-
2
-
-
33947324879
-
Comparative studies on purgative potency among three spieces of certified rhubarb
-
Wang, J.K.; Li, A.; Wang, H.; Xu, X.Y. Comparative studies on purgative potency among three spieces of certified rhubarb. Zhongguo Zhong Yao Za Zhi, 2006, 31(23), 1987-1991.
-
(2006)
Zhongguo Zhong Yao Za Zhi
, vol.31
, Issue.23
, pp. 1987-1991
-
-
Wang, J.K.1
Li, A.2
Wang, H.3
Xu, X.Y.4
-
3
-
-
79960303808
-
Perspectives on medicinal properties of plumbagin and its analogs
-
Epub ahead of print
-
Padhye, S.; Dandawate, P.; Yusufi, M.; Ahmad, A.; Sarkar, F.H. Perspectives on medicinal properties of plumbagin and its analogs. Med. Res. Rev., 2010, [Epub ahead of print]
-
(2010)
Med. Res. Rev
-
-
Padhye, S.1
Dandawate, P.2
Yusufi, M.3
Ahmad, A.4
Sarkar, F.H.5
-
4
-
-
69549105800
-
Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells
-
Aithal, B.K.; Kumar, M.R.; Rao, B.N.; Udupa, N.; Rao, B.S. Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells. Cell Biol. Int., 2009, 33(10), 1039-1049.
-
(2009)
Cell Biol. Int
, vol.33
, Issue.10
, pp. 1039-1049
-
-
Aithal, B.K.1
Kumar, M.R.2
Rao, B.N.3
Udupa, N.4
Rao, B.S.5
-
5
-
-
0027438950
-
Rhein and aloe-emodin kinetics from senna laxatives in man
-
Krumbiegel, G.; Schulz, H.U. Rhein and aloe-emodin kinetics from senna laxatives in man. Pharmacol., 1993, 47(Suppl 1), 120-124.
-
(1993)
Pharmacol
, vol.47
, Issue.SUPPL. 1
, pp. 120-124
-
-
Krumbiegel, G.1
Schulz, H.U.2
-
6
-
-
0034284560
-
Antifungal activity of anthraquinone derivatives from Rheum emodi
-
Agarwal, S.K.; Singh, S.S.; Verma, S.; Kumar, S. Antifungal activity of anthraquinone derivatives from Rheum emodi. J. Ethnopharmacol., 2000, 72(1-2), 43-46.
-
(2000)
J. Ethnopharmacol
, vol.72
, Issue.1-2
, pp. 43-46
-
-
Agarwal, S.K.1
Singh, S.S.2
Verma, S.3
Kumar, S.4
-
7
-
-
0025743413
-
In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives
-
Andersen, D.O.; Weber, N.D.; Wood, S.G.; Hughes, B.G.; Murray, B.K.; North, J.A. In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives. Antiviral. Res., 1991, 16(2), 185-196.
-
(1991)
Antiviral. Res
, vol.16
, Issue.2
, pp. 185-196
-
-
Andersen, D.O.1
Weber, N.D.2
Wood, S.G.3
Hughes, B.G.4
Murray, B.K.5
North, J.A.6
-
8
-
-
0033678216
-
Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride
-
Arosio, B.; Gagliano, N.; Fusaro, L.M.; Parmeggiani, L.; Tagliabue, J.; Galetti, P.; De Castri, D.; Moscheni, C.; Annoni, G. Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. Pharmacol. Toxicol., 2000, 87(5), 229-233.
-
(2000)
Pharmacol. Toxicol
, vol.87
, Issue.5
, pp. 229-233
-
-
Arosio, B.1
Gagliano, N.2
Fusaro, L.M.3
Parmeggiani, L.4
Tagliabue, J.5
Galetti, P.6
de Castri, D.7
Moscheni, C.8
Annoni, G.9
-
9
-
-
0017114436
-
Tumor inhibitors. 114. Aloe emodin: Antileukemic principle isolated from Rhamnus frangula L
-
Kupchan, S.M.; Karim, A. Tumor inhibitors. 114. Aloe emodin: antileukemic principle isolated from Rhamnus frangula L. Lloydia., 1976, 39, (4), 223-224.
-
(1976)
Lloydia
, vol.39
, Issue.4
, pp. 223-224
-
-
Kupchan, S.M.1
Karim, A.2
-
10
-
-
0034212761
-
Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors
-
Pecere, T.; Gazzola, M.V.; Mucignat, C.; Parolin, C.; Vecchia, F.D.; Cavaggioni, A.; Basso, G.; Diaspro, A.; Salvato, B.; Carli, M.; Palu, G. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res., 2000, 60(11), 2800-2804.
-
(2000)
Cancer Res
, vol.60
, Issue.11
, pp. 2800-2804
-
-
Pecere, T.1
Gazzola, M.V.2
Mucignat, C.3
Parolin, C.4
Vecchia, F.D.5
Cavaggioni, A.6
Basso, G.7
Diaspro, A.8
Salvato, B.9
Carli, M.10
Palu, G.11
-
11
-
-
84857918973
-
Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-kappaB
-
Suboj, P.; Babykutty, S.; Valiyaparambil Gopi, D.R.; Nair, R.S.; Srinivas, P.; Gopala, S. Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-kappaB. Eur. J. Pharm. Sci., 2012, 45(5), 581-591.
-
(2012)
Eur. J. Pharm. Sci
, vol.45
, Issue.5
, pp. 581-591
-
-
Suboj, P.1
Babykutty, S.2
Valiyaparambil, G.D.R.3
Nair, R.S.4
Srinivas, P.5
Gopala, S.6
-
12
-
-
79952572370
-
Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells
-
Lin, M.L.; Lu, Y.C.; Su, H.L.; Lin, H.T.; Lee, C.C.; Kang, S.E.; Lai, T.C.; Chung, J.G.; Chen, S.S. Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells. J. Cell Biochem., 2011, 112(4), 1176-1191.
-
(2011)
J. Cell Biochem
, vol.112
, Issue.4
, pp. 1176-1191
-
-
Lin, M.L.1
Lu, Y.C.2
Su, H.L.3
Lin, H.T.4
Lee, C.C.5
Kang, S.E.6
Lai, T.C.7
Chung, J.G.8
Chen, S.S.9
-
13
-
-
33745346257
-
Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells
-
Lee, H.Z.; Lin, C.J.; Yang, W.H.; Leung, W.C.; Chang, S.P. Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells. Cancer Lett., 2006, 239(1), 55-63.
-
(2006)
Cancer Lett
, vol.239
, Issue.1
, pp. 55-63
-
-
Lee, H.Z.1
Lin, C.J.2
Yang, W.H.3
Leung, W.C.4
Chang, S.P.5
-
14
-
-
77950076456
-
Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway
-
N G.S
-
Lin, M.L.; Lu, Y.C.; Chung, J.G.; Li, Y.C.; Wang, S.G.; N, G.S.; Wu, C.Y.; Su, H.L.; Chen, S.S. Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway. Cancer Lett., 2010, 291(1), 46-58.
-
(2010)
Cancer Lett
, vol.291
, Issue.1
, pp. 46-58
-
-
Lin, M.L.1
Lu, Y.C.2
Chung, J.G.3
Li, Y.C.4
Wang, S.G.5
Wu, C.Y.6
Su, H.L.7
Chen, S.S.8
-
15
-
-
36649034064
-
Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation
-
Guo, J.M.; Xiao, B.X.; Liu, Q.; Zhang, S.; Liu, D.H.; Gong, Z.H. Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. Acta. Pharmacol. Sin., 2007, 28(12), 1991-1995.
-
(2007)
Acta. Pharmacol. Sin
, vol.28
, Issue.12
, pp. 1991-1995
-
-
Guo, J.M.1
Xiao, B.X.2
Liu, Q.3
Zhang, S.4
Liu, D.H.5
Gong, Z.H.6
-
16
-
-
42649128395
-
Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells
-
Guo, J.; Xiao, B.; Liu, Q.; Gong, Z.; Le, Y. Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells. Cancer Invest., 2008, 26(4), 369-374.
-
(2008)
Cancer Invest
, vol.26
, Issue.4
, pp. 369-374
-
-
Guo, J.1
Xiao, B.2
Liu, Q.3
Gong, Z.4
Le, Y.5
-
17
-
-
34548403112
-
Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells
-
Xiao, B.; Guo, J.; Liu, D.; Zhang, S. Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells. Oral. Oncol., 2007, 43(9), 905-910.
-
(2007)
Oral. Oncol
, vol.43
, Issue.9
, pp. 905-910
-
-
Xiao, B.1
Guo, J.2
Liu, D.3
Zhang, S.4
-
18
-
-
0037031787
-
The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines
-
Kuo, P.L.; Lin, T.C.; Lin, C.C. The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Life Sci., 2002, 71(16), 1879-1892.
-
(2002)
Life Sci
, vol.71
, Issue.16
, pp. 1879-1892
-
-
Kuo, P.L.1
Lin, T.C.2
Lin, C.C.3
-
19
-
-
75149121479
-
Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells
-
Chiu, T.H.; Lai, W.W.; Hsia, T.C.; Yang, J.S.; Lai, T.Y.; Wu, P.P.; Ma, C.Y.; Yeh, C.C.; Ho, C.C.; Lu, H.F.; Wood, W.G.; Chung, J.G. Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells. Anticancer Res., 2009, 29(11), 4503-4511.
-
(2009)
Anticancer Res
, vol.29
, Issue.11
, pp. 4503-4511
-
-
Chiu, T.H.1
Lai, W.W.2
Hsia, T.C.3
Yang, J.S.4
Lai, T.Y.5
Wu, P.P.6
Ma, C.Y.7
Yeh, C.C.8
Ho, C.C.9
Lu, H.F.10
Wood, W.G.11
Chung, J.G.12
-
20
-
-
33846068065
-
Evaluation of the anti-angiogenic effect of aloe-emodin
-
Cardenas, C.; Quesada, A.R.; Medina, M.A. Evaluation of the anti-angiogenic effect of aloe-emodin. Cell Mol. Life Sci., 2006, 63(24), 3083-3089.
-
(2006)
Cell Mol. Life Sci
, vol.63
, Issue.24
, pp. 3083-3089
-
-
Cardenas, C.1
Quesada, A.R.2
Medina, M.A.3
-
21
-
-
77950455995
-
Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9
-
Chen, Y.Y.; Chiang, S.Y.; Lin, J.G.; Ma, Y.S.; Liao, C.L.; Weng, S.W.; Lai, T.Y.; Chung, J.G. Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9. Int. J. Oncol., 2010, 36(5), 1113-1120.
