-
2
-
-
84949122997
-
The bacteriostasis and hermostasis functions of Parispolyphylla Smith var. Chinensis (French.) Hera
-
(in Chinese)
-
Wang Q, Cheng YB. The bacteriostasis and hermostasis functions of Parispolyphylla Smith var. Chinensis (French.) Hera. The Journal of China Pharmaceutical University. 1989; 20:251-253. (in Chinese)
-
(1989)
The Journal of China Pharmaceutical University
, vol.20
, pp. 251-253
-
-
Wang, Q.1
Cheng, Y.B.2
-
3
-
-
84866845167
-
Saponins used in traditional and modern medicine and Saponins Used in Food and Agriculture
-
Harborne JB. Saponins used in traditional and modern medicine and Saponins Used in Food and Agriculture. Phytochemistry. 1997; 46:1301-1303.
-
(1997)
Phytochemistry
, vol.46
, pp. 1301-1303
-
-
Harborne, J.B.1
-
4
-
-
60749124499
-
The study and application of Paris plant
-
(in Chinese)
-
XC ZX. The study and application of Paris plant. Journal of Chinese Herbal Technology. 2000; 7:346-347. (in Chinese)
-
(2000)
Journal of Chinese Herbal Technology
, vol.7
, pp. 346-347
-
-
Xc, Z.X.1
-
5
-
-
66849095590
-
The antitumoral effect of Paris saponin I associated with the induction of apoptosis through the mitochondrial pathway
-
Xiao X, Bai P, Bui Nguyen TM, Xiao J, Liu S, Yang G, Hu L, Chen X, Zhang X, Liu J, Wang H. The antitumoral effect of Paris saponin I associated with the induction of apoptosis through the mitochondrial pathway. Mol Cancer Ther. 2009; 8:1179-1188.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1179-1188
-
-
Xiao, X.1
Bai, P.2
Bui Nguyen, T.M.3
Xiao, J.4
Liu, S.5
Yang, G.6
Hu, L.7
Chen, X.8
Zhang, X.9
Liu, J.10
Wang, H.11
-
6
-
-
44149127948
-
A new phenylpropanoid glycosides from Paris polyphylla var. yunnanensis
-
Yan L, Gao W, Zhang Y, Wang Y. A new phenylpropanoid glycosides from Paris polyphylla var. yunnanensis. Fitoterapia. 2008; 79:306-307.
-
(2008)
Fitoterapia
, vol.79
, pp. 306-307
-
-
Yan, L.1
Gao, W.2
Zhang, Y.3
Wang, Y.4
-
7
-
-
34247607276
-
A novel phenylpropanoid glycosides and a new derivation of phenolic glycoside from Paris polyphylla var. yunnanensis
-
Wang Y, Gao WY, Zhang TJ, Guo YQ. A novel phenylpropanoid glycosides and a new derivation of phenolic glycoside from Paris polyphylla var. yunnanensis. Chin Chem Lett. 2007; 18:548-550.
-
(2007)
Chin Chem Lett.
, vol.18
, pp. 548-550
-
-
Wang, Y.1
Gao, W.Y.2
Zhang, T.J.3
Guo, Y.Q.4
-
8
-
-
34247573718
-
Antitumor constituents from Paris polyphylla
-
Wang Y, Gao WY, Liu XQ, Zuo YT, Chen HX, Duan HQ. Antitumor constituents from Paris polyphylla. Asian J Tradit Med. 2006; 1:7-10.
-
(2006)
Asian J Tradit Med
, vol.1
, pp. 7-10
-
-
Wang, Y.1
Gao, W.Y.2
Liu, X.Q.3
Zuo, Y.T.4
Chen, H.X.5
Duan, H.Q.6
-
9
-
-
55149092516
-
Proteomic analysis of anti-tumor effects by Rhizoma Paridis total saponin treatment in HepG2 cells
-
Cheng ZX, Liu BR, Qian XP, Ding YT, Hu WJ, Sun J, Yu LX. Proteomic analysis of anti-tumor effects by Rhizoma Paridis total saponin treatment in HepG2 cells. J Ethnopharmacol. 2008; 120:129-137.
