Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines

Apoptosis

Volumn 16, Issue 2, 2011, Pages 184-197

  Kim, Byeong Mo ^a   Hong, Sung Hee ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

Apoptosis; Caspase 2; Caspase 8; Cell death mechanisms; Human colon carcinoma (HCC); Saikosaponin a (SSa)

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; INITIATOR CASPASE; PROTEIN BAX; SAIKOSAPONIN A; SMALL INTERFERING RNA; SURVIVIN; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; COLON CARCINOMA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE; GENE SILENCING; HUMAN; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BLOTTING, WESTERN; CASPASE 2; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYCLOSPORINE; FLOW CYTOMETRY; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MITOCHONDRIA; OLEANOLIC ACID; OLIGOPEPTIDES; POLY(ADP-RIBOSE) POLYMERASES; RNA, SMALL INTERFERING; SAPONINS; SIGNAL TRANSDUCTION;

EID: 79951581748     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-010-0557-x     Document Type: Article

References (43)

1. MJ Just MC Recio RM Giner MJ Cuéllar S Máñez AR Bilia, et al. 1998 Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens Planta Med 64 404 407 1:CAS:528:DyaK1cXktVKlsbc%3D 10.1055/s-2006-957469 9690340 (Pubitemid 28298690)
2. H Wang J Gao J Kou D Zhu B Yu 2008 Anti-inflammatory activities of triterpenoid saponins from Polygala japonica Phytomedicine 15 321 326 1:CAS:528:DC%2BD1cXotlGjs7c%3D 10.1016/j.phymed.2007.09.014 17951039 (Pubitemid 351508397)
3. RN Yadava N Chakravarti 2008 Anti-inflammatory activity of a new triterpenoid saponin from carthamus tinctorius linn J Enzyme Inhib Med Chem 23 543 548 1:CAS:528:DC%2BD1cXptFSktrg%3D 10.1080/14756360701715422 18666001
4. T Hattori H Maruyama H Nishimura Y Nakai I Sakakibara Y Kase, et al. 2006 Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats Clin Exp Nephrol 10 13 18 1:CAS:528:DC%2BD28XjvVCisLw%3D 10.1007/s10157-005-0402-7 16544173
5. P Ai G Yong G Dingkun Z Qiuyu Z Kaiyuan L Shanyan 2008 Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide J Ethnopharmacol 116 413 421 1:CAS:528: DC%2BD1cXjtVCitL0%3D 10.1016/j.jep.2007.12.005 18243612
6. D Gallo GF Zannoni I De Stefano M Mosca C Ferlini E Mantuano 2008 Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice J Nutr 138 1360 1364 1:CAS:528:DC%2BD1cXnsVOltbs%3D 18567761 (Pubitemid 351931003)
7. RA Toshkova IN Krasteva DW Wesselinova SD Nikolov 2007 Influence of purified saponin mixture from Astragalus corniculatus Bieb. on phagocytic cells in Graffi-tumor bearing hamsters J Ethnopharmacol 109 394 399 1:CAS:528:DC%2BD2sXltV2lsg%3D%3D 10.1016/j.jep.2006.08.006 16979313 (Pubitemid 46054369)
8. Y Motto N Sawabu 1994 Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines Cancer Lett 86 91 95 10.1016/0304- 3835(94)90184-8 (Pubitemid 24318987)
9. L Qian T Murakami Y Kimura M Takahashi K Okita 1995 Saikosaponin A-induced cell death of a human hepatoma cell line (HuH-7): the significance of the 'sub-G1 peak' in a DNA histogram Pathol Int 45 207 214 1:CAS:528: DyaK2MXls1KmtLg%3D 10.1111/j.1440-1827.1995.tb03444.x 7787991
10. LC Chiang LT Ng LT Liu DE Shieh CC Lin 2003 Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species Planta Med 69 705 709 1:CAS:528:DC%2BD3sXotFKquro%3D 10.1055/s-2003-42797 14531019 (Pubitemid 37215018)
11. YL Hsu PL Kuo LC Chiang CC Lin 2004 Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines Cancer Lett 213 213 221 1:CAS:528:DC%2BD2cXmvFWrsrs%3D 10.1016/j.canlet.2004.03.044 15327837 (Pubitemid 39140980)
