Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor

Chemico-Biological Interactions

Volumn 233, Issue , 2015, Pages 25-34

  Joo, Eun Ji ^a,b   Chun, Jaemoo ^a   Ha, Young Wan ^c   Ko, Hye Jin ^a   Xu, Mei Ying ^a   Kim, Yeong Shik ^a  

^a Seoul National University   (South Korea)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c SAMSUNG Electronics   (South Korea)

Author keywords

Apoptosis; EGFR; EGFR internalization; Ginsenoside Rg3

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GINSENOSIDE RG 3; MITOGEN ACTIVATED PROTEIN KINASE; ANTINEOPLASTIC AGENT; GINSENOSIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL MEMBRANE TRANSPORT; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; DIMERIZATION; DNA FRAGMENTATION; DRUG ACCUMULATION; HUMAN; HUMAN CELL; IN VIVO STUDY; INTERNALIZATION; LUNG ADENOCARCINOMA; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; TUMOR VOLUME; ADENOCARCINOMA; ANIMAL; C57BL MOUSE; CHEMISTRY; DOWN REGULATION; DRUG EFFECTS; LUNG; LUNG NEOPLASMS; METABOLISM; PANAX; PATHOLOGY; PROTEIN MULTIMERIZATION; TUMOR CELL LINE;

PANAX GINSENG;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; DOWN-REGULATION; GINSENOSIDES; HUMANS; LUNG; LUNG NEOPLASMS; MALE; MICE, INBRED C57BL; PANAX; PROTEIN MULTIMERIZATION; PROTEOLYSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84926138166     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.03.016     Document Type: Article

References (29)

