Combined effect of sodium selenite and ginsenoside Rh2 on HCT116 human colorectal carcinoma cells

Archives of Iranian Medicine

Volumn 19, Issue 1, 2016, Pages 9-15

  Zhu, Changlai ^a   Liu, Fang ^a   Qian, Wenbo ^a   Zhang, Tianyi ^a   Li, Feng ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Colorectal carcinoma; Ginsenoside Rh2; Sodium selenite; Synergistic effect

Indexed keywords

CASPASE 3; GINSENOSIDE RH 2; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SODIUM SELENITE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; AUTOPHAGY; CELL COUNTING; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; COLORECTAL CARCINOMA; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; FLOW CYTOMETRY; GROWTH INHIBITION; HCT116 CELL LINE; HUMAN; HUMAN CELL; IC50; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84949549148     PISSN: 10292977     EISSN: 17353947     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Li Z, Meng J, Xu TJ, Qin XY, Zhou XD. Sodium selenite induces apoptosis in colon cancer cells via Bax-dependent mitochondrial pathway. Eur Rev Med Pharmacol Sci. 2013; 17: 2166-2171.
2. Kralova V, Brigulova K, Cervinka M, Rudolf E. Antiproliferative and cytotoxic effects of sodium selenite in human colon cancer cells. Toxi­col In Vitro. 2009; 23: 1497-1503.
3. van Meer S, de Man RA, Siersema PD, van Erpecum KJ. Surveillance for hepatocellular carcinoma in chronic liver disease: evidence and controversies. World J Gastroenterol. 2012; 19: 6744-6756.
4. Menter DG, Sabichi AL, Lippman SM. Selenium effects on prostate cell growth. Cancer Epidemiol Biomarkers Prev. 2000; 9: 1171-1182.
5. Li GX, Hu H, Jiang C, Schuster T, Lu J. Differential involvement of reactive oxygen species in apoptosis induced by two classes of sele­nium compounds in human prostate cancer cells. Int J Cancer. 2007; 120: 2034-2043.
6. Reagan-Shaw S, Nihal M, Ahsan H, Mukhtar H, Ahmad N. Combination of vitamin E and selenium causes an induction of apoptosis of human prostate cancer cells by enhancing Bax/Bcl-2 ratio. Prostate. 2008; 68: 1624-1634.
7. Nadiminty N, Gao AC. Mechanisms of selenium chemoprevention and therapy in prostate cancer. Mol Nutr Food Res. 2008; 52: 1247-1260.
8. Wei WQ, Abnet CC, Qiao YL, Dawsey SM, Dong ZW, Sun XD, et al. Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death. Am J ClinNutr. 2004; 79: 80-85.
9. Gu Y, Wang GJ, Sun JG, Jia YW, Wang W, Xu MJ, et al. Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs. Food Chem Toxicol. 2009; 47: 2257-2268.
10. Wang CZ, Yuan CS. Potential role of ginseng in the treatment of colorectal cancer. Am J Chin Med. 2008; 36: 1019-1028.
11. Nakata H, Kikuchi Y, Todeb T, Hirata J, Kita T, Ishii K, et al. Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells. Jpn J Cancer Res. 1998; 89: 733-740.
12. Popovich DG, Kitts DD. Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells. J Biochem Mol Toxicol. 2004; 18: 143-149.
13. Jia WW, Bu X, Philips D, Yan H, Liu G, Chen X, et al. Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy. Can J Physiol Pharmacol, 2004; 82: 431-437.
14. Xie HT, Wang GJ, Sun JG, Tucker I, Zhao XC, Xie YY, et al. High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies. J Chromatogr B Analyt TechnolBiomedLife Sci. 2005; 818: 167-173.
15. Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, et al. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Research. 1988; 48: 589-601.
16. Freitas M, Alves V, Sarmento-Ribeiro AB, Mota-Pinto A. Combined effect of sodium selenite and docetaxel on PC3 metastatic prostate cancer cell line. BiochemBiophysRes Commun. 2011; 408: 713-719.
17. Rothe G, Valet G. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2',7'-dichlorofluorescin. J Leukoc Biol. 1990; 47: 440-448.
18. Popova NV. Perinatal selenium exposure decreases spontaneous liver tumorogenesis in CBA mice. Cancer Lett. 2002; 179: 39-42.
19. Combs, GF Jr., Clark LC, Turnbull BW. An analysis of cancer preven­tion by selenium. Biofactors. 2001; 14: 153-159.
20. Raich PC, J Lu, Thompson HJ, Combs, GF Jr. Selenium in cancer prevention: clinical issues and implications. Cancer Invest. 2001; 19: 540-553.
21. Jiang C, Wang Z, Ganther H, Lu J. Distinct effects of methylseleni-nic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells. Mol Cancer Ther. 2002; 1: 1059-1066.
22. Lee KY, Park JA, Chung E, Lee YH, Kim SI, Lee SK. Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells at the G1/S boundary by selectively inducing the protein expression of p27kip1. Cancer Lett. 1996; 110: 193-200.
23. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998; 281: 1322-1326.
24. Rosse T, Olivier R, Monney L, Rager M, Conus S, Fellay I, et al. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature. 1998; 391: 496-499.
25. Xiang N, Zhao R, Zhong W. Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells. Cancer Chemotherapy andPharmacology. 2009; 63: 351-362.
26. Kim YS, Jin SH. Ginsenoside Rh2 induces apoptosis via activation of caspase-1 and-3 and up-regulation of Bax in human neuroblastoma. Arch Pharm Res. 2004; 27: 834-839.
27. Kim YS, Jin SH, Lee YH, Kim SI, Park JD. Ginsenoside Rh2 induces apoptosis independently of Bcl-2, Bcl-xL, or Bax in C6Bu-1 cells. Arch Pharm Res. 1999; 22: 448-453.
28. Li B, Zhao J, Wang CZ, Searle J, He TC, Yuan CS, et al. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal can­cer cells through activation of p53. Cancer Lett. 2011; 301: 185-192.
29. Ham YM, Lim JH, Na HK, Choi JS, Park BD, Yim H, et al. Ginsen-oside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species-and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells. J Pharmacol Exp Ther. 2006; 319: 1276-1285.
30. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008; 451: 1069-1075.
31. Rosenfeldt MT, Ryan KM. The role of autophagy in tumour develop­ment and cancer therapy. Expert Rev Mol Med. 2009; 11: e36.
32. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004; 6: 463-477.
33. Cuervo AM. Autophagy: in sickness and in health. Trends Cell Biol. 2004; 14: 70-77.
34. Jiang Q, Shi KJ, Xu CM. Sodium selenite-induced activation of DAPK promotes autophagy in human leukemia HL60 cells. Biochemistry and Molecular Biology Reports. 2012; 45: 194-199.
35. Park SH, Kim JH, Chi GY, Kim GY, Chang YC, Moon SK, et al. Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species. Toxicology Letters. 2012; 212: 252-261.
36. Li B, Zhao J, Wang CZ, Searle J, He TC, Yuan CS, et al. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Letters. 2011; 301: 185-192.