Paris saponin VII suppresses osteosarcoma cell migration and invasion by inhibiting MMP-2/9 production via the p38 MAPK signaling pathway

Molecular Medicine Reports

Volumn 14, Issue 4, 2016, Pages 3199-3205

  Cheng, Gong ^a   Gao, Fengguang ^a   Sun, Xiujiang ^a   Bi, Haiyong ^a   Zhu, Yonglin ^a  

^a BINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Invasion; Migration; Osteosarcoma cells; P38; Paris saponin VII

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GELATINASE A; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SAPONIN; SAPONIN VII; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MATRIX METALLOPROTEINASE INHIBITOR; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; PARIS SAPONIN VII;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL INVASION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; MITOSIS INHIBITION; MMP2 GENE; MMP9 GENE; OSTEOSARCOMA; OSTEOSARCOMA CELL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BONE; BONE NEOPLASMS; CELL MOTION; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; PATHOLOGY; PREVENTION AND CONTROL; TRILLIUM; TUMOR CELL LINE; TUMOR INVASION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BONE AND BONES; BONE NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASE INHIBITORS; NEOPLASM INVASIVENESS; OSTEOSARCOMA; SAPONINS; TRILLIUM;

EID: 84988457182     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5663     Document Type: Article

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