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Volumn 12, Issue 3, 2013, Pages 274-285

Sensitization of TRAIL-induced cell death by 20(S)- Ginsenoside Rg 3 via CHOP-mediated DR5 upregulation in human hepatocellular carcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DEATH RECEPTOR 5; GINSENOSIDE RG 3; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 84874859650     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-0054     Document Type: Article
Times cited : (69)

References (50)
  • 1
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995;3: 673-82.
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1    Schooley, K.2    Smolak, P.J.3    Din, W.S.4    Huang, C.P.5    Nicholl, J.K.6
  • 2
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    • Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999;5: 157-63.
    • (1999) Nat Med , vol.5 , pp. 157-163
    • Walczak, H.1    Miller, R.E.2    Ariail, K.3    Gliniak, B.4    Griffith, T.S.5    Kubin, M.6
  • 4
    • 0032505127 scopus 로고    scopus 로고
    • Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
    • Juo P, Kuo CJ, Yuan J, Blenis J. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Curr Biol 1998;8: 1001-8.
    • (1998) Curr Biol , vol.8 , pp. 1001-1008
    • Juo, P.1    Kuo, C.J.2    Yuan, J.3    Blenis, J.4
  • 6
    • 4143115887 scopus 로고    scopus 로고
    • Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis
    • Jin Z, McDonald ER III, Dicker DT, El-Deiry WS. Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. J Biol Chem 2004;279: 35829-39.
    • (2004) J Biol Chem , vol.279 , pp. 35829-35839
    • Jin, Z.1    McDonald Iii, E.R.2    Dicker, D.T.3    El-Deiry, W.S.4
  • 8
    • 84875211007 scopus 로고    scopus 로고
    • On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics
    • Dimberg LY, Anderson CK, Camidge R, Behbakht K, Thorburn A, Ford HL. On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics. Oncogene 2012;164: 1-10.
    • (2012) Oncogene , vol.164 , pp. 1-10
    • Dimberg, L.Y.1    Anderson, C.K.2    Camidge, R.3    Behbakht, K.4    Thorburn, A.5    Ford, H.L.6
  • 9
    • 0032522738 scopus 로고    scopus 로고
    • IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
    • Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, et al. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J 1998; 17: 2215-23.
    • (1998) EMBO J , vol.17 , pp. 2215-2223
    • Deveraux, Q.L.1    Roy, N.2    Stennicke, H.R.3    Van Arsdale, T.4    Zhou, Q.5    Srinivasula, S.M.6
  • 10
    • 0036606414 scopus 로고    scopus 로고
    • Induction and regulation of tumor necrosis factor-related apoptosisinducing ligand/Apo-2 ligand-mediated apoptosis in renal cell carcinoma
    • Griffith TS, Fialkov JM, Scott DL, Azuhata T, Williams RD, Wall NR, et al. Induction and regulation of tumor necrosis factor-related apoptosisinducing ligand/Apo-2 ligand-mediated apoptosis in renal cell carcinoma. Cancer Res 2002;62: 3093-9.
    • (2002) Cancer Res , vol.62 , pp. 3093-3099
    • Griffith, T.S.1    Fialkov, J.M.2    Scott, D.L.3    Azuhata, T.4    Williams, R.D.5    Wall, N.R.6
  • 11
    • 0033523727 scopus 로고    scopus 로고
    • Inhibition of death receptor signaling by FLICEinhibitory protein as a mechanism for immune escape of tumors
    • French LE, Tschopp J. Inhibition of death receptor signaling by FLICEinhibitory protein as a mechanism for immune escape of tumors. J Exp Med 1999;190: 891-4.
    • (1999) J Exp Med , vol.190 , pp. 891-894
    • French, L.E.1    Tschopp, J.2
  • 12
    • 0037500905 scopus 로고    scopus 로고
    • X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: Sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-binding protein with low pl (Smac/DIABLO)
    • Ng CP, Bonavida B. X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-binding protein with low pl (Smac/DIABLO). Mol Cancer Ther 2002;1: 1051-8.