-
(2010)
Int. J. Oncol
, vol.36
, Issue.5
, pp. 1113-1120
-
-
Chen, Y.Y.1
Chiang, S.Y.2
Lin, J.G.3
Ma, Y.S.4
Liao, C.L.5
Weng, S.W.6
Lai, T.Y.7
Chung, J.G.8
-
22
-
-
77955776103
-
Antitumor properties of aloe-emodin and induction of transglutaminase 2 activity in B16-F10 melanoma cells
-
Tabolacci, C.; Lentini, A.; Mattioli, P.; Provenzano, B.; Oliverio, S.; Carlomosti, F.; Beninati, S. Antitumor properties of aloe-emodin and induction of transglutaminase 2 activity in B16-F10 melanoma cells. Life Sci., 2010, 87(9-10), 316-324.
-
(2010)
Life Sci
, vol.87
, Issue.9-10
, pp. 316-324
-
-
Tabolacci, C.1
Lentini, A.2
Mattioli, P.3
Provenzano, B.4
Oliverio, S.5
Carlomosti, F.6
Beninati, S.7
-
23
-
-
3543111540
-
Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma
-
Fenig, E.; Nordenberg, J.; Beery, E.; Sulkes, J.; Wasserman, L. Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma. Oncol. Rep., 2004, 11(1), 213-217.
-
(2004)
Oncol. Rep
, vol.11
, Issue.1
, pp. 213-217
-
-
Fenig, E.1
Nordenberg, J.2
Beery, E.3
Sulkes, J.4
Wasserman, L.5
-
24
-
-
34848899857
-
Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells
-
Lu, G.D.; Shen, H.M.; Chung, M.C.; Ong, C.N. Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells. Carcinogenesis, 2007, 28(9), 1937-1945.
-
(2007)
Carcinogenesis
, vol.28
, Issue.9
, pp. 1937-1945
-
-
Lu, G.D.1
Shen, H.M.2
Chung, M.C.3
Ong, C.N.4
-
25
-
-
0037531634
-
Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell
-
Yeh, F.T.; Wu, C.H.; Lee, H.Z. Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. Int. J. Cancer, 2003, 106(1), 26-33.
-
(2003)
Int. J. Cancer
, vol.106
, Issue.1
, pp. 26-33
-
-
Yeh, F.T.1
Wu, C.H.2
Lee, H.Z.3
-
26
-
-
0042839757
-
Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin
-
Pecere, T.; Sarinella, F.; Salata, C.; Gatto, B.; Bet, A.; Dalla Vecchia, F.; Diaspro, A.; Carli, M.; Palumbo, M.; Palu, G. Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. Int. J. Cancer, 2003, 106(6), 836-847.
-
(2003)
Int. J. Cancer
, vol.106
, Issue.6
, pp. 836-847
-
-
Pecere, T.1
Sarinella, F.2
Salata, C.3
Gatto, B.4
Bet, A.5
Dalla Vecchia, F.6
Diaspro, A.7
Carli, M.8
Palumbo, M.9
Palu, G.10
-
27
-
-
16844386205
-
Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth
-
Cha, T.L.; Qiu, L.; Chen, C.T.; Wen, Y.; Hung, M.C. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Res., 2005, 65(6), 2287-2295.
-
(2005)
Cancer Res
, vol.65
, Issue.6
, pp. 2287-2295
-
-
Cha, T.L.1
Qiu, L.2
Chen, C.T.3
Wen, Y.4
Hung, M.C.5
-
28
-
-
52049098936
-
Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells
-
Shi, P.; Huang, Z.; Chen, G. Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells. Am. J. Chin. Med., 2008, 36(4), 805-813.
-
(2008)
Am. J. Chin. Med
, vol.36
, Issue.4
, pp. 805-813
-
-
Shi, P.1
Huang, Z.2
Chen, G.3
-
29
-
-
73449090077
-
Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo
-
Chun-Guang, W.; Jun-Qing, Y.; Bei-Zhong, L.; Dan-Ting, J.; Chong, W.; Liang, Z.; Dan, Z.; Yan, W. Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. Eur. J. Pharmacol., 2010, 627(1-3), 33-41.
-
(2010)
Eur. J. Pharmacol
, vol.627
, Issue.1-3
, pp. 33-41
-
-
Chun-Guang, W.1
Jun-Qing, Y.2
Bei-Zhong, L.3
Dan-Ting, J.4
Chong, W.5
Liang, Z.6
Dan, Z.7
Yan, W.8
-
30
-
-
77951040905
-
Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells
-
Chen, Y.Y.; Chiang, S.Y.; Lin, J.G.; Yang, J.S.; Ma, Y.S.; Liao, C.L.; Lai, T.Y.; Tang, N.Y.; Chung, J.G. Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells. Anticancer Res., 2010, 30(3), 945-951.
-
(2010)
Anticancer Res
, vol.30
, Issue.3
, pp. 945-951
-
-
Chen, Y.Y.1
Chiang, S.Y.2
Lin, J.G.3
Yang, J.S.4
Ma, Y.S.5
Liao, C.L.6
Lai, T.Y.7
Tang, N.Y.8
Chung, J.G.9
-
31
-
-
79960555687
-
Anti-cancer natural products isolated from chinese medicinal herbs
-
Tan, W.; Lu, J.; Huang, M.; Li, Y.; Chen, M.; Wu, G.; Gong, J.; Zhong, Z.; Xu, Z.; Dang, Y.; Guo, J.; Chen, X.; Wang, Y. Anti-cancer natural products isolated from chinese medicinal herbs. Chin. Med., 2011, 6(1), 27.
-
(2011)
Chin. Med
, vol.6
, Issue.1
, pp. 27
-
-
Tan, W.1
Lu, J.2
Huang, M.3
Li, Y.4
Chen, M.5
Wu, G.6
Gong, J.7
Zhong, Z.8
Xu, Z.9
Dang, Y.10
Guo, J.11
Chen, X.12
Wang, Y.13
-
32
-
-
77954648680
-
Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells
-
Lu, C.C.; Yang, J.S.; Huang, A.C.; Hsia, T.C.; Chou, S.T.; Kuo, C.L.; Lu, H.F.; Lee, T.H.; Wood, W.G.; Chung, J.G. Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol. Nutr. Food Res., 2010, 54(7), 967-976.
-
(2010)
Mol. Nutr. Food Res
, vol.54
, Issue.7
, pp. 967-976
-
-
Lu, C.C.1
Yang, J.S.2
Huang, A.C.3
Hsia, T.C.4
Chou, S.T.5
Kuo, C.L.6
Lu, H.F.7
Lee, T.H.8
Wood, W.G.9
Chung, J.G.10
-
33
-
-
42049111396
-
Preparation of 1,8-di-O-alkylaloe-emodins and 15-amino-, 15-thiocyano-, and 15-selenocyanochrysophanol derivatives from aloe-emodin and studying their cytotoxic effects
-
Cui, X.R.; Takahashi, K.; Shimamura, T.; Koyanagi, J.; Komada, F.; Saito, S. Preparation of 1,8-di-O-alkylaloe-emodins and 15-amino-, 15-thiocyano-, and 15-selenocyanochrysophanol derivatives from aloe-emodin and studying their cytotoxic effects. Chem. Pharm. Bull., 2008, 56(4), 497-503.
-
(2008)
Chem. Pharm. Bull
, vol.56
, Issue.4
, pp. 497-503
-
-
Cui, X.R.1
Takahashi, K.2
Shimamura, T.3
Koyanagi, J.4
Komada, F.5
Saito, S.6
-
34
-
-
77952920105
-
Juglone inhibits the proliferation of human esophageal carcinoma EC1 cells
-
Li, L.; Chen, P.; Lian, H.K.; Zhao, J.M.; Ma, J.F.; Dong, Z.M. Juglone inhibits the proliferation of human esophageal carcinoma EC1 cells. World Chin. J. Digestol., 2010, 18(11), 1147-1151.
-
(2010)
World Chin. J. Digestol
, vol.18
, Issue.11
, pp. 1147-1151
-
-
Li, L.1
Chen, P.2
Lian, H.K.3
Zhao, J.M.4
Ma, J.F.5
Dong, Z.M.6
-
35
-
-
79958800036
-
Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: In vivo and in vitro studies
-
Aithal, K.B.; Kumar, S.; Rao, B.N.; Udupa, N.; Rao, S.B. Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: in vivo and in vitro studies. Integr. Cancer Ther., 2011, 11(1), 68-80.
-
(2011)
Integr. Cancer Ther
, vol.11
, Issue.1
, pp. 68-80
-
-
Aithal, K.B.1
Kumar, S.2
Rao, B.N.3
Udupa, N.4
Rao, S.B.5
-
36
-
-
0032523875
-
Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats
-
Sugie, S.; Okamoto, K.; Rahman, K.M.; Tanaka, T.; Kawai, K.; Yamahara, J.; Mori, H. Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett., 1998, 127(1-2), 177-183.
-
(1998)
Cancer Lett
, vol.127
, Issue.1-2
, pp. 177-183
-
-
Sugie, S.1
Okamoto, K.2
Rahman, K.M.3
Tanaka, T.4
Kawai, K.5
Yamahara, J.6
Mori, H.7
-
37
-
-
1042304329
-
Antitumor and immunostimulating activity of 5-hydroxy-1,4-naphthoquinone (juglone) o- and s-acetylglycosides
-
Polonik, S.G.; Prokof'eva, N.G.; Agafonova, I.G.; Uvarova, N.I. Antitumor and immunostimulating activity of 5-hydroxy-1,4-naphthoquinone (juglone) o- and s-acetylglycosides. Pharm. Chem. J., 2003, 37(8), 397-398.
-
(2003)
Pharm. Chem. J
, vol.37
, Issue.8
, pp. 397-398
-
-
Polonik, S.G.1
Prokof'eva, N.G.2
Agafonova, I.G.3
Uvarova, N.I.4
-
38
-
-
79951708802
-
Peptidyl prolyl isomerase, Pin1 is a potential target for enhancing the therapeutic efficacy of etoposide
-
Mathur, R.; Chandna, S.P.N.K.B.S.D. Peptidyl prolyl isomerase, Pin1 is a potential target for enhancing the therapeutic efficacy of etoposide. Curr. Cancer Drug Tar., 2011, 11(3), 380-392.
-
(2011)
Curr. Cancer Drug Tar
, vol.11
, Issue.3
, pp. 380-392
-
-
Mathur, R.1
Chandna, S.P.N.K.B.S.D.2
-
39
-
-
80255131064
-
Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes
-
Seshadri, P.; Rajaram, A.; Rajaram, R. Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes. Free Radic. Biol. Med., 2011, 51(11), 2090-2107.
