Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion

European Journal of Pharmacology

Volumn 774, Issue , 2016, Pages 105-117

  Si, Lingling ^a   Zheng, Lingli ^a   Xu, Lina ^a   Yin, Lianhong ^a   Han, Xu ^a   Qi, Yan ^a   Xu, Youwei ^a   Wang, Changyuan ^a   Peng, Jinyong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle arrest; Dioscin; Laryngeal cancer; Tumor invasion

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYTOCHROME C; DIOSCIN; DNA; GELATINASE A; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; DIOSGENIN; PROTEIN KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; HUMAN; HUMAN CELL; LARYNGEAL CANCER CELL LINE; PRIORITY JOURNAL; UPREGULATION; ANALOGS AND DERIVATIVES; CELL CYCLE CHECKPOINT; CELL MOTION; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; LARYNX TUMOR; METABOLISM; MITOCHONDRION; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR INVASION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CYTOCHROMES C; DIOSGENIN; DNA DAMAGE; HUMANS; LARYNGEAL NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM INVASIVENESS; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES;

EID: 84958879723     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.02.009     Document Type: Article

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