Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells

European Journal of Pharmacology

Volumn 749, Issue , 2015, Pages 81-88

  Li, Ting ^a   Tang, Zheng Hai ^a   Xu, Wen Shan ^a   Wu, Guo Sheng ^a   Wang, Ya Fang ^a   Chang, Lin Lin ^b   Zhu, Hong ^b   Chen, Xiu Ping ^a   Wang, Yi Tao ^a   Chen, Yi ^c   Lu, Jin Jian ^a,c  

^a China jack1987168 163com   (Macao)

^b ZHEJIANG UNIVERSITY   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Autophagy; Chloroquine; ERK; HepG2; Platycodin D; Protective

Indexed keywords

ANTINEOPLASTIC AGENT; BAFILOMYCIN A1; CHLOROQUINE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 II; MITOGEN ACTIVATED PROTEIN KINASE; PLATYCODIN D; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; PROTEIN ULK1; S6 KINASE; UNCLASSIFIED DRUG; MACROLIDE; SAPONIN; TRITERPENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS INHIBITION; PROTEIN EXPRESSION; DRUG EFFECTS; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; TUMOR CELL LINE;

AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHLOROQUINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LIVER NEOPLASMS; MACROLIDES; SAPONINS; TRITERPENES;

EID: 84921484806     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.01.003     Document Type: Article

References (50)

