.; Yue, P.Y.; Liu, L. Saikosaponin-D enhances the anticancer potency of TNF-via overcoming its undesirable response of activating NF-B signalling in cancer cells. Evid.-Based Complement. Altern. Med. 2013, 2013, 745295.
    • (2013) Evid.-Based Complement. Altern. Med 2013 , pp. 745295
    • Wong, V.K.1    Zhang, M.M.2    Zhou, H.3    Lam, K.Y.4    Chan, P.L.5    Law, C.K.6    Yue, P.Y.7    Liu, L.8
  • 190
    • 84968754597 scopus 로고    scopus 로고
    • Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cells
    • Xia, T.;Wang, J.;Wang, Y.;Wang, Y.; Cai, J.;Wang, M.; Chen, Q.; Song, J.; Yu, Z.; Huang, W.; et al. Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cells. Oncotarget 2016.
    • (2016) Oncotarget
    • Xia, T.1    Wang, J.2    Wang, Y.3    Wang, Y.4    Cai, J.5    Wang, M.6    Chen, Q.7    Song, J.8    Yu, Z.9    Huang, W.10
  • 191
    • 84949549148 scopus 로고    scopus 로고
    • Combined effect of sodium selenite and ginsenoside Rh2 on HCT116 human colorectal carcinoma cells
    • Zhu, C.; Liu, F.; Qian, W.; Zhang, T.; Li, F. Combined effect of sodium selenite and ginsenoside Rh2 on HCT116 human colorectal carcinoma cells. Arch. Iran. Med. 2016, 19, 23-29.
    • (2016) Arch. Iran. Med , vol.19 , pp. 23-29
    • Zhu, C.1    Liu, F.2    Qian, W.3    Zhang, T.4    Li, F.5
  • 192
    • 84954437414 scopus 로고    scopus 로고
    • Esterification of ginsenoside Rh2 enhanced its cellular uptake and antitumor activity in human HepG2 cells
    • Chen, F.; Deng, Z.Y.; Zhang, B.; Xiong, Z.X.; Zheng, S.L.; Tan, C.L.; Hu, J.N. Esterification of ginsenoside Rh2 enhanced its cellular uptake and antitumor activity in human HepG2 cells. J. Agric. Food Chem. 2016, 64, 253-261.
    • (2016) J. Agric. Food Chem , vol.64 , pp. 253-261
    • Chen, F.1    Deng, Z.Y.2    Zhang, B.3    Xiong, Z.X.4    Zheng, S.L.5    Tan, C.L.6    Hu, J.N.7
  • 194
    • 77956680962 scopus 로고    scopus 로고
    • Stereospecificity of hydroxyl group at c-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells
    • Liu, J.; Shimizu, K.; Yu, H.; Zhang, C.; Jin, F.; Kondo, R. Stereospecificity of hydroxyl group at c-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells. Fitoterapia 2010, 81, 902-905.
    • (2010) Fitoterapia , vol.81 , pp. 902-905
    • Liu, J.1    Shimizu, K.2    Yu, H.3    Zhang, C.4    Jin, F.5    Kondo, R.6
  • 195
    • 39449132110 scopus 로고    scopus 로고
    • 20(S)-25-methoxyl-dammarane-3 12, 20-Triol, a novel natural product for prostate cancer therapy: Activity in vitro and in vivo and mechanisms of action
    • Wang, W.;Wang, H.; Rayburn, E.R.; Zhao, Y.; Hill, D.L.; Zhang, R. 20(S)-25-methoxyl-dammarane-3, 12, 20-Triol, a novel natural product for prostate cancer therapy: Activity in vitro and in vivo and mechanisms of action. Br. J. Cancer 2008, 98, 792-802.
    • (2008) Br. J. Cancer , vol.98 , pp. 792-802
    • Wang, W.1    Wang, H.2    Rayburn, E.R.3    Zhao, Y.4    Hill, D.L.5    Zhang, R.6
  • 196
    • 84939891306 scopus 로고    scopus 로고
    • Cytotoxic activities of chemical constituents from rhizomes of Anemarrhena asphodeloides and their analogues
    • Guo, J.; Xu, C.; Xue, R.; Jiang, W.; Wu, B.; Huang, C. Cytotoxic activities of chemical constituents from rhizomes of Anemarrhena asphodeloides and their analogues. Arch. Pharm. Res. 2015, 38, 598-603.