12. H Yano A Mizoguchi K Fukuda M Haramaki S Ogasawara S Momosaki, et al. 1994 The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase Cancer Res 54 448 454 1:CAS:528:DyaK2cXhsFehs74%3D 8275481 (Pubitemid 24053184)
13. M Kato MY Pu K Isobe T Hattori N Yanagita I Nakashima 1995 Cell type-oriented differential modulatory actions of saikosaponin-d on growth responses and DNA fragmentation of lymphocytes triggered by receptor-mediated and receptor-bypassed pathway Immunopharmacology 29 207 213 1:CAS:528: DyaK2MXltVyksLY%3D 10.1016/0162-3109(95)00059-3 7622352
14. Z Zong K Fujikawa-Yamamoto M Tanino K Teraoka H Yamagishi S Odashima 1996 Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity Biochem Biophys Res Commun 219 480 485 1:CAS:528:DyaK28XhtlKlt7Y%3D 10.1006/bbrc.1996.0259 8605013
15. YL Hsu PL Kuo CC Lin 2004 The proliferative inhibition and apoptotic mechanism of Saikosaponin D in human non-small cell lung cancer A549 cells Life Sci 75 1231 1242 1:CAS:528:DC%2BD2cXltF2rtLo%3D 10.1016/j.lfs.2004.03.008 15219811 (Pubitemid 38829348)
16. KG Shyu SC Tsai BW Wang YC Liu CC Lee 2004 Saikosaponin C induces endothelial cells growth, migration and capillary tube formation Life Sci 76 813 826 1:CAS:528:DC%2BD2cXhtVCltb7F 10.1016/j.lfs.2004.10.003 15581913 (Pubitemid 39576155)
17. SJ Wu YH Lin CC Chu YH Tsai JC Chao 2008 Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats J Med Food 11 224 229 1:CAS:528:DC%2BD1cXotVCjsb0%3D 10.1089/jmf.2007.555 18598162 (Pubitemid 351948171)
18. JC Chen NW Chang JG Chung KC Chen 2003 Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells Am J Chin Med 31 363 377 1:CAS:528:DC%2BD3sXlvFemsrk%3D 10.1142/S0192415X03001065 12943168 (Pubitemid 41758823)
19. G Nuñez MA Benedict Y Hu N Inohara 1998 Caspases: the proteases of the apoptotic pathway Oncogene 17 3237 3245 10.1038/sj.onc.1202581 9916986 (Pubitemid 29043976)
20. GS Salvesen 1999 Caspase 8: igniting the death machine Structure 7 R225 R229 1:CAS:528:DyaK1MXntFCiu7c%3D 10.1016/S0969-2126(00)80048-9 10545333 (Pubitemid 29482977)
21. B Zhivotovsky S Orrenius 2005 Caspase-2 function in response to DNA damage Biochem Biophys Res Commun 331 859 867 1:CAS:528:DC%2BD2MXjslKjtLc%3D 10.1016/j.bbrc.2005.03.191 15865942 (Pubitemid 40615517)
22. CF Lin CL Chen WT Chang MS Jan LJ Hsu RH Wu, et al. 2004 Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramide and etoposide-induced apoptosis J Biol Chem 279 40755 40761 1:CAS:528: DC%2BD2cXnslWntL0%3D 10.1074/jbc.M404726200 15262979 (Pubitemid 39287671)
23. H Yamaguchi HG Wang 2001 The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change Oncogene 20 7779 7786 1:CAS:528:DC%2BD3MXptFOntL0%3D 10.1038/sj.onc.1204984 11753656 (Pubitemid 33121951)
24. CA Wu YW Yang 2004 Induction of cell death by saponin and antigen delivery Pharm Res 21 271 277 1:CAS:528:DC%2BD2cXhtlWqt74%3D 10.1023/B:PHAM.0000016239.04067.66 15032308 (Pubitemid 38221972)
25. PC Gerkens R Dobson N Tabatadze V Mshviladzade R Elias OJ Peulen, et al. 2007 Apoptosis and cytolysis induced by giganteosides and hederacolchisides in HL-60 cells Anticancer Res 27 2529 2534 1:CAS:528:DC%2BD2sXpvFChsLw%3D 17695549 (Pubitemid 47228099)
26. N Zamzami P Marchetti M Castedo C Zanin JL Vayssière PX Petit, et al. 1995 Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo J Exp Med 181 1661 1672 1:CAS:528:DyaK2MXlsVGhtb8%3D 10.1084/jem.181.5.1661 7722446