-
(2008)
J Ethnopharmacol
, vol.120
, pp. 129-137
-
-
Cheng, Z.X.1
Liu, B.R.2
Qian, X.P.3
Ding, Y.T.4
Hu, W.J.5
Sun, J.6
Yu, L.X.7
-
10
-
-
70350564909
-
Antitumor and antimetastatic activities of Rhizoma Paridis saponins
-
Man S, Gao W, Zhang Y, Yan L, Ma C, Liu C, Huang L. Antitumor and antimetastatic activities of Rhizoma Paridis saponins. Steroids. 2009; 74:1051-1056.
-
(2009)
Steroids
, vol.74
, pp. 1051-1056
-
-
Man, S.1
Gao, W.2
Zhang, Y.3
Yan, L.4
Ma, C.5
Liu, C.6
Huang, L.7
-
12
-
-
0026366264
-
Bioactive glycosides from Chinese medicines
-
Zhou J. Bioactive glycosides from Chinese medicines. Mem Inst Oswaldo Cruz. 1991; 86 (Suppl 2):231-234.
-
(1991)
Mem Inst Oswaldo Cruz
, vol.86
, Issue.SUPPL. 2
, pp. 231-234
-
-
Zhou, J.1
-
13
-
-
36549043882
-
In vitro anticancer activity of aqueous extracts and ethanol extracts of fifteen traditional Chinese medicines on human digestive tumor cell lines
-
Sun J, Liu BR, Hu WJ, Yu LX, Qian XP. In vitro anticancer activity of aqueous extracts and ethanol extracts of fifteen traditional Chinese medicines on human digestive tumor cell lines. Phytother Res. 2007; 21:1102-1104.
-
(2007)
Phytother Res
, vol.21
, pp. 1102-1104
-
-
Sun, J.1
Liu, B.R.2
Hu, W.J.3
Yu, L.X.4
Qian, X.P.5
-
14
-
-
33646422206
-
Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft
-
Lee MS, Yuet-Wa JC, Kong SK, Yu B, Eng-Choon VO, Nai-Ching HW, Chung-Wai TM, Fung KP. Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft. Cancer Biol Ther. 2005; 4:1248-1254.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 1248-1254
-
-
Lee, M.S.1
Yuet-Wa, J.C.2
Kong, S.K.3
Yu, B.4
Eng-Choon, V.O.5
Nai-Ching, H.W.6
Chung-Wai, T.M.7
Fung, K.P.8
-
15
-
-
0026448271
-
Immunomodulating effects of the hydrolysis products of formosanin C and betaecdysone from Paris formosana Hayata
-
Chiang HC, Wang JJ, Wu RT. Immunomodulating effects of the hydrolysis products of formosanin C and betaecdysone from Paris formosana Hayata. Anticancer Res. 1992; 12:1475-1478.
-
(1992)
Anticancer Res
, vol.12
, pp. 1475-1478
-
-
Chiang, H.C.1
Wang, J.J.2
Wu, R.T.3
-
16
-
-
0025111221
-
Formosanin-C, an immunomodulator with antitumor activity
-
Wu RT, Chiang HC, Fu WC, Chien KY, Chung YM, Horng LY. Formosanin-C, an immunomodulator with antitumor activity. Int J Immunopharmacol. 1990; 12:777-786.
-
(1990)
Int J Immunopharmacol
, vol.12
, pp. 777-786
-
-
Wu, R.T.1
Chiang, H.C.2
Fu, W.C.3
Chien, K.Y.4
Chung, Y.M.5
Horng, L.Y.6
-
17
-
-
62849095014
-
Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential
-
Lee JC, Su CL, Chen LL, Won SJ. Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential. Cancer Sci. 2009; 100:503-513.
-
(2009)
Cancer Sci
, vol.100
, pp. 503-513
-
-
Lee, J.C.1
Su, C.L.2
Chen, L.L.3
Won, S.J.4
-
18
-
-
81855224771
-
Traditional Chinese medicine in cancer care: A review of case reports published in Chinese literature
-
Liu J, Li X, Liu J, Ma L, Li X, Fønnebø V. Traditional Chinese medicine in cancer care: A review of case reports published in Chinese literature. Forsch Komplementmed. 2011; 18:257-263.
