Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells

Acta Pharmacologica Sinica

Volumn 36, Issue 12, 2015, Pages 1503-1513

  Li, Ting ^a   Xu, Xiao Huang ^a   Tang, Zheng Hai ^a   Wang, Ya Fang ^a   Leung, Chung Hang ^a   Ma, Dik Lung ^b   Chen, Xiu Ping ^a   Wang, Yi Tao ^a   Chen, Yi ^c   Lu, Jin Jian ^a,c  

^a UNIVERSITY OF MACAU   (Macao)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

apoptosis; autophagy; ERK; BAF; BEL 7402 cells; chloroquine; human hepatocellular carcinoma; JNK; platycodin D; SP600125; U0126

Indexed keywords

ANTINEOPLASTIC AGENT; DANSYLCADAVERINE; PLATYCODIN D; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG; SAPONIN; TRITERPENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL LINE; CELL PROLIFERATION; CELL VACUOLE; CHINESE HERB; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MTT ASSAY; TUMOR VOLUME; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; DRUG EFFECTS; FEMALE; LIVER; LIVER NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; PLATYCODON; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; FEMALE; HUMANS; LIVER; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE, INBRED BALB C; MICE, NUDE; PLATYCODON; SAPONINS; TRITERPENES;

EID: 84949184502     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2015.99     Document Type: Article

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