Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release

Oncotarget

Volumn 7, Issue 30, 2016, Pages 47387-47402

  Liao, Chenghui ^a   Zheng, Kai ^a,b   Li, Yan ^c   Xu, Hong ^d   Kang, Qiangrong ^a   Fan, Long ^a   Hu, Xiaopeng ^a   Jin, Zhe ^a   Zeng, Yong ^c   Kong, Xiaoli ^a   Zhang, Jian ^a   Wu, Xuli ^a   Wu, Haiqiang ^a   Liu, Lizhong ^a   Xiao, Xiaohua ^d   Wang, Yifei ^b   He, Zhendan ^a  

^a Shenzhen University   (China)

^b JINAN UNIVERSITY   (China)

^c KUNMING MEDICAL UNIVERSITY   (China)

^d SHENZHEN UNIVERSITY   (China)

Author keywords

Autophagic flux inhibition; Ca2+ release; ROS; Unfolded protein response; Vacuolation

Indexed keywords

CALCIUM ION; GYPENOSIDE L; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG; CALCIUM; GYPENOSIDE; PLANT EXTRACT;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CALCIUM TRANSPORT; CANCER CELL; CELL CYCLE; CELL SWELLING; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; ENDOPLASMIC RETICULUM STRESS; ESOPHAGEAL CANCER CELL LINE; ESOPHAGUS CANCER; GENETIC TRANSFECTION; GYNOSTEMMA PENTAPHYLLUM; HUMAN; HUMAN CELL; LYSOSOME; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA INTERFERENCE; TRANSMISSION ELECTRON MICROSCOPY; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING; DRUG EFFECTS; ESOPHAGUS TUMOR; GYNOSTEMMA; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; CALCIUM; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; ESOPHAGEAL NEOPLASMS; GYNOSTEMMA; HUMANS; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; UBIQUITINATION;

EID: 84982803440     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10159     Document Type: Article

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