-
(2011)
Free Radic. Biol. Med
, vol.51
, Issue.11
, pp. 2090-2107
-
-
Seshadri, P.1
Rajaram, A.2
Rajaram, R.3
-
40
-
-
1642498276
-
Cytotoxic action of juglone and plumbagin: A mechanistic study using HaCaT keratinocytes
-
Inbaraj, J.J.; Chignell, C.F. Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes. Chem. Res. Toxicol., 2004, 17(1), 55-62.
-
(2004)
Chem. Res. Toxicol
, vol.17
, Issue.1
, pp. 55-62
-
-
Inbaraj, J.J.1
Chignell, C.F.2
-
41
-
-
27544443196
-
The natural toxin juglone causes degradation of p53 and induces rapid H2AX phosphorylation and cell death in human fibroblasts
-
Paulsen, M.T.; Ljungman, M. The natural toxin juglone causes degradation of p53 and induces rapid H2AX phosphorylation and cell death in human fibroblasts. Toxicol. Appl. Pharmacol., 2005, 209(1), 1-9.
-
(2005)
Toxicol. Appl. Pharmacol
, vol.209
, Issue.1
, pp. 1-9
-
-
Paulsen, M.T.1
Ljungman, M.2
-
42
-
-
78650171632
-
Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway
-
Ji Yu-Bin, Y.B.; Qu, Z.Y.; Zou, X. Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Exp. Toxicol. Pathol., 2011, 63(1-2), 69-78.
-
(2011)
Exp. Toxicol. Pathol
, vol.63
, Issue.1-2
, pp. 69-78
-
-
Ji, Y.B.1
Qu, Z.Y.2
Zou, X.3
-
43
-
-
84863232732
-
Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism
-
Xu, H.L.; Yu, X.F.; Qu, S.C.; Qu, X.R.; Jiang, Y.F.; Sui, D.Y. Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism. Food Chem. Toxicol., 2012, 50(3-4), 590-596.
-
(2012)
Food Chem. Toxicol
, vol.50
, Issue.3-4
, pp. 590-596
-
-
Xu, H.L.1
Yu, X.F.2
Qu, S.C.3
Qu, X.R.4
Jiang, Y.F.5
Sui, D.Y.6
-
44
-
-
52049111869
-
Juglone inactivates cysteine-rich proteins required for progression through mitosis
-
Fila, C.; Metz, C.; van der Sluijs, P. Juglone inactivates cysteine-rich proteins required for progression through mitosis. J. Biol. Chem., 2008, 283(31), 21714-21724.
-
(2008)
J. Biol. Chem
, vol.283
, Issue.31
, pp. 21714-21724
-
-
Fila, C.1
Metz, C.2
van der Sluijs, P.3
-
45
-
-
0035253619
-
Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription
-
Chao, S.H.; Greenleaf, A.L.; Price, D.H. Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. Nucleic Acids Res., 2001, 29(3), 767-773.
-
(2001)
Nucleic Acids Res
, vol.29
, Issue.3
, pp. 767-773
-
-
Chao, S.H.1
Greenleaf, A.L.2
Price, D.H.3
-
46
-
-
77949742297
-
The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1
-
Khanal, P.; Namgoong, G.M.; Kang, B.S.; Woo, E.R.; Choi, H.S. The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1. Mol. Cancer Ther., 2010, 9(3), 606-616.
-
(2010)
Mol. Cancer Ther
, vol.9
, Issue.3
, pp. 606-616
-
-
Khanal, P.1
Namgoong, G.M.2
Kang, B.S.3
Woo, E.R.4
Choi, H.S.5
-
47
-
-
77956184488
-
Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway
-
Xu, H.L.; Yu, X.F.; Qu, S.C.; Zhang, R.; Qu, X.R.; Chen, Y.P.; Ma, X.Y.; Sui, D.Y. Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway. Eur. J. Pharmacol., 2010, 645(1-3), 14-22.
-
(2010)
Eur. J. Pharmacol
, vol.645
, Issue.1-3
, pp. 14-22
-
-
Xu, H.L.1
Yu, X.F.2
Qu, S.C.3
Zhang, R.4
Qu, X.R.5
Chen, Y.P.6
Ma, X.Y.7
Sui, D.Y.8
-
48
-
-
77950057491
-
Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol
-
Bonifazi, E.L.; Rios-Luci, C.; Leon, L.G.; Burton, G.; Padron, J.M.; Misico, R.I. Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol. Bioorg. Med. Chem., 2010, 18(7), 2621-2630.
-
(2010)
Bioorg. Med. Chem
, vol.18
, Issue.7
, pp. 2621-2630
-
-
Bonifazi, E.L.1
Rios-Luci, C.2
Leon, L.G.3
Burton, G.4
Padron, J.M.5
Misico, R.I.6
-
49
-
-
34548266265
-
Lapachol: An overview
-
Hussain, H.; Krohn, K.; Ahmad, V.U.; Miana, G.A.; Green, I.R. Lapachol: an overview. Arkivoc, 2007, 2, 145-171.
-
(2007)
Arkivoc
, vol.2
, pp. 145-171
-
-
Hussain, H.1
Krohn, K.2
Ahmad, V.U.3
Miana, G.A.4
Green, I.R.5
-
50
-
-
77951898596
-
Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice
-
Medeiros, C.S.; Pontes-Filho, N.T.; Camara, C.A.; Lima-Filho, J.V.; Oliveira, P.C.; Lemos, S.A.; Leal, A.F.; Brandao, J.O.; Neves, R.P. Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice. Braz. J. Med. Biol. Res., 2010, 43(4), 345-349.
-
(2010)
Braz. J. Med. Biol. Res
, vol.43
, Issue.4
, pp. 345-349
-
-
Medeiros, C.S.1
Pontes-Filho, N.T.2
Camara, C.A.3
Lima-Filho, J.V.4
Oliveira, P.C.5
Lemos, S.A.6
Leal, A.F.7
Brandao, J.O.8
Neves, R.P.9
-
51
-
-
0021835907
-
Effects of beta-lapachone, a peroxide-generating quinone, on macromolecule synthesis and degradation in Trypanosoma cruzi
-
Goijman, S.G.; Stoppani, A.O. Effects of beta-lapachone, a peroxide-generating quinone, on macromolecule synthesis and degradation in Trypanosoma cruzi. Arch. Biochem. Biophys., 1985, 240(1), 273-280.
-
(1985)
Arch. Biochem. Biophys
, vol.240
, Issue.1
, pp. 273-280
-
-
Goijman, S.G.1
Stoppani, A.O.2
-
52
-
-
0018131050
-
Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria
-
Cruz, F.S.; Docampo, R.; Boveris, A. Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria. Antimicrob. Agents Chemother., 1978, 14(4), 630-633.
-
(1978)
Antimicrob. Agents Chemother
, vol.14
, Issue.4
, pp. 630-633
-
-
Cruz, F.S.1
Docampo, R.2
Boveris, A.3
-
53
-
-
0344406759
-
Selective killing of cancer cells by beta-lapachone: Direct checkpoint activation as a strategy against cancer
-
Li, Y.; Sun, X.; LaMont, J.T.; Pardee, A.B.; Li, C.J. Selective killing of cancer cells by beta-lapachone: direct checkpoint activation as a strategy against cancer. Proc. Natl. Acad. Sci. USA, 2003, 100(5), 2674-2678.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, Issue.5
, pp. 2674-2678
-
-
Li, Y.1
Sun, X.2
Lamont, J.T.3
Pardee, A.B.4
Li, C.J.5
-
54
-
-
0033539487
-
Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: Combining drugs imposes different artificial checkpoints
-
Li, C.J.; Li, Y.Z.; Pinto, A.V.; Pardee, A.B. Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: combining drugs imposes different artificial checkpoints. Proc. Natl. Acad. Sci. USA, 1999, 96(23), 13369-13374.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, Issue.23
, pp. 13369-13374
-
-
Li, C.J.1
Li, Y.Z.2
Pinto, A.V.3
Pardee, A.B.4
-
55
-
-
58849156956
-
Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapy
-
Dong, Y.; Chin, S.F.; Blanco, E.; Bey, E.A.; Kabbani, W.; Xie, X.J.; Bornmann, W.G.; Boothman, D.A.; Gao, J. Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapy. Clin. Cancer Res., 2009, 15(1), 131-139.
-
(2009)
Clin. Cancer Res
, vol.15
, Issue.1
, pp. 131-139
-
-
Dong, Y.1
Chin, S.F.2
Blanco, E.3
Bey, E.A.4
Kabbani, W.5
Xie, X.J.6
Bornmann, W.G.7
Boothman, D.A.8
Gao, J.9
-
56
-
-
33646439242
-
Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro
-
Suzuki, M.; Amano, M.; Choi, J.; Park, H.J.; Williams, B.W.; Ono, K.; Song, C.W. Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro. Radiat. Res., 2006, 165(5), 525-531.
-
(2006)
Radiat. Res
, vol.165
, Issue.5
, pp. 525-531
-
-
Suzuki, M.1
Amano, M.2
Choi, J.3
Park, H.J.4
Williams, B.W.5
Ono, K.6
Song, C.W.7
-
57
-
-
60149091195
-
In vitro metabolism of beta-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells
-
Miao, X.S.; Zhong, C.; Wang, Y.; Savage, R.E.; Yang, R.Y.; Kizer, D.; Volckova, E.; Ashwell, M.A.; Chan, T.C. In vitro metabolism of beta-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells. Rapid Commun. Mass Sp., 2009, 23(1), 12-22.
-
(2009)
Rapid Commun. Mass Sp
, vol.23
, Issue.1
, pp. 12-22
-
-
Miao, X.S.1
Zhong, C.2
Wang, Y.3
Savage, R.E.4
Yang, R.Y.5
Kizer, D.6
Volckova, E.7
Ashwell, M.A.8
Chan, T.C.9
-
58
-
-
0027377069
-
Beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin
-
Li, C.J.; Averboukh, L.; Pardee, A.B. Beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J. Biol. Chem., 1993, 268(30), 22463-22468.
-
(1993)
J. Biol. Chem
, vol.268
, Issue.30
, pp. 22463-22468
-
-
Li, C.J.1
Averboukh, L.2
Pardee, A.B.3
-
59
-
-
17544391279
-
Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones
-
Frydman, B.; Marton, L.J.; Sun, J.S.; Neder, K.; Witiak, D.T.; Liu, A.A.; Wang, H.M.; Mao, Y.; Wu, H.Y.; Sanders, M.M.; Liu, L.F. Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones. Cancer Res., 1997, 57(4), 620-627.
