Structure-activity relationships of 3-O-β-chacotriosyl oleanane-type triterpenoids as potential H5N1 entry inhibitors

European Journal of Medicinal Chemistry

Volumn 119, Issue , 2016, Pages 109-121

  Song, Gaopeng ^a   Shen, Xintian ^b,c   Li, Sumei ^d   Li, Yibin ^a   Si, Hongzong ^e   Fan, Jihong ^a   Li, Junhua ^a   Gao, Erqiang ^a   Liu, Shuwen ^b  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^b Birth Defects Prevention Research and Transformation Team   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^e QINGDAO UNIVERSITY   (China)

Author keywords

3 O chacotriosyl saponins; H5N1 entry inhibitors; Structure activity relationships

Indexed keywords

3ALPHA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] OLEAN 12 EN 28 OIC ACID METHYL ESTER; 3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] 11 OXO OLEAN 12 EN 28 OIC ACID METHYL ESTER; 3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] ERYTHRODIOL 28 METHYL ETHER; 3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] OLEAN 12 EN 28 OIC ACID; 3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] OLEAN 12 EN 28 OIC ACID BENZYL ESTER; 3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] OLEAN 12 EN 28 OIC ACID CYCLOPENTYL ESTER; 3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] OLEAN 12 EN 28 OIC ACID ETHYL ESTER; 3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] OLEAN 12 EN 28 OIC ACID METHYL ESTER; 3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] OLEAN 12 EN 28 OIC ACID N PENTYL ESTER; 3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] OLEANOALDEHYDE; AGLYCONE; CL 385319; HEMAGGLUTININ; N [3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] OLEAN 12 EN 28 OYL] DIMETHYLAMIN; N [3BETA O [2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSYL] OLEAN 12 EN 28 OYL] DIMETHYLAMINE; OLEANOLIC ACID; SAPONIN; SIALIDASE; TRITERPENOID; UNCLASSIFIED DRUG; VIRUS FUSION INHIBITOR; ANTIVIRUS AGENT; HEMAGGLUTININ, HUMAN INFLUENZA A VIRUS; INFLUENZA VIRUS HEMAGGLUTININ; OLEANANE; TRITERPENE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ERYTHROCYTE; HEMAGGLUTINATION; HEMAGGLUTINATION INHIBITION; IC50; IN VITRO STUDY; INFLUENZA A VIRUS (H5N1); MDCK CELL LINE; MOLECULAR MODEL; NONHUMAN; SELECTIVITY INDEX; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; VIRUS ENTRY; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; CHICKEN; DOG; DRUG EFFECTS; METABOLISM; MOLECULAR DOCKING; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE;

ANIMALS; ANTIVIRAL AGENTS; CHICKENS; DOGS; ERYTHROCYTES; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; INFLUENZA A VIRUS, H5N1 SUBTYPE; MADIN DARBY CANINE KIDNEY CELLS; MOLECULAR DOCKING SIMULATION; OLEANOLIC ACID; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES; VIRUS INTERNALIZATION;

EID: 84967138242     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.04.061     Document Type: Article

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