    • (2002) Mol Cancer Ther , vol.1 , pp. 1051-1058
    • Ng, C.P.1    Bonavida, B.2
  • 13
    • 79960341239 scopus 로고    scopus 로고
    • TRADD is critical for resistance to TRAIL-induced cell death through NF-kappaB activation
    • Kim JY, Lee JY, Kim DG, Koo GB, Yu JW, Kim YS. TRADD is critical for resistance to TRAIL-induced cell death through NF-kappaB activation. FEBS Lett 2011;585: 2144-50.
    • (2011) FEBS Lett , vol.585 , pp. 2144-2150
    • Kim, J.Y.1    Lee, J.Y.2    Kim, D.G.3    Koo, G.B.4    Yu, J.W.5    Kim, Y.S.6
  • 14
    • 79952205905 scopus 로고    scopus 로고
    • Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents
    • Menke C, Bin L, Thorburn J, Behbakht K, Ford HL, Thorburn A. Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. Cancer Res 2011; 71: 1883-92.
    • (2011) Cancer Res , vol.71 , pp. 1883-1892
    • Menke, C.1    Bin, L.2    Thorburn, J.3    Behbakht, K.4    Ford, H.L.5    Thorburn, A.6
  • 15
    • 79960913158 scopus 로고    scopus 로고
    • Targeting the extrinsic apoptosis signaling pathway for cancer therapy
    • Sayers TJ. Targeting the extrinsic apoptosis signaling pathway for cancer therapy. Cancer Immunol Immunother 2011;60: 1173-80.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1173-1180
    • Sayers, T.J.1
  • 17
    • 77952044952 scopus 로고    scopus 로고
    • Systemic treatment of hepatocellular carcinoma: Dawn of a new era?
    • Zhu AX. Systemic treatment of hepatocellular carcinoma: dawn of a new era? Ann Surg Oncol 2010;17: 1247-56.
    • (2010) Ann Surg Oncol , vol.17 , pp. 1247-1256
    • Zhu, A.X.1
  • 18
    • 7044239399 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Current management and future trends
    • Carr BI. Hepatocellular carcinoma: current management and future trends. Gastroenterology 2004;127:S218-24.
    • (2004) Gastroenterology , vol.127
    • Carr, B.I.1
  • 19
    • 0034090716 scopus 로고    scopus 로고
    • Hepatobiliary surgery
    • Bismuth H, Majno PE. Hepatobiliary surgery. J Hepatol 2000;32: 208-24.
    • (2000) J Hepatol , vol.32 , pp. 208-224
    • Bismuth, H.1    Majno, P.E.2
  • 20
    • 66449131460 scopus 로고    scopus 로고
    • Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway
    • Chen KF, Yeh PY, Hsu C, Hsu CH, Lu YS, Hsieh HP, et al. Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 2009;284: 11121-33.
    • (2009) J Biol Chem , vol.284 , pp. 11121-11133
    • Chen, K.F.1    Yeh, P.Y.2    Hsu, C.3    Hsu, C.H.4    Lu, Y.S.5    Hsieh, H.P.6
  • 21
    • 0032587043 scopus 로고    scopus 로고
    • Ginsenoside Rg3 mediates endothelium-dependent relaxation in response to ginsenosides in rat aorta: Role of K+ channels
    • Kim ND, Kang SY, Park JH, Schini-Kerth VB. Ginsenoside Rg3 mediates endothelium-dependent relaxation in response to ginsenosides in rat aorta: role of K+ channels. Eur J Pharmacol 1999;367: 41-9.
    • (1999) Eur J Pharmacol , vol.367 , pp. 41-49
    • Kim, N.D.1    Kang, S.Y.2    Park, J.H.3    Schini-Kerth, V.B.4
  • 22
    • 33845595321 scopus 로고    scopus 로고
    • Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice
    • Sun J, Hu S, Song X. Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice. Vaccine 2007;25: 1114-20.