-
(1997)
Cancer Res
, vol.57
, Issue.4
, pp. 620-627
-
-
Frydman, B.1
Marton, L.J.2
Sun, J.S.3
Neder, K.4
Witiak, D.T.5
Liu, A.A.6
Wang, H.M.7
Mao, Y.8
Wu, H.Y.9
Sanders, M.M.10
Liu, L.F.11
-
60
-
-
0017803823
-
Beta-lapachone, an inhibitor of oncornavirus reverse transcriptase and eukaryotic DNA polymerase-alpha. Inhibitory effect, thiol dependence and specificity
-
Schuerch, A.R.; Wehrli, W. Beta-lapachone, an inhibitor of oncornavirus reverse transcriptase and eukaryotic DNA polymerase-alpha. Inhibitory effect, thiol dependence and specificity. Eur. J. Biochem., 1978, 84(1), 197-205.
-
(1978)
Eur. J. Biochem
, vol.84
, Issue.1
, pp. 197-205
-
-
Schuerch, A.R.1
Wehrli, W.2
-
61
-
-
58149140268
-
Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis
-
Lien, Y.C.; Kung, H.N.; Lu, K.S.; Jeng, C.J.; Chau, Y.P. Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis. Histol. Histopathol., 2008, 23(11), 1299-1308.
-
(2008)
Histol. Histopathol
, vol.23
, Issue.11
, pp. 1299-1308
-
-
Lien, Y.C.1
Kung, H.N.2
Lu, K.S.3
Jeng, C.J.4
Chau, Y.P.5
-
62
-
-
0038398904
-
Phosphorylation of p53, induction of Bax and activation of caspases during beta-lapachone-mediated apoptosis in human prostate epithelial cells
-
Choi, Y.H.; Kim, M.J.; Lee, S.Y.; Lee, Y.N.; Chi, G.Y.; Eom, H.S.; Kim, N.D.; Choi, B.T. Phosphorylation of p53, induction of Bax and activation of caspases during beta-lapachone-mediated apoptosis in human prostate epithelial cells. Int. J. Oncol., 2002, 21(6), 1293-1299.
-
(2002)
Int. J. Oncol
, vol.21
, Issue.6
, pp. 1293-1299
-
-
Choi, Y.H.1
Kim, M.J.2
Lee, S.Y.3
Lee, Y.N.4
Chi, G.Y.5
Eom, H.S.6
Kim, N.D.7
Choi, B.T.8
-
63
-
-
0034009970
-
NAD(P)H: Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity
-
Pink, J.J.; Planchon, S.M.; Tagliarino, C.; Varnes, M.E.; Siegel, D.; Boothman, D.A. NAD(P)H: quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J. Biol. Chem., 2000, 275(8), 5416-5424.
-
(2000)
J. Biol. Chem
, vol.275
, Issue.8
, pp. 5416-5424
-
-
Pink, J.J.1
Planchon, S.M.2
Tagliarino, C.3
Varnes, M.E.4
Siegel, D.5
Boothman, D.A.6
-
64
-
-
0035374621
-
Calcium is a key signaling molecule in beta-lapachone-mediated cell death
-
Tagliarino, C.; Pink, J.J.; Dubyak, G.R.; Nieminen, A.L.; Boothman, D.A. Calcium is a key signaling molecule in beta-lapachone-mediated cell death. J. Biol. Chem., 2001, 276(22), 19150-19159.
-
(2001)
J. Biol. Chem
, vol.276
, Issue.22
, pp. 19150-19159
-
-
Tagliarino, C.1
Pink, J.J.2
Dubyak, G.R.3
Nieminen, A.L.4
Boothman, D.A.5
-
65
-
-
79251495155
-
Hyperthermia enhances the effect of beta-lapachone to cause gammaH2AX formations and cell death in human osteosarcoma cells
-
Hori, T.; Kondo, T.; Lee, H.; Song, C.W.; Park, H.J. Hyperthermia enhances the effect of beta-lapachone to cause gammaH2AX formations and cell death in human osteosarcoma cells. Int. J. Hyperthermia., 2011, 27, (1), 53-62.
-
(2011)
Int. J. Hyperthermia
, vol.27
, Issue.1
, pp. 53-62
-
-
Hori, T.1
Kondo, T.2
Lee, H.3
Song, C.W.4
Park, H.J.5
-
66
-
-
34547125117
-
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone
-
Bentle, M.S.; Reinicke, K.E.; Dong, Y.; Bey, E.A.; Boothman, D.A. Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone. Cancer Res., 2007, 67(14), 6936-6945.
-
(2007)
Cancer Res
, vol.67
, Issue.14
, pp. 6936-6945
-
-
Bentle, M.S.1
Reinicke, K.E.2
Dong, Y.3
Bey, E.A.4
Boothman, D.A.5
-
67
-
-
77953520689
-
Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB
-
Dong, G.Z.; Oh, E.T.; Lee, H.; Park, M.T.; Song, C.W.; Park, H.J. Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB. Exp. Mol. Med., 2010, 42, (5), 327-334.
-
(2010)
Exp. Mol. Med
, vol.42
, Issue.5
, pp. 327-334
-
-
Dong, G.Z.1
Oh, E.T.2
Lee, H.3
Park, M.T.4
Song, C.W.5
Park, H.J.6
-
68
-
-
84863987739
-
Recognition and evaluation of lapachol as an antitumor agent
-
Rao, K.V.; McBride, T.J.; Oleson, J.J. Recognition and evaluation of lapachol as an antitumor agent. Cancer Res., 1968, 28(10), 1952-1954.
-
(1968)
Cancer Res
, vol.28
, Issue.10
, pp. 1952-1954
-
-
Rao, K.V.1
McBride, T.J.2
Oleson, J.J.3
-
69
-
-
77953813028
-
Preclinical and Clinical Studies of Lapachol and Beta-Lapachone
-
Almeida, E.R.D. Preclinical and Clinical Studies of Lapachol and Beta-Lapachone. Open Nat. Prod. J., 2009, 2, 42-47.
-
(2009)
Open Nat. Prod. J
, vol.2
, pp. 42-47
-
-
Almeida, E.R.D.1
-
70
-
-
0348232355
-
Distribution of plumbagin in the mplumbaginaceae
-
L.M, v.d.V
-
L.M, v.d.V. Distribution of plumbagin in the mplumbaginaceae. Phytochemistry, 1972, 11(11), 3247-3248.
-
(1972)
Phytochemistry
, vol.11
, Issue.11
, pp. 3247-3248
-
-
-
71
-
-
78649591458
-
Anti-inflammatory and analgesic effect of plumbagin through inhibition of nuclear factor-kappaB activation
-
Luo, P.; Wong, Y.F.; Ge, L.; Zhang, Z.F.; Liu, Y.; Liu, L.; Zhou, H. Anti-inflammatory and analgesic effect of plumbagin through inhibition of nuclear factor-kappaB activation. J. Pharmacol. Exp. Ther., 2010, 335(3), 735-742.
-
(2010)
J. Pharmacol. Exp. Ther
, vol.335
, Issue.3
, pp. 735-742
-
-
Luo, P.1
Wong, Y.F.2
Ge, L.3
Zhang, Z.F.4
Liu, Y.5
Liu, L.6
Zhou, H.7
-
72
-
-
80052082287
-
Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression
-
Sun, J.; McKallip, R.J. Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression. Leuk. Res., 2011, 35(10), 1402-1408.
-
(2011)
Leuk. Res
, vol.35
, Issue.10
, pp. 1402-1408
-
-
Sun, J.1
McKallip, R.J.2
-
73
-
-
84863158729
-
Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-kappaB signaling pathway
-
Li, J.; Shen, L.; Lu, F.R.; Qin, Y.; Chen, R.; Li, Y.; Zhan, H.Z.; He, Y.Q. Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-kappaB signaling pathway. Acta. Pharmacol. Sin., 2012, 33(2), 242-249.
-
(2012)
Acta. Pharmacol. Sin
, vol.33
, Issue.2
, pp. 242-249
-
-
Li, J.1
Shen, L.2
Lu, F.R.3
Qin, Y.4
Chen, R.5
Li, Y.6
Zhan, H.Z.7
He, Y.Q.8
-
74
-
-
79955737810
-
Apoptosis inducing effect of plumbagin on colonic cancer cells depends on expression of COX-2
-
Subramaniya, B.R.; Srinivasan, G.; Sadullah, S.S.; Davis, N.; Subhadara, L.B.; Halagowder, D.; Sivasitambaram, N.D. Apoptosis inducing effect of plumbagin on colonic cancer cells depends on expression of COX-2. PLoS One, 2011, 6(4), e18695.
-
(2011)
PLoS One
, vol.6
, Issue.4
-
-
Subramaniya, B.R.1
Srinivasan, G.2
Sadullah, S.S.3
Davis, N.4
Subhadara, L.B.5
Halagowder, D.6
Sivasitambaram, N.D.7
-
75
-
-
0030276749
-
Niosomal plumbagin with reduced toxicity and improved anticancer activity in BALB/C mice
-
Naresh, R.A.; Udupa, N.; Devi, P.U. Niosomal plumbagin with reduced toxicity and improved anticancer activity in BALB/C mice. J. Pharm. Pharmacol., 1996, 48(11), 1128-1132.
-
(1996)
J. Pharm. Pharmacol
, vol.48
, Issue.11
, pp. 1128-1132
-
-
Naresh, R.A.1
Udupa, N.2
Devi, P.U.3
-
76
-
-
80052932440
-
Formulation of plumbagin loaded long circulating pegylated liposomes: In vivo evaluation in C57BL/6J mice bearing B16F1 melanoma
-
Kumar, M.R.; Aithal, B.K.; Udupa, N.; Reddy, M.S.; Raakesh, V.; Murthy, R.S.; Raju, D.P.; Rao, B.S. Formulation of plumbagin loaded long circulating pegylated liposomes: in vivo evaluation in C57BL/6J mice bearing B16F1 melanoma. Drug Deliv., 2011, 18(7), 511-522.
-
(2011)
Drug Deliv
, vol.18
, Issue.7
, pp. 511-522
-
-
Kumar, M.R.1
Aithal, B.K.2
Udupa, N.3
Reddy, M.S.4
Raakesh, V.5
Murthy, R.S.6
Raju, D.P.7
Rao, B.S.8
-
77
-
-
55349147671
-
Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer
-
Aziz, M.H.; Dreckschmidt, N.E.; Verma, A.K. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res., 2008, 68(21), 9024-9032.
