Stereospecificity of Ginsenoside Rg3 in the Promotion of Cellular Immunity in Hepatoma H22-Bearing Mice

Journal of Food Science

Volumn 79, Issue 7, 2014, Pages

  Wu, Rihui ^a   Ru, Qin ^a   Chen, Lin ^a   Ma, Baomiao ^a   Li, Chaoying ^a  

^a JIANGHAN UNIVERSITY   (China)

Author keywords

Cellular immunity; Cytokine; Ginsenoside Rg3; Hepatocellular carcinoma; Stereospecificity

Indexed keywords

ANTINEOPLASTIC AGENT; GINSENOSIDE; GINSENOSIDE RG 3;

ANIMAL; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CELLULAR IMMUNITY; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; LIVER NEOPLASMS; MOUSE; NEOPLASMS, EXPERIMENTAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; GINSENOSIDES; IMMUNITY, CELLULAR; LIVER NEOPLASMS; MICE; NEOPLASMS, EXPERIMENTAL;

EID: 84904262963     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/1750-3841.12518     Document Type: Article

References (39)

1. Bae EA, Han MJ, Choo MK, Park SY, Kim DH. 2002. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull 25(1):58-63.
2. Cao Y, Song Y, An N, Zeng S, Wang D, Yu L, Zhu T, Zhang T, Cui J, Zhou C, Deng X. 2009. The effects of telocinobufagin isolated from Chan Su on the activation and cytokine secretion of immunocytes in vitro. Fundam Clin Pharmacol 23(4):457-64.
3. Chen J, Peng H, Ou-Yang X, He X. 2008. Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells. Melanoma Res 18(5):322-9.
4. Chen L, Pan J, Li X. 2011. Endo-polysaccharide of Phellinus igniarius exhibited anti-tumor effect through enhancement of cell mediated immunity. Int Immunopharmacol 11(2):255-9.
5. Christensen LP. 2009. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 55:1-9.
6. Dandamudi UB, Ghebremichael M, Sosman JA, Clark JI, McDermott DF, Atkins MB, Dutcher JP, Urba WJ, Regan MM, Puzanov I, Crocenzi TS, Curti BD, Vaishampayan UN, Crosby NA, Margolin KA, Ernstoff MS. 2013. A phase II study of bevacizumab and high-dose interleukin-2 in patients with metastatic renal cell carcinoma: a cytokine working group study. J Immunother 36(9):490-505.
7. Deng W, Sun HX, Chen FY, Yao ML. 2009. Immunomodulatory activity of 3β, 6β-dihyd-roxyolean-12-en-27-oic acid in tumor-bearing mice. Chem Biodivers 6:1243-54.
8. Ewa SR. 2009. Immunotropic and anti-tumor effects of plant adaptogens. I. Panax ginseng. Centr Eur J Immunol 34(3):207-11.
9. Gerber SA, Sedlacek AL, Cron KR, Murphy SP, Frelinger JG, Lord EM. 2013. IFN-γ mediates the antitumor effects of radiation therapy in a murine colon tumor. Am J Pathol 182(6):2345-54.
10. Guma SR, Lee DA, Yu L, Gordon N, Hughes D, Stewart J, Wang WL, Kleinerman ES. 2014. Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis. Pediatr Blood Cancer 61(4):618-26.
11. Guo N, Liu M, Yang D, Huang Y, Niu X, Wu R, Liu Y, Ma G, Dou D. 2013. Quantitative LC-MS/MS analysis of seven ginsenosides and three aconitum alkaloids in Shen-Fu decoction. Chem Cent J 7(1):165-83.
12. Hu JY, Jin GZ. 2000. Arcuate nucleus of hypothalamus involved in analgesic action of l-THP. Acta Pharmacol Sin 21(5):439-44.
13. Jeong SM, Lee JH, Kim JH, Lee BH, Yoon IS, Lee JH, Kim DH, Rhim H, Kim Y, Nah SY. 2004. Stereospecificity of ginsenoside Rg3 action on ion channels. Mol Cells 18(3):383-9.
14. Kang DI, Lee JY, Yang JY, Jeong SM, Lee JH, Nah SY, Kim Y. 2005. Evidence that the tertiary structure of 20(S)-ginsenoside Rg3 with tight hydrophobic packing near the chiral center is important for Na(+) channel regulation. Biochem Biophys Res Commun 333(4):1194-201.
15. Kim JH, Cho SY, Kang CW, Yoon IS, Lee JH, Jeong SM, Lee BH, Lee JH, Pyo MK, Choi SH, Quan SF, Lee JH, Choi CB, Rhim H, Nah SY. 2006. Ginseng saponins diminish adverse vascular effects associated with chronic methionine-induced hyperhomocysteinemia. Biol Pharm Bull 29(12) 2425-31.
16. Kim JH, Lee JH, Jeong SM, Lee BH, Yoon IS, Lee JH, Choi SH, Kim DH, Park TK, Kim BK, Nah SY. 2006. Stereospecific effects of ginsenoside Rg3 epimers on swine coronary artery contractions. Biol Pharm Bull 29(2) 365-70.
17. Komine K, Kuroishi T, Komine Y, Watanabe K, Kobayashi J, Yamaguchi T, Kamata S, Kumagai K. 2004. Introduction of nitric oxide production mediated by tumor necrosis factor alpha on staphylococcal enterotoxin C-stimulated bovine mammary gland cells. Clin Diagn Lab Immunol 11(1):203-10.