    • (2015) Arch. Pharm. Res , vol.38 , pp. 598-603
    • Guo, J.1    Xu, C.2    Xue, R.3    Jiang, W.4    Wu, B.5    Huang, C.6
  • 197
    • 84939782127 scopus 로고    scopus 로고
    • 20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway
    • Zhang, F.; Li, M.; Wu, X.; Hu, Y.; Cao, Y.; Wang, X.; Xiang, S.; Li, H.; Jiang, L.; Tan, Z.; et al. 20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway. Drug Des. Dev. Ther. 2015, 9, 3969-3987.
    • (2015) Drug Des. Dev. Ther , vol.9 , pp. 3969-3987
    • Zhang, F.1    Li, M.2    Wu, X.3    Hu, Y.4    Cao, Y.5    Wang, X.6    Xiang, S.7    Li, H.8    Jiang, L.9    Tan, Z.10
  • 198
    • 84958975919 scopus 로고    scopus 로고
    • Potent effects of dioscin against gastric cancer in vitro and in vivo
    • Zhao, X.; Xu, L.; Zheng, L.; Yin, L.; Qi, Y.; Han, X.; Xu, Y.; Peng, J. Potent effects of dioscin against gastric cancer in vitro and in vivo. Phytomedicine 2016, 23, 274-282.
    • (2016) Phytomedicine , vol.23 , pp. 274-282
    • Zhao, X.1    Xu, L.2    Zheng, L.3    Yin, L.4    Qi, Y.5    Han, X.6    Xu, Y.7    Peng, J.8
  • 200
    • 84960153577 scopus 로고    scopus 로고
    • Gypenoside l, isolated from Gynostemma pentaphyllum, induces cytoplasmic vacuolation death in hepatocellular carcinoma cells through reactive-oxygen-species-mediated unfolded protein response
    • Zheng, K.; Liao, C.; Li, Y.; Fan, X.; Fan, L.; Xu, H.; Kang, Q.; Zeng, Y.; Wu, X.; Wu, H.; et al. Gypenoside l, isolated from Gynostemma pentaphyllum, induces cytoplasmic vacuolation death in hepatocellular carcinoma cells through reactive-oxygen-species-mediated unfolded protein response. J. Agric. Food Chem. 2016, 64, 1702-1711.
    • (2016) J. Agric. Food Chem , vol.64 , pp. 1702-1711
    • Zheng, K.1    Liao, C.2    Li, Y.3    Fan, X.4    Fan, L.5    Xu, H.6    Kang, Q.7    Zeng, Y.8    Wu, X.9    Wu, H.10
  • 201
    • 84982803440 scopus 로고    scopus 로고
    • Gypenoside l inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release
    • Liao, C.; Zheng, K.; Li, Y.; Xu, H.; Kang, Q.; Fan, L.; Hu, X.; Jin, Z.; Zeng, Y.; Kong, X.; et al. Gypenoside l inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. Oncotarget 2016.
    • (2016) Oncotarget
    • Liao, C.1    Zheng, K.2    Li, Y.3    Xu, H.4    Kang, Q.5    Fan, L.6    Hu, X.7    Jin, Z.8    Zeng, Y.9    Kong, X.10
  • 202
    • 84978401507 scopus 로고    scopus 로고
    • Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy in A549 cells
    • Chen, M.; Guo, Y.; Zhao, R.; Wang, X.; Jiang, M.; Fu, H.; Zhang, X. Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy in A549 cells. Int. J. Oncol. 2016, 49, 316-324.
    • (2016) Int. J. Oncol , vol.49 , pp. 316-324
    • Chen, M.1    Guo, Y.2    Zhao, R.3    Wang, X.4    Jiang, M.5    Fu, H.6    Zhang, X.7
  • 203
    • 84863985925 scopus 로고    scopus 로고
    • Astragaloside iv prevents MPP+-induced SH-SY5Y cell death via the inhibition of bax-mediated pathways and ROS production
    • Zhang, Z.G.;Wu, L.;Wang, J.L.; Yang, J.D.; Zhang, J.; Zhang, J.; Li, L.H.; Xia, Y.; Yao, L.B.; Qin, H.Z.; et al. Astragaloside iv prevents MPP+-induced SH-SY5Y cell death via the inhibition of bax-mediated pathways and ROS production. Mol. Cell. Biochem. 2012, 364, 209-216.
