메뉴 건너뛰기




Volumn 13, Issue 7, 2012, Pages 504-515

Ginsenoside Rg3 attenuates tumor angiogenesis via inhibiting bioactivities of endothelial progenitor cells

Author keywords

Anti angiogenesis; Endothelial progenitor cells; Ginsenoside Rg3; Tumor angiogenesis; VEGF signaling

Indexed keywords

GINSENOSIDE RG 3; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; VASCULOTROPIN;

EID: 84861176603     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.19599     Document Type: Article
Times cited : (76)

References (41)
  • 1
    • 33751583518 scopus 로고    scopus 로고
    • Drug insight: Vascular disrupting agents and angiogenesis - Novel approaches for drug delivery
    • PMID:17139319
    • Cooney MM, van Heeckeren W, Bhakta S, Ortiz J, Remick SC. Drug insight: vascular disrupting agents and angiogenesis - novel approaches for drug delivery. Nat Clin Pract Oncol 2006; 3:682-92; PMID:17139319; http://dx.doi.org/10.1038/ncponc0663.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 682-692
    • Cooney, M.M.1    Van Heeckeren, W.2    Bhakta, S.3    Ortiz, J.4    Remick, S.C.5
  • 2
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • PMID:12778130
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003; 3:401-10; PMID:12778130; http://dx.doi.org/10.1038/nrc1093.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 3
    • 19244365089 scopus 로고    scopus 로고
    • Bone marrow-derived cells and vascular growth
    • PMID:15117831
    • Skowasch D, Jabs A, Lüderitz B, Bauriedel G. Bone marrow-derived cells and vascular growth. Circ Res 2004; 94:71; PMID:15117831; http://dx.doi. org/10.1161/01.RES.0000126418.31311.F8.
    • (2004) Circ Res , vol.94 , pp. 71
    • Skowasch, D.1    Jabs, A.2    Lüderitz, B.3    Bauriedel, G.4
  • 4
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • PMID:18328425
    • Du R, Lu KV, Petritsch C, Liu P, Ganss R, PasseguéE, et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008; 13:206-20; PMID:18328425; http://dx.doi. org/10.1016/j.ccr.2008.01.034.
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3    Liu, P.4    Ganss, R.5    Passegué, E.6
  • 5
    • 34548710861 scopus 로고    scopus 로고
    • Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha/CXCR4 via PI3K/Akt/eNOS signal transduction pathway
    • PMID:17878755
    • Zheng H, Fu G, Dai T, Huang H. Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha/CXCR4 via PI3K/Akt/eNOS signal transduction pathway. J Cardiovasc Pharmacol 2007; 50:274-80; PMID:17878755; http://dx.doi. org/10.1097/FJC.0b013e318093ec8f.
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 274-280
    • Zheng, H.1    Fu, G.2    Dai, T.3    Huang, H.4
  • 6
    • 66149092730 scopus 로고    scopus 로고
    • G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
    • PMID:19346489
    • Shojaei F, Wu X, Qu X, Kowanetz M, Yu L, Tan M, et al. G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc Natl Acad Sci USA 2009; 106:6742-7; PMID:19346489; http://dx.doi.org/10.1073/pnas.0902280106.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6742-6747
    • Shojaei, F.1    Wu, X.2    Qu, X.3    Kowanetz, M.4    Yu, L.5    Tan, M.6
  • 7
    • 0035160312 scopus 로고    scopus 로고
    • Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    • PMID:11689883
    • Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 2001; 7:1194-201; PMID:11689883; http://dx.doi. org/10.1038/nm1101-94.
    • (2001) Nat Med , vol.7 , pp. 1194-1201
    • Lyden, D.1    Hattori, K.2    Dias, S.3    Costa, C.4    Blaikie, P.5    Butros, L.6
  • 8
    • 34250719709 scopus 로고    scopus 로고
    • Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization
    • PMID:17575055
    • Nolan DJ, Ciarrocchi A, Mellick AS, Jaggi JS, Bambino K, Gupta S, et al. Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev 2007; 21:1546-58; PMID:17575055; http://dx.doi.org/10.1101/gad.436307.
