Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins

Cancer Biology and Therapy

Volumn 13, Issue 3, 2012, Pages 138-147

  Wang, Zhiyu ^a   Cheng, Yue ^c   Wang, Neng ^a   Wang, Dong Mei ^c   Li, Ying Wei ^a   Han, Feng ^c   Shen, Jian Gang ^a   Yang, De Po ^c   Guan, Xin Yuan ^b   Chen, Jian Ping ^a  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Apoptosis; Dioscin; Esophageal cancer; Peroxiredoxins; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; DIOSCIN; PEROXIREDOXIN; PEROXIREDOXIN 1; PEROXIREDOXIN 6; REACTIVE OXYGEN METABOLITE; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CASPASE; DIOSGENIN; DRUG DERIVATIVE; PRDX1 PROTEIN, HUMAN; PRDX6 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE REGULATION; CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; ESOPHAGUS CANCER; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN GEL BLOT ANALYSIS; PROTEOMICS; CELL CYCLE CHECKPOINT; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DIOSGENIN; DOWN-REGULATION; GENE EXPRESSION PROFILING; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; PEROXIREDOXIN VI; PEROXIREDOXINS; REACTIVE OXYGEN SPECIES;

EID: 84863131822     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.13.3.18693     Document Type: Article

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