Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines

Steroids

Volumn 71, Issue 9, 2006, Pages 828-833

  He, Xiangjiu ^a,b   Qiao, Aimin ^c   Wang, Xinluan ^c   Liu, Bo ^d   Jiang, Miaomiao ^c   Su, Lina ^c   Yao, Xinsheng ^a,c  

^a JINAN UNIVERSITY   (China)

^b Department of Obstetrics Gynecology   (United States)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Antiproliferative activities; Furostanol saponin; Methyl protodioscin; Steroid metabolism; Structural identification of metabolites

Indexed keywords

26 O BETA DEXTRO GLUCOPYRANNOSYLFURAN 5 ENE 3BETA, 22ALPHA, 26 TRIHYDROXY 3 O ALPHA LEVO RHAMNOPYRANOSYL(1-4) BETA DEXTRO GLUCOPYRANOSIDE; 26 O BETA DEXTRO GLUCOPYRANOSYLFURAN 5 ENE 3BETA,26 DIHYDROXY 22 METHOXY 3 O ALPHA LEVO RHAMNOPYRANOSYL(1-4) BETA DEXTRO GLUCOPYRAONOSIDE; DIOSCIN; DIOSGENIN; DIOSGENIN 3 O BETA DEXTRO GLUCOPYRANOSIDE; DRUG METABOLITE; METHYLPROTOBIOSIDE; METHYLPROTODIOSCIN; PREGNA 5,16 DIEN 3BETA OL 20 ONE O ALPHA LEVO RHAMNOPYRANOSYL(1-2) [ALPHA LEVO RHAMNOPYRANOSYL(1-4)]BETA DEXTRO GLUCOPYRANOSIDE; PROSAPOGENIN A OF DIOSCIN; PROSAPOGENIN B OF DIOSCIN; PROTOBIOSIDE; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; HEMATOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; TUMOR CELL LINE; URINE;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DIOSGENIN; HUMANS; MALE; MODELS, MOLECULAR; NEOPLASMS; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS;

EID: 33745967292     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2006.05.013     Document Type: Article

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