Inhibition of NF-κB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel

Archives of Pharmacal Research

Volumn 32, Issue 5, 2009, Pages 755-765

  Kim, Sun Mi ^a,b   Lee, So Yong ^a   Yuk, Dong Yeon ^a   Moon, Dong Cheul ^a   Choi, Sang Sook ^a   Kim, Youngsoo ^a   Han, Sang Bae ^a   Oh, Ki Wan ^a   Hong, Jin Tae ^a  

^a Chungbuk National University   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

Author keywords

Apoptotic cell death; Chemotherapeutics; Colon cancer; NF B; Prostate cancer; Rg3

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CISPLATIN; DOCETAXEL; DOXORUBICIN; GINSENOSIDE RG 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; PACLITAXEL; PROTEIN BAX; PROTEIN BCL 2; APOPTOSIS REGULATORY PROTEIN; CELL CYCLE PROTEIN; GINSENOSIDE; TAXOID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BCL 2 GENE; C JUN GENE; CANCER CELL; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; COX 2 GENE; CYCLIN D1 GENE; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; GENE; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IAP 1 GENE; IC 50; ONCOGENE C FOS; PROTEIN EXPRESSION; XIAP GENE; CELL STRAIN HCT116; COLON TUMOR; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PATHOLOGY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CISPLATIN; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; GINSENOSIDES; HCT116 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; NF-KAPPA B; PACLITAXEL; TAXOIDS;

EID: 67649361895     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-1515-4     Document Type: Article

References (47)

