Stereoisomer-specific anticancer activities of ginsenoside Rg3 and Rh2 in HepG2 cells: Disparity in cytotoxicity and autophagy-inducing effects due to 20(S)-epimers

Biological and Pharmaceutical Bulletin

Volumn 38, Issue 1, 2015, Pages 102-108

  Cheong, Jong Hye ^a   Kim, Hyeryung ^a   Hong, Min Jee ^a   Yang, Min Hye ^a   Kim, Jung Wha ^a   Yoo, Hunseung ^a   Yang, Heejung ^a   Park, Jeong Hill ^a   Sung, Sang Hyun ^a   Kim, Hong Pyo ^b   Kim, Jinwoong ^a  

^a Seoul National University   (South Korea)

^b Ajou University   (South Korea)

Author keywords

Autophagy; Ginsenoside Rg3; Ginsenoside Rh2; HepG2; Red ginseng; Stereoisomer

Indexed keywords

ACETOXYMETHYL ESTER; CALCIUM; ESTER DERIVATIVE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FAS ANTIGEN; GINSENOSIDE RG 3; GINSENOSIDE RH 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; TAMOXIFEN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GINSENOSIDE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CALCIUM CELL LEVEL; CELL DAMAGE; CELL DEATH; CELL FATE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; ELECTRON MICROSCOPY; EPIMER; GINSENG; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LD 50; MALE; NONHUMAN; RAT; STEREOISOMERISM; TUMOR CELL; UPREGULATION; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; LIVER CELL; SPRAGUE DAWLEY RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CELL SURVIVAL; CELLS, CULTURED; GINSENOSIDES; HEP G2 CELLS; HEPATOCYTES; HUMANS; MALE; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 84920507410     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b14-00603     Document Type: Article

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