메뉴 건너뛰기




Volumn 46, Issue 2, 2015, Pages 775-781

Ginsenoside 20(S)-Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells

Author keywords

20(S) R g3; Ovarian cancer; STAT 3; Warburg effect

Indexed keywords

GINSENOSIDE RG 3; HEXOKINASE; PYRUVATE KINASE; PYRUVATE KINASE M2; STAT3 PROTEIN; TYROSINE; UNCLASSIFIED DRUG; GINSENOSIDE; GINSENOSIDE 20S-PROTOPANAXATRIOL; SAPOGENIN; STAT3 PROTEIN, HUMAN;

EID: 84918570803     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2767     Document Type: Article
Times cited : (71)

References (30)
  • 1
    • 66149083645 scopus 로고    scopus 로고
    • Ovarian cancer
    • Cho KR and Shih IeM: Ovarian cancer. Annu Rev Pathol 4: 287-313, 2009.
    • (2009) Annu Rev Pathol , vol.4 , pp. 287-313
    • Cho, K.R.1    Iem, S.2
  • 2
    • 84862209283 scopus 로고    scopus 로고
    • Molecular scores to predict ovarian cancer outcomes: A worthy goal, but not ready for prime time
    • Swisher EM, Taniguchi T and Karlan BY: Molecular scores to predict ovarian cancer outcomes: a worthy goal, but not ready for prime time. J Natl Cancer Inst 104: 642-645, 2012.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 642-645
    • Swisher, E.M.1    Taniguchi, T.2    Karlan, B.Y.3
  • 4
    • 0030757369 scopus 로고    scopus 로고
    • Panax ginseng pharmacology: A nitric oxide link?
    • Gillis CN: Panax ginseng pharmacology: a nitric oxide link? Biochem Pharmacol 54: 1-8, 1997.
    • (1997) Biochem Pharmacol , vol.54 , pp. 1-8
    • Gillis, C.N.1
  • 5
    • 0036180097 scopus 로고    scopus 로고
    • Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro
    • Liao B, Newmark H and Zhou R: Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exp Neurol 173: 224-234, 2002.
    • (2002) Exp Neurol , vol.173 , pp. 224-234
    • Liao, B.1    Newmark, H.2    Zhou, R.3
  • 6
    • 84865039191 scopus 로고    scopus 로고
    • Ginsenosides as anticancer agents: In vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action
    • Nag SA, Qin JJ, Wang W, Wang MH, Wang H and Zhang R: Ginsenosides as anticancer agents: in vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action. Front Pharmacol 3: 25, 2012.
    • (2012) Front Pharmacol , vol.3 , pp. 25
    • Nag, S.A.1    Qin, J.J.2    Wang, W.3    Wang, M.H.4    Wang, H.5    Zhang, R.6
  • 7
    • 69149110615 scopus 로고    scopus 로고
    • Ginseng compounds: An update on their molecular mechanisms and medical applications
    • Lü JM, Yao Q and Chen C: Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol 7: 293-302, 2009.
    • (2009) Curr Vasc Pharmacol , vol.7 , pp. 293-302
    • Lü, J.M.1    Yao, Q.2    Chen, C.3
  • 8
    • 67249166275 scopus 로고    scopus 로고
    • Proteomic analysis of the anti-cancer effect of 20S-ginsenoside Rg3 in human colon cancer cell lines
    • Lee SY, Kim GT, Roh SH, et al: Proteomic analysis of the anti-cancer effect of 20S-ginsenoside Rg3 in human colon cancer cell lines. Biosci Biotechnol Biochem 73: 811-816, 2009.
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 811-816
    • Lee, S.Y.1    Kim, G.T.2    Roh, S.H.3
  • 9
    • 0029098678 scopus 로고
    • Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-R b2, 20(R)-.and 20(S)-ginsenoside-R g3, of red ginseng
    • Mochizuki M, Yoo YC, Matsuzawa K, et al: Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-R b2, 20(R)-.and 20(S)-ginsenoside-R g3, of red ginseng. Biol Pharm Bull 18: 1197-1202, 1995.
    • (1995) Biol Pharm Bull , vol.18 , pp. 1197-1202
    • Mochizuki, M.1    Yoo, Y.C.2    Matsuzawa, K.3
  • 10
    • 33745683962 scopus 로고    scopus 로고
    • Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gammastimulated BV- 2 microglial cells
