Saikosaponin-D enhances radiosensitivity of hepatoma cells under hypoxic conditions by inhibiting hypoxia-inducible factor-1

Cellular Physiology and Biochemistry

Volumn 33, Issue 1, 2014, Pages 37-51

  Wang, Bao Feng ^a   Wang, Xi Jing ^a   Kang, Hua Feng ^a   Bai, Ming Hua ^a   Guan, Hai Tao ^a   Wang, Zhong Wei ^a   Zan, Ying ^a   Song, Ling Qin ^a   Min, Wei Li ^a   Lin, Shuai ^a   Cheng, Yan An ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Cobalt chloride; HCC; HIF 1; Hypoxia; Radiation

Indexed keywords

4 [BIS(2 CHLOROETHYL)OXIDOAMINO]PHENYLALANINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PIMONIDAZOLE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SAIKOSAPONIN D; VASCULOTROPIN; OLEANOLIC ACID; SAIKOSAPONIN; SAPONIN; VASCULOTROPIN A; RADIOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CANCER RADIOTHERAPY; CELL GROWTH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MOUSE; MTT ASSAY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; SURVIVAL RATE; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL HYPOXIA; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; NUDE MOUSE; PATHOLOGY; RADIATION TOLERANCE; TUMOR CELL LINE; TUMOR STEM CELL ASSAY; ANIMAL TISSUE; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENTIATION; GROWTH; HEPATOCELLULAR CARCINOMA CELL LINE; HEPG2 CELL LINE; IC50; IN VITRO STUDY; MONOTHERAPY; PROTEIN DEGRADATION; RADIOSENSITIZATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; MALE; MICE, INBRED BALB C; MICE, NUDE; OLEANOLIC ACID; RADIATION TOLERANCE; SAPONINS; TUMOR STEM CELL ASSAY; TUMOR SUPPRESSOR PROTEIN P53; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84891687907     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000356648     Document Type: Article

References (43)

