메뉴 건너뛰기




Volumn 13, Issue 3, 2013, Pages 456-463

Quinones derived from plant secondary metabolites as anti-cancer agents

Author keywords

Plant; Quinone; Secondary metabolites; Tumor

Indexed keywords

ALOE EMODIN; ANTINEOPLASTIC AGENT; BETA LAPACHOL; CHRYSOPHANIC ACID; CISPLATIN; DOXORUBICIN; EMODIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; GEMCITABINE; IMATINIB; JUGLONE; OXALIPLATIN; PACLITAXEL; PLANT MEDICINAL PRODUCT; PLUMBAGIN; PROTEIN BAX; PROTEIN BCL 2; QUINONE DERIVATIVE; RHEIN; SALVICINE; SHIKONIN; THYMOQUINONE; UNCLASSIFIED DRUG;

EID: 84876706171     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520611313030008     Document Type: Review
Times cited : (126)

References (151)
  • 2
    • 33947324879 scopus 로고    scopus 로고
    • Comparative studies on purgative potency among three spieces of certified rhubarb
    • Wang, J.K.; Li, A.; Wang, H.; Xu, X.Y. Comparative studies on purgative potency among three spieces of certified rhubarb. Zhongguo Zhong Yao Za Zhi, 2006, 31(23), 1987-1991.
    • (2006) Zhongguo Zhong Yao Za Zhi , vol.31 , Issue.23 , pp. 1987-1991
    • Wang, J.K.1    Li, A.2    Wang, H.3    Xu, X.Y.4
  • 3
    • 79960303808 scopus 로고    scopus 로고
    • Perspectives on medicinal properties of plumbagin and its analogs
    • Epub ahead of print
    • Padhye, S.; Dandawate, P.; Yusufi, M.; Ahmad, A.; Sarkar, F.H. Perspectives on medicinal properties of plumbagin and its analogs. Med. Res. Rev., 2010, [Epub ahead of print]
    • (2010) Med. Res. Rev
    • Padhye, S.1    Dandawate, P.2    Yusufi, M.3    Ahmad, A.4    Sarkar, F.H.5
  • 4
    • 69549105800 scopus 로고    scopus 로고
    • Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells
    • Aithal, B.K.; Kumar, M.R.; Rao, B.N.; Udupa, N.; Rao, B.S. Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells. Cell Biol. Int., 2009, 33(10), 1039-1049.
    • (2009) Cell Biol. Int , vol.33 , Issue.10 , pp. 1039-1049
    • Aithal, B.K.1    Kumar, M.R.2    Rao, B.N.3    Udupa, N.4    Rao, B.S.5
  • 5
    • 0027438950 scopus 로고
    • Rhein and aloe-emodin kinetics from senna laxatives in man
    • Krumbiegel, G.; Schulz, H.U. Rhein and aloe-emodin kinetics from senna laxatives in man. Pharmacol., 1993, 47(Suppl 1), 120-124.
    • (1993) Pharmacol , vol.47 , Issue.SUPPL. 1 , pp. 120-124
    • Krumbiegel, G.1    Schulz, H.U.2
  • 6
    • 0034284560 scopus 로고    scopus 로고
    • Antifungal activity of anthraquinone derivatives from Rheum emodi
    • Agarwal, S.K.; Singh, S.S.; Verma, S.; Kumar, S. Antifungal activity of anthraquinone derivatives from Rheum emodi. J. Ethnopharmacol., 2000, 72(1-2), 43-46.
    • (2000) J. Ethnopharmacol , vol.72 , Issue.1-2 , pp. 43-46
    • Agarwal, S.K.1    Singh, S.S.2    Verma, S.3    Kumar, S.4
  • 7
    • 0025743413 scopus 로고
    • In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives
    • Andersen, D.O.; Weber, N.D.; Wood, S.G.; Hughes, B.G.; Murray, B.K.; North, J.A. In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives. Antiviral. Res., 1991, 16(2), 185-196.
    • (1991) Antiviral. Res , vol.16 , Issue.2 , pp. 185-196
    • Andersen, D.O.1    Weber, N.D.2    Wood, S.G.3    Hughes, B.G.4    Murray, B.K.5    North, J.A.6
  • 9
    • 0017114436 scopus 로고
    • Tumor inhibitors. 114. Aloe emodin: Antileukemic principle isolated from Rhamnus frangula L
    • Kupchan, S.M.; Karim, A. Tumor inhibitors. 114. Aloe emodin: antileukemic principle isolated from Rhamnus frangula L. Lloydia., 1976, 39, (4), 223-224.
    • (1976) Lloydia , vol.39 , Issue.4 , pp. 223-224
    • Kupchan, S.M.1    Karim, A.2
  • 11
    • 84857918973 scopus 로고    scopus 로고
    • Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-kappaB
    • Suboj, P.; Babykutty, S.; Valiyaparambil Gopi, D.R.; Nair, R.S.; Srinivas, P.; Gopala, S. Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-kappaB. Eur. J. Pharm. Sci., 2012, 45(5), 581-591.
    • (2012) Eur. J. Pharm. Sci , vol.45 , Issue.5 , pp. 581-591
    • Suboj, P.1    Babykutty, S.2    Valiyaparambil, G.D.R.3    Nair, R.S.4    Srinivas, P.5    Gopala, S.6
  • 12
    • 79952572370 scopus 로고    scopus 로고
    • Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells
    • Lin, M.L.; Lu, Y.C.; Su, H.L.; Lin, H.T.; Lee, C.C.; Kang, S.E.; Lai, T.C.; Chung, J.G.; Chen, S.S. Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells. J. Cell Biochem., 2011, 112(4), 1176-1191.
    • (2011) J. Cell Biochem , vol.112 , Issue.4 , pp. 1176-1191
    • Lin, M.L.1    Lu, Y.C.2    Su, H.L.3    Lin, H.T.4    Lee, C.C.5    Kang, S.E.6    Lai, T.C.7    Chung, J.G.8    Chen, S.S.9
  • 13
    • 33745346257 scopus 로고    scopus 로고
    • Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells
    • Lee, H.Z.; Lin, C.J.; Yang, W.H.; Leung, W.C.; Chang, S.P. Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells. Cancer Lett., 2006, 239(1), 55-63.
    • (2006) Cancer Lett , vol.239 , Issue.1 , pp. 55-63
    • Lee, H.Z.1    Lin, C.J.2    Yang, W.H.3    Leung, W.C.4    Chang, S.P.5
  • 14
    • 77950076456 scopus 로고    scopus 로고
    • Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway
    • N G.S
    • Lin, M.L.; Lu, Y.C.; Chung, J.G.; Li, Y.C.; Wang, S.G.; N, G.S.; Wu, C.Y.; Su, H.L.; Chen, S.S. Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway. Cancer Lett., 2010, 291(1), 46-58.
    • (2010) Cancer Lett , vol.291 , Issue.1 , pp. 46-58
    • Lin, M.L.1    Lu, Y.C.2    Chung, J.G.3    Li, Y.C.4    Wang, S.G.5    Wu, C.Y.6    Su, H.L.7    Chen, S.S.8
  • 15
    • 36649034064 scopus 로고    scopus 로고
    • Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation
    • Guo, J.M.; Xiao, B.X.; Liu, Q.; Zhang, S.; Liu, D.H.; Gong, Z.H. Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. Acta. Pharmacol. Sin., 2007, 28(12), 1991-1995.
    • (2007) Acta. Pharmacol. Sin , vol.28 , Issue.12 , pp. 1991-1995
    • Guo, J.M.1    Xiao, B.X.2    Liu, Q.3    Zhang, S.4    Liu, D.H.5    Gong, Z.H.6
  • 16
    • 42649128395 scopus 로고    scopus 로고
    • Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells
    • Guo, J.; Xiao, B.; Liu, Q.; Gong, Z.; Le, Y. Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells. Cancer Invest., 2008, 26(4), 369-374.
    • (2008) Cancer Invest , vol.26 , Issue.4 , pp. 369-374
    • Guo, J.1    Xiao, B.2    Liu, Q.3    Gong, Z.4    Le, Y.5
  • 17
    • 34548403112 scopus 로고    scopus 로고
    • Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells
    • Xiao, B.; Guo, J.; Liu, D.; Zhang, S. Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells. Oral. Oncol., 2007, 43(9), 905-910.
    • (2007) Oral. Oncol , vol.43 , Issue.9 , pp. 905-910
    • Xiao, B.1    Guo, J.2    Liu, D.3    Zhang, S.4
  • 18
    • 0037031787 scopus 로고    scopus 로고
    • The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines
    • Kuo, P.L.; Lin, T.C.; Lin, C.C. The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Life Sci., 2002, 71(16), 1879-1892.
