Apoptosis of human ovarian cancer cells induced by Paris Chinensis Dioscin via a Ca2+-mediated mitochondrion pathway

Asian Pacific Journal of Cancer Prevention

Volumn 12, Issue 5, 2011, Pages 1361-1366

  Gao, Lin Lin ^a   Li, Fu Rong ^a   Jiao, Peng ^a   Yao, Shu Tong ^a   Sang, Hui ^a   Si, Yan Hong ^a  

^a Taian Medical University   (China)

Author keywords

Apoptosis; Cytochrome C; Ovarian Cancer cells; Paris chinensis dioscin

Indexed keywords

EID: 84857974205     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Bernardi P, Colonna R, Costantini P, et al, (1998). The mitochondrial permeability transition. Biofactors, 8, 273-81.
2. Chang CY, Huang ZN, Yu HH, et al, (2008). The adjuvant effects of Antrodia camphorate extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells. J Ethnopharmacol, 18, 387-95.
3. Cheung JY, Ong RC, Suen YK, et al, (2005). Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells. Cancer Letters, 217, 203-11.
4. Choi DW (1995). Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci, 18, 58-60.
5. Corbiere C, Liagre B, Terro F, et al, (2004). Induction of antiproliferative effect by diosgenin through activation of p53,release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells. Cell Res, 4, 188-96.
6. Dai ZJ, Gao J, Ji ZZ, et al, (2009). Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3. J Ethnopharmacol, 123, 91-6
7. Deng S, Yu B, Hui Y, et al, (1999). Synthesis of three diosgenyl saponins:dioscin, polyphyllin D, and balanitin 7. Carbohydr Res, 317, 53-62.
8. Fesik SW (2005). Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer, 5, 876-85.
9. Hung JH, Lu YS, Wang YC, et al, (2008). FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase c signaling. Cancer Res, 68, 1204-12.
10. Jemal A, Siegel R, Xu J, et al, (2010). Cancer statistics, 2010. CA Cancer J Clin, 60, 277-300.
11. Lee MS, Yuet-Wa JC, Kong SK, et al, (2005). Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft. Cancer Biol Ther, 4, 1248-54.
12. Li XT, Wang YL, Wang JX et al, (1996). Effects of tetrandrine on cytosolic free calcium in cultured rat myocardial cells. Acta Pharmacol Sin, 17, 55-8.
13. Lynch K, Fernandez G, Pappalardo A, et al, (2000). Basic fibroblast growth factor inhibits apoptosis of spontaneously immortalized granulosa cells by regulating intracellular free calcium levels through a protein kinase Cdelta-dependent pathway. Endocrinology, 141, 4209-17.
14. Martikainen P, Kyprianou N, Tucker RW, et al, (1991). Programmed death of nonproliferating androgen-independent prostatic cancer cells. Cancer Res, 51, 4693-700.
15. Petronilli V, Nicolli A, Costantini P, et al, (1994). Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A. Biochim Biophys Acta, 1187, 255-9.
16. 2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J, 20, 2690-701.
17. Rasmussen HE, Blobaum KR, Park YK, et al. (2008). Lipid extract of Nostoc commune var. sphaeroides Kutzing, a blue-green alga, inhibits the activation of sterol regulatory element binding proteins in HepG2 cells. J Nutr, 138, 476-81.
18. Sara Leo, Katiuscia Bianchi, Marisa Brini et al. (2005). Mitochondrial calcium signalling in cell death. FEBS Journal, 272, 4013-22.
19. Sgonc R, Wick G (1994). Methods for the detection of apoptosis. Int Arch Allergy Immunol, 105, 327-32.
20. Shoemaker M, Hamilton B, Dairkee SH, et al. (2005). In vitro anticancer activity of twelve Chinese medicinal herbs. Phytother Res, 19, 649-51.
21. Skulachev VP (1996). Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell. FEBS Lett, 397, 7-10.
22. Wertz IE, Dixit VM (2000). Characterization of calcium releaseactivated apoptosis of LNCaP prostate cancer cells. J Biol Chem, 275, 11470-7.
23. Yang SY, Sales KM, Fuller B, et al. (2009). Apoptosis and colorectal cancer: Implications for therapy. Trends Mol Med, 15, 225.
24. Ye B, Gagnon A, Mok SC. (2007). Recent technical strategies to identify diagnostic biomarkers for ovarian cancer. Expert Rev Proteomics, 4, 121-31.