-
(2011)
Forsch Komplementmed
, vol.18
, pp. 257-263
-
-
Liu, J.1
Li, X.2
Liu, J.3
Ma, L.4
Li, X.5
Fønnebø, V.6
-
19
-
-
44449083811
-
Isolation and identification of major steroidal saponins of Paris polyphylla Smith var stenophylla Franch
-
(in Chinese)
-
Yin HX, Xue D, Bai N, Chen C, Chen Y, Zhang H. Isolation and identification of major steroidal saponins of Paris polyphylla Smith var stenophylla Franch. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008; 39:485-488. (in Chinese)
-
(2008)
Sichuan Da Xue Xue Bao Yi Xue Ban
, vol.39
, pp. 485-488
-
-
Yin, H.X.1
Xue, D.2
Bai, N.3
Chen, C.4
Chen, Y.5
Zhang, H.6
-
20
-
-
58749100897
-
Simultaneous quantification of both triterpenoid and steroidal saponins in various Yunnan Baiyao preparations using HPLC-UV and HPLC-MS
-
Liu XX, Wang L, Chen XQ, Deng XT, Cao Y, Wang Q. Simultaneous quantification of both triterpenoid and steroidal saponins in various Yunnan Baiyao preparations using HPLC-UV and HPLC-MS. J Sep Sci. 2008; 31:3834-3846.
-
(2008)
J Sep Sci
, vol.31
, pp. 3834-3846
-
-
Liu, X.X.1
Wang, L.2
Chen, X.Q.3
Deng, X.T.4
Cao, Y.5
Wang, Q.6
-
21
-
-
70349255753
-
Polyphyllin D exerts potent anti-tumour effects on Lewis cancer cells under hypoxic conditions
-
Ma DD, Lu HX, Xu LS, Xiao W. Polyphyllin D exerts potent anti-tumour effects on Lewis cancer cells under hypoxic conditions. J Int Med Res. 2009; 37:631-640.
-
(2009)
J Int Med Res
, vol.37
, pp. 631-640
-
-
Ma, D.D.1
Lu, H.X.2
Xu, L.S.3
Xiao, W.4
-
22
-
-
79955074266
-
Paridis saponins inhibiting carcinoma growth and metastasis in vitro and in vivo
-
Shuli M, Wenyuan G, Yanjun Z, Chaoyi M, Liu Y, Yiwen L. Paridis saponins inhibiting carcinoma growth and metastasis in vitro and in vivo. Arch Pharm Res. 2011; 34:43-50.
-
(2011)
Arch Pharm Res
, vol.34
, pp. 43-50
-
-
Shuli, M.1
Wenyuan, G.2
Yanjun, Z.3
Chaoyi, M.4
Liu, Y.5
Yiwen, L.6
-
23
-
-
79952761256
-
Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma
-
Man S, Gao W, Zhang Y, Liu Z, Yan L, Huang L, Liu C. Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma. Cancer Biol Ther. 2011; 11:592-598.
-
(2011)
Cancer Biol Ther
, vol.11
, pp. 592-598
-
-
Man, S.1
Gao, W.2
Zhang, Y.3
Liu, Z.4
Yan, L.5
Huang, L.6
Liu, C.7
-
24
-
-
33947728683
-
Immuno-stimulating properties of diosgenyl saponins isolated from Paris polyphylla
-
Zhang XF, Cui Y, Huang JJ, Zhang YZ, Nie Z, Wang LF, Yan BZ, Tang YL, Liu Y. Immuno-stimulating properties of diosgenyl saponins isolated from Paris polyphylla. Bioorg Med Chem Lett. 2007; 17:2408-2413.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 2408-2413
-
-
Zhang, X.F.1
Cui, Y.2
Huang, J.J.3
Zhang, Y.Z.4
Nie, Z.5
Wang, L.F.6
Yan, B.Z.7
Tang, Y.L.8
Liu, Y.9
-
26
-
-
0026648674
-
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
-
Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992; 119:493-501.
-
(1992)
J Cell Biol
, vol.119
, pp. 493-501
-
-
Gavrieli, Y.1
Sherman, Y.2
Ben-Sasson, S.A.3
-
27
-
-
23044447260
-
Establishment of an immortalised human ovarian surface epithelial cell line without chromosomal instability
-
Maeda T, Tashiro H, Katabuchi H, Begum M, Ohtake H, Kiyono T, Okamura H. Establishment of an immortalised human ovarian surface epithelial cell line without chromosomal instability. Br J Cancer. 2005; 93:116-123.