1. K.S. Chung, S.H. Cho, J.S. Shin, D.H. Kim, J.H. Choi, S.Y. Choi, Y.K. Rhee, H.D. Hong, and K.T. Lee Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression Carcinogenesis 34 2013 331 340
2. X.X. Guo, Y. Li, C. Sun, D. Jiang, Y.J. Lin, F.X. Jin, S.K. Lee, and Y.H. Jin P53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells Protein & Cell 5 2014 224 234
3. S.M. Kim, S.Y. Lee, D.Y. Yuk, D.C. Moon, S.S. Choi, Y. Kim, S.B. Han, K.W. Oh, and J.T. Hong Inhibition of NF-κB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel Arch. Pharm. Res. 32 2009 755 765
4. S.M. Kim, S.Y. Lee, J.S. Cho, S.M. Son, S.S. Choi, Y.P. Yun, H.S. Yoo, Y. Yoon do, K.W. Oh, S.B. Han, and J.T. Hong Combination of ginsenoside Rg3 with docetaxel enhances the susceptibility of prostate cancer cells via inhibition of NF-κB Eur. J. Pharmacol. 631 2010 1 9
5. B.M. Kim, D.H. Kim, J.H. Park, H.K. Na, and Y.J. Surh Ginsenoside Rg3 induces apoptosis of human breast cancer (MDA-MB-231) cells J. Cancer Prev. 18 2013 177 185
6. Y.J. Choi, H.J. Lee, D.W. Kang, I.H. Han, B.K. Choi, and W.H. Cho Ginsenoside Rg3 induces apoptosis in the U87MG human glioblastoma cell line through the MEK signaling pathway and reactive oxygen species Oncol. Rep. 30 2013 1362 1370
7. S.Y. Lee, G.T. Kim, S.H. Roh, J.S. Song, H.J. Kim, S.S. Hong, S.W. Kwon, and J.H. Park Proteomic analysis of the anti-cancer effect of 20S-ginsenoside Rg3 in human colon cancer cell lines Biosci. Biotechnol. Biochem. 73 2009 811 816
8. X. Luo, C.Z. Wang, J. Chen, W.X. Song, J. Luo, N. Tang, B.C. He, Q. Kang, Y. Wang, W. Du, T.C. He, and C.S. Yuan Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells Int. J. Oncol. 32 2008 975 983
9. N.E. Hynes, and H.A. Lane ERBB receptors and cancer: the complexity of targeted inhibitors Nat. Rev. Cancer 5 2005 341 354
10. T.J. Lynch, D.W. Bell, R. Sordella, S. Gurubhagavatula, R.A. Okimoto, B.W. Brannigan, P.L. Harris, S.M. Haserlat, J.G. Supko, F.G. Haluska, D.N. Louis, D.C. Christiani, J. Settleman, and D.A. Haber Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N. Engl. J. Med. 350 2004 2129 2139
11. G. Gorgisen, D. Ozes, S. Pehlivanoglu, A. Erdogan, L. Dertsiz, G. Ozbilim, I.H. Ozbudak, B. Savas, and O.N. Ozes Differential expression and activation of epidermal growth factor receptor 1 EGFR1), ERK, AKT, STAT3, and TWIST1 in nonsmall cell lung cancer (NSCLC Exp. Lung Res. 39 2013 387 398
12. C. Le Roy, and J.L. Wrana Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling Nat. Rev. Mol. Cell Biol. 6 2005 112 126
13. G. Levkowitz, H. Waterman, S.A. Ettenberg, M. Katz, A.Y. Tsygankov, I. Alroy, S. Lavi, K. Iwai, Y. Reiss, A. Ciechanover, S. Lipkowitz, and Y. Yarden Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 Mol. Cell 4 1999 1029 1040
14. C.A. Joazeiro, S.S. Wing, H. Huang, J.D. Leverson, T. Hunter, and Y.C. Liu The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase Science 286 1999 309 312
15. J.L. Countaway, P. McQuilkin, N. Girones, and R.J. Davis Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation J. Biol. Chem. 265 1990 3407 3416
16. S.J. Theroux, K. Stanley, D.A. Campbell, and R.J. Davis Mutational removal of the major site of serine phosphorylation of the epidermal growth factor receptor causes potentiation of signal transduction: role of receptor down-regulation Mol. Endocrinol. 6 1992 1849 1857
17. U. Dougherty, R. Mustafi, Y. Wang, M.W. Musch, C.Z. Wang, V.J. Konda, A. Kulkarni, J. Hart, G. Dawson, K.E. Kim, C.S. Yuan, E.B. Chang, and M. Bissonnette American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR BMC Comp. Altern. Med. 11 2011 111
18. Y.W. Ha, S.S. Lim, I.J. Ha, Y.C. Na, J.J. Seo, H. Shin, S.H. Son, and Y.S. Kim Preparative isolation of four ginsenosides from Korean red ginseng (steam-treated Panax ginseng C. A. Meyer), by high-speed counter-current chromatography coupled with evaporative light scattering detection J. Chromatogr. A 1151 2007 37 44
19. E.J. Joo, H. Yang, Y. Park, N.Y. Park, T. Toida, R.J. Linhardt, and Y.S. Kim Induction of nucleolin translocation by acharan sulfate in A549 human lung adenocarcinoma J. Cell. Biochem. 110 2010 1272 1278
20. J. Turkson STAT proteins as novel targets for cancer drug discovery Exp. Opin. Ther. Targets 8 2004 409 422
21. E.J. Joo, Y.W. Ha, H. Shin, S.H. Son, and Y.S. Kim Generation and characterization of monoclonal antibody to ginsenoside rg3 Biol. Pharm. Bull. 32 2009 548 552
22. J. Chun, and Y.S. Kim Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways Chem. Biol. Interact. 205 2013 212 221
23. S. Adachi, T. Nagao, H.I. Ingolfsson, F.R. Maxfield, O.S. Andersen, L. Kopelovich, and I.B. Weinstein The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells Cancer Res. 67 2007 6493 6501
24. S. Adachi, T. Nagao, S. To, A.K. Joe, M. Shimizu, R. Matsushima-Nishiwaki, O. Kozawa, H. Moriwaki, F.R. Maxfield, and I.B. Weinstein (-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells Carcinogenesis 29 2008 1986 1993
25. M. Masuda, T. Wakasaki, S. Toh, M. Shimizu, and S. Adachi Chemoprevention of head and neck cancer by green rea extract: EGCG-the role of EGFR signaling and "lipid raft" J. Oncol. 2011 2011 540148
26. I.H. Madshus, and E. Stang Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking J. Cell Sci. 122 2009 3433 3439
27. L.M. Sturla, G. Amorino, M.S. Alexander, R.B. Mikkelsen, K. Valerie, and R.K. Schmidt-Ullrichr Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2 J. Biol. Chem. 280 2005 14597 14604
28. S. Zimmer, P. Kahl, T.M. Buhl, S. Steiner, E. Wardelmann, S. Merkelbach-Bruse, R. Buettner, and L.C. Heukamp Epidermal growth factor receptor mutations in non-small cell lung cancer influence downstream Akt, MAPK and Stat3 signaling J. Cancer Res. Clin. Oncol. 135 2009 723 730
29. M.V. Grandal, and I.H. Madshus Epidermal growth factor receptor and cancer: control of oncogenic signalling by endocytosis J. Cell Mol. Med. 12 2008 1527 1534