Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators

In Vivo

Volumn 23, Issue 4, 2009, Pages 545-550

  Ivanova, Antoaneta ^a   Serly, Julianna ^b   Dinchev, Dragomir ^a   Ocsovszki, Imre ^b   Kostova, Ivanka ^a   Molnar, Joseph ^b  

^a BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Efflux pump; MDR reversal; Multidrug resistance; P glycoprotein; Smilax excelsa; Steroidal saponins; Tribulus terrestris

Indexed keywords

DACTYLIFERIC ACID; DOXORUBICIN; METHYLPROTODIOSCIN; METHYLPROTOTRIBESTIN; MULTIDRUG RESISTANCE PROTEIN 1; PLANT EXTRACT; PROSAPOGENIN A; PSEUDOPROTODIOSCIN; SAPONIN DERIVATIVE; SMILAX EXCELSA EXTRACT; TRIBESTIN; TRIBULUS TERRESTRIS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; GENETIC TRANSFECTION; LYMPHOMA CELL LINE; MOUSE; NONHUMAN; SARSAPARILLA; SMILAX EXCELSA;

EID: 67650979464     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Endicott JA and Ling V: The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58: 137-171, 1989. (Pubitemid 19172967)
2. Rao BK, Kawase M, Tanaka T, Tani S, Motohashi N, Satoh K, Sakagami H, Terakubo S, Nakashima H, Wolfard K and Molnar J: Biological activity of an Indian medicinal plant Indigofera cordifolia. Oriental Pharm Exp Medicine 4: 179-185, 2004.
3. Ferreira MJ, Duarte N, Gyemant N, Radies R, Cherepnev G, Varga A and Molnar J: Interaction between doxorubicin and the resistance modifier stilbene on multidrug resistance mouse lymphoma and human breast cancer cells. Anticancer Res 26: 3541-3546, 2006. (Pubitemid 44701535)
4. Motohashi N, Wakabayashi H, Kurihara T, Takada Y, Maruyama S, Sakagami H, Nakashima H, Tani S, Shirataki Y, Kawase M, Wolfard K and Molnar J: Cytotoxic and multidrug resistance reversal activity of a vegetable 'Anastasia Red', a variety of sweet pepper. Phytother Res 17: 348-352, 2003.
5. Honbu T, Ikeda T, Zhu XH, Yoshida O, Okawa M, Nafady AM and Nohara T: New steroidal glycosides from the fruits of Solanum anguivi. J Nat Prod 65: 1918-1920, 2002.
6. He X, Wang X, Liu B, Su L, Wang G, Qu G, Yao Zh, Liu RH and Yao X: Microbial transformation of methylprotodioscin by Cunninghamella elegans. J Molecular Cat B: Enzymatic 35: 33-40, 2005. (Pubitemid 40933745)
7. Roupe KA, Remsberg CM, Yáñez JA and Davies NM: Pharmacometrics of stilbenes: Seguing towards the clinic. Curr Clin Pharmacol 1: 81-101, 2006.
8. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S and Takada Y: Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24: 2783-2840, 2004. (Pubitemid 39409568)
9. Kubo S, Mimaki Y, Sashida Y, Nikaido T and Ohmoto T: Steroidal saponins from Smilax riparia and S. china. Phytochemistry 31: 2439-2443, 1992.
10. Ng TB and Yu YL: Isolation of a novel heterodimeric agglutinin from rhizomes of Smilax glabra, the Chinese medicinal material tufuling. Int J Biochem Cell Biol 33: 269-277, 2001.
11. Kostova I and Dinchev D: Saponins in Tribulus terrestris - chemistry and bioactivity. Phytochem Rev 4: 111-137, 2005. (Pubitemid 41752171)
12. Ivanova A, Mikhova B, Klaiber I, Dinchev D and Kostova I: Steroidal saponins from Smilax excelsa rhizomes. Nat Prod Res, 2009, in press.
13. Ivanova A, Mikhova B, Kostova I and Evstatieva L: Bioactive chemical constituents from Smilax excelsa L. Nat Prod Comm, 2009, submitted.
14. Kostova I, Dinchev D, Rentsch GH, Dimitrov V and Ivanova A: Two new sulfated furostanol saponins from Tribulus terrestris. Z Naturforsch [C] 57: 33-38, 2002. (Pubitemid 34234329)
15. Dinchev D, Janda B, Evstatieva L, Oleszek W, Aslani MR and Kostova I: Distribution of steroidal saponins in Tribulus terrestris from different geographical regions. Phytochemistry 69: 176-186, 2008. (Pubitemid 350256796)
16. Conrad J, Dinchev D, Klaiber I, Mika S, Kostova I and Kraus W: A novel furostanol saponin from Tribulus terrestris of Bulgarian origin. Fitoterapia 75: 117-122, 2004. (Pubitemid 38353073)
17. Hoyer GA, Sucrow W and Winkler D: Diosgenin saponins from Dioscorea floribunda. Phytochemistry 14: 539-542, 1975.
18. Espejo O, Llavot C, Jung H and Giral F: Spirostanic diosgenin precursors from Dioscorea composita tubers. Phytochemistry 21: 413-416, 1982.
19. Mashchenko NE, Gyulemetova R, Kintya PK and Shashkov AS: A sulfated glycoside from the preparation 'tribestan'. Khim Prirod Soed 5: 649-652, 1990.
20. Cornwell MM, Pastan I and Gottesmann MM: Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J Biol Chem 262: 2166-2170, 1987. (Pubitemid 17102655)
21. Engi H, Gyemant N, Lorand T, Levai A, Ocsovszki I and Molnar J: Cinnamylidene ketones as potential modulators of multidrug resistance in mouse lymphoma and human colon cancer cell lines. In Vivo 20: 119-124, 2006. (Pubitemid 43103727)
22. Molnar J, Mucsi I, Nacsa J, Hever A, Gyemant N, Ugocsai K, Hegyes P, Kiessig S, Gaal D, Lage H and Varga A: New silicon compounds as resistance modifiers against multidrug resistant cancer cells. Anticancer Res 24: 865-871, 2004. (Pubitemid 38625034)
23. Chowdhury SA, Kishino K, Satoh R, Hashimoto K, Kikuchi H, Nishikawa H, Shirotaki Y and Sakagami H: Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids. Anticancer Res 25: 2055-2063, 2005. (Pubitemid 40904604)
24. Shirataki J, Kawase M, Sakagami H, Nakashima H, Tani S, TanakaT, Sohara Y, Schelz Zs, Molnar J and Motohashi N: Bioactivities of anastasia black (Russian sweet pepper). Anticancer Res 25: 1991-1999, 2005.
25. Fang S, Hao C, Sun W, Liu Z and Liu S: Rapid analysis of steroidal saponin mixture using electrospray ionization mass spectrometry combined with sequential tandem mass spectrometry. Rapid Commun Mass Spectrom 12: 589-594, 1998. (Pubitemid 28222699)