    • Bae EA, Kim EJ, Park JS, Kim HS, Ryu JH and Kim DH: Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gammastimulated BV- 2 microglial cells. Planta Med 72: 627-633, 2006.
    • (2006) Planta Med , vol.72 , pp. 627-633
    • Bae, E.A.1    Kim, E.J.2    Park, J.S.3    Kim, H.S.4    Ryu, J.H.5    Kim, D.H.6
  • 11
    • 0037293063 scopus 로고    scopus 로고
    • Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression NF- kappaB activation and tumor promotion
    • Keum YS, Han SS, Chun KS, et al: Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF- kappaB activation and tumor promotion. Mutat Res 523-524: 75-85, 2003.
    • (2003) Mutat Res , vol.523-524 , pp. 75-85
    • Keum, Y.S.1    Han, S.S.2    Chun, K.S.3
  • 12
    • 84880435950 scopus 로고    scopus 로고
    • Electrospun poly(L-lactide) fiber with ginsenoside rg3 for inhibiting scar hyperplasia of skin
    • Cui W, Cheng L, Hu C, Li H, Zhang Y and Chang J: Electrospun poly(L-lactide) fiber with ginsenoside rg3 for inhibiting scar hyperplasia of skin. PLoS One 8: e68771, 2013.
    • (2013) PLoS One , vol.8 , pp. e68771
    • Cui, W.1    Cheng, L.2    Hu, C.3    Li, H.4    Zhang, Y.5    Chang, J.6
  • 13
    • 33745938530 scopus 로고    scopus 로고
    • The angiosuppressive effects of 20(R)-ginsenoside Rg3
    • Yue PY, Wong DY, Wu PK, et al: The angiosuppressive effects of 20(R)-ginsenoside Rg3. Biochem Pharmacol 72: 437-445, 2006.
    • (2006) Biochem Pharmacol , vol.72 , pp. 437-445
    • Yue, P.Y.1    Wong, D.Y.2    Wu, P.K.3
  • 14
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O: On the origin of cancer cells. Science 123: 309-314, 1956.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 15
    • 33749478922 scopus 로고    scopus 로고
    • Cancer's molecular sweet tooth and the Warburg effect
    • Kim JW and Dang CV: Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 66: 8927-8930, 2006.
    • (2006) Cancer Res , vol.66 , pp. 8927-8930
    • Kim, J.W.1    Dang, C.V.2
  • 16
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC and Thompson CB: Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033, 2009.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 17
    • 31544460437 scopus 로고    scopus 로고
    • Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression
    • Diaz N, Minton S, Cox C, et al: Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res 12: 20-28, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 20-28
    • Diaz, N.1    Minton, S.2    Cox, C.3
  • 18
    • 35348893870 scopus 로고    scopus 로고
    • Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy
    • Germain D and Frank DA: Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res 13: 5665-5669, 2007.
    • (2007) Clin Cancer Res , vol.13 , pp. 5665-5669
    • Germain, D.1    Frank, D.A.2
  • 19
    • 84894455965 scopus 로고    scopus 로고
    • The IL- 6/JA K/STAT 3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)
    • Wang SW and Sun YM: The IL- 6/JA K/STAT 3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review). Int J Oncol 44: 1032-1040, 2014.
    • (2014) Int J Oncol , vol.44 , pp. 1032-1040
    • Wang, S.W.1    Sun, Y.M.2
  • 20
    • 84900429098 scopus 로고    scopus 로고
    • S-phase cell cycle arrest, apoptosis, and molecular mechanisms of aplasia ras homolog member I- induced human ovarian cancer SKOV 3 cell lines
    • Zhu Q, Hu J, Meng H, Shen Y, Zhou J and Zhu Z: S-phase cell cycle arrest, apoptosis, and molecular mechanisms of aplasia ras homolog member I- induced human ovarian cancer SKOV 3 cell lines. Int J Gynecol Cancer 24: 629-634, 2014.
    • (2014) Int J Gynecol Cancer , vol.24 , pp. 629-634
    • Zhu, Q.1    Hu, J.2    Meng, H.3    Shen, Y.4    Zhou, J.5    Zhu, Z.6
  • 21
    • 84862812020 scopus 로고    scopus 로고