-
(2005)
Br J Cancer
, vol.93
, pp. 116-123
-
-
Maeda, T.1
Tashiro, H.2
Katabuchi, H.3
Begum, M.4
Ohtake, H.5
Kiyono, T.6
Okamura, H.7
-
28
-
-
2442623486
-
The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells
-
Nguyen TT, Tran E, Nguyen TH, Do PT, Huynh TH, Huynh H. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis. 2004; 25:647-659.
-
(2004)
Carcinogenesis
, vol.25
, pp. 647-659
-
-
Nguyen, T.T.1
Tran, E.2
Nguyen, T.H.3
Do, P.T.4
Huynh, T.H.5
Huynh, H.6
-
29
-
-
42549167500
-
Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway
-
Cusimano A, Foderà D, D'Alessandro N, Lampiasi N, Azzolina A, Montalto G, Cervello M. Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. Cancer Biol Ther. 2007; 6:1461-1468.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 1461-1468
-
-
Cusimano, A.1
Foderà, D.2
D'Alessandro, N.3
Lampiasi, N.4
Azzolina, A.5
Montalto, G.6
Cervello, M.7
-
30
-
-
33845626635
-
Apoptosismediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002
-
discussion 1014-1015
-
Kunnimalaiyaan M, Ndiaye M, Chen H. Apoptosismediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery. 2006; 140:1009-1014; discussion 1014-1015.
-
(2006)
Surgery
, vol.140
, pp. 1009-1014
-
-
Kunnimalaiyaan, M.1
Ndiaye, M.2
Chen, H.3
-
31
-
-
0032081487
-
Determination of steroidal saponins in Rhizoma Paridis by RP-HPLC
-
(in Chinese)
-
Wei J. Determination of steroidal saponins in Rhizoma Paridis by RP-HPLC. Yao Xue Xue Bao. 1998; 33:465-458. (in Chinese)
-
(1998)
Yao Xue Xue Bao
, vol.33
, pp. 465-458
-
-
Wei, J.1
-
32
-
-
33846304270
-
Quantitative analysis of steroidal saponins in Chinese material medica Rhizoma Paridis by HPLC-ELSD
-
(in Chinese)
-
Huang Y, Cui LJ, Liu WN, Wang Q. Quantitative analysis of steroidal saponins in Chinese material medica Rhizoma Paridis by HPLC-ELSD. Zhongguo Zhong Yao Za Zhi. 2006; 31:1230-1233. (in Chinese)
-
(2006)
Zhongguo Zhong Yao Za Zhi
, vol.31
, pp. 1230-1233
-
-
Huang, Y.1
Cui, L.J.2
Liu, W.N.3
Wang, Q.4
-
33
-
-
11144295689
-
Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells
-
Cheung JY, Ong RC, Suen YK, Ooi V, Wong HN, Mak TC, Fung KP, Yu B, Kong SK. Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells. Cancer Lett. 2005; 217:203-211.
-
(2005)
Cancer Lett
, vol.217
, pp. 203-211
-
-
Cheung, J.Y.1
Ong, R.C.2
Suen, Y.K.3
Ooi, V.4
Wong, H.N.5
Mak, T.C.6
Fung, K.P.7
Yu, B.8
Kong, S.K.9
-
34
-
-
0032777770
-
Synthesis of three diosgenyl saponins: Dioscin, polyphyllin D, and balanitin 7
-
Deng S, Yu B, Hui Y, Yu H, Han X. Synthesis of three diosgenyl saponins: Dioscin, polyphyllin D, and balanitin 7. Carbohydr Res. 1999; 317:53-62.
-
(1999)
Carbohydr Res
, vol.317
, pp. 53-62
-
-
Deng, S.1
Yu, B.2
Hui, Y.3
Yu, H.4
Han, X.5
-
35
-
-
0035831360
-
An improved synthesis of the saponin, polyphyllin D
-
Li B, Yu B, Hui Y, Li M, Han X, Fung KP. An improved synthesis of the saponin, polyphyllin D. Carbohydr Res. 2001; 331:1-7.
