Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats

Neuroscience Letters

Volumn 421, Issue 2, 2007, Pages 147-151

  Li, Tie Jun ^a   Qiu, Yan ^a   Yang, Peng Yuan ^a   Rui, Yao Cheng ^a   Chen, Wan Sheng ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Focal cerebral ischemia; Inflammation; Timosaponin B II; Vascular dementia

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; PLANT EXTRACT; SAPOGENIN; TIMOSAPONIN B 2; UNCLASSIFIED DRUG;

ANEMARRHENA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; LEARNING DISORDER; MALE; MAZE TEST; MEMORY DISORDER; MIDDLE CEREBRAL ARTERY OCCLUSION; MULTIINFARCT DEMENTIA; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCAPE REACTION; GENE EXPRESSION REGULATION; INTERLEUKIN-10; LEARNING DISORDERS; MALE; MAZE LEARNING; MEMORY DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SAPONINS; STEROIDS;

EID: 34250183791     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.04.082     Document Type: Article

References (25)

1. Aisen P.S., Davis K.L., Berg J.D., Schafer K., Campbell K., Thomas R.G., Weiner M.F., Farlow M.R., Sano M., Grundman M., and Thal L.J. A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study. Neurology 54 (2000) 588-593
2. Engelhart M.J., Geerlings M.I., Meijer J., Kiliaan A., Ruitenberg A., van Swieten J.C., Stijnen T., Hofman A., Witteman J.C., and Breteler M.M. Inflammatory proteins in plasma and the risk of dementia: the rotterdam study. Arch. Neurol. 61 (2004) 668-672
3. Grilli M., Barbieri I., Basudev H., Brusa R., Casati C., Lozza G., and Ongini E. Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage. Eur. J. Neurosci. 12 (2000) 2265-2272
4. Hu Y.-E., Sun Q.-X., and Xia Z.-Q. The effect of ZMS, an active component of Zhimu, on NGF and BDNF in brains of aged rats. Chin. Pharmacol. Bull. 19 (2003) 149-151
5. Hu Y., Xia Z., Sun Q., Orsi A., and Rees D. A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models. Brain Res. 1060 (2005) 26-39
6. Jorm A.F., and O'Brien J. The epidemiology of vascular dementia: an overview and commentary. In: O'Brien J., Ames D., Chiu E., Gustafson L., and Folstein M. (Eds). Cerebrovascular Disease, Cognitive Impairments and Dementia (2004), Martin Dunitz, London 95-100
7. Knoblach S.M., and Faden A.I. Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury. Exp. Neurol. 153 (1998) 143-151
8. Krupa D.J., Thompson J.K., and Thompson R.F. Localization of a memory trace in the mammalian brain. Science 260 (1993) 989-991
9. Lee B., Choi Y., Kim H., Kim S.Y., Hahm D.H., Lee H.J., and Shim I. Protective effects of methanol extract of Acori graminei rhizoma and Uncariae Ramulus et Uncus on ischemia-induced neuronal death and cognitive impairments in the rat. Life Sci. 74 (2003) 435-450
10. Longa E.Z., Weinstein P.R., Carlson S., and Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1989) 84-91
11. Moore K.W., de Waal Malefyt R., Coffman R.L., and O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19 (2001) 683-765
12. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11 (1984) 47-60
13. Okada M., Nakanishi H., Tamura A., Urae A., Mine K., Yamamoto K., and Fujiwara M. Long-term spatial cognitive impairment after middle cerebral artery occlusion in rats: no involvement of the hippocampus. J. Cereb. Blood Flow Metab. 15 (1995) 1012-1021
14. Olsen G.M., Scheel-Kruger J., Moller A., and Jensen L.H. Relation of spatial learning of rats in the Morris water maze task to the number of viable CA1 neurons following four-vessel occlusion. Behav. Neurosci. 108 (1994) 681-690
15. Ooboshi H., Ibayashi S., Shichita T., Kumai Y., Takada J., Ago T., Arakawa S., Sugimori H., Kamouchi M., Kitazono T., and Iida M. Postischemic gene transfer of interleukin-10 protects against both focal and global brain ischemia. Circulation 111 (2005) 913-919
16. Raghavendra V., and Kulkarni S.K. Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks. Free Rad. Biol. Med. 30 (2001) 595-602
17. Roman G.C. Brain hypoperfusion: a critical factor in vascular dementia. Neurol. Res. 26 (2004) 454-458
18. Roman G.C., Tatemichi T.K., Erkinjuntti T., Cummings J.L., Masdeu J.C., Garcia J.H., Amaducci L., Orgogozo J.M., Brun A., Hofman A., Moody D.M., O'Brien M.D., Yamaguchi T., Grafman J., Drayer B.P., Bennett D.A., Fisher M., Ogata J., Kokmen E., Bermejo F., Wolf P.A., Gorelick P.B., Bick K.L., Pajeau A.K., Bell M.A., DeCarli C., Culebras A., Korczyn A.D., Bogousslavsky J., Hartmann A., and Scheinberg P. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 43 (1993) 250-260
19. Scharf S., Mander A., Ugoni A., Vajda F., and Christophidis N. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology 53 (1999) 197-201
20. Sopala M., and Danysz W. Chronic cerebral hypoperfusion in the rat enhances age-related deficits in spatial memory. J. Neural. Transm. 108 (2001) 1445-1456
21. Szczepanik A.M., and Ringheim G.E. IL-10 and glucocorticoids inhibit Abeta(1-42)- and lipopolysaccharide-induced pro-inflammatory cytokine and chemokine induction in the central nervous system. J. Alzheimers Dis. 5 (2003) 105-117
22. Tarkowski E. Cytokines in dementias. Curr. Drug Targets 1 (2002) 193-200
23. Tarkowski E., Liljeroth A.M., Minthon L., Tarkowski A., Wallin A., and Blennow K. Cerebral pattern of pro- and anti-inflammatory cytokines in dementias. Brain Res. Bull. 61 (2003) 255-260
24. Wilson C.J., Finch C.E., and Cohen H.J. Cytokines and cognition-the case for a head-to-toe inflammatory paradigm. J. Am. Geriatr. Soc. 50 (2002) 2041-2056
25. Zhang J., Zhang M., Sugahara K., Sagara Y., Meng Z., Xu S., and Kodama H. Effect of steroidal saponins of Anemarrhenae rhizoma on superoxide generation in human neutrophils. Biochem. Biophys. Res. Commun. 259 (1999) 636-639