-
(2008)
Cancer Res
, vol.68
, Issue.21
, pp. 9024-9032
-
-
Aziz, M.H.1
Dreckschmidt, N.E.2
Verma, A.K.3
-
78
-
-
84863021288
-
Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2
-
Lai, L.; Liu, J.; Zhai, D.; Lin, Q.; He, L.; Dong, Y.; Zhang, J.; Lu, B.; Chen, Y.; Yi, Z.; Liu, M. Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2. Br. J. Pharmacol., 2012, 165(4b), 1084-1096.
-
(2012)
Br. J. Pharmacol
, vol.165
, Issue.4 b
, pp. 1084-1096
-
-
Lai, L.1
Liu, J.2
Zhai, D.3
Lin, Q.4
He, L.5
Dong, Y.6
Zhang, J.7
Lu, B.8
Chen, Y.9
Yi, Z.10
Liu, M.11
-
79
-
-
0031666507
-
Effect of plumbagin on the radiation induced cytogenetic and cell cycle changes in mouse Ehrlich ascites carcinoma in vivo
-
Devi, P.U.; Rao, B.S.; Solomon, F.E. Effect of plumbagin on the radiation induced cytogenetic and cell cycle changes in mouse Ehrlich ascites carcinoma in vivo. Indian J. Exp. Biol., 1998, 36(9), 891-895.
-
(1998)
Indian J. Exp. Biol
, vol.36
, Issue.9
, pp. 891-895
-
-
Devi, P.U.1
Rao, B.S.2
Solomon, F.E.3
-
80
-
-
84855378113
-
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas
-
Sand, J.M.; Hafeez, B.B.; Jamal, M.S.; Witkowsky, O.; Siebers, E.M.; Fischer, J.; Verma, A.K. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas. Carcinogenesis, 2012, 33(1), 184-190.
-
(2012)
Carcinogenesis
, vol.33
, Issue.1
, pp. 184-190
-
-
Sand, J.M.1
Hafeez, B.B.2
Jamal, M.S.3
Witkowsky, O.4
Siebers, E.M.5
Fischer, J.6
Verma, A.K.7
-
81
-
-
33745967219
-
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo
-
Hsu, Y.L.; Cho, C.Y.; Kuo, P.L.; Huang, Y.T.; Lin, C.C. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo. J. Pharmacol. Exp. Ther., 2006, 318(2), 484-494.
-
(2006)
J. Pharmacol. Exp. Ther
, vol.318
, Issue.2
, pp. 484-494
-
-
Hsu, Y.L.1
Cho, C.Y.2
Kuo, P.L.3
Huang, Y.T.4
Lin, C.C.5
-
82
-
-
33846233374
-
Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells
-
Kuo, P.L.; Hsu, Y.L.; Cho, C.Y. Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol. Cancer Ther., 2006, 5(12), 3209-3221.
-
(2006)
Mol. Cancer Ther
, vol.5
, Issue.12
, pp. 3209-3221
-
-
Kuo, P.L.1
Hsu, Y.L.2
Cho, C.Y.3
-
83
-
-
37049005766
-
Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
-
Wang, C.C.; Chiang, Y.M.; Sung, S.C.; Hsu, Y.L.; Chang, J.K.; Kuo, P.L. Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells. Cancer Lett., 2008, 259(1), 82-98.
-
(2008)
Cancer Lett
, vol.259
, Issue.1
, pp. 82-98
-
-
Wang, C.C.1
Chiang, Y.M.2
Sung, S.C.3
Hsu, Y.L.4
Chang, J.K.5
Kuo, P.L.6
-
84
-
-
42549115710
-
Anticancer mechanism of plumbagin, a natural compound, on non-small cell lung cancer cells
-
Gomathinayagam, R.; Sowmyalakshmi, S.; Mardhatillah, F.; Kumar, R.; Akbarsha, M.A.; Damodaran, C. Anticancer mechanism of plumbagin, a natural compound, on non-small cell lung cancer cells. Anticancer Res., 2008, 28(2A), 785-792.
-
(2008)
Anticancer Res
, vol.28
, Issue.2 A
, pp. 785-792
-
-
Gomathinayagam, R.1
Sowmyalakshmi, S.2
Mardhatillah, F.3
Kumar, R.4
Akbarsha, M.A.5
Damodaran, C.6
-
85
-
-
4043159799
-
Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells
-
Srinivas, P.; Gopinath, G.; Banerji, A.; Dinakar, A.; Srinivas, G. Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells. Mol. Carcinog., 2004, 40(4), 201-211.
-
(2004)
Mol. Carcinog
, vol.40
, Issue.4
, pp. 201-211
-
-
Srinivas, P.1
Gopinath, G.2
Banerji, A.3
Dinakar, A.4
Srinivas, G.5
-
86
-
-
84855241139
-
Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells
-
Tian, L.; Yin, D.; Ren, Y.; Gong, C.; Chen, A.; Guo, F.J. Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. Mol. Med. Report., 2012, 5(1), 126-132.
-
(2012)
Mol. Med. Report
, vol.5
, Issue.1
, pp. 126-132
-
-
Tian, L.1
Yin, D.2
Ren, Y.3
Gong, C.4
Chen, A.5
Guo, F.J.6
-
87
-
-
49549083508
-
Plumbagin-induced apoptosis in human prostate cancer cells is associated with modulation of cellular redox status and generation of reactive oxygen species
-
Powolny, A.A.; Singh, S.V. Plumbagin-induced apoptosis in human prostate cancer cells is associated with modulation of cellular redox status and generation of reactive oxygen species. Pharm. Res., 2008, 25(9), 2171-2180.
-
(2008)
Pharm. Res
, vol.25
, Issue.9
, pp. 2171-2180
-
-
Powolny, A.A.1
Singh, S.V.2
-
88
-
-
77950085770
-
Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo
-
Xu, K.H.; Lu, D.P. Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo. Leuk. Res., 2010, 34(5), 658-665.
-
(2010)
Leuk. Res
, vol.34
, Issue.5
, pp. 658-665
-
-
Xu, K.H.1
Lu, D.P.2
-
89
-
-
11144322792
-
Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone
-
Ding, Y.; Chen, Z.J.; Liu, S.; Che, D.; Vetter, M.; Chang, C.H. Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone. J. Pharm. Pharmacol., 2005, 57(1), 111-116.
-
(2005)
J. Pharm. Pharmacol
, vol.57
, Issue.1
, pp. 111-116
-
-
Ding, Y.1
Chen, Z.J.2
Liu, S.3
Che, D.4
Vetter, M.5
Chang, C.H.6
-
90
-
-
34548414657
-
Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II
-
Kawiak, A.; Piosik, J.; Stasilojc, G.; Gwizdek-Wisniewska, A.; Marczak, L.; Stobiecki, M.; Bigda, J.; Lojkowska, E. Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II. Toxicol. Appl. Pharmacol., 2007, 223(3), 267-276.
-
(2007)
Toxicol. Appl. Pharmacol
, vol.223
, Issue.3
, pp. 267-276
-
-
Kawiak, A.1
Piosik, J.2
Stasilojc, G.3
Gwizdek-Wisniewska, A.4
Marczak, L.5
Stobiecki, M.6
Bigda, J.7
Lojkowska, E.8
-
91
-
-
33745220306
-
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents
-
Sandur, S.K.; Ichikawa, H.; Sethi, G.; Ahn, K.S.; Aggarwal, B.B. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. J. Biol. Chem., 2006, 281(25), 17023-17033.
-
(2006)
J. Biol. Chem
, vol.281
, Issue.25
, pp. 17023-17033
-
-
Sandur, S.K.1
Ichikawa, H.2
Sethi, G.3
Ahn, K.S.4
Aggarwal, B.B.5
-
92
-
-
80052167167
-
Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4
-
Manu, K.A.; Shanmugam, M.K.; Rajendran, P.; Li, F.; Ramachandran, L.; Hay, H.S.; Kannaiyan, R.; Swamy, S.N.; Vali, S.; Kapoor, S.; Ramesh, B.; Bist, P.; Koay, E.S.; Lim, L.H.; Ahn, K.S.; Kumar, A.P.; Sethi, G. Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4. Mol. Cancer, 2011, 10, 107.
-
(2011)
Mol. Cancer
, vol.10
, pp. 107
-
-
Manu, K.A.1
Shanmugam, M.K.2
Rajendran, P.3
Li, F.4
Ramachandran, L.5
Hay, H.S.6
Kannaiyan, R.7
Swamy, S.N.8
Vali, S.9
Kapoor, S.10
Ramesh, B.11
Bist, P.12
Koay, E.S.13
Lim, L.H.14
Ahn, K.S.15
Kumar, A.P.16
Sethi, G.17
-
93
-
-
37549017367
-
The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2
-
Shukla, S.; Wu, C.P.; Nandigama, K.; Ambudkar, S.V. The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2. Mol. Cancer Ther., 2007, 6(12 Pt 1), 3279-3286.
-
(2007)
Mol. Cancer Ther
, vol.6
, Issue.12 PT 1
, pp. 3279-3286
-
-
Shukla, S.1
Wu, C.P.2
Nandigama, K.3
Ambudkar, S.V.4
-
94
-
-
77953013923
-
Inhibition of mycobacterial growth by plumbagin derivatives
-
Mathew, R.; Kruthiventi, A.K.; Prasad, J.V.; Kumar, S.P.; Srinu, G.; Chatterji, D. Inhibition of mycobacterial growth by plumbagin derivatives. Chem. Biol. Drug Des., 2010, 76(1), 34-42.
-
(2010)
Chem. Biol. Drug Des
, vol.76
, Issue.1
, pp. 34-42
-
-
Mathew, R.1
Kruthiventi, A.K.2
Prasad, J.V.3
Kumar, S.P.4
Srinu, G.5
Chatterji, D.6
-
95
-
-
67650892417
-
Synthesis and insect antifeedant activity of plumbagin derivatives with the amino acid moiety
-
Sreelatha, T.; Hymavathi, A.; Babu, K.S.; Murthy, J.M.; Pathipati, U.R.; Rao, J.M. Synthesis and insect antifeedant activity of plumbagin derivatives with the amino acid moiety. J. Agric. Food Chem., 2009, 57(14), 6090-6094.
-
(2009)
J. Agric. Food Chem
, vol.57
, Issue.14
, pp. 6090-6094
-
-
Sreelatha, T.1
Hymavathi, A.2
Babu, K.S.3
Murthy, J.M.4
Pathipati, U.R.5
Rao, J.M.6
-
96
-
-
84859826209
-
Synthesis, characterization, molecular docking and cytotoxic activity of novel plumbagin hydrazones against breast cancer cells
-
Dandawate, P.; Khan, E.; Padhye, S.; Gaba, H.; Sinha, S.; Deshpande, J.; Venkateswara Swamy, K.; Khetmalas, M.; Ahmad, A.; Sarkar, F.H. Synthesis, characterization, molecular docking and cytotoxic activity of novel plumbagin hydrazones against breast cancer cells. Bioorg. Med. Chem. Lett., 2012, 22(9), 3104-3108.
