Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line

European Journal of Pharmacology

Volumn 735, Issue 1, 2014, Pages 52-58

  Wang, Ying ^a   He, Qing Yu ^b   Chiu, Jen Fu ^c,d  

^a China Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute   (Macao)

^b JINAN UNIVERSITY   (China)

^c SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Dioscin; MAPK; Mitochondria; Reactive oxygen species; Saponin

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTILEUKEMIC AGENT; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; DIOSCIN; LAMIN A; LAMIN C; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; SAPONIN DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CASPASE; DIOSGENIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MYELOID LEUKEMIA; PHYTOCHEMISTRY; POLYGONATUM; POLYGONATUM ZANLANSCIANENSE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; ANALOGS AND DERIVATIVES; CELL SURVIVAL; DRUG EFFECTS; HL 60 CELL LINE; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL SURVIVAL; DIOSGENIN; HL-60 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 84899664695     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.04.018     Document Type: Article

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