Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition

Free Radical Biology and Medicine

Volumn 84, Issue , 2015, Pages 103-115

  Tao, Xufeng ^a   Sun, Xiance ^a   Yin, Lianhong ^a   Han, Xu ^a   Xu, Lina ^a   Qi, Yan ^a   Xu, Youwei ^a   Li, Hua ^a   Lin, Yuan ^a   Liu, Kexin ^a   Peng, Jinyong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral ischemia reperfusion; Dioscin; HMGB 1; Inflammation; TLR4 signaling pathway

Indexed keywords

DIOSCIN; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; SAPONIN DERIVATIVE; SMALL INTERFERING RNA; STAT3 PROTEIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; DIOSGENIN; HBP1 PROTEIN, RAT; LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENT; TLR4 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DOWN REGULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CELL SURVIVAL; GENE EXPRESSION; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; PATHOLOGY; PC12 CELL LINE; PROTEIN TRANSPORT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; CELL SURVIVAL; DIOSGENIN; GENE EXPRESSION; HMGB1 PROTEIN; INFARCTION, MIDDLE CEREBRAL ARTERY; L-LACTATE DEHYDROGENASE; MALE; NEUROPROTECTIVE AGENTS; PC12 CELLS; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84928784665     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.03.003     Document Type: Article

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