1. A. B. Amer D. Baltimore 1996 An essential role for NF-κB in preventing TNF-α induced cell death Science 274 782 784
2. J. O. Ban D. Y. Yuk K. S. Woo T. M. Kim U. S. Lee H. S. Jeong D. J. Kim Y. B. Chung B. Y. Hwang K. W. Oh J. T. Hong 2007 Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells J. Pharmacol. Sci. 104 374 383
3. M. Barkett T. D. Gilmore 1999 Control of apoptosis by Rel/NF-κB transcription factors Oncogene 18 6910 6924
4. B. K. Bednarski X. Ding K. Coombe A. S. Baldwin H. J. Kim 2008 Active roles for inhibitory kappaB kinases alpha and beta in nuclear factor-kappaB-mediated chemoresistance to doxorubicin Mol. Cancer. Ther. 7 1827 1835
5. V. Bours E. Dejardin F. Goujon-Letawe M. P. Merville V. Castronovo 1994 The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B related proteins in tumor cell lines Biochem. Pharmacol. 47 145 149
6. S. E. Chuang P. Y. Yeh Y. S. Lu 2002 Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells Biochem. Pharmacol. 63 1709 1716
7. J. E. Cortes R. Pazdur 1995 Docetaxel J. Clin. Oncol. 13 2643 2655
8. J. C. Cusack Jr. R. Liu A. S. Baldwin Jr. 2000 Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation Cancer Res. 60 2323 2330
9. E. Diaz-Rubio 2004 New chemotherapeutic advances in pancreatic, colorectal, and gastric cancers Oncologist. 9 282 294
10. Q. G. Dong G. M. Sclabas S. Fujioka 2002 The function of multiple IkappaB: NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis Oncogene 21 6510 6519
11. V. Ferraresi M. Milella A. Vaccaro A. M. D'Ottavio P. Papaldo C. Nisticò M. F. Thorel A. Marsella A. Carpino D. Giannarelli E. Terzoli F. Cognetti 2000 Toxicity and activity of docetaxel in anthracycline-pretreated breast cancer patients: a phase II study Am. J. Clin. Oncol. 23 132 139
12. F. V. Fossella R. DeVore R. N. Kerr J. Crawford R. R. Natale F. Dunphy L. Kalman V. Miller J. S. Lee M. Moore D. Gandara D. Karp E. Vokes M. Kris Y. Kim F. Gamza L. Hammershaimb 2000 Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non-Small Cell Lung Cancer Study Group J. Clin. Oncol. 18 2354 2362
13. A. Garg B. B. Aggarwal 2002 Nuclear transcription factor-kappaB as a target for cancer drug development Leukemia 16 1053 1068
14. F. R. Greten L. Eckmann T. F. Greten J. M. Park Z. W. Li L. J. Egan 2004 IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer Cell 118 285 296
15. S. Helms 2004 Cancer prevention and therapeutics: Panax ginseng Altern. Med. Rev. 9 259 274
16. Y. Huang K. R. Johnson J. S. Norris W. Fan 2000 Nuclear factor-kappaB/ IkappaB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells Cancer Res. 60 4426 4432
17. S. Kasibhatla T. Brunner L. Genestier F. Echeverri A. Mahboubi D. R. Green 1998 DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1 Mol. Cell. 1 543 551
18. Y. S. Keum S. S. Han K. S. Chun K. K. Park J. H. Park S. K. Lee Y. J. Surh 2003 Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion Mutat. Res. 524 75 85
19. S. H. Lee C. W. Lee J. W. Lee M. S. Choi D. J. Son Y. B. Chung C. K. Lee K. W. Oh D. C. Moon B. M. Kwon J. T. Hong 2005 Induction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells Biochem. Pharmacol. 70 1147 1157
20. Y. Li K. L. Ellis S. Ali 2004 Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line Pancreas. 28 90 95
21. Z. P. Lin Y. C. Boller S. M. Amer R. L. Russell K. A. Pacelli S. R. Patierno K. A. Kennedy 1998 Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-κB activation in drug resistance Cancer Res. 58 3059 3065
22. D. S. Lind S. N. Hochwald J. Malaty S. Rekkas P. Hebig G. Mishra L. L. Moldawer E. M. Copeland III S. MacKay 2001 Nuclear factor-kappa B is upregulated in colorectal cancer Surgery 130 363 369
23. S. Mabuchi M. Ohmichi Y. Nishio T. Hayasaka A. Kimura T. Ohta J. Kawagoe K. Takahashi N. Yada-Hashimoto H. Seino-Noda M. Sakata T. Motoyama H. Kurachi J. R. Testa K. Tasaka Y. Murata 2004 Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models Clin. Cancer Res. 10 7645 7654
24. P. Marianneau A. Cardona L. Edelman V. Deubel P. Despres 1997 Dengue virus replication in human hepatoma cells activates NF-κB which in turn induces apoptotic cell death J. Virol. 71 3244 3249