    • (2002) Life Sci , vol.71 , Issue.16 , pp. 1879-1892
    • Kuo, P.L.1    Lin, T.C.2    Lin, C.C.3
  • 19
  • 20
    • 33846068065 scopus 로고    scopus 로고
    • Evaluation of the anti-angiogenic effect of aloe-emodin
    • Cardenas, C.; Quesada, A.R.; Medina, M.A. Evaluation of the anti-angiogenic effect of aloe-emodin. Cell Mol. Life Sci., 2006, 63(24), 3083-3089.
    • (2006) Cell Mol. Life Sci , vol.63 , Issue.24 , pp. 3083-3089
    • Cardenas, C.1    Quesada, A.R.2    Medina, M.A.3
  • 21
    • 77950455995 scopus 로고    scopus 로고
    • Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9
    • Chen, Y.Y.; Chiang, S.Y.; Lin, J.G.; Ma, Y.S.; Liao, C.L.; Weng, S.W.; Lai, T.Y.; Chung, J.G. Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9. Int. J. Oncol., 2010, 36(5), 1113-1120.
    • (2010) Int. J. Oncol , vol.36 , Issue.5 , pp. 1113-1120
    • Chen, Y.Y.1    Chiang, S.Y.2    Lin, J.G.3    Ma, Y.S.4    Liao, C.L.5    Weng, S.W.6    Lai, T.Y.7    Chung, J.G.8
  • 22
    • 77955776103 scopus 로고    scopus 로고
    • Antitumor properties of aloe-emodin and induction of transglutaminase 2 activity in B16-F10 melanoma cells
    • Tabolacci, C.; Lentini, A.; Mattioli, P.; Provenzano, B.; Oliverio, S.; Carlomosti, F.; Beninati, S. Antitumor properties of aloe-emodin and induction of transglutaminase 2 activity in B16-F10 melanoma cells. Life Sci., 2010, 87(9-10), 316-324.
    • (2010) Life Sci , vol.87 , Issue.9-10 , pp. 316-324
    • Tabolacci, C.1    Lentini, A.2    Mattioli, P.3    Provenzano, B.4    Oliverio, S.5    Carlomosti, F.6    Beninati, S.7
  • 23
    • 3543111540 scopus 로고    scopus 로고
    • Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma
    • Fenig, E.; Nordenberg, J.; Beery, E.; Sulkes, J.; Wasserman, L. Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma. Oncol. Rep., 2004, 11(1), 213-217.
    • (2004) Oncol. Rep , vol.11 , Issue.1 , pp. 213-217
    • Fenig, E.1    Nordenberg, J.2    Beery, E.3    Sulkes, J.4    Wasserman, L.5
  • 24
    • 34848899857 scopus 로고    scopus 로고
    • Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells
    • Lu, G.D.; Shen, H.M.; Chung, M.C.; Ong, C.N. Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells. Carcinogenesis, 2007, 28(9), 1937-1945.
    • (2007) Carcinogenesis , vol.28 , Issue.9 , pp. 1937-1945
    • Lu, G.D.1    Shen, H.M.2    Chung, M.C.3    Ong, C.N.4
  • 25
    • 0037531634 scopus 로고    scopus 로고
    • Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell
    • Yeh, F.T.; Wu, C.H.; Lee, H.Z. Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. Int. J. Cancer, 2003, 106(1), 26-33.
    • (2003) Int. J. Cancer , vol.106 , Issue.1 , pp. 26-33
    • Yeh, F.T.1    Wu, C.H.2    Lee, H.Z.3
  • 27
    • 16844386205 scopus 로고    scopus 로고
    • Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth
    • Cha, T.L.; Qiu, L.; Chen, C.T.; Wen, Y.; Hung, M.C. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Res., 2005, 65(6), 2287-2295.
    • (2005) Cancer Res , vol.65 , Issue.6 , pp. 2287-2295
    • Cha, T.L.1    Qiu, L.2    Chen, C.T.3    Wen, Y.4    Hung, M.C.5
  • 28
    • 52049098936 scopus 로고    scopus 로고
    • Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells
    • Shi, P.; Huang, Z.; Chen, G. Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells. Am. J. Chin. Med., 2008, 36(4), 805-813.
    • (2008) Am. J. Chin. Med , vol.36 , Issue.4 , pp. 805-813
    • Shi, P.1    Huang, Z.2    Chen, G.3
  • 29
    • 73449090077 scopus 로고    scopus 로고
    • Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo
    • Chun-Guang, W.; Jun-Qing, Y.; Bei-Zhong, L.; Dan-Ting, J.; Chong, W.; Liang, Z.; Dan, Z.; Yan, W. Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. Eur. J. Pharmacol., 2010, 627(1-3), 33-41.
    • (2010) Eur. J. Pharmacol , vol.627 , Issue.1-3 , pp. 33-41
    • Chun-Guang, W.1    Jun-Qing, Y.2    Bei-Zhong, L.3    Dan-Ting, J.4    Chong, W.5    Liang, Z.6    Dan, Z.7    Yan, W.8
  • 30
    • 77951040905 scopus 로고    scopus 로고
    • Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells
    • Chen, Y.Y.; Chiang, S.Y.; Lin, J.G.; Yang, J.S.; Ma, Y.S.; Liao, C.L.; Lai, T.Y.; Tang, N.Y.; Chung, J.G. Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells. Anticancer Res., 2010, 30(3), 945-951.
    • (2010) Anticancer Res , vol.30 , Issue.3 , pp. 945-951
    • Chen, Y.Y.1    Chiang, S.Y.2    Lin, J.G.3    Yang, J.S.4    Ma, Y.S.5    Liao, C.L.6    Lai, T.Y.7    Tang, N.Y.8    Chung, J.G.9
  • 32
    • 77954648680 scopus 로고    scopus 로고
    • Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells
    • Lu, C.C.; Yang, J.S.; Huang, A.C.; Hsia, T.C.; Chou, S.T.; Kuo, C.L.; Lu, H.F.; Lee, T.H.; Wood, W.G.; Chung, J.G. Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol. Nutr. Food Res., 2010, 54(7), 967-976.
    • (2010) Mol. Nutr. Food Res , vol.54 , Issue.7 , pp. 967-976
    • Lu, C.C.1    Yang, J.S.2    Huang, A.C.3    Hsia, T.C.4    Chou, S.T.5    Kuo, C.L.6    Lu, H.F.7    Lee, T.H.8    Wood, W.G.9    Chung, J.G.10
  • 33
    • 42049111396 scopus 로고    scopus 로고
    • Preparation of 1,8-di-O-alkylaloe-emodins and 15-amino-, 15-thiocyano-, and 15-selenocyanochrysophanol derivatives from aloe-emodin and studying their cytotoxic effects
    • Cui, X.R.; Takahashi, K.; Shimamura, T.; Koyanagi, J.; Komada, F.; Saito, S. Preparation of 1,8-di-O-alkylaloe-emodins and 15-amino-, 15-thiocyano-, and 15-selenocyanochrysophanol derivatives from aloe-emodin and studying their cytotoxic effects. Chem. Pharm. Bull., 2008, 56(4), 497-503.
    • (2008) Chem. Pharm. Bull , vol.56 , Issue.4 , pp. 497-503
    • Cui, X.R.1    Takahashi, K.2    Shimamura, T.3    Koyanagi, J.4    Komada, F.5    Saito, S.6
  • 34
    • 77952920105 scopus 로고    scopus 로고
    • Juglone inhibits the proliferation of human esophageal carcinoma EC1 cells
    • Li, L.; Chen, P.; Lian, H.K.; Zhao, J.M.; Ma, J.F.; Dong, Z.M. Juglone inhibits the proliferation of human esophageal carcinoma EC1 cells. World Chin. J. Digestol., 2010, 18(11), 1147-1151.
    • (2010) World Chin. J. Digestol , vol.18 , Issue.11 , pp. 1147-1151
    • Li, L.1    Chen, P.2    Lian, H.K.3    Zhao, J.M.4    Ma, J.F.5    Dong, Z.M.6
  • 35
    • 79958800036 scopus 로고    scopus 로고
    • Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: In vivo and in vitro studies
    • Aithal, K.B.; Kumar, S.; Rao, B.N.; Udupa, N.; Rao, S.B. Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: in vivo and in vitro studies. Integr. Cancer Ther., 2011, 11(1), 68-80.
    • (2011) Integr. Cancer Ther , vol.11 , Issue.1 , pp. 68-80
    • Aithal, K.B.1    Kumar, S.2    Rao, B.N.3    Udupa, N.4    Rao, S.B.5
  • 36
    • 0032523875 scopus 로고    scopus 로고
    • Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats
    • Sugie, S.; Okamoto, K.; Rahman, K.M.; Tanaka, T.; Kawai, K.; Yamahara, J.; Mori, H. Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett., 1998, 127(1-2), 177-183.