-
(2012)
Bioorg. Med. Chem. Lett
, vol.22
, Issue.9
, pp. 3104-3108
-
-
Dandawate, P.1
Khan, E.2
Padhye, S.3
Gaba, H.4
Sinha, S.5
Deshpande, J.6
Venkateswara, S.K.7
Khetmalas, M.8
Ahmad, A.9
Sarkar, F.H.10
-
97
-
-
0035990608
-
Cellular pharmacology studies of shikonin derivatives
-
Chen, X.; Yang, L.; Oppenheim, J.J.; Howard, M.Z. Cellular pharmacology studies of shikonin derivatives. Phytother. Res., 2002, 16(3), 199-209.
-
(2002)
Phytother. Res
, vol.16
, Issue.3
, pp. 199-209
-
-
Chen, X.1
Yang, L.2
Oppenheim, J.J.3
Howard, M.Z.4
-
98
-
-
1242339613
-
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo
-
Staniforth, V.; Wang, S.Y.; Shyur, L.F.; Yang, N.S. Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. J. Biol. Chem., 2004, 279(7), 5877-5885.
-
(2004)
J. Biol. Chem
, vol.279
, Issue.7
, pp. 5877-5885
-
-
Staniforth, V.1
Wang, S.Y.2
Shyur, L.F.3
Yang, N.S.4
-
99
-
-
77955267120
-
Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity
-
Wang, Z.; Liu, T.; Gan, L.; Wang, T.; Yuan, X.; Zhang, B.; Chen, H.; Zheng, Q. Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity. Eur. J. Pharmacol., 2010, 643(2-3), 211-217.
-
(2010)
Eur. J. Pharmacol
, vol.643
, Issue.2-3
, pp. 211-217
-
-
Wang, Z.1
Liu, T.2
Gan, L.3
Wang, T.4
Yuan, X.5
Zhang, B.6
Chen, H.7
Zheng, Q.8
-
100
-
-
64249097600
-
Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo
-
Yang, H.; Zhou, P.; Huang, H.; Chen, D.; Ma, N.; Cui, Q.C.; Shen, S.; Dong, W.; Zhang, X.; Lian, W.; Wang, X.; Dou, Q.P.; Liu, J. Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. Int. J. Cancer, 2009, 124(10), 2450-2459.
-
(2009)
Int. J. Cancer
, vol.124
, Issue.10
, pp. 2450-2459
-
-
Yang, H.1
Zhou, P.2
Huang, H.3
Chen, D.4
Ma, N.5
Cui, Q.C.6
Shen, S.7
Dong, W.8
Zhang, X.9
Lian, W.10
Wang, X.11
Dou, Q.P.12
Liu, J.13
-
101
-
-
1642545128
-
Ikejima, T. p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells
-
Wu, Z.; Wu, L.; Li, L.; Tashiro, S.; Onodera, S.; Ikejima, T. p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells. J. Pharmacol. Sci., 2004, 94(2), 166-176.
-
(2004)
J. Pharmacol. Sci
, vol.94
, Issue.2
, pp. 166-176
-
-
Wu, Z.1
Wu, L.2
Li, L.3
Tashiro, S.4
Onodera, S.5
-
102
-
-
3042636192
-
Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis
-
Wu, Z.; Wu, L.J.; Li, L.H.; Tashiro, S.; Onodera, S.; Ikejima, T. Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis. J. Asian Nat. Prod. Res., 2004, 6(3), 155-166.
-
(2004)
J. Asian Nat. Prod. Res
, vol.6
, Issue.3
, pp. 155-166
-
-
Wu, Z.1
Wu, L.J.2
Li, L.H.3
Tashiro, S.4
Onodera, S.5
Ikejima, T.6
-
103
-
-
37349073187
-
Shikonin-induced apoptosis involves caspase-3 activity in a human bladder cancer cell line (T24)
-
Yeh, C.C.; Kuo, H.M.; Li, T.M.; Lin, J.P.; Yu, F.S.; Lu, H.F.; Chung, J.G.; Yang, J.S. Shikonin-induced apoptosis involves caspase-3 activity in a human bladder cancer cell line (T24). In Vivo, 2007, 21(6), 1011-1019.
-
(2007)
In Vivo
, vol.21
, Issue.6
, pp. 1011-1019
-
-
Yeh, C.C.1
Kuo, H.M.2
Li, T.M.3
Lin, J.P.4
Yu, F.S.5
Lu, H.F.6
Chung, J.G.7
Yang, J.S.8
-
104
-
-
0032796797
-
Shikonin, an ingredient of Lithospermum erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line
-
Yoon, Y.; Kim, Y.O.; Lim, N.Y.; Jeon, W.K.; Sung, H.J. Shikonin, an ingredient of Lithospermum erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line. Planta Med., 1999, 65(6), 532-535.
-
(1999)
Planta Med
, vol.65
, Issue.6
, pp. 532-535
-
-
Yoon, Y.1
Kim, Y.O.2
Lim, N.Y.3
Jeon, W.K.4
Sung, H.J.5
-
105
-
-
79953756477
-
Shikonin inhibits tumor invasion via down-regulation of NF-kappaB-mediated MMP-9 expression in human ACC-M cells
-
Min, R.; Zun, Z.; Min, Y.; Wenhu, D.; Wenjun, Y.; Chenping, Z. Shikonin inhibits tumor invasion via down-regulation of NF-kappaB-mediated MMP-9 expression in human ACC-M cells. Oral. Dis., 2011, 17(4), 362-369.
-
(2011)
Oral. Dis
, vol.17
, Issue.4
, pp. 362-369
-
-
Min, R.1
Zun, Z.2
Min, Y.3
Wenhu, D.4
Wenjun, Y.5
Chenping, Z.6
-
106
-
-
77952397814
-
Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells
-
Chang, I.C.; Huang, Y.J.; Chiang, T.I.; Yeh, C.W.; Hsu, L.S. Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells. Biol. Pharm. Bull., 2010, 33(5), 816-824.
-
(2010)
Biol. Pharm. Bull
, vol.33
, Issue.5
, pp. 816-824
-
-
Chang, I.C.1
Huang, Y.J.2
Chiang, T.I.3
Yeh, C.W.4
Hsu, L.S.5
-
107
-
-
40849147137
-
Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappaB pathway
-
Min, R.; Tong, J.; Wenjun, Y.; Wenhu, D.; Xiaojian, Z.; Jiacai, H.; Jian, Z.; Wantao, C.; Chenping, Z. Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappaB pathway. Phytother. Res., 2008, 22(3), 407-415.
-
(2008)
Phytother. Res
, vol.22
, Issue.3
, pp. 407-415
-
-
Min, R.1
Tong, J.2
Wenjun, Y.3
Wenhu, D.4
Xiaojian, Z.5
Jiacai, H.6
Jian, Z.7
Wantao, C.8
Chenping, Z.9
-
108
-
-
0026458552
-
Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikonin
-
Fujii, N.; Yamashita, Y.; Arima, Y.; Nagashima, M.; Nakano, H. Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikonin. Antimicrob. Agents Chemother., 1992, 36(12), 2589-2594.
-
(1992)
Antimicrob. Agents Chemother
, vol.36
, Issue.12
, pp. 2589-2594
-
-
Fujii, N.1
Yamashita, Y.2
Arima, Y.3
Nagashima, M.4
Nakano, H.5
-
109
-
-
33746377985
-
SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor
-
Yang, F.; Chen, Y.; Duan, W.; Zhang, C.; Zhu, H.; Ding, J. SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor. Int. J. Cancer, 2006, 119(5), 1184-1193.
-
(2006)
Int. J. Cancer
, vol.119
, Issue.5
, pp. 1184-1193
-
-
Yang, F.1
Chen, Y.2
Duan, W.3
Zhang, C.4
Zhu, H.5
Ding, J.6
-
110
-
-
77951297556
-
A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells
-
Yao, Y.; Zhou, Q. A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells. Breast Cancer Res. Tr., 2010, 121(1), 233-240.
-
(2010)
Breast Cancer Res. Tr
, vol.121
, Issue.1
, pp. 233-240
-
-
Yao, Y.1
Zhou, Q.2
-
111
-
-
69049111714
-
Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells
-
Zhang, Y.; Qian, R.Q.; Li, P.P. Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells. Cancer Lett., 2009, 284(1), 47-54.
-
(2009)
Cancer Lett
, vol.284
, Issue.1
, pp. 47-54
-
-
Zhang, Y.1
Qian, R.Q.2
Li, P.P.3
-
112
-
-
80054883247
-
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
-
Chen, J.; Xie, J.; Jiang, Z.; Wang, B.; Wang, Y.; Hu, X. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene, 2011, 30(42), 4297-4306.
-
(2011)
Oncogene
, vol.30
, Issue.42
, pp. 4297-4306
-
-
Chen, J.1
Xie, J.2
Jiang, Z.3
Wang, B.4
Wang, Y.5
Hu, X.6
-
113
-
-
80052939147
-
Synthesis and antitumour activity of beta-hydroxyisovalerylshikonin analogs
-
Rao, Z.; Liu, X.; Zhou, W.; Yi, J.; Li, S.S. Synthesis and antitumour activity of beta-hydroxyisovalerylshikonin analogs. Eur. J. Med. Chem., 2011, 46(9), 3934-3941.
-
(2011)
Eur. J. Med. Chem
, vol.46
, Issue.9
, pp. 3934-3941
-
-
Rao, Z.1
Liu, X.2
Zhou, W.3
Yi, J.4
Li, S.S.5
-
114
-
-
84859883498
-
Inhibitory effects of beta,beta-dimethylacrylshikonin on hepatocellular carcinoma in vitro and in vivo
-
Wu, Y.Y.; Wan, L.H.; Zheng, X.W.; Shao, Z.J.; Chen, J.; Chen, X.J.; Liu, L.T.; Kuang, W.J.; Tan, X.S.; Zhou, L.M. Inhibitory effects of beta,beta-dimethylacrylshikonin on hepatocellular carcinoma in vitro and in vivo. Phytother. Res., 2012, 26(5), 764-771.