    • (2012) Mol. Cell. Biochem , vol.364 , pp. 209-216
    • Zhang, Z.G.1    Wu, L.2    Wang, J.L.3    Yang, J.D.4    Zhang, J.5    Zhang, J.6    Li, L.H.7    Xia, Y.8    Yao, L.B.9    Qin, H.Z.10
  • 204
    • 84897011458 scopus 로고    scopus 로고
    • Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells
    • Li, T.; Xu, W.S.; Wu, G.S.; Chen, X.P.; Wang, Y.T.; Lu, J.J. Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells. Asian Pac. J. Cancer Prev. 2014, 15, 1745-1749.
    • (2014) Asian Pac. J. Cancer Prev , vol.15 , pp. 1745-1749
    • Li, T.1    Xu, W.S.2    Wu, G.S.3    Chen, X.P.4    Wang, Y.T.5    Lu, J.J.6
  • 205
    • 84949184502 scopus 로고    scopus 로고
    • Platycodin D induces apoptosis and triggers ERK-And JNK-mediated autophagy in human hepatocellular carcinoma Bel-7402 cells
    • Li, T.; Xu, X.H.; Tang, Z.H.; Wang, Y.F.; Leung, C.H.; Ma, D.L.; Chen, X.P.; Wang, Y.T.; Chen, Y.; Lu, J.J. Platycodin D induces apoptosis and triggers ERK-And JNK-mediated autophagy in human hepatocellular carcinoma Bel-7402 cells. Acta Pharmacol. Sin. 2015, 36, 1503-1513.
    • (2015) Acta Pharmacol. Sin , vol.36 , pp. 1503-1513
    • Li, T.1    Xu, X.H.2    Tang, Z.H.3    Wang, Y.F.4    Leung, C.H.5    Ma, D.L.6    Chen, X.P.7    Wang, Y.T.8    Chen, Y.9    Lu, J.J.10
  • 206
    • 84921484806 scopus 로고    scopus 로고
    • Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells
    • Li, T.; Tang, Z.H.; Xu, W.S.; Wu, G.S.; Wang, Y.F.; Chang, L.L.; Zhu, H.; Chen, X.P.; Wang, Y.T.; Chen, Y.; et al. Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells. Eur. J. Pharmacol. 2015, 749, 81-88.
    • (2015) Eur. J. Pharmacol , vol.749 , pp. 81-88
    • Li, T.1    Tang, Z.H.2    Xu, W.S.3    Wu, G.S.4    Wang, Y.F.5    Chang, L.L.6    Zhu, H.7    Chen, X.P.8    Wang, Y.T.9    Chen, Y.10
  • 207
    • 84903540897 scopus 로고    scopus 로고
    • Platycodin D from Platycodonis radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells
    • Tang, Z.H.; Li, T.; Gao, H.W.; Sun, W.; Chen, X.P.; Wang, Y.T.; Lu, J.J. Platycodin D from Platycodonis radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells. Chin. Med. 2014, 9.
    • (2014) Chin. Med , vol.9
    • Tang, Z.H.1    Li, T.2    Gao, H.W.3    Sun, W.4    Chen, X.P.5    Wang, Y.T.6    Lu, J.J.7
  • 210
    • 84970983729 scopus 로고    scopus 로고
    • Vaccine adjuvant ginsenoside Rg1 enhances immune responses against hepatitis B surface antigen in mice
    • Yuan, D.; Yuan, Q.; Cui, Q.; Liu, C.; Zhou, Z.; Zhao, H.; Dun, Y.; Wang, T.; Zhang, C. Vaccine adjuvant ginsenoside Rg1 enhances immune responses against hepatitis B surface antigen in mice. Can. J. Physiol. Pharmacol. 2016, 94, 676-681.
    • (2016) Can. J. Physiol. Pharmacol , vol.94 , pp. 676-681
    • Yuan, D.1    Yuan, Q.2    Cui, Q.3    Liu, C.4    Zhou, Z.5    Zhao, H.6    Dun, Y.7    Wang, T.8    Zhang, C.9
  • 211
    • 84981333717 scopus 로고    scopus 로고
    • Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor activation in primary mouse macrophages
    • Wei, Z.;Wang, J.; Shi, M.; Liu, W.; Yang, Z.; Fu, Y. Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor activation in primary mouse macrophages. Oncotarget 2016.
    • (2016) Oncotarget
    • Wei, Z.1    Wang, J.2    Shi, M.3    Liu, W.4    Yang, Z.5    Fu, Y.6
  • 212
    • 84968719095 scopus 로고    scopus 로고
    • Platycodin D exerts anti-Tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis
    • Li, W.; Tian, Y.H.; Liu, Y.; Wang, Z.; Tang, S.; Zhang, J.; Wang, Y.P. Platycodin D exerts anti-Tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. J. Toxicol. Sci. 2016, 41, 417-428.