    • (1998) Cancer Lett , vol.127 , Issue.1-2 , pp. 177-183
    • Sugie, S.1    Okamoto, K.2    Rahman, K.M.3    Tanaka, T.4    Kawai, K.5    Yamahara, J.6    Mori, H.7
  • 37
    • 1042304329 scopus 로고    scopus 로고
    • Antitumor and immunostimulating activity of 5-hydroxy-1,4-naphthoquinone (juglone) o- and s-acetylglycosides
    • Polonik, S.G.; Prokof'eva, N.G.; Agafonova, I.G.; Uvarova, N.I. Antitumor and immunostimulating activity of 5-hydroxy-1,4-naphthoquinone (juglone) o- and s-acetylglycosides. Pharm. Chem. J., 2003, 37(8), 397-398.
    • (2003) Pharm. Chem. J , vol.37 , Issue.8 , pp. 397-398
    • Polonik, S.G.1    Prokof'eva, N.G.2    Agafonova, I.G.3    Uvarova, N.I.4
  • 38
    • 79951708802 scopus 로고    scopus 로고
    • Peptidyl prolyl isomerase, Pin1 is a potential target for enhancing the therapeutic efficacy of etoposide
    • Mathur, R.; Chandna, S.P.N.K.B.S.D. Peptidyl prolyl isomerase, Pin1 is a potential target for enhancing the therapeutic efficacy of etoposide. Curr. Cancer Drug Tar., 2011, 11(3), 380-392.
    • (2011) Curr. Cancer Drug Tar , vol.11 , Issue.3 , pp. 380-392
    • Mathur, R.1    Chandna, S.P.N.K.B.S.D.2
  • 39
    • 80255131064 scopus 로고    scopus 로고
    • Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes
    • Seshadri, P.; Rajaram, A.; Rajaram, R. Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes. Free Radic. Biol. Med., 2011, 51(11), 2090-2107.
    • (2011) Free Radic. Biol. Med , vol.51 , Issue.11 , pp. 2090-2107
    • Seshadri, P.1    Rajaram, A.2    Rajaram, R.3
  • 40
    • 1642498276 scopus 로고    scopus 로고
    • Cytotoxic action of juglone and plumbagin: A mechanistic study using HaCaT keratinocytes
    • Inbaraj, J.J.; Chignell, C.F. Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes. Chem. Res. Toxicol., 2004, 17(1), 55-62.
    • (2004) Chem. Res. Toxicol , vol.17 , Issue.1 , pp. 55-62
    • Inbaraj, J.J.1    Chignell, C.F.2
  • 41
    • 27544443196 scopus 로고    scopus 로고
    • The natural toxin juglone causes degradation of p53 and induces rapid H2AX phosphorylation and cell death in human fibroblasts
    • Paulsen, M.T.; Ljungman, M. The natural toxin juglone causes degradation of p53 and induces rapid H2AX phosphorylation and cell death in human fibroblasts. Toxicol. Appl. Pharmacol., 2005, 209(1), 1-9.
    • (2005) Toxicol. Appl. Pharmacol , vol.209 , Issue.1 , pp. 1-9
    • Paulsen, M.T.1    Ljungman, M.2
  • 42
    • 78650171632 scopus 로고    scopus 로고
    • Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway
    • Ji Yu-Bin, Y.B.; Qu, Z.Y.; Zou, X. Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Exp. Toxicol. Pathol., 2011, 63(1-2), 69-78.
    • (2011) Exp. Toxicol. Pathol , vol.63 , Issue.1-2 , pp. 69-78
    • Ji, Y.B.1    Qu, Z.Y.2    Zou, X.3
  • 43
    • 84863232732 scopus 로고    scopus 로고
    • Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism
    • Xu, H.L.; Yu, X.F.; Qu, S.C.; Qu, X.R.; Jiang, Y.F.; Sui, D.Y. Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism. Food Chem. Toxicol., 2012, 50(3-4), 590-596.
    • (2012) Food Chem. Toxicol , vol.50 , Issue.3-4 , pp. 590-596
    • Xu, H.L.1    Yu, X.F.2    Qu, S.C.3    Qu, X.R.4    Jiang, Y.F.5    Sui, D.Y.6
  • 44
    • 52049111869 scopus 로고    scopus 로고
    • Juglone inactivates cysteine-rich proteins required for progression through mitosis
    • Fila, C.; Metz, C.; van der Sluijs, P. Juglone inactivates cysteine-rich proteins required for progression through mitosis. J. Biol. Chem., 2008, 283(31), 21714-21724.
    • (2008) J. Biol. Chem , vol.283 , Issue.31 , pp. 21714-21724
    • Fila, C.1    Metz, C.2    van der Sluijs, P.3
  • 45
    • 0035253619 scopus 로고    scopus 로고
    • Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription
    • Chao, S.H.; Greenleaf, A.L.; Price, D.H. Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. Nucleic Acids Res., 2001, 29(3), 767-773.
    • (2001) Nucleic Acids Res , vol.29 , Issue.3 , pp. 767-773
    • Chao, S.H.1    Greenleaf, A.L.2    Price, D.H.3
  • 46
    • 77949742297 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1
    • Khanal, P.; Namgoong, G.M.; Kang, B.S.; Woo, E.R.; Choi, H.S. The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1. Mol. Cancer Ther., 2010, 9(3), 606-616.
    • (2010) Mol. Cancer Ther , vol.9 , Issue.3 , pp. 606-616
    • Khanal, P.1    Namgoong, G.M.2    Kang, B.S.3    Woo, E.R.4    Choi, H.S.5
  • 47
    • 77956184488 scopus 로고    scopus 로고
    • Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway
    • Xu, H.L.; Yu, X.F.; Qu, S.C.; Zhang, R.; Qu, X.R.; Chen, Y.P.; Ma, X.Y.; Sui, D.Y. Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway. Eur. J. Pharmacol., 2010, 645(1-3), 14-22.
    • (2010) Eur. J. Pharmacol , vol.645 , Issue.1-3 , pp. 14-22
    • Xu, H.L.1    Yu, X.F.2    Qu, S.C.3    Zhang, R.4    Qu, X.R.5    Chen, Y.P.6    Ma, X.Y.7    Sui, D.Y.8
  • 48
    • 77950057491 scopus 로고    scopus 로고
    • Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol
    • Bonifazi, E.L.; Rios-Luci, C.; Leon, L.G.; Burton, G.; Padron, J.M.; Misico, R.I. Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol. Bioorg. Med. Chem., 2010, 18(7), 2621-2630.
    • (2010) Bioorg. Med. Chem , vol.18 , Issue.7 , pp. 2621-2630
    • Bonifazi, E.L.1    Rios-Luci, C.2    Leon, L.G.3    Burton, G.4    Padron, J.M.5    Misico, R.I.6
  • 50
    • 77951898596 scopus 로고    scopus 로고
    • Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice
    • Medeiros, C.S.; Pontes-Filho, N.T.; Camara, C.A.; Lima-Filho, J.V.; Oliveira, P.C.; Lemos, S.A.; Leal, A.F.; Brandao, J.O.; Neves, R.P. Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice. Braz. J. Med. Biol. Res., 2010, 43(4), 345-349.
    • (2010) Braz. J. Med. Biol. Res , vol.43 , Issue.4 , pp. 345-349
    • Medeiros, C.S.1    Pontes-Filho, N.T.2    Camara, C.A.3    Lima-Filho, J.V.4    Oliveira, P.C.5    Lemos, S.A.6    Leal, A.F.7    Brandao, J.O.8    Neves, R.P.9
  • 51
    • 0021835907 scopus 로고
    • Effects of beta-lapachone, a peroxide-generating quinone, on macromolecule synthesis and degradation in Trypanosoma cruzi
    • Goijman, S.G.; Stoppani, A.O. Effects of beta-lapachone, a peroxide-generating quinone, on macromolecule synthesis and degradation in Trypanosoma cruzi. Arch. Biochem. Biophys., 1985, 240(1), 273-280.
    • (1985) Arch. Biochem. Biophys , vol.240 , Issue.1 , pp. 273-280
    • Goijman, S.G.1    Stoppani, A.O.2
  • 52
    • 0018131050 scopus 로고
    • Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria
    • Cruz, F.S.; Docampo, R.; Boveris, A. Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria. Antimicrob. Agents Chemother., 1978, 14(4), 630-633.