1. K.S. Ahn, B.S. Hahn, K.B. Kwack, E.B. Lee, and Y.S. Kim Platycodin D-induced apoptosis through nuclear factor-kappa B activation in immortalized keratinocytes Eur. J. Pharmacol. 537 2006 1 11
2. R.K. Amaravadi, D.B. Yu, A. Thomas-Tikhonenko, and C.B. Thompson Chloroquine inhibits autophagy, enhances p53-dependent apoptosis, and delays tumor recurrence in a mouse model of B cell lymphoma Blood 106 2005 681a
3. C. Bellodi, M.R. Lidonnici, A. Hamilton, G.V. Helgason, A.R. Soliera, M. Ronchetti, S. Galavotti, K.W. Young, T. Selmi, R. Yacobi, R.A. Van Etten, N. Donato, A. Hunter, D. Dinsdale, E. Tirro, P. Vigneri, P. Nicotera, M.J. Dyer, T. Holyoake, P. Salomoni, and B. Calabretta Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells J. Clin. Invest. 119 2009 1109 1123
4. C.H. Choi, Y.K. Jung, and S.H. Oh Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis Mol. Pharmacol. 78 2010 114 125
5. S.S. Choi, E.J. Han, T.H. Lee, K.J. Han, H.K. Lee, and H.W. Suh Antinociceptive profiles of platycodin D in the mouse Am. J. Chin. Med. 32 2004 257 268
6. J. Chun, E.J. Joo, M. Kang, and Y.S. Kim Platycodin D induces anoikis and caspase-mediated apoptosis via p38 MAPK in AGS human gastric cancer cells J. Cell. Biochem. 114 2013 456 470
7. J. Chun, and Y.S. Kim Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Ala and MAPK pathways Chem-Biol. Interact. 205 2013 212 221
8. Q. Dai, Z. Chen, Y.Q. Ge, P. Liu, H.B. Wang, X.Q. Ma, and B.H. Wu Mechanism of platycodin D-induced apoptosis in A549 human lung cancer cells Zhongguo Zhong Yao Za Zhi 37 2012 2626 2629
9. J.V. Duncia, J.B. Santella, C.A. Higley, W.J. Pitts, J. Wityak, W.E. Frietze, F.W. Rankin, J.H. Sun, R.A. Earl, A.C. Tabaka, C.A. Teleha, K.F. Blom, M.F. Favata, E.J. Manos, A.J. Daulerio, D.A. Stradley, K. Horiuchi, R.A. Copeland, P.A. Scherle, J.M. Trzaskos, R.L. Magolda, G.L. Trainor, R.R. Wexler, F.W. Hobbs, and R.E. Olson MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products Bioorg. Med. Chem. Lett. 8 1998 2839 2844
10. E.L. Eskelinen, F. Reggiori, M. Baba, A.L. Kovacs, and P.O. Seglen Seeing is believing: the impact of electron microscopy on autophagy research Autophagy 7 2011 935 956
11. D.A. Guertin, and D.M. Sabatini Defining the role of mTOR in cancer Cancer Cell 12 2007 9 22
12. D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
13. A.M. Hau, J.A. Greenwood, C.V. Lohr, J.D. Serrill, P.J. Proteau, I.G. Ganley, K.L. McPhail, and J.E. Ishmael Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells Plos One 8 2013 e65250
14. M.J. Hsieh, T.L. Tsai, Y.S. Hsieh, C.J. Wang, and H.L. Chiou Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines Arch. Toxicol. 87 2013 1927 1937
15. Y.P. Hwang, J.H. Choi, H.G. Kim, T. Khanal, G.Y. Song, M.S. Nam, H.S. Lee, Y.C. Chung, Y.C. Lee, and H.G. Jeong Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells Toxicol. App. Pharmacol. 267 2013 174 183
16. Y. Kabeya, N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, T. Noda, E. Kominami, Y. Ohsumi, and T. Yoshimori LC3, a mammalian homolog of yeast Apg8p, is localized in autophagosome membranes after processing (vol 19, pg 5720, 2000 Embo J. 22 2003 4577
17. M.O. Kim, D.O. Moon, Y.H. Choi, J.D. Lee, N.D. Kim, and G.Y. Kim Platycodin D induces mitotic arrest in vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells Int. J. Cancer 122 2008 2674 2681
18. M.O. Kim, D.O. Moon, Y.H. Choi, D.Y. Shin, H.S. Kang, B.T. Choi, J.D. Lee, W. Li, and G.Y. Kim Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells Cancer Lett. 261 2008 98 107
19. T.W. Kim, I.B. Song, H.K. Lee, M.S. Kim, J.H. Lim, and H.I. Yun Platycodin D, a triterpenoid saponin isolated from Platycodon grandiflorum ameliorates cisplatin-induced renal injury in mice J. Vet. Pharmacol. Ther. 35 2012 97 98
20. H. Lee, R. Kang, Y.S. Kim, S.I. Chung, and Y. Yoon Platycodin D inhibits adipogenesis of 3T3-L1 cells by modulating kruppel-like factor 2 and peroxisome proliferator-activated receptor gamma Phytother. Res. 24 2010 S161 S167
21. S.K. Lee, K.K. Park, Y.S. Kim, Y.W. Ha, and W.Y. Chung The effect of platycodin D on tumor-induced osteolysis in breast cancer bone metastasis Cancer Treat. Rev. 34 2008 S64
22. B. Levine Cell biology: autophagy and cancer Nature 446 2007 745 747
23. T. Li, W.S. Xu, G.S. Wu, X.P. Chen, Y.T. Wang, and J.J. Lu Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells Asian Pac. J. Cancer Prev. 15 2014 1745 1749
24. R.A. Lockshin, and Z. Zakeri Apoptosis, autophagy, and more Int. J. Biochem. Cell Biol. 36 2004 2405 2419
25. M.B. Menon, A. Kotlyarov, and M. Gaestel SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition Plos One 6 2011 e23054
