Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1, ICAM-1 and EL expression via the NF-κB pathway

Biochimie

Volumn 110, Issue , 2015, Pages 62-72

  Wu, Shan ^a   Xu, Hui ^b   Peng, Jinyong ^a   Wang, Changyuan ^a   Jin, Yue ^a   Liu, Kexin ^a   Sun, Huijun ^a   Qin, Jianhua ^b  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

Dioscin; EL; HUVECs; Monocytes; NF B pathways; TNF

Indexed keywords

ANTIINFLAMMATORY AGENT; DIOSGENIN 3 YL ALPHA LEVO RHAMNOPYRANOSYL (1-2) [ALPHA LEVO RHAMNOPYRANOSYL (1-4)] BETA DEXTRO GLYCOPYRANOSIDE; HERBACEOUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; SAPONIN DERIVATIVE; TRIACYLGLYCEROL LIPASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; DIOSCIN; DIOSGENIN; I KAPPA B KINASE; LIPG PROTEIN, HUMAN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MONOCYTE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN DEGRADATION;

ANTI-INFLAMMATORY AGENTS; CELL ADHESION; CELL PROLIFERATION; DIOSGENIN; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; INTERCELLULAR ADHESION MOLECULE-1; LIPASE; MONOCYTES; NF-KAPPA B; PROTEOLYSIS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84921325073     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2014.12.022     Document Type: Article

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