    • (1978) Antimicrob. Agents Chemother , vol.14 , Issue.4 , pp. 630-633
    • Cruz, F.S.1    Docampo, R.2    Boveris, A.3
  • 53
    • 0344406759 scopus 로고    scopus 로고
    • Selective killing of cancer cells by beta-lapachone: Direct checkpoint activation as a strategy against cancer
    • Li, Y.; Sun, X.; LaMont, J.T.; Pardee, A.B.; Li, C.J. Selective killing of cancer cells by beta-lapachone: direct checkpoint activation as a strategy against cancer. Proc. Natl. Acad. Sci. USA, 2003, 100(5), 2674-2678.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.5 , pp. 2674-2678
    • Li, Y.1    Sun, X.2    Lamont, J.T.3    Pardee, A.B.4    Li, C.J.5
  • 54
    • 0033539487 scopus 로고    scopus 로고
    • Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: Combining drugs imposes different artificial checkpoints
    • Li, C.J.; Li, Y.Z.; Pinto, A.V.; Pardee, A.B. Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: combining drugs imposes different artificial checkpoints. Proc. Natl. Acad. Sci. USA, 1999, 96(23), 13369-13374.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , Issue.23 , pp. 13369-13374
    • Li, C.J.1    Li, Y.Z.2    Pinto, A.V.3    Pardee, A.B.4
  • 56
    • 33646439242 scopus 로고    scopus 로고
    • Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro
    • Suzuki, M.; Amano, M.; Choi, J.; Park, H.J.; Williams, B.W.; Ono, K.; Song, C.W. Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro. Radiat. Res., 2006, 165(5), 525-531.
    • (2006) Radiat. Res , vol.165 , Issue.5 , pp. 525-531
    • Suzuki, M.1    Amano, M.2    Choi, J.3    Park, H.J.4    Williams, B.W.5    Ono, K.6    Song, C.W.7
  • 58
    • 0027377069 scopus 로고
    • Beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin
    • Li, C.J.; Averboukh, L.; Pardee, A.B. Beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J. Biol. Chem., 1993, 268(30), 22463-22468.
    • (1993) J. Biol. Chem , vol.268 , Issue.30 , pp. 22463-22468
    • Li, C.J.1    Averboukh, L.2    Pardee, A.B.3
  • 60
    • 0017803823 scopus 로고
    • Beta-lapachone, an inhibitor of oncornavirus reverse transcriptase and eukaryotic DNA polymerase-alpha. Inhibitory effect, thiol dependence and specificity
    • Schuerch, A.R.; Wehrli, W. Beta-lapachone, an inhibitor of oncornavirus reverse transcriptase and eukaryotic DNA polymerase-alpha. Inhibitory effect, thiol dependence and specificity. Eur. J. Biochem., 1978, 84(1), 197-205.
    • (1978) Eur. J. Biochem , vol.84 , Issue.1 , pp. 197-205
    • Schuerch, A.R.1    Wehrli, W.2
  • 61
    • 58149140268 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis
    • Lien, Y.C.; Kung, H.N.; Lu, K.S.; Jeng, C.J.; Chau, Y.P. Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis. Histol. Histopathol., 2008, 23(11), 1299-1308.
    • (2008) Histol. Histopathol , vol.23 , Issue.11 , pp. 1299-1308
    • Lien, Y.C.1    Kung, H.N.2    Lu, K.S.3    Jeng, C.J.4    Chau, Y.P.5
  • 62
    • 0038398904 scopus 로고    scopus 로고
    • Phosphorylation of p53, induction of Bax and activation of caspases during beta-lapachone-mediated apoptosis in human prostate epithelial cells
    • Choi, Y.H.; Kim, M.J.; Lee, S.Y.; Lee, Y.N.; Chi, G.Y.; Eom, H.S.; Kim, N.D.; Choi, B.T. Phosphorylation of p53, induction of Bax and activation of caspases during beta-lapachone-mediated apoptosis in human prostate epithelial cells. Int. J. Oncol., 2002, 21(6), 1293-1299.
    • (2002) Int. J. Oncol , vol.21 , Issue.6 , pp. 1293-1299
    • Choi, Y.H.1    Kim, M.J.2    Lee, S.Y.3    Lee, Y.N.4    Chi, G.Y.5    Eom, H.S.6    Kim, N.D.7    Choi, B.T.8
  • 63
    • 0034009970 scopus 로고    scopus 로고
    • NAD(P)H: Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity
    • Pink, J.J.; Planchon, S.M.; Tagliarino, C.; Varnes, M.E.; Siegel, D.; Boothman, D.A. NAD(P)H: quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J. Biol. Chem., 2000, 275(8), 5416-5424.
    • (2000) J. Biol. Chem , vol.275 , Issue.8 , pp. 5416-5424
    • Pink, J.J.1    Planchon, S.M.2    Tagliarino, C.3    Varnes, M.E.4    Siegel, D.5    Boothman, D.A.6
  • 64
    • 0035374621 scopus 로고    scopus 로고
    • Calcium is a key signaling molecule in beta-lapachone-mediated cell death
    • Tagliarino, C.; Pink, J.J.; Dubyak, G.R.; Nieminen, A.L.; Boothman, D.A. Calcium is a key signaling molecule in beta-lapachone-mediated cell death. J. Biol. Chem., 2001, 276(22), 19150-19159.
    • (2001) J. Biol. Chem , vol.276 , Issue.22 , pp. 19150-19159
    • Tagliarino, C.1    Pink, J.J.2    Dubyak, G.R.3    Nieminen, A.L.4    Boothman, D.A.5
  • 65
    • 79251495155 scopus 로고    scopus 로고
    • Hyperthermia enhances the effect of beta-lapachone to cause gammaH2AX formations and cell death in human osteosarcoma cells
    • Hori, T.; Kondo, T.; Lee, H.; Song, C.W.; Park, H.J. Hyperthermia enhances the effect of beta-lapachone to cause gammaH2AX formations and cell death in human osteosarcoma cells. Int. J. Hyperthermia., 2011, 27, (1), 53-62.
    • (2011) Int. J. Hyperthermia , vol.27 , Issue.1 , pp. 53-62
    • Hori, T.1    Kondo, T.2    Lee, H.3    Song, C.W.4    Park, H.J.5
  • 66
    • 34547125117 scopus 로고    scopus 로고
    • Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone
    • Bentle, M.S.; Reinicke, K.E.; Dong, Y.; Bey, E.A.; Boothman, D.A. Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone. Cancer Res., 2007, 67(14), 6936-6945.
    • (2007) Cancer Res , vol.67 , Issue.14 , pp. 6936-6945
    • Bentle, M.S.1    Reinicke, K.E.2    Dong, Y.3    Bey, E.A.4    Boothman, D.A.5
  • 67
    • 77953520689 scopus 로고    scopus 로고
    • Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB
    • Dong, G.Z.; Oh, E.T.; Lee, H.; Park, M.T.; Song, C.W.; Park, H.J. Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB. Exp. Mol. Med., 2010, 42, (5), 327-334.
    • (2010) Exp. Mol. Med , vol.42 , Issue.5 , pp. 327-334
    • Dong, G.Z.1    Oh, E.T.2    Lee, H.3    Park, M.T.4    Song, C.W.5    Park, H.J.6
  • 68
    • 84863987739 scopus 로고
    • Recognition and evaluation of lapachol as an antitumor agent
    • Rao, K.V.; McBride, T.J.; Oleson, J.J. Recognition and evaluation of lapachol as an antitumor agent. Cancer Res., 1968, 28(10), 1952-1954.
    • (1968) Cancer Res , vol.28 , Issue.10 , pp. 1952-1954
    • Rao, K.V.1    McBride, T.J.2    Oleson, J.J.3
  • 69
    • 77953813028 scopus 로고    scopus 로고
    • Preclinical and Clinical Studies of Lapachol and Beta-Lapachone
    • Almeida, E.R.D. Preclinical and Clinical Studies of Lapachol and Beta-Lapachone. Open Nat. Prod. J., 2009, 2, 42-47.
    • (2009) Open Nat. Prod. J , vol.2 , pp. 42-47
    • Almeida, E.R.D.1
  • 70
    • 0348232355 scopus 로고
    • Distribution of plumbagin in the mplumbaginaceae
    • L.M, v.d.V
    • L.M, v.d.V. Distribution of plumbagin in the mplumbaginaceae. Phytochemistry, 1972, 11(11), 3247-3248.
    • (1972) Phytochemistry , vol.11 , Issue.11 , pp. 3247-3248
  • 71
    • 78649591458 scopus 로고    scopus 로고
    • Anti-inflammatory and analgesic effect of plumbagin through inhibition of nuclear factor-kappaB activation
    • Luo, P.; Wong, Y.F.; Ge, L.; Zhang, Z.F.; Liu, Y.; Liu, L.; Zhou, H. Anti-inflammatory and analgesic effect of plumbagin through inhibition of nuclear factor-kappaB activation. J. Pharmacol. Exp. Ther., 2010, 335(3), 735-742.
