Saikosaponin-d inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase

Molecular Medicine Reports

Volumn 10, Issue 1, 2014, Pages 365-372

  Yao, Min ^a   Yang, Jingbo ^a   Cao, Lanqing ^a   Zhang, Lian ^a   Qu, Shanshan ^a   Gao, Hongwen ^a  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

Anticancer; Apoptosis; DU145 cells; G0 G1 phase arrest; Saikosaponin d

Indexed keywords

CASPASE 3; CYTOCHROME C; PROTEIN P21; PROTEIN P53; SAIKOSAPONIN D; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; OLEANOLIC ACID; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SAIKOSAPONIN; SAPONIN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROSTATE CANCER CELL LINE; PROSTATE CARCINOMA; UPREGULATION; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; METABOLISM; PATHOLOGY; PROSTATE TUMOR; TOXICITY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOCHROMES C; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; OLEANOLIC ACID; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SAPONINS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84901441873     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2153     Document Type: Article

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