    • (2016) J. Toxicol. Sci , vol.41 , pp. 417-428
    • Li, W.1    Tian, Y.H.2    Liu, Y.3    Wang, Z.4    Tang, S.5    Zhang, J.6    Wang, Y.P.7
  • 213
    • 38049053109 scopus 로고    scopus 로고
    • Toxicity testing of saponin-containing Yucca schidigera Roetzl juice in relation to hepato-And nephrotoxicity of Narthecium ossifragum L.)
    • Wisloff, H.; Uhlig, S.; Scheie, E.; Loader, J.;Wilkins, A.; Flaoyen, A. Toxicity testing of saponin-containing Yucca schidigera Roetzl. juice in relation to hepato-And nephrotoxicity of Narthecium ossifragum (L.) Huds. Toxicon 2008, 51, 140-150.
    • (2008) Huds. Toxicon , vol.51 , pp. 140-150
    • Wisloff, H.1    Uhlig, S.2    Scheie, E.3    Loader, J.4    Wilkins, A.5    Flaoyen, A.6
  • 214
    • 84908375357 scopus 로고    scopus 로고
    • The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells
    • Lorent, J.H.; Quetin-Leclercq, J.; Mingeot-Leclercq, M.P. The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells. Org. Biomol. Chem. 2014, 12, 8803-8822.
    • (2014) Org. Biomol. Chem , vol.12 , pp. 8803-8822
    • Lorent, J.H.1    Quetin-Leclercq, J.2    Mingeot-Leclercq, M.P.3
  • 215
    • 84861891478 scopus 로고    scopus 로고
    • Disposition, and pharmacokinetics of saponins from Chinese medicinal herbs: What do we know and what do we need to know more?
    • Yu, K.; Chen, F.; Li, C. Absorption, disposition, and pharmacokinetics of saponins from Chinese medicinal herbs: What do we know and what do we need to know more? Curr. Drug Metab. 2012, 13, 577-598.
    • (2012) Curr Drug Metab , vol.13 , pp. 577-598
    • Yu, K.1    Chen, F.2    Absorption, L.C.3
  • 216
    • 84876751379 scopus 로고    scopus 로고
    • Bioavailability challenges associated with development of saponins as therapeutic and chemopreventive agents
    • Gao, S.; Basu, S.; Yang, Z.; Deb, A.; Hu, M. Bioavailability challenges associated with development of saponins as therapeutic and chemopreventive agents. Curr. Drug Targets 2012, 13, 1885-1899.
    • (2012) Curr. Drug Targets , vol.13 , pp. 1885-1899
    • Gao, S.1    Basu, S.2    Yang, Z.3    Deb, A.4    Hu, M.5
  • 217
    • 84951182838 scopus 로고    scopus 로고
    • Improvement of oral availability of ginseng fruit saponins by a proliposome delivery system containing sodium deoxycholate
    • Hao, F.; He, Y.; Sun, Y.; Zheng, B.; Liu, Y.; Wang, X.; Zhang, Y.; Lee, R.J.; Teng, L.; Xie, J. Improvement of oral availability of ginseng fruit saponins by a proliposome delivery system containing sodium deoxycholate. Saudi J. Biol. Sci. 2016, 23, S113-S125.
    • (2016) Saudi J. Biol. Sci , vol.23 , pp. S113-S125
    • Hao, F.1    He, Y.2    Sun, Y.3    Zheng, B.4    Liu, Y.5    Wang, X.6    Zhang, Y.7    Lee, R.J.8    Teng, L.9    Xie, J.10
  • 218
    • 84923380372 scopus 로고    scopus 로고
    • Nanocomplexes based on amphiphilic hyaluronic acid derivative and polyethylene glycol-lipid for ginsenoside Rg3 delivery
    • Lee, J.Y.; Yang, H.; Yoon, I.S.; Kim, S.B.; Ko, S.H.; Shim, J.S.; Sung, S.H.; Cho, H.J.; Kim, D.D. Nanocomplexes based on amphiphilic hyaluronic acid derivative and polyethylene glycol-lipid for ginsenoside Rg3 delivery. J. Pharm. Sci. 2014, 103, 3254-3262.
    • (2014) J. Pharm. Sci , vol.103 , pp. 3254-3262
    • Lee, J.Y.1    Yang, H.2    Yoon, I.S.3    Kim, S.B.4    Ko, S.H.5    Shim, J.S.6    Sung, S.H.7    Cho, H.J.8    Kim, D.D.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.