    • (2010) J. Pharmacol. Exp. Ther , vol.335 , Issue.3 , pp. 735-742
    • Luo, P.1    Wong, Y.F.2    Ge, L.3    Zhang, Z.F.4    Liu, Y.5    Liu, L.6    Zhou, H.7
  • 72
    • 80052082287 scopus 로고    scopus 로고
    • Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression
    • Sun, J.; McKallip, R.J. Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression. Leuk. Res., 2011, 35(10), 1402-1408.
    • (2011) Leuk. Res , vol.35 , Issue.10 , pp. 1402-1408
    • Sun, J.1    McKallip, R.J.2
  • 73
    • 84863158729 scopus 로고    scopus 로고
    • Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-kappaB signaling pathway
    • Li, J.; Shen, L.; Lu, F.R.; Qin, Y.; Chen, R.; Li, Y.; Zhan, H.Z.; He, Y.Q. Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-kappaB signaling pathway. Acta. Pharmacol. Sin., 2012, 33(2), 242-249.
    • (2012) Acta. Pharmacol. Sin , vol.33 , Issue.2 , pp. 242-249
    • Li, J.1    Shen, L.2    Lu, F.R.3    Qin, Y.4    Chen, R.5    Li, Y.6    Zhan, H.Z.7    He, Y.Q.8
  • 75
    • 0030276749 scopus 로고    scopus 로고
    • Niosomal plumbagin with reduced toxicity and improved anticancer activity in BALB/C mice
    • Naresh, R.A.; Udupa, N.; Devi, P.U. Niosomal plumbagin with reduced toxicity and improved anticancer activity in BALB/C mice. J. Pharm. Pharmacol., 1996, 48(11), 1128-1132.
    • (1996) J. Pharm. Pharmacol , vol.48 , Issue.11 , pp. 1128-1132
    • Naresh, R.A.1    Udupa, N.2    Devi, P.U.3
  • 76
    • 80052932440 scopus 로고    scopus 로고
    • Formulation of plumbagin loaded long circulating pegylated liposomes: In vivo evaluation in C57BL/6J mice bearing B16F1 melanoma
    • Kumar, M.R.; Aithal, B.K.; Udupa, N.; Reddy, M.S.; Raakesh, V.; Murthy, R.S.; Raju, D.P.; Rao, B.S. Formulation of plumbagin loaded long circulating pegylated liposomes: in vivo evaluation in C57BL/6J mice bearing B16F1 melanoma. Drug Deliv., 2011, 18(7), 511-522.
    • (2011) Drug Deliv , vol.18 , Issue.7 , pp. 511-522
    • Kumar, M.R.1    Aithal, B.K.2    Udupa, N.3    Reddy, M.S.4    Raakesh, V.5    Murthy, R.S.6    Raju, D.P.7    Rao, B.S.8
  • 77
    • 55349147671 scopus 로고    scopus 로고
    • Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer
    • Aziz, M.H.; Dreckschmidt, N.E.; Verma, A.K. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res., 2008, 68(21), 9024-9032.
    • (2008) Cancer Res , vol.68 , Issue.21 , pp. 9024-9032
    • Aziz, M.H.1    Dreckschmidt, N.E.2    Verma, A.K.3
  • 78
    • 84863021288 scopus 로고    scopus 로고
    • Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2
    • Lai, L.; Liu, J.; Zhai, D.; Lin, Q.; He, L.; Dong, Y.; Zhang, J.; Lu, B.; Chen, Y.; Yi, Z.; Liu, M. Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2. Br. J. Pharmacol., 2012, 165(4b), 1084-1096.
    • (2012) Br. J. Pharmacol , vol.165 , Issue.4 b , pp. 1084-1096
    • Lai, L.1    Liu, J.2    Zhai, D.3    Lin, Q.4    He, L.5    Dong, Y.6    Zhang, J.7    Lu, B.8    Chen, Y.9    Yi, Z.10    Liu, M.11
  • 79
    • 0031666507 scopus 로고    scopus 로고
    • Effect of plumbagin on the radiation induced cytogenetic and cell cycle changes in mouse Ehrlich ascites carcinoma in vivo
    • Devi, P.U.; Rao, B.S.; Solomon, F.E. Effect of plumbagin on the radiation induced cytogenetic and cell cycle changes in mouse Ehrlich ascites carcinoma in vivo. Indian J. Exp. Biol., 1998, 36(9), 891-895.
    • (1998) Indian J. Exp. Biol , vol.36 , Issue.9 , pp. 891-895
    • Devi, P.U.1    Rao, B.S.2    Solomon, F.E.3
  • 80
    • 84855378113 scopus 로고    scopus 로고
    • Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas
    • Sand, J.M.; Hafeez, B.B.; Jamal, M.S.; Witkowsky, O.; Siebers, E.M.; Fischer, J.; Verma, A.K. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas. Carcinogenesis, 2012, 33(1), 184-190.
    • (2012) Carcinogenesis , vol.33 , Issue.1 , pp. 184-190
    • Sand, J.M.1    Hafeez, B.B.2    Jamal, M.S.3    Witkowsky, O.4    Siebers, E.M.5    Fischer, J.6    Verma, A.K.7
  • 81
    • 33745967219 scopus 로고    scopus 로고
    • Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo
    • Hsu, Y.L.; Cho, C.Y.; Kuo, P.L.; Huang, Y.T.; Lin, C.C. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo. J. Pharmacol. Exp. Ther., 2006, 318(2), 484-494.
    • (2006) J. Pharmacol. Exp. Ther , vol.318 , Issue.2 , pp. 484-494
    • Hsu, Y.L.1    Cho, C.Y.2    Kuo, P.L.3    Huang, Y.T.4    Lin, C.C.5
  • 82
    • 33846233374 scopus 로고    scopus 로고
    • Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells
    • Kuo, P.L.; Hsu, Y.L.; Cho, C.Y. Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol. Cancer Ther., 2006, 5(12), 3209-3221.
    • (2006) Mol. Cancer Ther , vol.5 , Issue.12 , pp. 3209-3221
    • Kuo, P.L.1    Hsu, Y.L.2    Cho, C.Y.3
  • 83
    • 37049005766 scopus 로고    scopus 로고
    • Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
    • Wang, C.C.; Chiang, Y.M.; Sung, S.C.; Hsu, Y.L.; Chang, J.K.; Kuo, P.L. Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells. Cancer Lett., 2008, 259(1), 82-98.
    • (2008) Cancer Lett , vol.259 , Issue.1 , pp. 82-98
    • Wang, C.C.1    Chiang, Y.M.2    Sung, S.C.3    Hsu, Y.L.4    Chang, J.K.5    Kuo, P.L.6
  • 85
    • 4043159799 scopus 로고    scopus 로고
    • Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells
    • Srinivas, P.; Gopinath, G.; Banerji, A.; Dinakar, A.; Srinivas, G. Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells. Mol. Carcinog., 2004, 40(4), 201-211.
    • (2004) Mol. Carcinog , vol.40 , Issue.4 , pp. 201-211
    • Srinivas, P.1    Gopinath, G.2    Banerji, A.3    Dinakar, A.4    Srinivas, G.5
  • 86
    • 84855241139 scopus 로고    scopus 로고
    • Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells
    • Tian, L.; Yin, D.; Ren, Y.; Gong, C.; Chen, A.; Guo, F.J. Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. Mol. Med. Report., 2012, 5(1), 126-132.
    • (2012) Mol. Med. Report , vol.5 , Issue.1 , pp. 126-132
    • Tian, L.1    Yin, D.2    Ren, Y.3    Gong, C.4    Chen, A.5    Guo, F.J.6
  • 87
    • 49549083508 scopus 로고    scopus 로고
    • Plumbagin-induced apoptosis in human prostate cancer cells is associated with modulation of cellular redox status and generation of reactive oxygen species
    • Powolny, A.A.; Singh, S.V. Plumbagin-induced apoptosis in human prostate cancer cells is associated with modulation of cellular redox status and generation of reactive oxygen species. Pharm. Res., 2008, 25(9), 2171-2180.
    • (2008) Pharm. Res , vol.25 , Issue.9 , pp. 2171-2180
    • Powolny, A.A.1    Singh, S.V.2
  • 88
    • 77950085770 scopus 로고    scopus 로고
    • Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo
    • Xu, K.H.; Lu, D.P. Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo. Leuk. Res., 2010, 34(5), 658-665.