-
(2001)
Carbohydr Res
, vol.331
, pp. 1-7
-
-
Li, B.1
Yu, B.2
Hui, Y.3
Li, M.4
Han, X.5
Fung, K.P.6
-
36
-
-
49749104260
-
Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways
-
Siu FM, Ma DL, Cheung YW, Lok CN, Yan K, Yang Z, Yang M, Xu S, Ko BC, He QY, Che CM. Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways. Proteomics. 2008; 8:3105-3117.
-
(2008)
Proteomics
, vol.8
, pp. 3105-3117
-
-
Siu, F.M.1
Ma, D.L.2
Cheung, Y.W.3
Lok, C.N.4
Yan, K.5
Yang, Z.6
Yang, M.7
Xu, S.8
Ko, B.C.9
He, Q.Y.10
Che, C.M.11
-
37
-
-
79955749202
-
Identification of chemical constituents in Rhizoma Paridis saponins and their oral administration in rat plasma by UPLC/Q-TOF/MS
-
Man S, Gao W, Zhang Y, Huang L, Liu C. Identification of chemical constituents in Rhizoma Paridis saponins and their oral administration in rat plasma by UPLC/Q-TOF/MS. Biomed Chromatogr. 2011; 25:712-719.
-
(2011)
Biomed Chromatogr
, vol.25
, pp. 712-719
-
-
Man, S.1
Gao, W.2
Zhang, Y.3
Huang, L.4
Liu, C.5
-
38
-
-
4043124898
-
Diosgenin, a steroid saponin of Trigonella foenum-graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells
-
Raju J, Patlolla JM, Swamy MV, Rao CV. Diosgenin, a steroid saponin of Trigonella foenum-graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomarkers Prev. 2004; 13:1392-1398.
-
(2004)
Cancer Epidemiol Biomarkers Prev
, vol.13
, pp. 1392-1398
-
-
Raju, J.1
Patlolla, J.M.2
Swamy, M.V.3
Rao, C.V.4
-
40
-
-
84865127061
-
Prevention of ovarian cancer - let's do something
-
Westgren M. Prevention of ovarian cancer - let's do something. Acta Obstet Gynecol Scand. 2012; 91:1009-1010.
-
(2012)
Acta Obstet Gynecol Scand
, vol.91
, pp. 1009-1010
-
-
Westgren, M.1
-
41
-
-
33645156429
-
From acute ER stressto physiological roles of the Unfolded Protein Response
-
Wu J, Kaufman RJ. From acute ER stressto physiological roles of the Unfolded Protein Response. Cell Death Differ. 2006; 13:374-384.
-
(2006)
Cell Death Differ
, vol.13
, pp. 374-384
-
-
Wu, J.1
Kaufman, R.J.2
-
42
-
-
1842843855
-
Roles of CHOP/GADD153 in endoplasmic reticulum stress
-
Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004; 11:381-389.
-
(2004)
Cell Death Differ
, vol.11
, pp. 381-389
-
-
Oyadomari, S.1
Mori, M.2
-
43
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
-
McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol. 2001; 21:1249-1259.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.O.3
Aw, T.Y.4
Holbrook, N.J.5
-
44
-
-
37549048240
-
A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signalregulated kinase activation in hypertrophic chondrocytes
-
Provot S, Nachtrab G, Paruch J, Chen AP, Silva A, Kronenberg HM. A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signalregulated kinase activation in hypertrophic chondrocytes. Mol Cell Biol. 2008; 28:344-357.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 344-357
-
-
Provot, S.1
Nachtrab, G.2
Paruch, J.3
Chen, A.P.4
Silva, A.5
Kronenberg, H.M.6
-
45
-
-
21744453318
-
ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis
-
Svensson S, Jirström K, Rydén L, Roos G, Emdin S, Ostrowski MC, Landberg G. ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis. Oncogene. 2005; 24:4370-4379.
-
(2005)
Oncogene
, vol.24
, pp. 4370-4379
-
-
Svensson, S.1
Jirström, K.2
Rydén, L.3
Roos, G.4
Emdin, S.5
Ostrowski, M.C.6
Landberg, G.7
-
46
-
-
0038726089
-
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
-
Allan LA, Morrice N, Brady S, Magee G, Pathak S, Clarke PR. Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol. 2003; 5:647-654.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 647-654
-
-
Allan, L.A.1
Morrice, N.2
Brady, S.3
Magee, G.4
Pathak, S.5
Clarke, P.R.6
|