Folding fan mode counter-current chromatography offers fast blind screening for drug discovery. Case study: Finding anti-enterovirus 71 agents from Anemarrhena asphodeloides

Journal of Chromatography A

Volumn 1368, Issue , 2014, Pages 116-124

  Liu, Mengshun ^a,b,c   Tao, Ling ^a,d   Chau, Siu Leung ^c   Wu, Rong ^a,b   Zhang, Hong ^a,b   Yang, Yifu ^a   Yang, Dajian ^d   Bian, Zhaoxiang ^c   Lu, Aiping ^c   Han, Quanbin ^c   Xu, Hongxi ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery   (China)

^c HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^d CHONGQING ACADEMY OF CHINESE MATERIA MEDICA   (China)

Author keywords

A. asphodeloides; Bioassay guided counter current chromatography; Enterovirus 71; Folding fan mode; Structure activity relationship

Indexed keywords

AMIDES; LIQUID CHROMATOGRAPHY; SEPARATION; STRUCTURES (BUILT OBJECTS);

A. ASPHODELOIDES; COUNTERCURRENT CHROMATOGRAPHY; ENTEROVIRUS 71; FOLDING FAN MODE; STRUCTURE ACTIVITY RELATIONSHIPS;

ORGANIC SOLVENTS;

ACETIC ACID ETHYL ESTER; ALCOHOL; ANEMARRHENA ASPHODELOIDES EXTRACT; ANEMARRHENASAPONIN II; ANEMARSAPONIN B; ANTIVIRUS AGENT; BUTANOL; DIOSCIN; DIOSGENIN; GRACILLIN; HEXANE; MANGIFERIN; METHANOL; PROSAPOGENIN A; RIBAVIRIN; SAPONIN; SAPONIN DERIVATIVE; SARSASAPOGENIN; SHATAVARIN IV; TIGOGENIN; TIMOSAPONIN A III; TIMOSAPONIN A IV; TIMOSAPONIN B II; TIMOSAPONIN G; UNCLASSIFIED DRUG; WATER; PLANT EXTRACT;

ANEMARRHENA ASPHODELOIDES; ANTIVIRAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CASE STUDY; CHEMICAL PROCEDURES; CONCENTRATION RESPONSE; CONTROLLED STUDY; COUNTER CURRENT CHROMATOGRAPHY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG SCREENING; ENTEROVIRUS 71; FOLDING FAN MODE COUNTER CURRENT CHROMATOGRAPHY; IC50; IN VITRO STUDY; NONHUMAN; PHYTOCHEMISTRY; RHIZOME; SEPARATION TECHNIQUE; SOLVENT EFFECT; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; TWO PHASE SOLVENT SYSTEM; VERO CELL LINE; ANEMARRHENA; ANIMAL; CELL SURVIVAL; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ENTEROVIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; PROCEDURES;

ANEMARRHENA; ANIMALS; ANTIVIRAL AGENTS; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DISCOVERY; ENTEROVIRUS; PLANT EXTRACTS; VERO CELLS;

EID: 84908210397     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.09.064     Document Type: Article

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