25. R. Millikan L. Baez T. Banerjee J. Wade K. Edwards R. Winn T. L. Smith C. Logothetis 2001 Randomized phase 2 trial of ketoconazole and ketoconazole/doxorubicin in androgen independent prostate cancer Urol. Oncol. 6 111 115
26. S. Okada Y. Sakata S. Matsuno M. Kurihara Y. Sasaki Y. Ohashi T. Taguchi 1999 Phase II study of docetaxel in patients with metastatic pancreatic cancer: a Japanese cooperative study. Cooperative Group of Docetaxel for Pancreatic Cancer in Japan Br. J. Cancer 80 438 443
27. H. Oyaizu Y. Adachi T. Okumura 2001 Proteasome inhibitor 1 enhances paclitaxel-induced apoptosis in human lung adenocarcinoma cell line Oncol. Rep. 8 825 829
28. N. D. Perkins 2000 The Rel/NF-κB family: friend and foe Trends. Biochem. Sci. 25 434 440
29. E. Pikarsky R. M. Porat I. Stein R. Abramovitch S. Amit S. Kasem 2004 NF-kappaB functions as a tumour promoter in inflammation-associated cancer Nature 431 461 466
30. Z. H. Qin Y. Wang M. Nakai T. N. Chase 1998 Nuclear factor-κB contributes to excitotoxin-induced apoptosis in rat striatum Mol. Pharmacol. 53 33 42
31. D. P. Ryan M. H. Kulke C. S. Fuchs M. L. Grossbard S. R. Grossman J. A. Morgan C. C. Earle R. Shivdasani H. Kim R. J. Mayer J. W. Clark 2002 A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma Cancer 94 97 103 (Pubitemid 34049046)
32. A. Schneider A. Martin-Villalba F. Weih J. Vogel T. Wirth M. Schwaninger 1999 NF-κB is activated and promotes cell death in focal cerebral ischemia Nat. Med. 5 554 559
33. S. Singh M. K. Bhat 2004 Carboplatin induces apoptotic cell death through downregulation of constitutively active nuclear factor-kappaB in human HPV-18 E6-positive HEp-2 cells Biochem. Biophys. Res. Commun. 318 346 353
34. D. J. Son M. H. Park S. J. Chae S. O. Moon J. W. Lee H. S. Song D. C. Moon S. S. Kang Y. E. Kwon J. T. Hong 2007 Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor kappaB Mol. Cancer Ther. 6 675 683
35. F. Strasser S. Hailemariam M. Hauser B. C. Pestalozzi 1999 A 53-year-old patient with unilateral pulmonary infiltrates following a single dose of mitomycin, vindesine and cisplatin chemotherapy for non-small-cell lung cancer Respiration 66 562 572
36. Suh, Y., Afaq, F., Johnson, J. J., and Mukhtar, H., A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-{kappa}B signaling pathways. Carcinogenesis, Epub ahead of print, (2008)
37. K. L. Tedesco A. D. Thor D. H. Johnson Y. Shyr K. A. Blum L. J. Goldstein W. J. Gradishar B. P. Nicholson D. E. Merkel D. Murrey S. Edgerton G. W. Sledge Jr. 2004 Docetaxel combined with trastuzumab is an active regimen in HER-2 3+ overexpressing and fluorescent in situ hybridization-positive metastatic breast cancer: a multi-institutional phase II trial J. Clin. Oncol. 22 1071 1077
38. A. K. Tyagi R. P. Singh C. Agarwal D. C. Chan R. Agarwal 2002 Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis Clin. Cancer Res. 8 3512 9
39. D. J. Van Antwerp S. J. Martin T. Kafri D. R. Green I. M. Verma 1996 Suppression of TNF-α-induced apoptosis by NF-κB Science. 274 787 789
40. K. G. Waddick F. M. Uckun 1999 Innovative treatment programs against cancer: II. Nuclear factor-κB (NF-κB) as a molecular target Biochem. Pharmacol. 57 9 17
41. C. Y. Wang J. C. Cusack R. Liu A. S. Baldwin Jr. 1999 Control of inducible chemoresistance: enhanced antitumor therapy through increased apoptosis by inhibition of NF-κB Nat. Med. 5 412 417
42. C. Y. Wang M. W. Mayo A. S. Baldwin Jr. 1996 TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB Science. 274 784 787
43. C. B. Weldon M. E. Burow K. W. Rolfe J. L. Clayton B. M. Jaffe B. S. Beckman 2001 NF-kappa B-mediated chemoresistance in breast cancer cells Surgery 130 143 150
44. W. Xiuli W. Yan Z. Wenqian Z. Yixuan 2008 Fungal biotransformation of ginsenoside Rg3 Wei Sheng Wu Xue Bao 48 1181 5
45. T. K. Yun 2003 Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds Mutat. Res. 523-524 63 74
46. H. Zhang T. Morisaki C. Nakahara 2003 PSK-mediated NF-kappaB inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells NOR-P1 Oncogene 22 2088 2096
47. Y. Zhao W. Wang L. Han E. R. Rayburn D. L. Hill H. Wang R. Zhang 2007 Isolation, structural determination, and evaluation of the biological activity of 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol [20(S)-25-OCH3-PPD], a novel natural product from Panax notoginseng Med. Chem. 3 51 60