    • (2007) Genes Dev , vol.21 , pp. 1546-1558
    • Nolan, D.J.1    Ciarrocchi, A.2    Mellick, A.S.3    Jaggi, J.S.4    Bambino, K.5    Gupta, S.6
  • 9
    • 38149006909 scopus 로고    scopus 로고
    • Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis
    • PMID:18187653
    • Gao DC, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 2008; 319:195-8; PMID:18187653; http://dx.doi.org/10.1126/ science.1150224.
    • (2008) Science , vol.319 , pp. 195-198
    • Gao, D.C.1    Nolan, D.J.2    Mellick, A.S.3    Bambino, K.4    McDonnell, K.5    Mittal, V.6
  • 10
    • 33646812605 scopus 로고    scopus 로고
    • Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue
    • PMID:16567962
    • Kopp HG, Ramos CA, Rafii S. Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue. Curr Opin Hematol 2006; 13:175-81; PMID:16567962; http://dx.doi.org/10. 1097/01. moh.0000219664.26528.da.
    • (2006) Curr Opin Hematol , vol.13 , pp. 175-181
    • Kopp, H.G.1    Ramos, C.A.2    Rafii, S.3
  • 11
    • 0033565540 scopus 로고    scopus 로고
    • VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
    • PMID:10406801
    • Asahara T, Takahashi T, Masuda H, Kalka C, Chen DH, Iwaguro H, et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J 1999; 18:3964-72; PMID:10406801; http://dx.doi.org/10.1093/emboj/18.14.3964.
    • (1999) EMBO J , vol.18 , pp. 3964-3972
    • Asahara, T.1    Takahashi, T.2    Masuda, H.3    Kalka, C.4    Chen, D.H.5    Iwaguro, H.6
  • 12
    • 28444476260 scopus 로고    scopus 로고
    • Angiogenic inhibitors: A new therapeutic strategy in oncology
    • PMID:16270097
    • Gasparini G, Longo R, Toi M, Ferrara N. Angiogenic inhibitors: a new therapeutic strategy in oncology. Nat Clin Pract Oncol 2005; 2:562-77; PMID:16270097; http://dx.doi.org/10.1038/ncponc0342.
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 562-577
    • Gasparini, G.1    Longo, R.2    Toi, M.3    Ferrara, N.4
  • 13
    • 20444490772 scopus 로고    scopus 로고
    • Targeting angiogenesis in cancer: Clinical development of bevacizumab
    • PMID:16264798
    • Kerr DJ. Targeting angiogenesis in cancer: clinical development of bevacizumab. Nat Clin Pract Oncol 2004; 1:39-43; PMID:16264798; http://dx.doi. org/10.1038/ncponc0026.
    • (2004) Nat Clin Pract Oncol , vol.1 , pp. 39-43
    • Kerr, D.J.1
  • 15
    • 78049250867 scopus 로고    scopus 로고
    • Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NFκB signaling
    • PMID:20665661
    • Wong VK, Cheung SS, Li T, Jiang ZH, Wang JR, Dong H, et al. Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NFκB signaling. J Cell Biochem 2010; 111:899-910; PMID:20665661; http://dx.doi.org/10.1002/jcb.22778.
    • (2010) J Cell Biochem , vol.111 , pp. 899-910
    • Wong, V.K.1    Cheung, S.S.2    Li, T.3    Jiang, Z.H.4    Wang, J.R.5    Dong, H.6
  • 16
    • 0035651290 scopus 로고    scopus 로고
    • Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer
    • PMID:11748375
    • Surh YJ, Na HK, Lee JY, Keum YS. Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer. J Korean Med Sci 2001; 16:38-41; PMID:11748375.
    • (2001) J Korean Med Sci , vol.16 , pp. 38-41
    • Surh, Y.J.1    Na, H.K.2    Lee, J.Y.3    Keum, Y.S.4
  • 17
    • 0026504109 scopus 로고
    • Recent advances on ginseng research in China
    • PMID:1501490
    • Liu CX, Xiao PG. Recent advances on ginseng research in China. J Ethnopharmacol 1992; 36:27-38; PMID:1501490; http://dx.doi.org/10.1016/0378- 8741(92)90057-X.
