Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways

Toxicology and Applied Pharmacology

Volumn 281, Issue 2, 2014, Pages 166-173

  Tong, Qingyi ^a   Qing, Yong ^b   Wu, Yang ^a   Hu, Xiaojuan ^b   Jiang, Lei ^b   Wu, Xiaohua ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

AKT MAPK; Angiogenesis; Antitumor; Dioscin; HUVECs; VEGFR2

Indexed keywords

ANGIOGENESIS INHIBITOR; DIOSCIN; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; DIOSGENIN; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; METASTASIS INHIBITION; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; SIGNAL TRANSDUCTION; SOLID TUMOR; TUMOR INVASION; TUMOR VASCULARIZATION; UMBILICAL VEIN ENDOTHELIAL CELL; ANALOGS AND DERIVATIVES; ANGIOGENESIS; ANIMAL; BAGG ALBINO MOUSE; CELL MOTION; CELL PROLIFERATION; COLONIC NEOPLASMS; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TIME; TUMOR CELL LINE; TUMOR VOLUME; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; DIOSGENIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; TIME FACTORS; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84912093121     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.07.026     Document Type: Article

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