    • A novel miR- 155/miR- 143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells
    • Jiang S, Zhang LF, Zhang HW, et al: A novel miR- 155/miR- 143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. EMBO J 31: 1985-1998, 2012.
    • (2012) EMBO J , vol.31 , pp. 1985-1998
    • Jiang, S.1    Zhang, L.F.2    Zhang, H.W.3
  • 22
    • 79952666779 scopus 로고    scopus 로고
    • A STAT 3-mediated metabolic switch is involved in tumour transformation and STAT 3 addiction
    • Demaria M, Giorgi C, Lebiedzinska M, et al: A STAT 3-mediated metabolic switch is involved in tumour transformation and STAT 3 addiction. Aging (Albany NY ) 2: 823-842, 2010.
    • (2010) Aging (Albany NY) , vol.2 , pp. 823-842
    • Demaria, M.1    Giorgi, C.2    Lebiedzinska, M.3
  • 23
    • 84907467704 scopus 로고    scopus 로고
    • Clinical impact of the Warburg effect in gastrointestinal cancer (Review)
    • Sawayama H, Ishimoto T, Sugihara H, et al: Clinical impact of the Warburg effect in gastrointestinal cancer (Review). Int J Oncol 45: 1345-1354, 2014.
    • (2014) Int J Oncol , vol.45 , pp. 1345-1354
    • Sawayama, H.1    Ishimoto, T.2    Sugihara, H.3
  • 24
    • 0033521595 scopus 로고    scopus 로고
    • STAT 3 is required for the gp130-mediated full activation of the c-myc gene
    • Kiuchi N, Nakajima K, Ichiba M, et al: STAT 3 is required for the gp130-mediated full activation of the c-myc gene. J Exp Med 189: 63-73, 1999.
    • (1999) J Exp Med , vol.189 , pp. 63-73
    • Kiuchi, N.1    Nakajima, K.2    Ichiba, M.3
  • 25
    • 77950945700 scopus 로고    scopus 로고
    • Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase-3
    • Ando M, Uehara I, Kogure K, et al: Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase-3. J Nippon Med Sch 77: 97-105, 2010.
    • (2010) J Nippon Med Sch , vol.77 , pp. 97-105
    • Ando, M.1    Uehara, I.2    Kogure, K.3
  • 26
    • 76549121864 scopus 로고    scopus 로고
    • Combination of ginsenoside Rg3 with docetaxel enhances the susceptibility of prostate cancer cells via inhibition of NF- kappaB
    • Kim SM, Lee SY, Cho JS, et al: Combination of ginsenoside Rg3 with docetaxel enhances the susceptibility of prostate cancer cells via inhibition of NF- kappaB. Eur J Pharmacol 631: 1-9, 2010.
    • (2010) Eur J Pharmacol , vol.631 , pp. 1-9
    • Kim, S.M.1    Lee, S.Y.2    Cho, J.S.3
  • 27
    • 84874859650 scopus 로고    scopus 로고
    • Sensitization of TRAIL- induced cell death by 20(S)-ginsenoside Rg3 via CHOP-mediated DR5 upregulation in human hepatocellular carcinoma cells
    • Lee JY, Jung KH, Morgan MJ, et al: Sensitization of TRAIL- induced cell death by 20(S)-ginsenoside Rg3 via CHOP-mediated DR5 upregulation in human hepatocellular carcinoma cells. Mol Cancer Ther 12: 274-285, 2013.
    • (2013) Mol Cancer Ther , vol.12 , pp. 274-285
    • Lee, J.Y.1    Jung, K.H.2    Morgan, M.J.3
  • 28
    • 84881269149 scopus 로고    scopus 로고
    • Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT 3 inactivation in human breast cancer cells
    • Liu CY, Tseng LM, Su JC, et al: Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT 3 inactivation in human breast cancer cells. Breast Cancer Res 15: R63, 2013.
    • (2013) Breast Cancer Res , vol.15 , pp. R63
    • Liu, C.Y.1    Tseng, L.M.2    Su, J.C.3
  • 29
    • 60249083822 scopus 로고    scopus 로고
    • Hexokinase-2 bound to mitochondria: Cancer's stygian link to the 'Warburg Effect' and a pivotal target for effective therapy
    • Mathupala SP, Ko YH and Pedersen PL: Hexokinase-2 bound to mitochondria: cancer's stygian link to the 'Warburg Effect' and a pivotal target for effective therapy. Semin Cancer Biol 19: 17-24, 2009.
    • (2009) Semin Cancer Biol , vol.19 , pp. 17-24
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.