    • (2007) Vaccine , vol.25 , pp. 1114-1120
    • Sun, J.1    Hu, S.2    Song, X.3
  • 23
    • 0036062657 scopus 로고    scopus 로고
    • Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation
    • Cho JY, Kim AR, Yoo ES, Baik KU, Park MH. Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation. Planta Med 2002;68: 497-500.
    • (2002) Planta Med , vol.68 , pp. 497-500
    • Cho, J.Y.1    Kim, A.R.2    Yoo, E.S.3    Baik, K.U.4    Park, M.H.5
  • 24
    • 79955545463 scopus 로고    scopus 로고
    • Effects of Panax ginseng on tumor necrosis factoralpha- mediated inflammation: A mini-review
    • Lee DC, Lau AS. Effects of Panax ginseng on tumor necrosis factoralpha- mediated inflammation: a mini-review. Molecules 2011;16: 2802-16.
    • (2011) Molecules , vol.16 , pp. 2802-2816
    • Lee, D.C.1    Lau, A.S.2
  • 25
    • 79955762933 scopus 로고    scopus 로고
    • Amiodarone sensitizes human glioma cells but not astrocytes to TRAILinduced apoptosis via CHOP-mediated DR5 upregulation
    • Kim IY, Kang YJ, Yoon MJ, Kim EH, Kim SU, Kwon TK, et al. Amiodarone sensitizes human glioma cells but not astrocytes to TRAILinduced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol 2011;13: 267-79.
    • (2011) Neuro Oncol , vol.13 , pp. 267-279
    • Kim, I.Y.1    Kang, Y.J.2    Yoon, M.J.3    Kim, E.H.4    Kim, S.U.5    Kwon, T.K.6
  • 27
    • 28644442090 scopus 로고    scopus 로고
    • Biological activities and chemistry of saponins from Panax ginseng CA Meyer
    • Park JD, Rhee DK, Lee YH. Biological activities and chemistry of saponins from Panax ginseng CA Meyer. Phytochem Rev 2005;4: 159-75.
    • (2005) Phytochem Rev , vol.4 , pp. 159-175
    • Park, J.D.1    Rhee, D.K.2    Lee, Y.H.3
  • 28
    • 0032530612 scopus 로고    scopus 로고
    • Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
    • Griffith TS, Chin WA, Jackson GC, Lynch DH, Kubin MZ. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J Immunol 1998;161: 2833-40.
    • (1998) J Immunol , vol.161 , pp. 2833-2840
    • Griffith, T.S.1    Chin, W.A.2    Jackson, G.C.3    Lynch, D.H.4    Kubin, M.Z.5
  • 29
    • 0037043594 scopus 로고    scopus 로고
    • The involvement of oxidative stress in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in HeLa cells
    • Lee MW, Park SC, Kim JH, Kim IK, Han KS, Kim KY, et al. The involvement of oxidative stress in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in HeLa cells. Cancer Lett 2002;182: 75-82.
    • (2002) Cancer Lett , vol.182 , pp. 75-82
    • Lee, M.W.1    Park, S.C.2    Kim, J.H.3    Kim, I.K.4    Han, K.S.5    Kim, K.Y.6
  • 31
    • 21344453520 scopus 로고    scopus 로고
    • Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein
    • Yoshida T, Shiraishi T, Nakata S, Horinaka M, Wakada M, Mizutani Y, et al. Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein. Cancer Res 2005;65: 5662-7.
    • (2005) Cancer Res , vol.65 , pp. 5662-5667
    • Yoshida, T.1    Shiraishi, T.2    Nakata, S.3    Horinaka, M.4    Wakada, M.5    Mizutani, Y.6
  • 32
    • 22244472001 scopus 로고    scopus 로고
    • Tunicamycin enhances tumor necrosis factor-related apoptosisinducing ligand-induced apoptosis in human prostate cancer cells
    • Shiraishi T, Yoshida T, Nakata S, Horinaka M, Wakada M, Mizutani Y, et al. Tunicamycin enhances tumor necrosis factor-related apoptosisinducing ligand-induced apoptosis in human prostate cancer cells. Cancer Res 2005;65: 6364-70.