    • (2010) Leuk. Res , vol.34 , Issue.5 , pp. 658-665
    • Xu, K.H.1    Lu, D.P.2
  • 89
    • 11144322792 scopus 로고    scopus 로고
    • Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone
    • Ding, Y.; Chen, Z.J.; Liu, S.; Che, D.; Vetter, M.; Chang, C.H. Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone. J. Pharm. Pharmacol., 2005, 57(1), 111-116.
    • (2005) J. Pharm. Pharmacol , vol.57 , Issue.1 , pp. 111-116
    • Ding, Y.1    Chen, Z.J.2    Liu, S.3    Che, D.4    Vetter, M.5    Chang, C.H.6
  • 91
    • 33745220306 scopus 로고    scopus 로고
    • Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents
    • Sandur, S.K.; Ichikawa, H.; Sethi, G.; Ahn, K.S.; Aggarwal, B.B. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. J. Biol. Chem., 2006, 281(25), 17023-17033.
    • (2006) J. Biol. Chem , vol.281 , Issue.25 , pp. 17023-17033
    • Sandur, S.K.1    Ichikawa, H.2    Sethi, G.3    Ahn, K.S.4    Aggarwal, B.B.5
  • 93
    • 37549017367 scopus 로고    scopus 로고
    • The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2
    • Shukla, S.; Wu, C.P.; Nandigama, K.; Ambudkar, S.V. The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2. Mol. Cancer Ther., 2007, 6(12 Pt 1), 3279-3286.
    • (2007) Mol. Cancer Ther , vol.6 , Issue.12 PT 1 , pp. 3279-3286
    • Shukla, S.1    Wu, C.P.2    Nandigama, K.3    Ambudkar, S.V.4
  • 95
    • 67650892417 scopus 로고    scopus 로고
    • Synthesis and insect antifeedant activity of plumbagin derivatives with the amino acid moiety
    • Sreelatha, T.; Hymavathi, A.; Babu, K.S.; Murthy, J.M.; Pathipati, U.R.; Rao, J.M. Synthesis and insect antifeedant activity of plumbagin derivatives with the amino acid moiety. J. Agric. Food Chem., 2009, 57(14), 6090-6094.
    • (2009) J. Agric. Food Chem , vol.57 , Issue.14 , pp. 6090-6094
    • Sreelatha, T.1    Hymavathi, A.2    Babu, K.S.3    Murthy, J.M.4    Pathipati, U.R.5    Rao, J.M.6
  • 97
    • 0035990608 scopus 로고    scopus 로고
    • Cellular pharmacology studies of shikonin derivatives
    • Chen, X.; Yang, L.; Oppenheim, J.J.; Howard, M.Z. Cellular pharmacology studies of shikonin derivatives. Phytother. Res., 2002, 16(3), 199-209.
    • (2002) Phytother. Res , vol.16 , Issue.3 , pp. 199-209
    • Chen, X.1    Yang, L.2    Oppenheim, J.J.3    Howard, M.Z.4
  • 98
    • 1242339613 scopus 로고    scopus 로고
    • Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo
    • Staniforth, V.; Wang, S.Y.; Shyur, L.F.; Yang, N.S. Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. J. Biol. Chem., 2004, 279(7), 5877-5885.
    • (2004) J. Biol. Chem , vol.279 , Issue.7 , pp. 5877-5885
    • Staniforth, V.1    Wang, S.Y.2    Shyur, L.F.3    Yang, N.S.4
  • 99
    • 77955267120 scopus 로고    scopus 로고
    • Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity
    • Wang, Z.; Liu, T.; Gan, L.; Wang, T.; Yuan, X.; Zhang, B.; Chen, H.; Zheng, Q. Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity. Eur. J. Pharmacol., 2010, 643(2-3), 211-217.
    • (2010) Eur. J. Pharmacol , vol.643 , Issue.2-3 , pp. 211-217
    • Wang, Z.1    Liu, T.2    Gan, L.3    Wang, T.4    Yuan, X.5    Zhang, B.6    Chen, H.7    Zheng, Q.8
  • 101
    • 1642545128 scopus 로고    scopus 로고
    • Ikejima, T. p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells
    • Wu, Z.; Wu, L.; Li, L.; Tashiro, S.; Onodera, S.; Ikejima, T. p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells. J. Pharmacol. Sci., 2004, 94(2), 166-176.
    • (2004) J. Pharmacol. Sci , vol.94 , Issue.2 , pp. 166-176
    • Wu, Z.1    Wu, L.2    Li, L.3    Tashiro, S.4    Onodera, S.5
  • 102
    • 3042636192 scopus 로고    scopus 로고
    • Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis
    • Wu, Z.; Wu, L.J.; Li, L.H.; Tashiro, S.; Onodera, S.; Ikejima, T. Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis. J. Asian Nat. Prod. Res., 2004, 6(3), 155-166.
    • (2004) J. Asian Nat. Prod. Res , vol.6 , Issue.3 , pp. 155-166
    • Wu, Z.1    Wu, L.J.2    Li, L.H.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 103
    • 37349073187 scopus 로고    scopus 로고
    • Shikonin-induced apoptosis involves caspase-3 activity in a human bladder cancer cell line (T24)
    • Yeh, C.C.; Kuo, H.M.; Li, T.M.; Lin, J.P.; Yu, F.S.; Lu, H.F.; Chung, J.G.; Yang, J.S. Shikonin-induced apoptosis involves caspase-3 activity in a human bladder cancer cell line (T24). In Vivo, 2007, 21(6), 1011-1019.
    • (2007) In Vivo , vol.21 , Issue.6 , pp. 1011-1019
    • Yeh, C.C.1    Kuo, H.M.2    Li, T.M.3    Lin, J.P.4    Yu, F.S.5    Lu, H.F.6    Chung, J.G.7    Yang, J.S.8
  • 104
    • 0032796797 scopus 로고    scopus 로고
    • Shikonin, an ingredient of Lithospermum erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line
    • Yoon, Y.; Kim, Y.O.; Lim, N.Y.; Jeon, W.K.; Sung, H.J. Shikonin, an ingredient of Lithospermum erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line. Planta Med., 1999, 65(6), 532-535.
    • (1999) Planta Med , vol.65 , Issue.6 , pp. 532-535
    • Yoon, Y.1    Kim, Y.O.2    Lim, N.Y.3    Jeon, W.K.4    Sung, H.J.5
  • 105
    • 79953756477 scopus 로고    scopus 로고
    • Shikonin inhibits tumor invasion via down-regulation of NF-kappaB-mediated MMP-9 expression in human ACC-M cells
    • Min, R.; Zun, Z.; Min, Y.; Wenhu, D.; Wenjun, Y.; Chenping, Z. Shikonin inhibits tumor invasion via down-regulation of NF-kappaB-mediated MMP-9 expression in human ACC-M cells. Oral. Dis., 2011, 17(4), 362-369.
    • (2011) Oral. Dis , vol.17 , Issue.4 , pp. 362-369
    • Min, R.1    Zun, Z.2    Min, Y.3    Wenhu, D.4    Wenjun, Y.5    Chenping, Z.6
  • 106
    • 77952397814 scopus 로고    scopus 로고
    • Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells
    • Chang, I.C.; Huang, Y.J.; Chiang, T.I.; Yeh, C.W.; Hsu, L.S. Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells. Biol. Pharm. Bull., 2010, 33(5), 816-824.
    • (2010) Biol. Pharm. Bull , vol.33 , Issue.5 , pp. 816-824
    • Chang, I.C.1    Huang, Y.J.2    Chiang, T.I.3    Yeh, C.W.4    Hsu, L.S.5
  • 107
    • 40849147137 scopus 로고    scopus 로고
    • Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappaB pathway
    • Min, R.; Tong, J.; Wenjun, Y.; Wenhu, D.; Xiaojian, Z.; Jiacai, H.; Jian, Z.; Wantao, C.; Chenping, Z. Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappaB pathway. Phytother. Res., 2008, 22(3), 407-415.
    • (2008) Phytother. Res , vol.22 , Issue.3 , pp. 407-415
    • Min, R.1    Tong, J.2    Wenjun, Y.3    Wenhu, D.4    Xiaojian, Z.5    Jiacai, H.6    Jian, Z.7    Wantao, C.8    Chenping, Z.9
  • 108
    • 0026458552 scopus 로고
    • Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikonin
    • Fujii, N.; Yamashita, Y.; Arima, Y.; Nagashima, M.; Nakano, H. Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikonin. Antimicrob. Agents Chemother., 1992, 36(12), 2589-2594.
    • (1992) Antimicrob. Agents Chemother , vol.36 , Issue.12 , pp. 2589-2594
    • Fujii, N.1    Yamashita, Y.2    Arima, Y.3    Nagashima, M.4    Nakano, H.5
  • 109
    • 33746377985 scopus 로고    scopus 로고
    • SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor
    • Yang, F.; Chen, Y.; Duan, W.; Zhang, C.; Zhu, H.; Ding, J. SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor. Int. J. Cancer, 2006, 119(5), 1184-1193.
