Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition

Journal of Natural Products

Volumn 76, Issue 5, 2013, Pages 909-914

  Wang, Lijuan ^a   Meng, Qiang ^a   Wang, Changyuan ^a   Liu, Qi ^a   Peng, Jinyong ^a   Huo, Xiaokui ^a   Sun, Huijun ^a   Ma, Xiaochi ^a   Liu, Kexin ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DIOSCIN; DOXORUBICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PLANT EXTRACT; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DOWN REGULATION; HUMAN; HUMAN CELL; LEUKEMIA; MULTIDRUG RESISTANCE;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; DIOSCOREA; DIOSGENIN; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; I-KAPPA B PROTEINS; K562 CELLS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; LUCIFERASES; NF-KAPPA B; P-GLYCOPROTEIN; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84878237899     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np400071c     Document Type: Article

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