    • (2005) Cancer Res , vol.65 , pp. 6364-6370
    • Shiraishi, T.1    Yoshida, T.2    Nakata, S.3    Horinaka, M.4    Wakada, M.5    Mizutani, Y.6
  • 33
    • 0032054744 scopus 로고    scopus 로고
    • CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
    • Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 1998;12: 982-95.
    • (1998) Genes Dev , vol.12 , pp. 982-995
    • Zinszner, H.1    Kuroda, M.2    Wang, X.3    Batchvarova, N.4    Lightfoot, R.T.5    Remotti, H.6
  • 34
    • 3342894130 scopus 로고    scopus 로고
    • Targeting death receptors in cancer with Apo2L/TRAIL
    • Kelley SK, Ashkenazi A. Targeting death receptors in cancer with Apo2L/TRAIL. Curr Opin Pharmacol 2004;4: 333-9.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 333-339
    • Kelley, S.K.1    Ashkenazi, A.2
  • 35
    • 0035001741 scopus 로고    scopus 로고
    • The potential of TRAIL for cancer chemotherapy
    • Nagane M, Huang HJ, Cavenee WK. The potential of TRAIL for cancer chemotherapy. Apoptosis 2001;6: 191-7.
    • (2001) Apoptosis , vol.6 , pp. 191-197
    • Nagane, M.1    Huang, H.J.2    Cavenee, W.K.3
  • 36
    • 12544255082 scopus 로고    scopus 로고
    • Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling
    • Kelley RF, Totpal K, Lindstrom SH, Mathieu M, Billeci K, Deforge L, et al. Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling. J Biol Chem 2005;280: 2205-12.
    • (2005) J Biol Chem , vol.280 , pp. 2205-2212
    • Kelley, R.F.1    Totpal, K.2    Lindstrom, S.H.3    Mathieu, M.4    Billeci, K.5    Deforge, L.6
  • 37
    • 0033662433 scopus 로고    scopus 로고
    • Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
    • Kischkel FC, Lawrence DA, Chuntharapai A, Schow P, Kim KJ, Ashkenazi A. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 2000;12: 611-20.
    • (2000) Immunity , vol.12 , pp. 611-620
    • Kischkel, F.C.1    Lawrence, D.A.2    Chuntharapai, A.3    Schow, P.4    Kim, K.J.5    Ashkenazi, A.6
  • 39
    • 33745822415 scopus 로고    scopus 로고
    • Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation
    • Ziauddin MF, Yeow WS, Maxhimer JB, Baras A, Chua A, Reddy RM, et al. Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation. Neoplasia 2006;8: 446-57.
    • (2006) Neoplasia , vol.8 , pp. 446-457
    • Ziauddin, M.F.1    Yeow, W.S.2    Maxhimer, J.B.3    Baras, A.4    Chua, A.5    Reddy, R.M.6
  • 40
    • 0036684548 scopus 로고    scopus 로고
    • Mitochondria-dependent and -independent mechanisms in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis are both regulated by interferongamma in human breast tumour cells
    • Ruiz-Ruiz C, Lopez-Rivas A. Mitochondria-dependent and -independent mechanisms in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis are both regulated by interferongamma in human breast tumour cells. Biochem J 2002;365: 825-32.
    • (2002) Biochem J , vol.365 , pp. 825-832
    • Ruiz-Ruiz, C.1    Lopez-Rivas, A.2
  • 41
    • 8544283103 scopus 로고    scopus 로고
    • CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
    • Yamaguchi H, Wang HG. CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 2004;279: 45495-502.