    • (2006) Int. J. Cancer , vol.119 , Issue.5 , pp. 1184-1193
    • Yang, F.1    Chen, Y.2    Duan, W.3    Zhang, C.4    Zhu, H.5    Ding, J.6
  • 110
    • 77951297556 scopus 로고    scopus 로고
    • A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells
    • Yao, Y.; Zhou, Q. A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells. Breast Cancer Res. Tr., 2010, 121(1), 233-240.
    • (2010) Breast Cancer Res. Tr , vol.121 , Issue.1 , pp. 233-240
    • Yao, Y.1    Zhou, Q.2
  • 111
    • 69049111714 scopus 로고    scopus 로고
    • Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells
    • Zhang, Y.; Qian, R.Q.; Li, P.P. Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells. Cancer Lett., 2009, 284(1), 47-54.
    • (2009) Cancer Lett , vol.284 , Issue.1 , pp. 47-54
    • Zhang, Y.1    Qian, R.Q.2    Li, P.P.3
  • 112
    • 80054883247 scopus 로고    scopus 로고
    • Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
    • Chen, J.; Xie, J.; Jiang, Z.; Wang, B.; Wang, Y.; Hu, X. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene, 2011, 30(42), 4297-4306.
    • (2011) Oncogene , vol.30 , Issue.42 , pp. 4297-4306
    • Chen, J.1    Xie, J.2    Jiang, Z.3    Wang, B.4    Wang, Y.5    Hu, X.6
  • 113
    • 80052939147 scopus 로고    scopus 로고
    • Synthesis and antitumour activity of beta-hydroxyisovalerylshikonin analogs
    • Rao, Z.; Liu, X.; Zhou, W.; Yi, J.; Li, S.S. Synthesis and antitumour activity of beta-hydroxyisovalerylshikonin analogs. Eur. J. Med. Chem., 2011, 46(9), 3934-3941.
    • (2011) Eur. J. Med. Chem , vol.46 , Issue.9 , pp. 3934-3941
    • Rao, Z.1    Liu, X.2    Zhou, W.3    Yi, J.4    Li, S.S.5
  • 116
    • 58149316180 scopus 로고    scopus 로고
    • Naturally-occurring shikonin analogs--a class of necroptotic inducers that circumvent cancer drug resistance
    • Xuan, Y.; Hu, X. Naturally-occurring shikonin analogs--a class of necroptotic inducers that circumvent cancer drug resistance. Cancer Lett., 2009, 274(2), 233-242.
    • (2009) Cancer Lett , vol.274 , Issue.2 , pp. 233-242
    • Xuan, Y.1    Hu, X.2
  • 118
    • 67650466020 scopus 로고    scopus 로고
    • Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
    • Banerjee, S.; Kaseb, A.O.; Wang, Z.; Kong, D.; Mohammad, M.; Padhye, S.; Sarkar, F.H.; Mohammad, R.M. Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res., 2009, 69(13), 5575-5583.
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5575-5583
    • Banerjee, S.1    Kaseb, A.O.2    Wang, Z.3    Kong, D.4    Mohammad, M.5    Padhye, S.6    Sarkar, F.H.7    Mohammad, R.M.8
  • 120
    • 70349528180 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells
    • Chehl, N.; Chipitsyna, G.; Gong, Q.; Yeo, C.J.; Arafat, H.A. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB, 2009, 11(5), 373-381.
    • (2009) HPB , vol.11 , Issue.5 , pp. 373-381
    • Chehl, N.1    Chipitsyna, G.2    Gong, Q.3    Yeo, C.J.4    Arafat, H.A.5
  • 121
    • 26444457920 scopus 로고    scopus 로고
    • Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
    • El-Mahdy, M.A.; Zhu, Q.; Wang, Q.E.; Wani, G.; Wani, A.A. Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int. J. Cancer, 2005, 117(3), 409-417.
    • (2005) Int. J. Cancer , vol.117 , Issue.3 , pp. 409-417
    • El-Mahdy, M.A.1    Zhu, Q.2    Wang, Q.E.3    Wani, G.4    Wani, A.A.5
  • 123
    • 84888034888 scopus 로고    scopus 로고
    • Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation
    • Epub ahead of print
    • Kolli-Bouhafs, K.; Boukhari, A.; Abusnina, A.; Velot, E.; Gies, J.P.; Lugnier, C.; Ronde, P. Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation. Invest. New Drugs, 2011, [Epub ahead of print]
    • (2011) Invest. New Drugs
    • Kolli-Bouhafs, K.1    Boukhari, A.2    Abusnina, A.3    Velot, E.4    Gies, J.P.5    Lugnier, C.6    Ronde, P.7
  • 124
    • 34548015409 scopus 로고    scopus 로고
    • Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer
    • Kaseb, A.O.; Chinnakannu, K.; Chen, D.; Sivanandam, A.; Tejwani, S.; Menon, M.; Dou, Q.P.; Reddy, G.P. Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer. Cancer Res., 2007, 67(16), 7782-7788.
    • (2007) Cancer Res , vol.67 , Issue.16 , pp. 7782-7788
    • Kaseb, A.O.1    Chinnakannu, K.2    Chen, D.3    Sivanandam, A.4    Tejwani, S.5    Menon, M.6    Dou, Q.P.7    Reddy, G.P.8
  • 127
    • 78650420222 scopus 로고    scopus 로고
    • Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
    • Arafa el, S.A.; Zhu, Q.; Shah, Z.I.; Wani, G.; Barakat, B.M.; Racoma, I.; El-Mahdy, M.A.; Wani, A.A. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutat. Res., 2011, 706(1-2), 28-35.
    • (2011) Mutat. Res , vol.706 , Issue.1-2 , pp. 28-35
    • Arafael, S.A.1    Zhu, Q.2    Shah, Z.I.3    Wani, G.4    Barakat, B.M.5    Racoma, I.6    El-Mahdy, M.A.7    Wani, A.A.8
  • 128
    • 84855839231 scopus 로고    scopus 로고
    • Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo
    • Lei, X.; Lv, X.; Liu, M.; Yang, Z.; Ji, M.; Guo, X.; Dong, W. Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo. Biochem. Biophys. Res. Commun., 2012, 417(2), 864-868.
    • (2012) Biochem. Biophys. Res. Commun , vol.417 , Issue.2 , pp. 864-868
    • Lei, X.1    Lv, X.2    Liu, M.3    Yang, Z.4    Ji, M.5    Guo, X.6    Dong, W.7
  • 129
    • 79960929095 scopus 로고    scopus 로고
    • Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-gamma pathway
    • Woo, C.C.; Loo, S.Y.; Gee, V.; Yap, C.W.; Sethi, G.; Kumar, A.P.; Tan, K.H. Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-gamma pathway. Biochem. Pharmacol., 2011, 82(5), 464-475.
    • (2011) Biochem. Pharmacol , vol.82 , Issue.5 , pp. 464-475
    • Woo, C.C.1    Loo, S.Y.2    Gee, V.3    Yap, C.W.4    Sethi, G.5    Kumar, A.P.6    Tan, K.H.7
  • 130
    • 79952446077 scopus 로고    scopus 로고
    • Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma
    • Hussain, A.R.; Ahmed, M.; Ahmed, S.; Manogaran, P.; Alvi, S.N.; Platanias, L.C.; Al-Kuraya, K.S.; Uddin, S. Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma. Free. Radic. Biol. Med., 2011, 50(8), 978-987.
    • (2011) Free. Radic. Biol. Med , vol.50 , Issue.8 , pp. 978-987
    • Hussain, A.R.1    Ahmed, M.2    Ahmed, S.3    Manogaran, P.4    Alvi, S.N.5    Platanias, L.C.6    Al-Kuraya, K.S.7    Uddin, S.8
  • 131
    • 83455203366 scopus 로고    scopus 로고
    • Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl-XL expression
    • Badr, G.; Mohany, M.; Abu-Tarboush, F. Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl-XL expression. Lipids Health Dis., 2011, 10, 236.
    • (2011) Lipids Health Dis , vol.10 , pp. 236
    • Badr, G.1    Mohany, M.2    Abu-Tarboush, F.3
  • 132
    • 50349098189 scopus 로고    scopus 로고
    • Targeting nuclear factor-kappa B activation pathway by thymoquinone: Role in suppression of antiapoptotic gene products and enhancement of apoptosis
    • Sethi, G.; Ahn, K.S.; Aggarwal, B.B. Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res., 2008, 6(6), 1059-1070.