    • (1992) J Ethnopharmacol , vol.36 , pp. 27-38
    • Liu, C.X.1    Xiao, P.G.2
  • 18
    • 33644618424 scopus 로고    scopus 로고
    • Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on Lewis lung carcinoma
    • PMID:16499874
    • Zhang QY, Kang XM, Zhao WH. Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on Lewis lung carcinoma. Biochem Biophys Res Commun 2006; 342:824-8; PMID:16499874; http://dx.doi.org/10.1016/j. bbrc.2006.02.044.
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 824-828
    • Zhang, Q.Y.1    Kang, X.M.2    Zhao, W.H.3
  • 19
    • 21744441158 scopus 로고    scopus 로고
    • Experimental study on effect of chemotherapy combined ginsengnoside Rg3 in treating pulmonary carcinoma
    • PMID:15719754
    • Yi C, Huang XB, Hou M. Experimental study on effect of chemotherapy combined ginsengnoside Rg3 in treating pulmonary carcinoma. Zhongguo Zhong Xi Yi Jie He Za Zhi 2005; 25:58-9; PMID:15719754.
    • (2005) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.25 , pp. 58-59
    • Yi, C.1    Huang, X.B.2    Hou, M.3
  • 20
    • 0030612896 scopus 로고    scopus 로고
    • Inhibition by ginsenoside Rg3 of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats
    • PMID:9344044
    • Iishi H, Tatsuta M, Baba M, Uehara H, Nakaizumi A, Shinkai K, et al. Inhibition by ginsenoside Rg3 of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. Clin Exp Metastasis 1997; 15:603-11; PMID:9344044; http://dx.doi. org/10.1023/A: 1018491314066.
    • (1997) Clin Exp Metastasis , vol.15 , pp. 603-611
    • Iishi, H.1    Tatsuta, M.2    Baba, M.3    Uehara, H.4    Nakaizumi, A.5    Shinkai, K.6
  • 21
    • 26944502768 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenoside-Rg3 on lung metastasis of mouse melanoma transfected with ribonuclease inhibitor
    • PMID:15733388
    • Liu JW, Chen JX, Yu LH, Tian YX, Cui XY, Yan Q, et al. [Inhibitory effect of ginsenoside-Rg3 on lung metastasis of mouse melanoma transfected with ribonuclease inhibitor]. Zhonghua Zhong Liu Za Zhi 2004; 26:722-5; PMID:15733388.
    • (2004) Zhonghua Zhong Liu Za Zhi , vol.26 , pp. 722-725
    • Liu, J.W.1    Chen, J.X.2    Yu, L.H.3    Tian, Y.X.4    Cui, X.Y.5    Yan, Q.6
  • 22
    • 62549151252 scopus 로고    scopus 로고
    • Why are tumour blood vessels abnormal and why is it important to know?
    • PMID:19240721
    • Nagy JA, Chang SH, Dvorak AM, Dvorak HF. Why are tumour blood vessels abnormal and why is it important to know? Br J Cancer 2009; 100:865-9; PMID:19240721; http://dx.doi.org/10.1038/sj.bjc.6604929.
    • (2009) Br J Cancer , vol.100 , pp. 865-869
    • Nagy, J.A.1    Chang, S.H.2    Dvorak, A.M.3    Dvorak, H.F.4
  • 23
    • 0034499732 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and the regulation of angiogenesis
    • Ferrara N. Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res 2000; 55:15-35.
    • (2000) Recent Prog Horm Res , vol.55 , pp. 15-35
    • Ferrara, N.1
  • 24
    • 70349782389 scopus 로고    scopus 로고
    • An overview of small-molecule inhibitors of VEGFR signaling
    • PMID:19736552
    • Ivy SP, Wick JY, Kaufman BM. An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 2009; 6:569-79; PMID:19736552; http://dx.doi.org/10.1038/nrclinonc.2009.130.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 569-579
    • Ivy, S.P.1    Wick, J.Y.2    Kaufman, B.M.3
  • 25
    • 70450175957 scopus 로고    scopus 로고
    • Targeting angiogenesis: Progress with anti-VEGF treatment with large molecules
    • PMID:19636328
    • Grothey A, Galanis E. Targeting angiogenesis: progress with anti-VEGF treatment with large molecules. Nat Rev Clin Oncol 2009; 6:507-18; PMID:19636328; http://dx.doi.org/10.1038/nrclinonc.2009.110.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 507-518
    • Grothey, A.1    Galanis, E.2
  • 26
    • 0037065852 scopus 로고    scopus 로고
    • Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration
    • PMID:11839630
    • Iwaguro H, Yamaguchi J, Kalka C, Murasawa S, Masuda H, Hayashi S, et al. Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation 2002; 105:732-8; PMID:11839630; http://dx.doi.org/10.1161/hc0602.103673.
