Cytotoxic triterpenoid glycosides (saikosaponins) from the roots of Bupleurum chinense

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 18, 2015, Pages 3887-3892

  Li, Dan Qi ^a   Wu, Jie ^a   Liu, Li Yin ^a   Wu, Ying Ying ^a   Li, Ling Zhi ^a   Huang, Xiao Xiao ^a   Liu, Qing Bo ^a   Yang, Jing Yu ^a   Song, Shao Jiang ^a   Wu, Chun Fu ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Bupleurum chinense DC.; Cytotoxicitie; Saikosaponins; Structure activity relationships (SAR)

Indexed keywords

BRIDGED COMPOUND; BUPLEURUM ROOT EXTRACT; CYTOTOXIC AGENT; FLUOROURACIL; GLYCOSIDE; HYDROXYL GROUP; SAIKOSAPONIN; TRITERPENOID; OLEANOLIC ACID; PLANT EXTRACT; SAPONIN;

A549 CELL LINE; ARTICLE; BUPLEURUM CHINENSE; CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ELECTROSPRAY MASS SPECTROMETRY; HEPG2 CELL LINE; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; MCF 7 CELL LINE; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PHYTOCHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; BUPLEURUM; CELL PROLIFERATION; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; ISOLATION AND PURIFICATION; PLANT ROOT; STEREOISOMERISM; TUMOR CELL LINE;

BUPLEURUM CHINENSE;

BUPLEURUM; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR CONFORMATION; OLEANOLIC ACID; PLANT EXTRACTS; PLANT ROOTS; SAPONINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84939252916     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.07.053     Document Type: Article

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