-
(2012)
Phytother. Res
, vol.26
, Issue.5
, pp. 764-771
-
-
Wu, Y.Y.1
Wan, L.H.2
Zheng, X.W.3
Shao, Z.J.4
Chen, J.5
Chen, X.J.6
Liu, L.T.7
Kuang, W.J.8
Tan, X.S.9
Zhou, L.M.10
-
115
-
-
84861561453
-
Naphthoquinones from Onosma paniculata Induce Cell-Cycle Arrest and Apoptosis in Melanoma Cells
-
Kretschmer, N.; Rinner, B.; Deutsch, A.J.; Lohberger, B.; Knausz, H.; Kunert, O.; Blunder, M.; Boechzelt, H.; Schaider, H.; Bauer, R. Naphthoquinones from Onosma paniculata Induce Cell-Cycle Arrest and Apoptosis in Melanoma Cells. J. Nat. Prod., 2012, 75(5), 865-869.
-
(2012)
J. Nat. Prod
, vol.75
, Issue.5
, pp. 865-869
-
-
Kretschmer, N.1
Rinner, B.2
Deutsch, A.J.3
Lohberger, B.4
Knausz, H.5
Kunert, O.6
Blunder, M.7
Boechzelt, H.8
Schaider, H.9
Bauer, R.10
-
116
-
-
58149316180
-
Naturally-occurring shikonin analogs--a class of necroptotic inducers that circumvent cancer drug resistance
-
Xuan, Y.; Hu, X. Naturally-occurring shikonin analogs--a class of necroptotic inducers that circumvent cancer drug resistance. Cancer Lett., 2009, 274(2), 233-242.
-
(2009)
Cancer Lett
, vol.274
, Issue.2
, pp. 233-242
-
-
Xuan, Y.1
Hu, X.2
-
117
-
-
58549114409
-
Mechanism of inhibition of tumor angiogenesis by beta-hydroxyisovalerylshikonin
-
Komi, Y.; Suzuki, Y.; Shimamura, M.; Kajimoto, S.; Nakajo, S.; Masuda, M.; Shibuya, M.; Itabe, H.; Shimokado, K.; Oettgen, P.; Nakaya, K.; Kojima, S. Mechanism of inhibition of tumor angiogenesis by beta-hydroxyisovalerylshikonin. Cancer Sci., 2009, 100(2), 269-277.
-
(2009)
Cancer Sci
, vol.100
, Issue.2
, pp. 269-277
-
-
Komi, Y.1
Suzuki, Y.2
Shimamura, M.3
Kajimoto, S.4
Nakajo, S.5
Masuda, M.6
Shibuya, M.7
Itabe, H.8
Shimokado, K.9
Oettgen, P.10
Nakaya, K.11
Kojima, S.12
-
118
-
-
67650466020
-
Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
-
Banerjee, S.; Kaseb, A.O.; Wang, Z.; Kong, D.; Mohammad, M.; Padhye, S.; Sarkar, F.H.; Mohammad, R.M. Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res., 2009, 69(13), 5575-5583.
-
(2009)
Cancer Res
, vol.69
, Issue.13
, pp. 5575-5583
-
-
Banerjee, S.1
Kaseb, A.O.2
Wang, Z.3
Kong, D.4
Mohammad, M.5
Padhye, S.6
Sarkar, F.H.7
Mohammad, R.M.8
-
119
-
-
77957377544
-
Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling
-
Sayed-Ahmed, M.M.; Aleisa, A.M.; Al-Rejaie, S.S.; Al-Yahya, A.A.; Al-Shabanah, O.A.; Hafez, M.M.; Nagi, M.N. Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling. Oxid. Med. Cell Longev., 2010, 3(4), 254-261.
-
(2010)
Oxid. Med. Cell Longev
, vol.3
, Issue.4
, pp. 254-261
-
-
Sayed-Ahmed, M.M.1
Aleisa, A.M.2
Al-Rejaie, S.S.3
Al-Yahya, A.A.4
Al-Shabanah, O.A.5
Hafez, M.M.6
Nagi, M.N.7
-
120
-
-
70349528180
-
Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells
-
Chehl, N.; Chipitsyna, G.; Gong, Q.; Yeo, C.J.; Arafat, H.A. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB, 2009, 11(5), 373-381.
-
(2009)
HPB
, vol.11
, Issue.5
, pp. 373-381
-
-
Chehl, N.1
Chipitsyna, G.2
Gong, Q.3
Yeo, C.J.4
Arafat, H.A.5
-
121
-
-
26444457920
-
Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
-
El-Mahdy, M.A.; Zhu, Q.; Wang, Q.E.; Wani, G.; Wani, A.A. Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int. J. Cancer, 2005, 117(3), 409-417.
-
(2005)
Int. J. Cancer
, vol.117
, Issue.3
, pp. 409-417
-
-
El-Mahdy, M.A.1
Zhu, Q.2
Wang, Q.E.3
Wani, G.4
Wani, A.A.5
-
122
-
-
77949263613
-
Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling
-
El-Najjar, N.; Chatila, M.; Moukadem, H.; Vuorela, H.; Ocker, M.; Gandesiri, M.; Schneider-Stock, R.; Gali-Muhtasib, H. Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling. Apoptosis, 2010, 15(2), 183-195.
-
(2010)
Apoptosis
, vol.15
, Issue.2
, pp. 183-195
-
-
El-Najjar, N.1
Chatila, M.2
Moukadem, H.3
Vuorela, H.4
Ocker, M.5
Gandesiri, M.6
Schneider-Stock, R.7
Gali-Muhtasib, H.8
-
123
-
-
84888034888
-
Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation
-
Epub ahead of print
-
Kolli-Bouhafs, K.; Boukhari, A.; Abusnina, A.; Velot, E.; Gies, J.P.; Lugnier, C.; Ronde, P. Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation. Invest. New Drugs, 2011, [Epub ahead of print]
-
(2011)
Invest. New Drugs
-
-
Kolli-Bouhafs, K.1
Boukhari, A.2
Abusnina, A.3
Velot, E.4
Gies, J.P.5
Lugnier, C.6
Ronde, P.7
-
124
-
-
34548015409
-
Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer
-
Kaseb, A.O.; Chinnakannu, K.; Chen, D.; Sivanandam, A.; Tejwani, S.; Menon, M.; Dou, Q.P.; Reddy, G.P. Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer. Cancer Res., 2007, 67(16), 7782-7788.
-
(2007)
Cancer Res
, vol.67
, Issue.16
, pp. 7782-7788
-
-
Kaseb, A.O.1
Chinnakannu, K.2
Chen, D.3
Sivanandam, A.4
Tejwani, S.5
Menon, M.6
Dou, Q.P.7
Reddy, G.P.8
-
125
-
-
77954039888
-
Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo
-
Jafri, S.H.; Glass, J.; Shi, R.; Zhang, S.; Prince, M.; Kleiner-Hancock, H. Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo. J. Exp. Clin. Cancer Res., 2010, 29, 87.
-
(2010)
J. Exp. Clin. Cancer Res
, vol.29
, pp. 87
-
-
Jafri, S.H.1
Glass, J.2
Shi, R.3
Zhang, S.4
Prince, M.5
Kleiner-Hancock, H.6
-
126
-
-
48649088554
-
Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells
-
Gali-Muhtasib, H.; Kuester, D.; Mawrin, C.; Bajbouj, K.; Diestel, A.; Ocker, M.; Habold, C.; Foltzer-Jourdainne, C.; Schoenfeld, P.; Peters, B.; Diab-Assaf, M.; Pommrich, U.; Itani, W.; Lippert, H.; Roessner, A.; Schneider-Stock, R. Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer Res., 2008, 68(14), 5609-5618.
-
(2008)
Cancer Res
, vol.68
, Issue.14
, pp. 5609-5618
-
-
Gali-Muhtasib, H.1
Kuester, D.2
Mawrin, C.3
Bajbouj, K.4
Diestel, A.5
Ocker, M.6
Habold, C.7
Foltzer-Jourdainne, C.8
Schoenfeld, P.9
Peters, B.10
Diab-Assaf, M.11
Pommrich, U.12
Itani, W.13
Lippert, H.14
Roessner, A.15
Schneider-Stock, R.16
-
127
-
-
78650420222
-
Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
-
Arafa el, S.A.; Zhu, Q.; Shah, Z.I.; Wani, G.; Barakat, B.M.; Racoma, I.; El-Mahdy, M.A.; Wani, A.A. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutat. Res., 2011, 706(1-2), 28-35.
-
(2011)
Mutat. Res
, vol.706
, Issue.1-2
, pp. 28-35
-
-
Arafael, S.A.1
Zhu, Q.2
Shah, Z.I.3
Wani, G.4
Barakat, B.M.5
Racoma, I.6
El-Mahdy, M.A.7
Wani, A.A.8
-
128
-
-
84855839231
-
Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo
-
Lei, X.; Lv, X.; Liu, M.; Yang, Z.; Ji, M.; Guo, X.; Dong, W. Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo. Biochem. Biophys. Res. Commun., 2012, 417(2), 864-868.
-
(2012)
Biochem. Biophys. Res. Commun
, vol.417
, Issue.2
, pp. 864-868
-
-
Lei, X.1
Lv, X.2
Liu, M.3
Yang, Z.4
Ji, M.5
Guo, X.6
Dong, W.7
-
129
-
-
79960929095
-
Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-gamma pathway
-
Woo, C.C.; Loo, S.Y.; Gee, V.; Yap, C.W.; Sethi, G.; Kumar, A.P.; Tan, K.H. Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-gamma pathway. Biochem. Pharmacol., 2011, 82(5), 464-475.
-
(2011)
Biochem. Pharmacol
, vol.82
, Issue.5
, pp. 464-475
-
-
Woo, C.C.1
Loo, S.Y.2
Gee, V.3
Yap, C.W.4
Sethi, G.5
Kumar, A.P.6
Tan, K.H.7
-
130
-
-
79952446077
-
Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma
-
Hussain, A.R.; Ahmed, M.; Ahmed, S.; Manogaran, P.; Alvi, S.N.; Platanias, L.C.; Al-Kuraya, K.S.; Uddin, S. Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma. Free. Radic. Biol. Med., 2011, 50(8), 978-987.
-
(2011)
Free. Radic. Biol. Med
, vol.50
, Issue.8
, pp. 978-987
-
-
Hussain, A.R.1
Ahmed, M.2
Ahmed, S.3
Manogaran, P.4
Alvi, S.N.5
Platanias, L.C.6
Al-Kuraya, K.S.7
Uddin, S.8
-
131
-
-
83455203366
-
Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl-XL expression
-
Badr, G.; Mohany, M.; Abu-Tarboush, F. Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl-XL expression. Lipids Health Dis., 2011, 10, 236.
