Timosaponin AIII mediates caspase activation and induces apoptosis through JNK1/2 pathway in human promyelocytic leukemia cells

Tumor Biology

Volumn 36, Issue 5, 2015, Pages 3489-3497

  Huang, Hsin Lien ^a   Chiang, Whei Ling ^a,b   Hsiao, Pei Ching ^a,b   Chien, Ming Hsien ^c,d   Chen, Hui Yu ^a   Weng, Wei Chun ^a,e   Hsieh, Ming Ju ^a,f   Yang, Shun Fa ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e TUNGS' TAICHUNG METROHARBOR HOSPITAL   (Taiwan)

^f CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

Author keywords

Acute myeloid leukemia; Apoptosis; JNK1 2 pathways; Timosaponin AIII

Indexed keywords

CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOTOXIC AGENT; JANUS KINASE 1; JANUS KINASE 2; SAPONIN; TIMOSAPONIN AIII; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE P38; STEROID;

ACUTE MYELOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG ISOLATION; ENZYME ACTIVATION; ENZYME INHIBITION; HL 60 CELL LINE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LEUKEMIA, PROMYELOCYTIC, ACUTE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SAPONINS; STEROIDS;

EID: 84929951447     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-2985-7     Document Type: Article

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