1. Parkin DM, Bray FI, Devesa SS: Cancer burden in the year. The global Picture. Eur J Cancer 2000;37:S4-S66.
2. Thorgeirsson SS, Grisham JW: Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002;31:339-346.
3. El-Serag HB, Rudolph KL: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557-2576.
4. Zeng ZC, Fan J, Tang ZY, Zhou J, Qin LX, Wang JH, Sun HC, Wang BL, Zhang JY, Jiang GL, Wang YQ: A comparison of treatment combinations with and without radiotherapy for hepatocellular carcinoma with portal vein and/or inferior vena cava tumor thrombus. Int J Radiation Oncology Boil Phys 2005;61:432-443.
5. Merle P, Mornex F, Trepo C: Innovative therapy for hepatocellular carcinoma: Three-dimensional high-dose photon radiotherapy. Cancer Lett 2009;286:129-133
6. Hawkins MA, Dawson LA: Radiation therapy for hepatocellular carcinoma: from palliation to cure. Cancer 2006;106:1653-1663.
7. Bache M, Kappler M, Said HM, Staab A, Vordermark D: Detection and specific targeting of hypoxic regions within solid tumors: current preclinical and clinical strategies. Curr Med Chem 2008;15:322-338.
8. Dewhirst MW, Cao Y, Moeller B: Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nature Rev Cancer 2008;8:425-437.
9. Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-732.
10. Aebersold DM, Burri P, Beer KT, Laissue J, Djonov V, Greiner RH, Semenza GL: Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001;61:2911-2916.
11. Singh-Gupta V, Zhang H, Banerjee S, Kong D, Raffoul JJ, Sarkar FH, Hillman GG: Radiation-induced HIF-1αlpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells. Int J Cancer 2009;124:1675-1684.
12. Harada H, Kizaka-Kondoh S, Li G, Itasaka S, Shibuya K, Inoue M, Hiraoka M: Significance of HIF-1-active cells in angiogenesis and radio-resistance. Oncogene 2007;26:7508-7516.
13. Staab A, Loeffler J, Said HM, Diehlmann D, Katzer A, Beyer M, Fleischer M, Schwab F, Baier K, Einsele H, Flentje M, Vordermark D: Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radio-sensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer 2007;7:213.
14. Lu CN, Yuan ZG, Zhang XL, Yan R, Zhao YQ, Liao M, Chen JX: Saikosaponin a and its epimer saikosaponin-d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway. Int Immunopharmacol 2012;14:121-126.
15. Hattori T, Nishimura H, Kase Y, Takeda S: Saireito and saikosaponin D prevent urinary protein excretion via glucocorticoid receptor in adrenalectomized WKY rats with heterologous-phase anti-GBM nephritis. Nephron Physiol 2008;109:19-27.
16. Fan J, Li X, Li P, Li N, Wang T, Shen H, Siow Y, Choy P, Gong Y: Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury. Biochem Cell Biol 2007;85:189-195.
17. Wang BF, Cheng YA, Dang SS: Angiogenesis inhibitory effect of saikosaponin-d on chicken embryo. Zhongguo Zhong Xi Yi Jie He Za Zhi 2009;29:425-429.
18. Hsu YL, Kuo PL, Chiang LC, Lin CC: Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines. Cancer Lett 2004;213:213-221.
19. Wang Q, Zheng XL, Yang L, Shi F, Gao LB, Zhong YJ, Sun H, He F, Lin Y, Wang X: Reactive oxygen species-mediated apoptosis contributes to chemosensiti-zation effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells. J Exp Clin Cancer Res 2010;29:159.
20. Yang W, Sun T, Cao J, Fan S: Hypoxia-Inducible Factor-1α Downregulation by Small Interfering RNA Inhibits Proliferation, Induces Apoptosis, and Enhances Radiosensitivity in Chemical Hypoxic Human Hepatoma SMMC-7721 Cells. Cancer Biother Radiopharm 2011;26:565-571.
21. Ji Z, Yang G, Shahzidi S, Tkacz-Stachowska K, Suo Z, Nesland JM, Peng Q: Induction of hypoxia-inducible factor-1alpha overexpression by cobalt chloride enhances cellular resistance to photodynamic therapy. Cancer Lett 2006;244:182-189.
22. Jiang H, Wang H, Tan Z, Hu S, Wang H, Shi B, Yang L, Li P, Gu J, Wang H, Li Z: Growth suppression of human hepatocellular carcinoma xenografts by a monoclonal antibody CH12 directed to epidermal growth factor receptor variant III. J Biol Chem 2011;286:5913-5920.
23. Wang H, Jiang H, Zhou M, Xu Z, Liu S, Shi B, Yao X, Yao M, Gu J, Li Z: Epidermal growth factor receptor vIII enhances tumorigenicity and resistance to 5-fluorouracil in human hepatocellular carcinoma. Cancer Lett 2009;279:30-38.
24. Nordsmark M, Loncaster J, Aquino-Parsons C, Chou SC, Ladekarl M, Havsteen H, Lindegaard JC, Davidson SE, Varia M, West C, Hunter R, Overgaard J, Raleigh JA.Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervixcarcinomas. Radiother Oncol 2003;67:35-44.
25. Dery MA, Yonuschot G, Winterson BJ: The effects of manually applied intermittent pulsation pressure to rat ventral thorax on lymph transport. Lymphology 2000;33:58-61.
26. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004;303:1010-1014.
27. Vousden KH, Prives C: Blinded by the light: the growing complexity of p53. Cell 2009;137:413-431.
28. Laptenko O, Prives C: Transcriptional regulation by p53: one protein Many possibilities. Cell Death Differ 2006;13:951-961.
29. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM: P53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003;11:577-590.
30. Henry H, Thomas A, Shen Y, White E: Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death. Oncogene 2002;21:748-760.
31. Menendez D, Inga A, Resnick MA: The expanding universe of p53 targets. Nat Rev Cancer 2009;9:724-737.
32. Koukourakis MI, Bentzen SM, Giatromanolaki A, Wilson GD, Daley FM, Saunders MI, Dische S, Sivridis E, Harris AL: Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2a and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHARTrandomized trial. J Clin Oncol 2006;24:727-735.
33. Rapisarda A, Uranchimeg B, Scudiero DA, Selby M, Sausville EA, Shoemaker RH, Melillo G: Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 2002;62:4316-4324.
34. Koh MY, Spivak-Kroizman T, Venturini S, Welsh S, Williams RR, Kirkpatrick DL, Powis G: Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1a. Mol Cancer Ther 2008;7:90-100.
35. Zhong H, Willard M, Simons J: NS398 reduces hypoxia-inducible factor (HIF)-1a and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms. Int J Cancer 2004;112:585-595.
36. Vousden KH: p53: death star. Cell 2000;103:691-694.
37. Ferguson DO, Alt FW: DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene 2001;20:5572-5579.
38. Liang L, Shao C, Deng L, Mendonca MS, Stambrook PJ, Tischfield JA: Radiation-induced genetic instability vivo depends on p53 status. Mutat Res 2002;502:69-80.
39. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ Jr: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992;71:587-597.
40. Sah NK, Munshi A, Nishikawa T, Mukhopadhyay T, Roth JA, Meyn RE: Adenovirus-mediated wild-type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity. Mol Cancer Ther 2003;2:1223-1231.
41. Samuni AM, Kasid U, Chuang EY, Suy S, Degraff W, Krishna MC, Russo A, Mitchell JB: Effects of Hypoxia on Radiation-Responsive Stress-Activated Protein Kinase, p53, and Caspase 3 Signals in TK6 Human Lymphoblastoid Cells. Cancer Res 2005;65:579-586.
42. Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengartner MO: HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature 2010;465:577-583.
43. Lee KB, Kim KR, Huh TL, Lee YM: Proton induces apoptosis of hypoxic tumor cells by the p53-dependent and p38/JNK MAPK signaling pathways. Int J Oncol 2008;33:1247-1256.