    • (2008) Mol Cancer Res , vol.6 , Issue.6 , pp. 1059-1070
    • Sethi, G.1    Ahn, K.S.2    Aggarwal, B.B.3
  • 133
    • 43149093993 scopus 로고    scopus 로고
    • Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions
    • Reindl, W.; Yuan, J.; Kramer, A.; Strebhardt, K.; Berg, T. Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Chem. Biol., 2008, 15(5), 459-466.
    • (2008) Chem. Biol , vol.15 , Issue.5 , pp. 459-466
    • Reindl, W.1    Yuan, J.2    Kramer, A.3    Strebhardt, K.4    Berg, T.5
  • 134
    • 84867890420 scopus 로고    scopus 로고
    • Anti-neoplastic agent thymoquinone induces degradation of alpha and beta tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts
    • Alhosin, M.; Ibrahim, A.; Boukhari, A.; Sharif, T.; Gies, J.P.; Auger, C.; Schini-Kerth, V.B. Anti-neoplastic agent thymoquinone induces degradation of alpha and beta tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts. Invest. New Drugs, 2012, 30(5), 1813-1819.
    • (2012) Invest. New Drugs , vol.30 , Issue.5 , pp. 1813-1819
    • Alhosin, M.1    Ibrahim, A.2    Boukhari, A.3    Sharif, T.4    Gies, J.P.5    Auger, C.6    Schini-Kerth, V.B.7
  • 137
    • 80052346775 scopus 로고    scopus 로고
    • Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis
    • Badr, G.; Lefevre, E.A.; Mohany, M. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. PLoS One, 2011, 6(9), e23741.
    • (2011) PLoS One , vol.6 , Issue.9
    • Badr, G.1    Lefevre, E.A.2    Mohany, M.3
  • 139
    • 67651083705 scopus 로고    scopus 로고
    • Effects of thymoquinone-fatty acid conjugates on cancer cells
    • Breyer, S.; Effenberger, K.; Schobert, R. Effects of thymoquinone-fatty acid conjugates on cancer cells. ChemMedChem, 2009, 4(5), 761-768.
    • (2009) ChemMedChem , vol.4 , Issue.5 , pp. 761-768
    • Breyer, S.1    Effenberger, K.2    Schobert, R.3
  • 140
    • 0020634673 scopus 로고
    • The mechanism of action of quinone antibiotics
    • Lown, J.W. The mechanism of action of quinone antibiotics. Mol. Cell. Biochem., 1983, 55(1), 17-40.
    • (1983) Mol. Cell. Biochem , vol.55 , Issue.1 , pp. 17-40
    • Lown, J.W.1
  • 141
    • 34548448874 scopus 로고    scopus 로고
    • Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation
    • Meng, L.H.; Ding, J. Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation. Acta. Pharmacol. Sin., 2007, 28(9), 1460-1465.
    • (2007) Acta. Pharmacol. Sin , vol.28 , Issue.9 , pp. 1460-1465
    • Meng, L.H.1    Ding, J.2
  • 142
    • 40349094835 scopus 로고    scopus 로고
    • Salvicine inactivates beta 1 integrin and inhibits adhesion of MDA-MB-435 cells to fibronectin via reactive oxygen species signaling
    • Zhou, J.; Chen, Y.; Lang, J.Y.; Lu, J.J.; Ding, J. Salvicine inactivates beta 1 integrin and inhibits adhesion of MDA-MB-435 cells to fibronectin via reactive oxygen species signaling. Mol. Cancer Res., 2008, 6(2), 194-204.
    • (2008) Mol. Cancer Res , vol.6 , Issue.2 , pp. 194-204
    • Zhou, J.1    Chen, Y.2    Lang, J.Y.3    Lu, J.J.4    Ding, J.5
  • 143
    • 42549144022 scopus 로고    scopus 로고
    • Reactive oxygen species contribute to cell killing and P-glycoprotein downregulation by salvicine in multidrug resistant K562/A02 cells
    • Cai, Y.; Lu, J.; Miao, Z.; Lin, L.; Ding, J. Reactive oxygen species contribute to cell killing and P-glycoprotein downregulation by salvicine in multidrug resistant K562/A02 cells. Cancer Biol. Ther., 2007, 6(11), 1794-1799.
    • (2007) Cancer Biol. Ther , vol.6 , Issue.11 , pp. 1794-1799
    • Cai, Y.1    Lu, J.2    Miao, Z.3    Lin, L.4    Ding, J.5
  • 144
    • 48449089245 scopus 로고    scopus 로고
    • Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition
    • Cai, Y.J.; Lu, J.J.; Zhu, H.; Xie, H.; Huang, M.; Lin, L.P.; Zhang, X.W.; Ding, J. Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition. Free. Radic. Biol. Med., 2008, 45(5), 627-635.
    • (2008) Free. Radic. Biol. Med , vol.45 , Issue.5 , pp. 627-635
    • Cai, Y.J.1    Lu, J.J.2    Zhu, H.3    Xie, H.4    Huang, M.5    Lin, L.P.6    Zhang, X.W.7    Ding, J.8
  • 145
    • 0035916938 scopus 로고    scopus 로고
    • Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation
    • Wang, H.; Mao, Y.; Chen, A.Y.; Zhou, N.; LaVoie, E.J.; Liu, L.F. Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation. Biochemistry, 2001, 40(11), 3316-3323.
    • (2001) Biochemistry , vol.40 , Issue.11 , pp. 3316-3323
    • Wang, H.1    Mao, Y.2    Chen, A.Y.3    Zhou, N.4    Lavoie, E.J.5    Liu, L.F.6
  • 146
    • 84856035765 scopus 로고    scopus 로고
    • The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells
    • Lu, J.J.; Chen, S.M.; Zhang, X.W.; Ding, J.; Meng, L.H. The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells. Invest. New Drugs, 2011, 29(6), 1276-1283.
    • (2011) Invest. New Drugs , vol.29 , Issue.6 , pp. 1276-1283
    • Lu, J.J.1    Chen, S.M.2    Zhang, X.W.3    Ding, J.4    Meng, L.H.5
  • 147
    • 77956024383 scopus 로고    scopus 로고
    • Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits
    • Dudgeon, D.D.; Shinde, S.; Hua, Y.; Shun, T.Y.; Lazo, J.S.; Strock, C.J.; Giuliano, K.A.; Taylor, D.L.; Johnston, P.A.; Johnston, P.A. Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits. J. Biomol. Screen, 2010, 15(7), 766-782.
    • (2010) J. Biomol. Screen , vol.15 , Issue.7 , pp. 766-782
    • Dudgeon, D.D.1    Shinde, S.2    Hua, Y.3    Shun, T.Y.4    Lazo, J.S.5    Strock, C.J.6    Giuliano, K.A.7    Taylor, D.L.8    Johnston, P.A.9    Johnston, P.A.10
  • 148
    • 65749103049 scopus 로고    scopus 로고
    • Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells
    • Youns, M.; Efferth, T.; Reichling, J.; Fellenberg, K.; Bauer, A.; Hoheisel, J.D. Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells. Biochem. Pharmacol., 2009, 78(3), 273-283.
    • (2009) Biochem. Pharmacol , vol.78 , Issue.3 , pp. 273-283
    • Youns, M.1    Efferth, T.2    Reichling, J.3    Fellenberg, K.4    Bauer, A.5    Hoheisel, J.D.6
  • 149
    • 0036090986 scopus 로고    scopus 로고
    • Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: A possible mechanism of action
    • Mansour, M.A.; Nagi, M.N.; El-Khatib, A.S.; Al-Bekairi, A.M. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem. Funct., 2002, 20(2), 143-151.
    • (2002) Cell Biochem. Funct , vol.20 , Issue.2 , pp. 143-151
    • Mansour, M.A.1    Nagi, M.N.2    El-Khatib, A.S.3    Al-Bekairi, A.M.4
  • 150
    • 84863085673 scopus 로고    scopus 로고
    • Multi-target drugs: The trend of drug research and development
    • Lu, J.J.; Pan, W.; Hu, H.J.; Wang, Y.T. Multi-target drugs: The trend of drug research and development. PLoS ONE, 2012, 7(6), e40262.
    • (2012) PLoS ONE , vol.7 , Issue.6
    • Lu, J.J.1    Pan, W.2    Hu, H.J.3    Wang, Y.T.4
  • 151
    • 41549108420 scopus 로고    scopus 로고
    • From single- to multi-target drugs in cancer therapy: When aspecificity becomes an advantage
    • Petrelli, A.; Giordano, S. From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage. Curr. Med. Chem., 2008, 15(5), 422-432.
    • (2008) Curr. Med. Chem , vol.15 , Issue.5 , pp. 422-432
    • Petrelli, A.1    Giordano, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.