    • (2002) Circulation , vol.105 , pp. 732-738
    • Iwaguro, H.1    Yamaguchi, J.2    Kalka, C.3    Murasawa, S.4    Masuda, H.5    Hayashi, S.6
  • 27
    • 33749005405 scopus 로고    scopus 로고
    • Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
    • PMID:16990548
    • Shaked Y, Ciarrocchi A, Franco M, Lee CR, Man S, Cheung AM, et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 2006; 313:1785-7; PMID:16990548; http://dx.doi.org/10.1126/ science.1127592.
    • (2006) Science , vol.313 , pp. 1785-1787
    • Shaked, Y.1    Ciarrocchi, A.2    Franco, M.3    Lee, C.R.4    Man, S.5    Cheung, A.M.6
  • 28
    • 33644785936 scopus 로고    scopus 로고
    • Akt1 in endothelial cell and angiogenesis
    • PMID:16552185
    • Somanath PR, Razorenova OV, Chen JH, Byzova TV. Akt1 in endothelial cell and angiogenesis. Cell Cycle 2006; 5:512-8; PMID:16552185; http://dx.doi. org/10.4161/cc.5.5.2538.
    • (2006) Cell Cycle , vol.5 , pp. 512-518
    • Somanath, P.R.1    Razorenova, O.V.2    Chen, J.H.3    Byzova, T.V.4
  • 29
    • 34147161209 scopus 로고    scopus 로고
    • Inhibition of tumor endothelial ERK activation, angiogenesis and tumor growth by sorafenib (BAY43-9006)
    • PMID:17071608
    • Murphy DA, Makonnen S, Lassoued W, Feldman MD, Carter C, Lee WMF. Inhibition of tumor endothelial ERK activation, angiogenesis and tumor growth by sorafenib (BAY43-9006). Am J Pathol 2006; 169:1875-85; PMID:17071608; http://dx.doi.org/10.2353/ajpath.2006.050711.
    • (2006) Am J Pathol , vol.169 , pp. 1875-1885
    • Murphy, D.A.1    Makonnen, S.2    Lassoued, W.3    Feldman, M.D.4    Carter, C.5    Lee, W.M.F.6
  • 30
    • 34047132303 scopus 로고    scopus 로고
    • Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression
    • PMID:17071632
    • Fang J, Zhou Q, Liu LZ, Xia C, Hu X, Shi X, et al. Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Carcinogenesis 2007; 28:858-64; PMID:17071632; http://dx.doi. org/10.1093/carcin/bgl205.
    • (2007) Carcinogenesis , vol.28 , pp. 858-864
    • Fang, J.1    Zhou, Q.2    Liu, L.Z.3    Xia, C.4    Hu, X.5    Shi, X.6
  • 31
    • 51049120763 scopus 로고    scopus 로고
    • Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extra-cellular signal-regulated kinase signaling pathways
    • PMID:18644991
    • Yi T, Cho SG, Yi Z, Pang X, Rodriguez M, Wang Y, et al. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extra-cellular signal-regulated kinase signaling pathways. Mol Cancer Ther 2008; 7:1789-96; PMID:18644991; http://dx.doi.org/10.1158/1535-7163.MCT-08-0124.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1789-1796
    • Yi, T.1    Cho, S.G.2    Yi, Z.3    Pang, X.4    Rodriguez, M.5    Wang, Y.6
  • 32
    • 27944442568 scopus 로고    scopus 로고
    • Angiogenesis: Update 2005
    • PMID:16102050
    • Dvorak HF. Angiogenesis: update 2005. J Thromb Haemost 2005; 3:1835-42; PMID:16102050; http://dx.doi.org/10.1111/j.1538-7836.2005.01361.x.
    • (2005) J Thromb Haemost , vol.3 , pp. 1835-1842
    • Dvorak, H.F.1
  • 33
    • 0033529618 scopus 로고    scopus 로고
    • Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    • Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999; 85:221-477.