-
(2011)
Lipids Health Dis
, vol.10
, pp. 236
-
-
Badr, G.1
Mohany, M.2
Abu-Tarboush, F.3
-
132
-
-
50349098189
-
Targeting nuclear factor-kappa B activation pathway by thymoquinone: Role in suppression of antiapoptotic gene products and enhancement of apoptosis
-
Sethi, G.; Ahn, K.S.; Aggarwal, B.B. Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res., 2008, 6(6), 1059-1070.
-
(2008)
Mol Cancer Res
, vol.6
, Issue.6
, pp. 1059-1070
-
-
Sethi, G.1
Ahn, K.S.2
Aggarwal, B.B.3
-
133
-
-
43149093993
-
Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions
-
Reindl, W.; Yuan, J.; Kramer, A.; Strebhardt, K.; Berg, T. Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Chem. Biol., 2008, 15(5), 459-466.
-
(2008)
Chem. Biol
, vol.15
, Issue.5
, pp. 459-466
-
-
Reindl, W.1
Yuan, J.2
Kramer, A.3
Strebhardt, K.4
Berg, T.5
-
134
-
-
84867890420
-
Anti-neoplastic agent thymoquinone induces degradation of alpha and beta tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts
-
Alhosin, M.; Ibrahim, A.; Boukhari, A.; Sharif, T.; Gies, J.P.; Auger, C.; Schini-Kerth, V.B. Anti-neoplastic agent thymoquinone induces degradation of alpha and beta tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts. Invest. New Drugs, 2012, 30(5), 1813-1819.
-
(2012)
Invest. New Drugs
, vol.30
, Issue.5
, pp. 1813-1819
-
-
Alhosin, M.1
Ibrahim, A.2
Boukhari, A.3
Sharif, T.4
Gies, J.P.5
Auger, C.6
Schini-Kerth, V.B.7
-
135
-
-
77649191011
-
Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1
-
Alhosin, M.; Abusnina, A.; Achour, M.; Sharif, T.; Muller, C.; Peluso, J.; Chataigneau, T.; Lugnier, C.; Schini-Kerth, V.B.; Bronner, C.; Fuhrmann, G. Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1. Biochem Pharmacol., 2010, 79(9), 1251-1260.
-
(2010)
Biochem Pharmacol
, vol.79
, Issue.9
, pp. 1251-1260
-
-
Alhosin, M.1
Abusnina, A.2
Achour, M.3
Sharif, T.4
Muller, C.5
Peluso, J.6
Chataigneau, T.7
Lugnier, C.8
Schini-Kerth, V.B.9
Bronner, C.10
Fuhrmann, G.11
-
136
-
-
77957913537
-
Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells
-
Gurung, R.L.; Lim, S.N.; Khaw, A.K.; Soon, J.F.; Shenoy, K.; Mohamed Ali, S.; Jayapal, M.; Sethu, S.; Baskar, R.; Hande, M.P. Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells. PLoS One, 2010, 5(8), e12124.
-
(2010)
PLoS One
, vol.5
, Issue.8
-
-
Gurung, R.L.1
Lim, S.N.2
Khaw, A.K.3
Soon, J.F.4
Shenoy, K.5
Mohamed, A.S.6
Jayapal, M.7
Sethu, S.8
Baskar, R.9
Hande, M.P.10
-
137
-
-
80052346775
-
Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis
-
Badr, G.; Lefevre, E.A.; Mohany, M. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. PLoS One, 2011, 6(9), e23741.
-
(2011)
PLoS One
, vol.6
, Issue.9
-
-
Badr, G.1
Lefevre, E.A.2
Mohany, M.3
-
138
-
-
77953180751
-
Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer
-
Banerjee, S.; Azmi, A.S.; Padhye, S.; Singh, M.W.; Baruah, J.B.; Philip, P.A.; Sarkar, F.H.; Mohammad, R.M. Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer. Pharm. Res., 2010, 27(6), 1146-1158.
-
(2010)
Pharm. Res
, vol.27
, Issue.6
, pp. 1146-1158
-
-
Banerjee, S.1
Azmi, A.S.2
Padhye, S.3
Singh, M.W.4
Baruah, J.B.5
Philip, P.A.6
Sarkar, F.H.7
Mohammad, R.M.8
-
139
-
-
67651083705
-
Effects of thymoquinone-fatty acid conjugates on cancer cells
-
Breyer, S.; Effenberger, K.; Schobert, R. Effects of thymoquinone-fatty acid conjugates on cancer cells. ChemMedChem, 2009, 4(5), 761-768.
-
(2009)
ChemMedChem
, vol.4
, Issue.5
, pp. 761-768
-
-
Breyer, S.1
Effenberger, K.2
Schobert, R.3
-
140
-
-
0020634673
-
The mechanism of action of quinone antibiotics
-
Lown, J.W. The mechanism of action of quinone antibiotics. Mol. Cell. Biochem., 1983, 55(1), 17-40.
-
(1983)
Mol. Cell. Biochem
, vol.55
, Issue.1
, pp. 17-40
-
-
Lown, J.W.1
-
141
-
-
34548448874
-
Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation
-
Meng, L.H.; Ding, J. Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation. Acta. Pharmacol. Sin., 2007, 28(9), 1460-1465.
-
(2007)
Acta. Pharmacol. Sin
, vol.28
, Issue.9
, pp. 1460-1465
-
-
Meng, L.H.1
Ding, J.2
-
142
-
-
40349094835
-
Salvicine inactivates beta 1 integrin and inhibits adhesion of MDA-MB-435 cells to fibronectin via reactive oxygen species signaling
-
Zhou, J.; Chen, Y.; Lang, J.Y.; Lu, J.J.; Ding, J. Salvicine inactivates beta 1 integrin and inhibits adhesion of MDA-MB-435 cells to fibronectin via reactive oxygen species signaling. Mol. Cancer Res., 2008, 6(2), 194-204.
-
(2008)
Mol. Cancer Res
, vol.6
, Issue.2
, pp. 194-204
-
-
Zhou, J.1
Chen, Y.2
Lang, J.Y.3
Lu, J.J.4
Ding, J.5
-
143
-
-
42549144022
-
Reactive oxygen species contribute to cell killing and P-glycoprotein downregulation by salvicine in multidrug resistant K562/A02 cells
-
Cai, Y.; Lu, J.; Miao, Z.; Lin, L.; Ding, J. Reactive oxygen species contribute to cell killing and P-glycoprotein downregulation by salvicine in multidrug resistant K562/A02 cells. Cancer Biol. Ther., 2007, 6(11), 1794-1799.
-
(2007)
Cancer Biol. Ther
, vol.6
, Issue.11
, pp. 1794-1799
-
-
Cai, Y.1
Lu, J.2
Miao, Z.3
Lin, L.4
Ding, J.5
-
144
-
-
48449089245
-
Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition
-
Cai, Y.J.; Lu, J.J.; Zhu, H.; Xie, H.; Huang, M.; Lin, L.P.; Zhang, X.W.; Ding, J. Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition. Free. Radic. Biol. Med., 2008, 45(5), 627-635.
-
(2008)
Free. Radic. Biol. Med
, vol.45
, Issue.5
, pp. 627-635
-
-
Cai, Y.J.1
Lu, J.J.2
Zhu, H.3
Xie, H.4
Huang, M.5
Lin, L.P.6
Zhang, X.W.7
Ding, J.8
-
145
-
-
0035916938
-
Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation
-
Wang, H.; Mao, Y.; Chen, A.Y.; Zhou, N.; LaVoie, E.J.; Liu, L.F. Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation. Biochemistry, 2001, 40(11), 3316-3323.
-
(2001)
Biochemistry
, vol.40
, Issue.11
, pp. 3316-3323
-
-
Wang, H.1
Mao, Y.2
Chen, A.Y.3
Zhou, N.4
Lavoie, E.J.5
Liu, L.F.6
-
146
-
-
84856035765
-
The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells
-
Lu, J.J.; Chen, S.M.; Zhang, X.W.; Ding, J.; Meng, L.H. The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells. Invest. New Drugs, 2011, 29(6), 1276-1283.
-
(2011)
Invest. New Drugs
, vol.29
, Issue.6
, pp. 1276-1283
-
-
Lu, J.J.1
Chen, S.M.2
Zhang, X.W.3
Ding, J.4
Meng, L.H.5
-
147
-
-
77956024383
-
Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits
-
Dudgeon, D.D.; Shinde, S.; Hua, Y.; Shun, T.Y.; Lazo, J.S.; Strock, C.J.; Giuliano, K.A.; Taylor, D.L.; Johnston, P.A.; Johnston, P.A. Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits. J. Biomol. Screen, 2010, 15(7), 766-782.
-
(2010)
J. Biomol. Screen
, vol.15
, Issue.7
, pp. 766-782
-
-
Dudgeon, D.D.1
Shinde, S.2
Hua, Y.3
Shun, T.Y.4
Lazo, J.S.5
Strock, C.J.6
Giuliano, K.A.7
Taylor, D.L.8
Johnston, P.A.9
Johnston, P.A.10
-
148
-
-
65749103049
-
Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells
-
Youns, M.; Efferth, T.; Reichling, J.; Fellenberg, K.; Bauer, A.; Hoheisel, J.D. Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells. Biochem. Pharmacol., 2009, 78(3), 273-283.
-
(2009)
Biochem. Pharmacol
, vol.78
, Issue.3
, pp. 273-283
-
-
Youns, M.1
Efferth, T.2
Reichling, J.3
Fellenberg, K.4
Bauer, A.5
Hoheisel, J.D.6
-
149
-
-
0036090986
-
Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: A possible mechanism of action
-
Mansour, M.A.; Nagi, M.N.; El-Khatib, A.S.; Al-Bekairi, A.M. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem. Funct., 2002, 20(2), 143-151.
-
(2002)
Cell Biochem. Funct
, vol.20
, Issue.2
, pp. 143-151
-
-
Mansour, M.A.1
Nagi, M.N.2
El-Khatib, A.S.3
Al-Bekairi, A.M.4
-
150
-
-
84863085673
-
Multi-target drugs: The trend of drug research and development
-
Lu, J.J.; Pan, W.; Hu, H.J.; Wang, Y.T. Multi-target drugs: The trend of drug research and development. PLoS ONE, 2012, 7(6), e40262.
-
(2012)
PLoS ONE
, vol.7
, Issue.6
-
-
Lu, J.J.1
Pan, W.2
Hu, H.J.3
Wang, Y.T.4
-
151
-
-
41549108420
-
From single- to multi-target drugs in cancer therapy: When aspecificity becomes an advantage
-
Petrelli, A.; Giordano, S. From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage. Curr. Med. Chem., 2008, 15(5), 422-432.
-
(2008)
Curr. Med. Chem
, vol.15
, Issue.5
, pp. 422-432
-
-
Petrelli, A.1
Giordano, S.2
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