    • (2004) J Biol Chem , vol.279 , pp. 45495-45502
    • Yamaguchi, H.1    Wang, H.G.2
  • 42
    • 0036792643 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines
    • Shetty S, Gladden JB, Henson ES, Hu X, Villanueva J, Haney N, et al. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines. Apoptosis 2002;7: 413-20.
    • (2002) Apoptosis , vol.7 , pp. 413-420
    • Shetty, S.1    Gladden, J.B.2    Henson, E.S.3    Hu, X.4    Villanueva, J.5    Haney, N.6
  • 43
    • 0034732258 scopus 로고    scopus 로고
    • Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site
    • Takimoto R, El-Deiry WS. Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site. Oncogene 2000;19: 1735-43.
    • (2000) Oncogene , vol.19 , pp. 1735-1743
    • Takimoto, R.1    El-Deiry, W.S.2
  • 44
    • 0032696587 scopus 로고    scopus 로고
    • CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins
    • Ubeda M, Vallejo M, Habener JF. CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol Cell Biol 1999;19: 7589-99.
    • (1999) Mol Cell Biol , vol.19 , pp. 7589-7599
    • Ubeda, M.1    Vallejo, M.2    Habener, J.F.3
  • 45
    • 78149256773 scopus 로고    scopus 로고
    • Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL
    • Sung B, Ravindran J, Prasad S, Pandey MK, Aggarwal BB. Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. J Biol Chem 2010;285: 35418-27.
    • (2010) J Biol Chem , vol.285 , pp. 35418-35427
    • Sung, B.1    Ravindran, J.2    Prasad, S.3    Pandey, M.K.4    Aggarwal, B.B.5
  • 46
    • 34250332128 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells
    • Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, et al. The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells. Cancer Res 2007;67: 4981-8.
    • (2007) Cancer Res , vol.67 , pp. 4981-4988
    • Liu, X.1    Yue, P.2    Chen, S.3    Hu, L.4    Lonial, S.5    Khuri, F.R.6
  • 47
    • 39449093377 scopus 로고    scopus 로고
    • Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells
    • Lu M, Xia L, Hua H, Jing Y. Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells. Cancer Res 2008;68: 1180-6.
    • (2008) Cancer Res , vol.68 , pp. 1180-1186
    • Lu, M.1    Xia, L.2    Hua, H.3    Jing, Y.4
  • 48
    • 80053064682 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via intrinsic apoptotic pathway
    • Jiang JW, Chen XM, Chen XH, Zheng SS. Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via intrinsic apoptotic pathway. World J Gastroenterol 2011;17: 3605-13.
    • (2011) World J Gastroenterol , vol.17 , pp. 3605-3613
    • Jiang, J.W.1    Chen, X.M.2    Chen, X.H.3    Zheng, S.S.4
  • 49
    • 46249091398 scopus 로고    scopus 로고
    • A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line
    • Huang J, Tang XH, Ikejima T, Sun XJ, Wang XB, Xi RG, et al. A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line. Arch Pharm Res 2008;31: 323-9.
    • (2008) Arch Pharm Res , vol.31 , pp. 323-329
    • Huang, J.1    Tang, X.H.2    Ikejima, T.3    Sun, X.J.4    Wang, X.B.5    Xi, R.G.6
  • 50
    • 16244362737 scopus 로고    scopus 로고
    • Anticarcinogenic effect of 20(R)-ginsenoside Rg3 on induced hepatocellular carcinoma in rats
    • Li X, Guan YS, Zhou XP, Sun L, Liu Y, He Q, et al. Anticarcinogenic effect of 20(R)-ginsenoside Rg3 on induced hepatocellular carcinoma in rats. Sichuan Da Xue Xue Bao Yi Xue Ban 2005;36: 217-20.
    • (2005) Sichuan da Xue Xue Bao Yi Xue Ban , vol.36 , pp. 217-220
    • Li, X.1    Guan, Y.S.2    Zhou, X.P.3    Sun, L.4    Liu, Y.5    He, Q.6


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