18. Korkaya H, Liu S, Wicha MS. 2011. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest 121(10):3804-9.
19. Kwok HH, Guo GL, Lau JK, Cheng YK, Wang JR, Jiang ZH, Keung MH, Mak NK, Yue PY, Wong RN. 2012. Stereoisomers ginsenosides-20(S)-Rg3 and -20(R)-Rg3 differentially induce angiogenesis through peroxisome proliferator-activated receptor-gamma. Biochem Pharmacol 83(7):893-902.
20. Li R, Rüttinger D, Li R, Si LS, Wang YL. 2003. Analysis of the immunological microenvironment at the tumor site in patients with non-small cell lung cancer. Langenbecks Arch Surg 88(6):406-12.
21. Liu TG, Huang Y, Cui DD, Huang XB, Mao SH, Ji LL, Song HB, Yi C. 2009. Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice. BMC Cancer 9:250-61.
22. Marciani DJ, Press JB, Reynolds RC, Pathak AK, Pathak V, Gundy LE, Farmer JT, Koratich MS, May RD. 2000. Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity. Vaccine 18(27):3141-51.
23. Mochizuki M, Yoo YC, Matsuzawa K, Sato K, Saiki I, Tono-oka S, Samukawa K, Azuma I. 1995. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3 of red ginseng. Biol Pharm Bull 18(9):1197-202.
24. Nah SY. 1997. Ginseng, recent advances and trend. Korea J Ginseng Sci 21(1):1-12.
25. Park D, Bae DK, Jeon JH, Lee J, Oh N, Yang G, Yang YH, Kim TK, Song J, Lee SH, Song BS, Jeon TH, Kang SJ, Joo SS, Kim SU, Kim YB. 2011. Immunopotentiation and antitumor effects of a ginsenoside Rg3-fortified red ginseng preparation in mice bearing H460 lung cancer cells. Environ Toxicol Pharmacol 31(3):397-405.
26. Sun J, Hu S, Song X. 2007. Adjuvant effects of protopanaxadiol and protopanaxatriol sapo-nins from ginseng roots on the immune responses to ovalbumin in mice. Vaccine 25(6):1114-20.
27. Van HR, Ten Hagen TL, Eggermont AM. 2006. TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility. Oncologist 11(4):397-408.
28. Vasievich EA, Huang L. 2011. The suppressive tumor microenvironment: a challenge in cancer immunotherapy. Mol Pharm 8(3):635-41.
29. Wei X, Chen J, Su F, Su X, Hu T, Hu S. 2012. Stereospecificity of ginsenoside Rg3 in promotion of the immune response to ovalbumin in mice. Int Immunol 24(7):465-71.
30. Wei X, Su F, Su X, Hu T, Hu S. 2012. Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative stress induced by cyclophosphamide in mice. Fitoterapia 83(4):636-42.
31. Wurz GT, Gutierrez AM, Greenberg BE, Vang DP, Griffey SM, Kao CJ, Wolf M, Degregorio MW. 2013. Antitumor effects of L-BLP25 antigen-specific tumor immunotherapy in a novel human MUC1 transgenic lung cancer mouse model. J Transl Med 11(1):64-77.
32. Xu TM, Xin Y, Cui MH, Jiang X, Gu LP. 2007. Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer. Chin Med J 120(7):584-8.
33. Yang B, Xiao B, Sun T. 2013. Antitumor and immunomodulatory activity of astragalus membranaceus polysaccharides in H22 tumor-bearing mice. Int J Biol Macromol 62C:287-90.
34. Yang YJ, Li XZ, Wang YH, Wang SD. 2012. CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model. Chin Sci Bull 57(1):48-53.
35. Yang Z, Xu J, Fu Q, Fu X, Shu T, Bi Y, Song B. 2013. Antitumor activity of a polysaccharide from Pleurotus eryngii on mice bearing renal cancer. Carbohydr Polym 95(2):615-20.
36. Zhang C, Liu L, Yu Y, Chen B, Tang C, Li X. 2012. Antitumor effects of ginsenoside Rg3 on human hepatocellular carcinoma cells. Mol Med Rep 5(5):1295-08.
37. Zhang W, Li J, Qiu S, Chen J, Zheng Y. 2008. Effects of the exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis on immunocytes of H22 tumor bearing mice. Fitoterapia 79(3):168-73.
38. Zhao H, Li Y, Wang YZ, Zhang J, Ou-yang XM, Peng RX, Yang J. 2012. Antitumor and immunostimulatory activity of a polysaccharide-protein complex from scolopendra Subspinipes mutilans L. Koch in tumor-bearing mice. Food Chem Toxicol 50(8):2648-55.
39. Zhao T, Mao G, Mao R, Zou Y, Zheng D, Feng W, Ren Y, Wang W, Zheng W, Song J, Chen Y, Yang L, Wu X. 2013. Antitumor and immunomodulatory activity of a water-soluble low molecular weight polysaccharide from Schisandra chinensis (Turcz.) Baill. Food Chem Toxicol 55, 609-16.