    • (1999) Circ Res , vol.85 , pp. 221-477
    • Asahara, T.1    Masuda, H.2    Takahashi, T.3    Kalka, C.4    Pastore, C.5    Silver, M.6
  • 34
    • 34250344915 scopus 로고    scopus 로고
    • Tumor angiogenesis promoted by ex vivo differentiated endothelial progenitor cells is effectively inhibited by an angiogenesis inhibitor, TK1-2
    • PMID:17510415
    • Oh HK, Ha JM OE, Lee BH, Lee SK, Shim BS, et al. Tumor angiogenesis promoted by ex vivo differentiated endothelial progenitor cells is effectively inhibited by an angiogenesis inhibitor, TK1-2. Cancer Res 2007; 67:4851-9; PMID:17510415; http://dx.doi. org/10.1158/0008-5472.CAN-06-2979.
    • (2007) Cancer Res , vol.67 , pp. 4851-4859
    • Oh, H.K.1    Ha, J.M.O.E.2    Lee, B.H.3    Lee, S.K.4    Shim, B.S.5
  • 35
    • 33744466541 scopus 로고    scopus 로고
    • Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
    • PMID:16728631
    • Kerbel RS. Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science 2006; 312:1171-5; PMID:16728631; http://dx.doi. org/10.1126/science.1125950.
    • (2006) Science , vol.312 , pp. 1171-1175
    • Kerbel, R.S.1
  • 36
    • 16644399181 scopus 로고    scopus 로고
    • Bone marrow-derived endothelial progenitor cells for neovascular formation
    • PMID:15617476
    • Nishimura H, Asahara T. Bone marrow-derived endothelial progenitor cells for neovascular formation. EXS 2005; 21:147-54; PMID:15617476; http://dx.doi. org/10.1007/3-7643-7311-3-10.
    • (2005) EXS , vol.21 , pp. 147-154
    • Nishimura, H.1    Asahara, T.2
  • 37
    • 0028909645 scopus 로고
    • Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
    • PMID:7739542
    • Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol 1995; 15:2612-24; PMID:7739542.
    • (1995) Mol Cell Biol , vol.15 , pp. 2612-2624
    • Ohtsubo, M.1    Theodoras, A.M.2    Schumacher, J.3    Roberts, J.M.4    Pagano, M.5
  • 38
    • 0030924438 scopus 로고    scopus 로고
    • Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb
    • PMID:9380698
    • Ezhevsky SA, Nagahara H, Vocero-Akbani AM, Gius DR, Wei MC, Dowdy SF. Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc Natl Acad Sci USA 1997; 94:10699-704; PMID:9380698; http://dx.doi.org/10.1073/pnas.94.20.10699.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10699-10704
    • Ezhevsky, S.A.1    Nagahara, H.2    Vocero-Akbani, A.M.3    Gius, D.R.4    Wei, M.C.5    Dowdy, S.F.6
  • 39
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • PMID:9447971
    • Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 1998; 18:753-61; PMID:9447971.
    • (1998) Mol Cell Biol , vol.18 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 40
    • 77952740229 scopus 로고    scopus 로고
    • Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway
    • PMID:20509930
    • Guo J, Schally AV, Zarandi M, Varga J, Leung PC. Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway. Reprod Biol Endocrinol 2010; 8:54; PMID:20509930; http://dx.doi.org/10.1186/1477-7827-8-54.
    • (2010) Reprod Biol Endocrinol , vol.8 , pp. 54
    • Guo, J.1    Schally, A.V.2    Zarandi, M.3    Varga, J.4    Leung, P.C.5
  • 41
    • 28744458919 scopus 로고    scopus 로고
    • Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro
    • PMID:16328162
    • Yue PY, Wong DY, Ha WY, Fung MC, Mak NK, Yeung HW, et al. Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro. Angiogenesis 2005; 8:205-16; PMID:16328162; http://dx.doi.org/10. 1007/s10456-005-9000-2.
    • (2005) Angiogenesis , vol.8 , pp. 205-216
    • Yue, P.Y.1    Wong, D.Y.2    Ha, W.Y.3    Fung, M.C.4    Mak, N.K.5    Yeung, H.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.