27. D Zhang MD Berry IA Paterson AA Boulton 1999 Loss of mitochondrial membrane potential is dependent on the apoptotic program activated: prevention by R-2HMP J Neurosci Res 58 284 292 1:CAS:528:DyaK1MXmslejsrY%3D 10.1002/(SICI)1097-4547(19991015)58:2<284::AID-JNR8>3.0.CO;2-I 10502284 (Pubitemid 29471429)
28. H Düssmann M Rehm D Kögel JH Prehn 2003 Outer mitochondrial membrane permeabilization during apoptosis triggers caspase-independent mitochondrial and caspase-dependent plasma membrane potential depolarization: a single-cell analysis J Cell Sci 116 525 536 10.1242/jcs.00236 12508113 (Pubitemid 36231292)
29. H Mehmet 2000 Caspases find a new place to hide Nature 403 29 30 1:CAS:528:DC%2BD3cXlsl2jtw%3D%3D 10.1038/47377 10638735 (Pubitemid 30038501)
30. CM Troy ML Shelanski 2003 Caspase-2 redux Cell Death Differ 10 101 107 1:CAS:528:DC%2BD3sXit12murc%3D 10.1038/sj.cdd.4401175 12655298 (Pubitemid 36511835)
31. D Chandra G Choy X Deng B Bhatia P Daniel DG Tang 2004 Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death Mol Cell Biol 24 6592 6607 1:CAS:528:DC%2BD2cXmtlKltLk%3D 10.1128/MCB.24.15.6592-6607.2004 15254227 (Pubitemid 38944340)
32. H Li H Zhu CJ Xu J Yuan 1998 Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 94 491 501 1:CAS:528:DyaK1cXlslOrsbY%3D 10.1016/S0092-8674(00)81590-1 9727492 (Pubitemid 28391865)
33. XM Sun M MacFarlane J Zhuang BB Wolf DR Green GM Cohen 1999 Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis J Biol Chem 274 5053 5060 1:CAS:528:DyaK1MXhsFSlsbo%3D 10.1074/jbc.274.8.5053 9988752 (Pubitemid 29113412)
34. M Kruidering GI Evan 2000 Caspase-8 in apoptosis: the beginning of "the end"? IUBMB Life 50 85 90 1:CAS:528:DC%2BD3cXoslWks7c%3D 11185963
35. X Luo I Budihardjo H Zou C Slaughter X Wang 1998 Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors Cells 94 481 490 1:CAS:528: DyaK1cXlslOrsbw%3D 10.1016/S0092-8674(00)81589-5 (Pubitemid 28391864)
36. MD Esposti 2002 The roles of Bid Apoptosis 7 433 440 1:CAS:528: DC%2BD38Xms12gu7s%3D 10.1023/A:1020035124855 12207176
37. S Desagher A Osen-Sand A Nichols R Eskes S Montessuit S Lauper, et al. 1999 Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis J Cell Biol 144 891 901 1:CAS:528:DyaK1MXhs1yqtbY%3D 10.1083/jcb.144.5.891 10085289 (Pubitemid 29238966)
38. R Eskes S Desagher B Antonsson JC Martinou 2000 Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane Mol Cell Biol 20 929 935 1:CAS:528:DC%2BD3cXmt1Sntg%3D%3D 10.1128/MCB.20.3.929-935. 2000 10629050 (Pubitemid 30044230)
39. Y Guo SM Srinivasula A Druilhe T Fernandes-Alnemri ES Alnemri 2002 Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria J Biol Chem 277 13430 13437 1:CAS:528:DC%2BD38XjsFWgtbs%3D 10.1074/jbc. M108029200 11832478 (Pubitemid 34967937)
40. JD Robertson M Enoksson M Suomela B Zhivotovsky S Orrenius 2002 Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis J Biol Chem 277 29803 29809 1:CAS:528: DC%2BD38XmsVKiu74%3D 10.1074/jbc.M204185200 12065594
41. T Panaretakis E Laane K Pokrovskaja AC Björklund A Moustakas B Zhivotovsky, et al. 2005 Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis Mol Biol Cell 16 3821 3831 1:CAS:528:DC%2BD2MXosVCns7g%3D 10.1091/mbc.E04-10-0862 15917298 (Pubitemid 41077090)
42. T Kuwana JJ Smith M Muzio V Dixit DD Newmeyer S Kornbluth 1998 Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c J Biol Chem 273 16589 16594 1:CAS:528:DyaK1cXkt1Gns7s%3D 10.1074/jbc.273.26.16589 9632731 (Pubitemid 28311447)
43. G Krumschnabel B Sohm F Bock C Manzl A Villunger 2009 The enigma of caspase-2: the laymen's view Cell Death Differ 16 195 207 1:CAS:528: DC%2BD1MXkslyruw%3D%3D 10.1038/cdd.2008.170 19023332