26. N. Mizushima, and T. Yoshimori How to interpret LC3 immunoblotting Autophagy 3 2007 542 545
27. L.O. Murphy, and J. Blenis MAPK signal specificity: the right place at the right time Trends Biochem. Sci. 31 2006 268 275
28. Pharmacopoeia Commission of the Ministry of Health of the P.R. China, 2010. Pharmacopoeia of the Peoples Republic of China. China Medical Science Press.
29. R. Pardo, Re, A. Lo, C. Archange, A. Ropolo, D.L. Papademetrio, C.D. Gonzalez, E.M. Alvarez, J.L. Iovanna, and M.I. Vaccaro Gemcitabine induces the VMP1-mediated autophagy pathway to promote apoptotic death in human pancreatic cancer cells Pancreatology 10 2010 19 26
30. S. Periyasamy-Thandavan, M. Jiang, P. Schoenlein, and Z. Dong Autophagy: molecular machinery, regulation, and implications for renal pathophysiology Am. J. Physiol. Renal. Physiol. 297 2009 244 256
31. H. Qin, X. Du, Y. Zhang, and R. Wang Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, induces G2/M arrest and apoptosis in human hepatoma HepG2 cells by modulating the PI3K/Akt pathway Tumour Biol. 35 2014 1267 1274
32. Y. Rong, C.K. McPhee, S. Deng, L. Huang, L. Chen, M. Liu, K. Tracy, E.H. Baehrecke, L. Yu, and M.J. Lenardo Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation Proc. Natl. Acad. Sci. USA 108 2011 7826 7831
33. B. Roy, A.K. Pattanaik, J. Das, S.K. Bhutia, B. Behera, P. Singh, and T.K. Maiti Role of PI3K/Akt/mTOR and MEK/ERK pathway in concanavalin A induced autophagy in HeLa cells Chem-Biol. Interact. 210 2014 96 102
34. S. Sarkar Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers Biochem. Soc. Trans. 41 2013 1103 1130
35. Y. Shi, J.J. Han, J.B. Tennakoon, F.F. Mehta, F.A. Merchant, A.R. Burns, M.K. Howe, D.P. McDonnell, and D.E. Frigo Androgens promote prostate cancer cell growth through induction of autophagy Mol. Endocrinol. 27 2013 280 295
36. N. Shinojima, T. Yokoyama, Y. Kondo, and S. Kondo Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy Autophagy 3 2007 635 637
37. T. Shintani, F. Yamazaki, T. Katoh, M. Umekawa, Y. Matahira, S. Hori, A. Kakizuka, K. Totani, K. Yamamoto, and H. Ashida Glucosamine induces autophagy via an mTOR-independent pathway Biochem. Bioph. Res. Commun. 391 2010 1775 1779
38. Z.H. Tang, T. Li, H.W. Gao, W. Sun, X.P. Chen, Y.T. Wang, and J.J. Lu Platycodin D from Platycodonis Radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells Chin. Med. 9 2014 16
39. D.N. Tripathi, R. Chowdhury, L.J. Trudel, A.R. Tee, R.S. Slack, C.L. Walker, and G.N. Wogan Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1 Proc. Natl. Acad. Sci. U.S.A. 110 2013 2950 2957
40. A.L. Wang, M.E. Boulton, W.A. Dunn, H.V. Rao, J. Cai, T.J. Lukas, and A.H. Neufeld Using LC3 to monitor autophagy flux in the retinal pigment epithelium Autophagy 5 2009 1190 1193
41. J. Wang, and G.S. Wu Role of autophagy in cisplatin resistance in ovarian cancer cells J. Biol. Chem. 289 2014 17163 17173
42. J.T. Wu, G.W. Yang, W.X. Zhu, W.J. Wen, F.M. Zhang, J.D. Yuan, and L.G. An Anti-atherosclerotic activity of platycodin D Derived from roots of Platycodon grandiflorum in human endothelial cells Biol. Pharm. Bull. 35 2012 1216 1221
43. Y. Xie, H.X. Sun, and D. Li Platycodin D is a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen Vaccine 27 2009 757 764
44. Y.F. Xu Autophagy: molecular machinery, regulation, and implications for renal pathophysiology. Int. J. Mol. Med. 30 2012 S14
45. Z. Yang, and D.J. Klionsky Mammalian autophagy: core molecular machinery and signaling regulation Curr. Opin. Cell Biol. 22 2010 124 131
46. P. Yla-Anttila, H. Vihinen, E. Jokitalo, and E.L. Eskelinen Monitoring autophagy by electron microscopy in mammalian cells Methods Enzymol. 452 Pt B 452 2009 143 164
47. Y.H. Yoon, K.S. Cho, J.J. Hwang, S.J. Lee, J.A. Choi, and J.Y. Koh Induction of lysosomal dilatation, arrested autophagy, and cell death by chloroquine in cultured ARPE-19 cells Invest. Ophthalmol. Vis. Sci. 51 2010 6030 6037
48. L. Yu, C.K. McPhee, L. Zheng, G.A. Mardones, Y. Rong, J. Peng, N. Mi, Y. Zhao, Z. Liu, F. Wan, D.W. Hailey, V. Oorschot, J. Klumperman, E.H. Baehrecke, and M.J. Lenardo Termination of autophagy and reformation of lysosomes regulated by mTOR Nature 465 2010 942 946
49. B. Zhai, F.L. Hu, X. Jiang, J. Xu, D.L. Zhao, B. Liu, S.H. Pan, X.S. Dong, G. Tan, Z. Wei, H.Q. Qiao, H.C. Jiang, and X.Y. Sun Inhibition of Akt reverses the acquired resistance to sorafenib by switching protective autophagy to autophagic cell death in hepatocellular carcinoma Mol. Cancer Ther. 13 2014 1589 1598
50. 2+/AMPK/mTOR pathway in A549 cells Biochem. Pharmacol. 86 2013 317 328